{"id":"https://openalex.org/W4399304657","doi":"https://doi.org/10.1021/acs.jcim.4c00360","title":"Anisotropic Network Analysis of Open/Closed HCN4 Channel Advocates Asymmetric Subunit Cooperativity in cAMP Modulation of Gating","display_name":"Anisotropic Network Analysis of Open/Closed HCN4 Channel Advocates Asymmetric Subunit Cooperativity in cAMP Modulation of Gating","publication_year":2024,"publication_date":"2024-06-03","ids":{"openalex":"https://openalex.org/W4399304657","doi":"https://doi.org/10.1021/acs.jcim.4c00360","pmid":"https://pubmed.ncbi.nlm.nih.gov/38830626"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.4c00360","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c00360","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11203669/pdf/ci4c00360.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037745462","display_name":"Patrick Kunzmann","orcid":"https://orcid.org/0000-0002-9756-0914"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Kunzmann","raw_affiliation_strings":["Department of Biology, Computational Biology & Simulation, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Computational Biology & Simulation, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003266213","display_name":"Jan H. Krumbach","orcid":"https://orcid.org/0009-0004-9999-7329"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan H. Krumbach","raw_affiliation_strings":["Department of Biology, Computational Biology & Simulation, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Computational Biology & Simulation, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002908284","display_name":"Andrea Saponaro","orcid":"https://orcid.org/0000-0001-5035-5174"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Saponaro","raw_affiliation_strings":["Department of Pharmacology and Biomolecular Sciences, University of Milano, via Balzaretti 9, 20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Biomolecular Sciences, University of Milano, via Balzaretti 9, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058892193","display_name":"Anna Moroni","orcid":"https://orcid.org/0000-0002-1860-406X"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Moroni","raw_affiliation_strings":["Department of Biosciences, Ion Channel Biophysics, University of Milan, via Celoria 26, 20133 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, Ion Channel Biophysics, University of Milan, via Celoria 26, 20133 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023603254","display_name":"Gerhard Thiel","orcid":"https://orcid.org/0000-0002-2335-1351"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gerhard Thiel","raw_affiliation_strings":["Centre for Synthetic Biology, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany","Department of Biology, Membrane Biophysics, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2335-1351","affiliations":[{"raw_affiliation_string":"Centre for Synthetic Biology, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]},{"raw_affiliation_string":"Department of Biology, Membrane Biophysics, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063890041","display_name":"Kay Hamacher","orcid":"https://orcid.org/0000-0002-6921-8345"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kay Hamacher","raw_affiliation_strings":["Centre for Synthetic Biology, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany","Department of Biology, Computational Biology & Simulation, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Synthetic Biology, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]},{"raw_affiliation_string":"Department of Biology, Computational Biology & Simulation, TU Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023603254","https://openalex.org/A5063890041"],"corresponding_institution_ids":["https://openalex.org/I31512782"],"apc_list":null,"apc_paid":null,"fwci":1.1912,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.76429313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"64","issue":"12","first_page":"4727","last_page":"4738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.8448308706283569},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.8297920227050781},{"id":"https://openalex.org/keywords/tetramer","display_name":"Tetramer","score":0.792117714881897},{"id":"https://openalex.org/keywords/gating","display_name":"Gating","score":0.764610767364502},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6184465289115906},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6112962961196899},{"id":"https://openalex.org/keywords/cooperative-binding","display_name":"Cooperative binding","score":0.563381016254425},{"id":"https://openalex.org/keywords/protein-subunit","display_name":"Protein subunit","score":0.5607934594154358},{"id":"https://openalex.org/keywords/hyperpolarization","display_name":"Hyperpolarization (physics)","score":0.5247958898544312},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"Transmembrane domain","score":0.4872978925704956},{"id":"https://openalex.org/keywords/nucleotide","display_name":"Nucleotide","score":0.4670768082141876},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.4663518965244293},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.4365045428276062},{"id":"https://openalex.org/keywords/hcn-channel","display_name":"HCN channel","score":0.4303951561450958},{"id":"https://openalex.org/keywords/cyclic-nucleotide-binding-domain","display_name":"Cyclic nucleotide-binding domain","score":0.42877358198165894},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.36268457770347595},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.35817545652389526},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.344421923160553},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.24613618850708008},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23962968587875366},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23146149516105652},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance-spectroscopy","display_name":"Nuclear magnetic resonance spectroscopy","score":0.14606285095214844}],"concepts":[{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.8448308706283569},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8297920227050781},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.792117714881897},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.764610767364502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6184465289115906},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6112962961196899},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.563381016254425},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5607934594154358},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.5247958898544312},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4872978925704956},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4670768082141876},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4663518965244293},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4365045428276062},{"id":"https://openalex.org/C2780965148","wikidata":"https://www.wikidata.org/wiki/Q3459035","display_name":"HCN channel","level":4,"score":0.4303951561450958},{"id":"https://openalex.org/C113027372","wikidata":"https://www.wikidata.org/wiki/Q24768350","display_name":"Cyclic nucleotide-binding domain","level":4,"score":0.42877358198165894},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36268457770347595},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.35817545652389526},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.344421923160553},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24613618850708008},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23962968587875366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23146149516105652},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.14606285095214844},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050052","descriptor_name":"TRPC Cation Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064428","descriptor_name":"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.4c00360","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c00360","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:38830626","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38830626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11203669","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11203669","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11203669/pdf/ci4c00360.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:145763","is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/145763/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artikel"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11203669","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11203669","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11203669/pdf/ci4c00360.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2344778479","display_name":null,"funder_award_id":"HA5261/6-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3623180032","display_name":null,"funder_award_id":"LFCR219CVD03","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G4632027149","display_name":null,"funder_award_id":"GGP200221","funder_id":"https://openalex.org/F4320321179","funder_display_name":"Fondazione Telethon"},{"id":"https://openalex.org/G4718224036","display_name":null,"funder_award_id":"TH558/34-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6820149244","display_name":null,"funder_award_id":"LFCR 219CVD03","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G7373368940","display_name":null,"funder_award_id":"HA561/6-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320309883","display_name":"Foundation for Cardiovascular Research","ror":null},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320321179","display_name":"Fondazione Telethon","ror":"https://ror.org/04xraxn18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399304657.pdf","grobid_xml":"https://content.openalex.org/works/W4399304657.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W15000766","https://openalex.org/W1607931568","https://openalex.org/W1666222727","https://openalex.org/W1974511160","https://openalex.org/W1986743126","https://openalex.org/W1987774535","https://openalex.org/W2008660560","https://openalex.org/W2011301426","https://openalex.org/W2014660839","https://openalex.org/W2022960044","https://openalex.org/W2029118067","https://openalex.org/W2039517095","https://openalex.org/W2049821301","https://openalex.org/W2063339881","https://openalex.org/W2066926304","https://openalex.org/W2083148298","https://openalex.org/W2083531892","https://openalex.org/W2087823674","https://openalex.org/W2099031115","https://openalex.org/W2112196515","https://openalex.org/W2113971181","https://openalex.org/W2113994268","https://openalex.org/W2123681603","https://openalex.org/W2151503017","https://openalex.org/W2154166729","https://openalex.org/W2159884214","https://openalex.org/W2166245415","https://openalex.org/W2168798454","https://openalex.org/W2169799159","https://openalex.org/W2173794755","https://openalex.org/W2331756548","https://openalex.org/W2342249984","https://openalex.org/W2509636029","https://openalex.org/W2552464041","https://openalex.org/W2572480523","https://openalex.org/W2573214534","https://openalex.org/W2576780822","https://openalex.org/W2750707643","https://openalex.org/W2775594986","https://openalex.org/W2809334386","https://openalex.org/W2811072336","https://openalex.org/W2893348872","https://openalex.org/W2921803407","https://openalex.org/W2944526838","https://openalex.org/W2990270178","https://openalex.org/W3003257820","https://openalex.org/W3028886274","https://openalex.org/W3028947668","https://openalex.org/W3035965352","https://openalex.org/W3099878876","https://openalex.org/W3103145119","https://openalex.org/W3122109253","https://openalex.org/W3150635270","https://openalex.org/W3163259015","https://openalex.org/W3173579119","https://openalex.org/W3175661216","https://openalex.org/W3210500140","https://openalex.org/W4200042848","https://openalex.org/W4210644165","https://openalex.org/W4211196614","https://openalex.org/W4229363733","https://openalex.org/W4379383636","https://openalex.org/W4391952536"],"related_works":["https://openalex.org/W129731552","https://openalex.org/W4224140448","https://openalex.org/W1997135566","https://openalex.org/W2067253151","https://openalex.org/W1004292963","https://openalex.org/W1533754708","https://openalex.org/W1986169335","https://openalex.org/W2078068721","https://openalex.org/W1978883012","https://openalex.org/W1964060218"],"abstract_inverted_index":{"Hyperpolarization-activated":[0],"cyclic":[1,15,84,136],"nucleotide-modulated":[2],"(HCN)":[3],"channels":[4,148],"are":[5,129],"opened":[6],"in":[7,37,43,88,124,146,156],"an":[8,67,141],"allosteric":[9],"manner":[10],"by":[11,132],"membrane":[12],"hyperpolarization":[13],"and":[14],"nucleotides":[16,137],"such":[17],"as":[18,51,149],"cAMP.":[19],"Because":[20],"of":[21,82,96,151],"conflicting":[22],"reports":[23],"from":[24,103],"experimental":[25],"studies":[26],"on":[27],"whether":[28],"cAMP":[29],"binding":[30,35,61],"to":[31,55,62,119],"the":[32,38,79,83,99],"four":[33],"available":[34],"sites":[36],"channel":[39],"tetramer":[40],"operates":[41],"cooperatively":[42],"gating,":[44],"we":[45,91],"employ":[46],"here":[47],"a":[48,52,93,120,152],"computational":[49],"approach":[50],"promising":[53],"route":[54],"examine":[56],"ligand-induced":[57],"conformational":[58],"changes":[59],"after":[60],"individual":[63],"sites.":[64],"By":[65],"combining":[66],"elastic":[68],"network":[69],"model":[70],"(ENM)":[71],"with":[72],"linear":[73],"response":[74],"theory":[75],"(LRT)":[76],"for":[77],"modeling":[78],"apo-holo":[80],"transition":[81],"nucleotide-binding":[85],"domain":[86],"(CNBD)":[87],"HCN":[89,113,147],"channels,":[90,127],"observe":[92],"distinct":[94],"pattern":[95,108],"cooperativity":[97,101,107,143],"matching":[98],"\"positive-negative-positive\"":[100],"reported":[102],"functional":[104],"studies.":[105],"This":[106,139],"is":[109],"highly":[110],"conserved":[111],"among":[112],"subtypes":[114],"(HCN4,":[115],"HCN1),":[116],"but":[117],"only":[118,130],"lesser":[121],"extent":[122],"visible":[123],"structurally":[125],"related":[126],"which":[128],"gated":[131],"voltage":[133],"(KAT1)":[134],"or":[135],"(TAX4).":[138],"suggests":[140],"inherent":[142],"between":[144],"subunits":[145],"part":[150],"ligand-triggered":[153],"gating":[154],"mechanism":[155],"these":[157],"channels.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-06-07T08:38:57.713557","created_date":"2025-10-10T00:00:00"}