{"id":"https://openalex.org/W4400283999","doi":"https://doi.org/10.1021/acs.jcim.4c00806","title":"Chemoinformatics Insights on Molecular Jackhammers and Cancer Cells","display_name":"Chemoinformatics Insights on Molecular Jackhammers and Cancer Cells","publication_year":2024,"publication_date":"2024-07-03","ids":{"openalex":"https://openalex.org/W4400283999","doi":"https://doi.org/10.1021/acs.jcim.4c00806","pmid":"https://pubmed.ncbi.nlm.nih.gov/38958581"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c00806","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c00806","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013926400","display_name":"Ciceron Ayala\u2010Orozco","orcid":"https://orcid.org/0000-0002-2574-0860"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciceron Ayala-Orozco","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":"https://orcid.org/0000-0002-2574-0860","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042785295","display_name":"Hamid Teimouri","orcid":"https://orcid.org/0000-0002-3319-1187"},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamid Teimouri","raw_affiliation_strings":["Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005, United States","Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109369402","display_name":"Angela Medvedeva","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Medvedeva","raw_affiliation_strings":["Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005, United States","Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092272529","display_name":"Bowen Li","orcid":"https://orcid.org/0000-0003-4359-1712"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bowen Li","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":"https://orcid.org/0000-0003-4359-1712","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099983046","display_name":"Alex Lathem","orcid":null},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Lathem","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438611","display_name":"Gang Li","orcid":"https://orcid.org/0000-0001-5295-7769"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Li","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040071198","display_name":"Anatoly B. Kolomeisky","orcid":"https://orcid.org/0000-0001-5677-6690"},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anatoly B. Kolomeisky","raw_affiliation_strings":["Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005, United States","Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, United States","Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":"https://orcid.org/0000-0001-5677-6690","affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056053028","display_name":"James M. Tour","orcid":"https://orcid.org/0000-0002-8479-9328"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James M. Tour","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States","Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005, United States","Department of Physics and Astronomy, Rice University, Houston, Texas 77005, United States","Rice Advanced Materials Institute, Rice University, Houston, Texas 77005, United States","Smalley-Curl Institute, Rice University, Houston, Texas 77005, United States"],"raw_orcid":"https://orcid.org/0000-0002-8479-9328","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Physics and Astronomy, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Rice Advanced Materials Institute, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Smalley-Curl Institute, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040071198","https://openalex.org/A5056053028"],"corresponding_institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"],"apc_list":null,"apc_paid":null,"fwci":1.0352,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.7794209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"64","issue":"14","first_page":"5570","last_page":"5579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9746999740600586,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.9575999975204468,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cheminformatics","display_name":"Cheminformatics","score":0.9400166273117065},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5263249278068542},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5184559226036072},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.43569493293762207},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3747844696044922},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22518372535705566},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.15456432104110718},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0808539092540741}],"concepts":[{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.9400166273117065},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5263249278068542},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5184559226036072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43569493293762207},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3747844696044922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22518372535705566},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.15456432104110718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0808539092540741}],"mesh":[{"descriptor_ui":"D000080911","descriptor_name":"Cheminformatics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000080911","descriptor_name":"Cheminformatics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000080911","descriptor_name":"Cheminformatics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.4c00806","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c00806","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:38958581","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38958581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2710006142","display_name":null,"funder_award_id":"R01 HL157714-02","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3001285880","display_name":null,"funder_award_id":"C-1559","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G448742916","display_name":null,"funder_award_id":"PHY-2019745","funder_id":"https://openalex.org/F4320336454","funder_display_name":"Division of Physics"},{"id":"https://openalex.org/G5529009873","display_name":null,"funder_award_id":"CHE-2246878","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G6029077982","display_name":null,"funder_award_id":"R01 GM 148537-02","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6423964270","display_name":null,"funder_award_id":"C-2017-20220330","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320317763","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29"},{"id":"https://openalex.org/F4320336454","display_name":"Division of Physics","ror":"https://ror.org/04ap5x931"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1487977490","https://openalex.org/W1903778810","https://openalex.org/W1970854248","https://openalex.org/W1975147762","https://openalex.org/W1981552604","https://openalex.org/W2046067887","https://openalex.org/W2046218546","https://openalex.org/W2088754604","https://openalex.org/W2100471896","https://openalex.org/W2100582970","https://openalex.org/W2102908828","https://openalex.org/W2105184616","https://openalex.org/W2108921478","https://openalex.org/W2148643283","https://openalex.org/W2171830166","https://openalex.org/W2266662601","https://openalex.org/W2269909407","https://openalex.org/W2312266417","https://openalex.org/W2487770199","https://openalex.org/W2525738616","https://openalex.org/W2766410089","https://openalex.org/W2767801660","https://openalex.org/W2777456282","https://openalex.org/W2791355014","https://openalex.org/W3000041699","https://openalex.org/W3104887532","https://openalex.org/W3119650898","https://openalex.org/W3184138602","https://openalex.org/W3201176321","https://openalex.org/W4210395111","https://openalex.org/W4224232334","https://openalex.org/W4386707959","https://openalex.org/W4389937737","https://openalex.org/W4390639839"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"One":[0],"of":[1,24,27,85,109,133,137,163],"the":[2,61,82,134,142,160],"most":[3],"challenging":[4],"tasks":[5],"in":[6,38],"modern":[7],"medicine":[8],"is":[9,34,42],"to":[10,80,98,115,147,153],"find":[11],"novel":[12],"efficient":[13],"cancer":[14,52,117],"therapeutic":[15],"methods":[16,97],"with":[17,54,77,95,112],"minimal":[18],"side":[19],"effects.":[20],"The":[21],"recent":[22],"discovery":[23],"several":[25,119],"classes":[26],"organic":[28],"molecules":[29,46,111],"known":[30,43],"as":[31],"\"molecular":[32],"jackhammers\"":[33],"a":[35,70,155],"promising":[36],"development":[37],"this":[39],"direction.":[40],"It":[41],"that":[44,72],"these":[45,110],"can":[47],"directly":[48],"target":[49],"and":[50,100,125,152],"eliminate":[51],"cells":[53],"no":[55],"impact":[56],"on":[57],"healthy":[58],"tissues.":[59],"However,":[60],"underlying":[62],"microscopic":[63,83],"picture":[64],"remains":[65],"poorly":[66],"understood.":[67],"We":[68],"present":[69],"study":[71],"utilizes":[73],"theoretical":[74,129],"analysis":[75,94,130],"together":[76],"experimental":[78],"measurements":[79],"clarify":[81],"aspects":[84],"jackhammers'":[86],"anticancer":[87,165],"activities.":[88],"Our":[89],"physical-chemical":[90,107,157],"approach":[91],"combines":[92],"statistical":[93],"chemoinformatics":[96],"design":[99,162],"optimize":[101],"molecular":[102,135],"jackhammers.":[103],"By":[104],"correlating":[105],"specific":[106],"properties":[108],"their":[113,150],"abilities":[114],"kill":[116],"cells,":[118],"important":[120],"structural":[121],"features":[122],"are":[123],"identified":[124],"discussed.":[126],"Although":[127],"our":[128],"enhances":[131],"understanding":[132],"interactions":[136],"jackhammers,":[138],"it":[139],"also":[140],"highlights":[141],"need":[143],"for":[144,159],"further":[145],"research":[146],"comprehensively":[148],"elucidate":[149],"mechanisms":[151],"develop":[154],"robust":[156],"framework":[158],"rational":[161],"targeted":[164],"drugs.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":4}],"updated_date":"2026-07-18T07:39:51.176621","created_date":"2025-10-10T00:00:00"}
