{"id":"https://openalex.org/W4403327554","doi":"https://doi.org/10.1021/acs.jcim.4c01037","title":"Improving Predictive Efficacy for Drug Resistance in Novel HIV-1 Protease Inhibitors through Transfer Learning Mechanisms","display_name":"Improving Predictive Efficacy for Drug Resistance in Novel HIV-1 Protease Inhibitors through Transfer Learning Mechanisms","publication_year":2024,"publication_date":"2024-10-11","ids":{"openalex":"https://openalex.org/W4403327554","doi":"https://doi.org/10.1021/acs.jcim.4c01037","pmid":"https://pubmed.ncbi.nlm.nih.gov/39393002"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c01037","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01037","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034916682","display_name":"H\u00fcseyin Tun\u00e7","orcid":"https://orcid.org/0000-0001-6450-5380"},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Huseyin Tunc","raw_affiliation_strings":["Department of Biostatistics and Medical Informatics, School of Medicine, Bahcesehir University, Istanbul 34734, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Medical Informatics, School of Medicine, Bahcesehir University, Istanbul 34734, Turkey","institution_ids":["https://openalex.org/I128277893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044691366","display_name":"S\u00fcmeyye Y\u0131lmaz","orcid":"https://orcid.org/0000-0002-2482-1570"},"institutions":[{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sumeyye Yilmaz","raw_affiliation_strings":["Department of Mathematical Engineering, Istanbul Technical University, Istanbul 34469, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Engineering, Istanbul Technical University, Istanbul 34469, Turkey","institution_ids":["https://openalex.org/I48912391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066797332","display_name":"B\u00fc\u015fra Nur Darendeli-Kiraz","orcid":"https://orcid.org/0000-0001-9611-3429"},"institutions":[{"id":"https://openalex.org/I4101805","display_name":"Y\u0131ld\u0131z Technical University","ror":"https://ror.org/0547yzj13","country_code":"TR","type":"education","lineage":["https://openalex.org/I4101805"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Busra Nur Darendeli Kiraz","raw_affiliation_strings":["Department of Bioengineering, Yildiz Technical University, Istanbul 34210, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Yildiz Technical University, Istanbul 34210, Turkey","institution_ids":["https://openalex.org/I4101805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022904317","display_name":"Murat Sar\u0131","orcid":"https://orcid.org/0000-0003-0508-2917"},"institutions":[{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Murat Sari","raw_affiliation_strings":["Department of Mathematical Engineering, Istanbul Technical University, Istanbul 34469, Turkey","Istanbul Technical University TRNC Campus, Mersin 10, Famagusta 99450, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Engineering, Istanbul Technical University, Istanbul 34469, Turkey","institution_ids":["https://openalex.org/I48912391"]},{"raw_affiliation_string":"Istanbul Technical University TRNC Campus, Mersin 10, Famagusta 99450, Turkey","institution_ids":["https://openalex.org/I48912391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052756842","display_name":"Seyfullah Kotil","orcid":"https://orcid.org/0000-0002-9588-3947"},"institutions":[{"id":"https://openalex.org/I4405392","display_name":"Bo\u011fazi\u00e7i University","ror":"https://ror.org/03z9tma90","country_code":"TR","type":"education","lineage":["https://openalex.org/I4405392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seyfullah Enes Kotil","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Bogazici University, Istanbul 34342, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Bogazici University, Istanbul 34342, Turkey","institution_ids":["https://openalex.org/I4405392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057659093","display_name":"\u00d6zge \u015eensoy","orcid":"https://orcid.org/0000-0001-5950-3436"},"institutions":[{"id":"https://openalex.org/I3125470973","display_name":"Istanbul Medipol University","ror":"https://ror.org/037jwzz50","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125470973"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozge Sensoy","raw_affiliation_strings":["Graduate School of Engineering and Natural Sciences, Istanbul Medipol University, Istanbul 34810, Turkey","Regenerative and Restorative Medicine Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul 34810, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-5950-3436","affiliations":[{"raw_affiliation_string":"Graduate School of Engineering and Natural Sciences, Istanbul Medipol University, Istanbul 34810, Turkey","institution_ids":["https://openalex.org/I3125470973"]},{"raw_affiliation_string":"Regenerative and Restorative Medicine Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul 34810, Turkey","institution_ids":["https://openalex.org/I3125470973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080235407","display_name":"Serdar Durda\u011f\u0131","orcid":"https://orcid.org/0000-0002-0426-0905"},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Serdar Durdagi","raw_affiliation_strings":["Lab for Innovative Drugs (Lab4IND), Computational Drug Design Center (HITMER), Istanbul 34734, Turkey","Molecular Therapy Lab, Department of Pharmaceutical Chemistry, School of Pharmacy, Bahcesehir University, Istanbul 34353, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-0426-0905","affiliations":[{"raw_affiliation_string":"Lab for Innovative Drugs (Lab4IND), Computational Drug Design Center (HITMER), Istanbul 34734, Turkey","institution_ids":[]},{"raw_affiliation_string":"Molecular Therapy Lab, Department of Pharmaceutical Chemistry, School of Pharmacy, Bahcesehir University, Istanbul 34353, Turkey","institution_ids":["https://openalex.org/I128277893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5034916682","https://openalex.org/A5080235407"],"corresponding_institution_ids":["https://openalex.org/I128277893"],"apc_list":null,"apc_paid":null,"fwci":2.0636,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.88387919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"64","issue":"20","first_page":"7844","last_page":"7863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5470068454742432},{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.5428341627120972},{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.5253654718399048},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.49221673607826233},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.47644951939582825},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.44487258791923523},{"id":"https://openalex.org/keywords/protease-inhibitor","display_name":"Protease inhibitor (pharmacology)","score":0.4220658540725708},{"id":"https://openalex.org/keywords/transfer-of-learning","display_name":"Transfer of learning","score":0.42028310894966125},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3957037031650543},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.35728520154953003},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3450542092323303},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3414158821105957},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2692931592464447},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.2484116554260254},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2406114637851715},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.22202768921852112},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.15285459160804749},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.14438363909721375},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.13437968492507935},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12444815039634705}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5470068454742432},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5428341627120972},{"id":"https://openalex.org/C2777583353","wikidata":"https://www.wikidata.org/wiki/Q410261","display_name":"HIV-1 protease","level":4,"score":0.5253654718399048},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.49221673607826233},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.47644951939582825},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44487258791923523},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4220658540725708},{"id":"https://openalex.org/C150899416","wikidata":"https://www.wikidata.org/wiki/Q1820378","display_name":"Transfer of learning","level":2,"score":0.42028310894966125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3957037031650543},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35728520154953003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3450542092323303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3414158821105957},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2692931592464447},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2484116554260254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2406114637851715},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.22202768921852112},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.15285459160804749},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14438363909721375},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.13437968492507935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12444815039634705}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.4c01037","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01037","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:39393002","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39393002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:polen.itu.edu.tr:11527/42124","is_oa":false,"landing_page_url":"https://hdl.handle.net/11527/42124","pdf_url":null,"source":{"id":"https://openalex.org/S4306400460","display_name":"Istanbul Technical University Academic Open Archive (Istanbul Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I48912391","host_organization_name":"Istanbul Technical University","host_organization_lineage":["https://openalex.org/I48912391"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5099999904632568,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2344948925","display_name":null,"funder_award_id":"TR10/21/YEP/0133","funder_id":"https://openalex.org/F4320325521","funder_display_name":"Istanbul Kalkinma Ajansi"},{"id":"https://openalex.org/G6815651154","display_name":null,"funder_award_id":"121C523","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"},{"id":"https://openalex.org/F4320325521","display_name":"Istanbul Kalkinma Ajansi","ror":"https://ror.org/05esrfe27"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1541395592","https://openalex.org/W1643307576","https://openalex.org/W1965865659","https://openalex.org/W1977852362","https://openalex.org/W1980843502","https://openalex.org/W1981730930","https://openalex.org/W1983478747","https://openalex.org/W1988037271","https://openalex.org/W1994773651","https://openalex.org/W2014619388","https://openalex.org/W2032735163","https://openalex.org/W2075602104","https://openalex.org/W2081112743","https://openalex.org/W2087453953","https://openalex.org/W2091110992","https://openalex.org/W2092452774","https://openalex.org/W2111988768","https://openalex.org/W2116159413","https://openalex.org/W2127036814","https://openalex.org/W2128479544","https://openalex.org/W2136431383","https://openalex.org/W2140227530","https://openalex.org/W2148512505","https://openalex.org/W2165910865","https://openalex.org/W2171365066","https://openalex.org/W2190790144","https://openalex.org/W2290847742","https://openalex.org/W2295598076","https://openalex.org/W2472085920","https://openalex.org/W2507538451","https://openalex.org/W2578240541","https://openalex.org/W2606056265","https://openalex.org/W2747271593","https://openalex.org/W2897254825","https://openalex.org/W2900090807","https://openalex.org/W2901810730","https://openalex.org/W2917003203","https://openalex.org/W2950389803","https://openalex.org/W2965659495","https://openalex.org/W2966230873","https://openalex.org/W2966357564","https://openalex.org/W2980010811","https://openalex.org/W3002802682","https://openalex.org/W3007309629","https://openalex.org/W3007946879","https://openalex.org/W3009319093","https://openalex.org/W3027658738","https://openalex.org/W3033814770","https://openalex.org/W3041133507","https://openalex.org/W3042826782","https://openalex.org/W3086587857","https://openalex.org/W3094280424","https://openalex.org/W3100157108","https://openalex.org/W3115393789","https://openalex.org/W3182608959","https://openalex.org/W3191439782","https://openalex.org/W3202242963","https://openalex.org/W4213077304","https://openalex.org/W4214866973","https://openalex.org/W4220897703","https://openalex.org/W4296901958","https://openalex.org/W4297914773","https://openalex.org/W4307479771","https://openalex.org/W4313886323","https://openalex.org/W4321851522","https://openalex.org/W4328121283","https://openalex.org/W4386012079","https://openalex.org/W4390221451","https://openalex.org/W4390990872","https://openalex.org/W4391361452"],"related_works":["https://openalex.org/W2049250591","https://openalex.org/W2126525653","https://openalex.org/W2801493643","https://openalex.org/W2256372280","https://openalex.org/W4245621070","https://openalex.org/W2075748968","https://openalex.org/W1516237426","https://openalex.org/W2128025541","https://openalex.org/W1986563007","https://openalex.org/W1969009510"],"abstract_inverted_index":{"of":[0,17,46,59],"0.727":[1],"for":[2,53],"the":[3,9,26,44,57],"unseen":[4],"external":[5],"PIs.":[6],"By":[7],"comparing":[8],"DIF-based":[10],"models":[11,28,48],"with":[12],"a":[13],"null":[14],"model":[15],"consisting":[16],"isolate-fold":[18],"change":[19],"(IF)":[20],"architecture,":[21],"it":[22],"is":[23],"observed":[24],"that":[25],"DIF":[27,47],"significantly":[29],"benefit":[30],"from":[31,36],"molecular":[32],"representations.":[33],"Combined":[34],"results":[35],"various":[37],"testing":[38,50],"strategies":[39],"and":[40],"statistical":[41],"tests":[42],"confirm":[43],"effectiveness":[45],"in":[49,56],"novel":[51],"PIs":[52],"drug":[54],"resistance":[55],"presence":[58],"an":[60],"isolate.":[61]},"counts_by_year":[{"year":2025,"cited_by_count":6}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}
