{"id":"https://openalex.org/W4401872967","doi":"https://doi.org/10.1021/acs.jcim.4c01100","title":"Synergistic Antimicrobial Mechanism of the Ultrashort Antimicrobial Peptide R<sub>3</sub>W<sub>4</sub>V with a Tadpole-like Conformation","display_name":"Synergistic Antimicrobial Mechanism of the Ultrashort Antimicrobial Peptide R<sub>3</sub>W<sub>4</sub>V with a Tadpole-like Conformation","publication_year":2024,"publication_date":"2024-08-26","ids":{"openalex":"https://openalex.org/W4401872967","doi":"https://doi.org/10.1021/acs.jcim.4c01100","pmid":"https://pubmed.ncbi.nlm.nih.gov/39186796"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c01100","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01100","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046217910","display_name":"Zanxia Cao","orcid":"https://orcid.org/0000-0002-8259-0918"},"institutions":[{"id":"https://openalex.org/I4210165547","display_name":"Dezhou University","ror":"https://ror.org/05mnjs436","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165547"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zanxia Cao","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China"],"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China","institution_ids":["https://openalex.org/I4210165547","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101962621","display_name":"Zhihong Shi","orcid":"https://orcid.org/0000-0002-7665-6685"},"institutions":[{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210165547","display_name":"Dezhou University","ror":"https://ror.org/05mnjs436","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165547"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihong Shi","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China"],"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China","institution_ids":["https://openalex.org/I4210165547","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101887436","display_name":"Mingqiong Tong","orcid":"https://orcid.org/0000-0002-7052-1018"},"institutions":[{"id":"https://openalex.org/I4210165547","display_name":"Dezhou University","ror":"https://ror.org/05mnjs436","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165547"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingqiong Tong","raw_affiliation_strings":["Shandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Medicine and Nursing, Dezhou University, Dezhou 253023, China"],"affiliations":[{"raw_affiliation_string":"Shandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Medicine and Nursing, Dezhou University, Dezhou 253023, China","institution_ids":["https://openalex.org/I4210165547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112083023","display_name":"Dongying Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165547","display_name":"Dezhou University","ror":"https://ror.org/05mnjs436","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165547"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongying Yang","raw_affiliation_strings":["Shandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Medicine and Nursing, Dezhou University, Dezhou 253023, China"],"affiliations":[{"raw_affiliation_string":"Shandong Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Medicine and Nursing, Dezhou University, Dezhou 253023, China","institution_ids":["https://openalex.org/I4210165547"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100349667","display_name":"Lei Liu","orcid":"https://orcid.org/0009-0009-3953-6500"},"institutions":[{"id":"https://openalex.org/I4210165547","display_name":"Dezhou University","ror":"https://ror.org/05mnjs436","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165547"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Liu","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China"],"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China","institution_ids":["https://openalex.org/I4210165547","https://openalex.org/I4210112540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5046217910","https://openalex.org/A5100349667"],"corresponding_institution_ids":["https://openalex.org/I4210112540","https://openalex.org/I4210165547"],"apc_list":null,"apc_paid":null,"fwci":1.0527,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.76429139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"64","issue":"17","first_page":"6838","last_page":"6849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9781000018119812,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9671000242233276,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial","display_name":"Antimicrobial","score":0.8687758445739746},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"Antimicrobial peptides","score":0.8654245734214783},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.6363513469696045},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.5791142582893372},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5042833089828491},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4943275451660156},{"id":"https://openalex.org/keywords/mode-of-action","display_name":"Mode of action","score":0.4922622740268707},{"id":"https://openalex.org/keywords/multiple-drug-resistance","display_name":"Multiple drug resistance","score":0.4396587610244751},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.38115841150283813},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.364524781703949},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.3296717703342438},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.28732234239578247},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2517698407173157},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13033834099769592},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.053350210189819336}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8687758445739746},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.8654245734214783},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6363513469696045},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5791142582893372},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5042833089828491},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4943275451660156},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.4922622740268707},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4396587610244751},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.38115841150283813},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.364524781703949},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3296717703342438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28732234239578247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2517698407173157},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13033834099769592},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.053350210189819336},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.4c01100","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01100","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:39186796","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39186796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1119380218","display_name":null,"funder_award_id":"61671107","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2487995308","display_name":null,"funder_award_id":"31670727","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4440003132","display_name":null,"funder_award_id":"2023xjrc208","funder_id":"https://openalex.org/F4320323303","funder_display_name":"Dezhou University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323303","display_name":"Dezhou University","ror":"https://ror.org/05mnjs436"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1895692106","https://openalex.org/W1967612331","https://openalex.org/W1982416589","https://openalex.org/W1990771438","https://openalex.org/W2015414493","https://openalex.org/W2021520922","https://openalex.org/W2044172327","https://openalex.org/W2048359754","https://openalex.org/W2056760934","https://openalex.org/W2061910359","https://openalex.org/W2079665383","https://openalex.org/W2086468436","https://openalex.org/W2118979881","https://openalex.org/W2121654620","https://openalex.org/W2123891429","https://openalex.org/W2140660145","https://openalex.org/W2175270296","https://openalex.org/W2213936404","https://openalex.org/W2293873067","https://openalex.org/W2323907991","https://openalex.org/W2329105392","https://openalex.org/W2331802097","https://openalex.org/W2562261325","https://openalex.org/W2736423475","https://openalex.org/W2766376540","https://openalex.org/W2886166342","https://openalex.org/W2921098500","https://openalex.org/W2964183478","https://openalex.org/W3027546445","https://openalex.org/W3028133901","https://openalex.org/W3036536751","https://openalex.org/W3045949487","https://openalex.org/W3099123759","https://openalex.org/W3103156673","https://openalex.org/W3146377562","https://openalex.org/W3168907395","https://openalex.org/W3185224352","https://openalex.org/W3194188670","https://openalex.org/W3198303770","https://openalex.org/W3210890336","https://openalex.org/W4309187548","https://openalex.org/W4315782488","https://openalex.org/W4316038367","https://openalex.org/W4317504869","https://openalex.org/W4366368407","https://openalex.org/W4366767049","https://openalex.org/W4386421128","https://openalex.org/W4386483189","https://openalex.org/W4388034253","https://openalex.org/W4388791062","https://openalex.org/W4390030695","https://openalex.org/W4390563465","https://openalex.org/W4395703018"],"related_works":["https://openalex.org/W2883687614","https://openalex.org/W2314450753","https://openalex.org/W4385723643","https://openalex.org/W2396126703","https://openalex.org/W2748808403","https://openalex.org/W2124907205","https://openalex.org/W1999190022","https://openalex.org/W2016045984","https://openalex.org/W171835744","https://openalex.org/W2991156602"],"abstract_inverted_index":{"Antimicrobial":[0],"peptides":[1],"(AMPs)":[2],"are":[3],"promising":[4],"candidates":[5],"in":[6,150,157,173],"combating":[7],"multidrug-resistant":[8],"microorganisms":[9],"because":[10],"of":[11,15,40,44,55,72,106,110,153,164,206,218,223,231,244],"their":[12,53],"unique":[13],"mode":[14,105],"action.":[16],"Among":[17],"these":[18],"peptides,":[19],"ultrashort":[20],"AMPs":[21],"(USAMPs)":[22],"possess":[23],"sequences":[24],"containing":[25],"less":[26],"than":[27],"10":[28],"amino":[29],"acids":[30],"and":[31,47,91,132],"have":[32],"some":[33,207],"advantages":[34],"over":[35],"traditional":[36,111,224],"AMPs.":[37,112,225],"However,":[38],"one":[39],"the":[41,58,69,73,102,139,151,154,162,167,174,180,192,198,241,245],"main":[42],"limitations":[43],"designing":[45],"novel":[46],"highly":[48,134],"active":[49],"USAMPs":[50,238],"is":[51,61,142],"that":[52,109,212,222],"mechanism":[54,71,217,230],"action":[56,107,219],"at":[57],"molecular":[59,94],"level":[60],"not":[62],"well-known.":[63],"In":[64],"this":[65,228],"article,":[66],"we":[67,97,233],"report":[68],"antimicrobial":[70,104,229],"USAMP":[74],"verine":[75,100,140,165,213],"(R<sub>3</sub>W<sub>4</sub>V)":[76],"with":[77,122],"high":[78],"antibacterial":[79],"activity":[80],"against":[81],"<i>Escherichia":[82],"coli</i>.":[83],"Here,":[84],"by":[85,127,203,239],"using":[86],"well-tempered":[87],"bias-exchange":[88],"metadynamics":[89],"simulations":[90],"long-time":[92],"conventional":[93],"dynamics":[95],"simulations,":[96],"evaluated":[98],"whether":[99],"exhibits":[101],"same":[103],"as":[108],"The":[113,183],"single":[114],"verine-membrane":[115],"system":[116],"exhibited":[117],"a":[118,158,204,215],"relatively":[119,171,188],"flat":[120],"surface":[121],"multiple":[123],"shallow":[124],"minima":[125],"separated":[126],"very":[128,143],"small":[129],"energy":[130],"barriers":[131],"adopted":[133],"dynamic":[135],"structural":[136,242],"ensembles.":[137],"Although":[138],"sequence":[141],"short,":[144],"it":[145],"can":[146,234],"still":[147],"exist":[148],"briefly":[149],"center":[152,176],"cell":[155],"membrane":[156,175,181,186],"transmembrane":[159,168,246],"state.":[160,247],"As":[161],"concentration":[163],"increased,":[166],"conformation":[169],"was":[170],"stabilized":[172],"or":[177],"proceeded":[178],"toward":[179],"bottom.":[182],"lipid":[184,199],"bilayer":[185],"showed":[187],"large":[189],"deformation,":[190],"including":[191],"phospholipid":[193],"head":[194],"groups":[195],"embedded":[196],"inside":[197],"hydrophobic":[200],"center,":[201],"accompanied":[202],"flip-flop":[205],"lipids.":[208],"Simulation":[209],"results":[210],"indicated":[211],"has":[214],"specific":[216],"different":[220],"from":[221],"Based":[226],"on":[227],"verine,":[232],"design":[235],"new":[236],"high-potential":[237],"enhancing":[240],"stability":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-03-24T08:02:53.985720","created_date":"2025-10-10T00:00:00"}