{"id":"https://openalex.org/W4387563390","doi":"https://doi.org/10.1021/acs.jcim.3c01212","title":"Discovery of Hit Compounds Targeting the P4 Allosteric Site of K-RAS, Identified through Ensemble-Based Virtual Screening","display_name":"Discovery of Hit Compounds Targeting the P4 Allosteric Site of K-RAS, Identified through Ensemble-Based Virtual Screening","publication_year":2023,"publication_date":"2023-10-12","ids":{"openalex":"https://openalex.org/W4387563390","doi":"https://doi.org/10.1021/acs.jcim.3c01212","pmid":"https://pubmed.ncbi.nlm.nih.gov/37824186"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.3c01212","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c01212","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c01212","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c01212","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068474716","display_name":"Patricia G\u00f3mez\u2010Gutierrez","orcid":"https://orcid.org/0000-0002-8887-9704"},"institutions":[{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Gomez-Gutierrez","raw_affiliation_strings":["Allinky Biopharma, Madrid Scientific Park, Faraday, 7, Madrid 28049, Spain","Department of Chemical Engineering. ETSEIB, Universitat Politecnica de Catalunya, Av. Diagonal, 647, Barcelona 08028, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8887-9704","affiliations":[{"raw_affiliation_string":"Allinky Biopharma, Madrid Scientific Park, Faraday, 7, Madrid 28049, Spain","institution_ids":[]},{"raw_affiliation_string":"Department of Chemical Engineering. ETSEIB, Universitat Politecnica de Catalunya, Av. Diagonal, 647, Barcelona 08028, Spain","institution_ids":["https://openalex.org/I9617848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100748660","display_name":"J. Rubio","orcid":"https://orcid.org/0000-0002-5529-2325"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jaime Rubio-Martinez","raw_affiliation_strings":["Department of Materials Science and Physical Chemistry, University of Barcelona and the Institut de Recerca en Quimica Teorica i Computacional (IQTCUB), Marti i Franques, 1, Barcelona 08028, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5529-2325","affiliations":[{"raw_affiliation_string":"Department of Materials Science and Physical Chemistry, University of Barcelona and the Institut de Recerca en Quimica Teorica i Computacional (IQTCUB), Marti i Franques, 1, Barcelona 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013455255","display_name":"Juan J. P\u00e9rez","orcid":"https://orcid.org/0000-0002-0748-8147"},"institutions":[{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan J. Perez","raw_affiliation_strings":["Department of Chemical Engineering. ETSEIB, Universitat Politecnica de Catalunya, Av. Diagonal, 647, Barcelona 08028, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0748-8147","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering. ETSEIB, Universitat Politecnica de Catalunya, Av. Diagonal, 647, Barcelona 08028, Spain","institution_ids":["https://openalex.org/I9617848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013455255"],"corresponding_institution_ids":["https://openalex.org/I9617848"],"apc_list":null,"apc_paid":null,"fwci":0.8539,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76259214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"63","issue":"20","first_page":"6412","last_page":"6422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.9221537113189697},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.8601182103157043},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"Guanine nucleotide exchange factor","score":0.6970493197441101},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6730546355247498},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5929023027420044},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.5130923986434937},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.43194544315338135},{"id":"https://openalex.org/keywords/peptidomimetic","display_name":"Peptidomimetic","score":0.41108939051628113},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35752546787261963},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25756531953811646},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.22320404648780823},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.12332156300544739}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.9221537113189697},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.8601182103157043},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.6970493197441101},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6730546355247498},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5929023027420044},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5130923986434937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43194544315338135},{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.41108939051628113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35752546787261963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25756531953811646},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.22320404648780823},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12332156300544739},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.3c01212","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c01212","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c01212","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:37824186","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37824186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:upcommons.upc.edu:2117/396953","is_oa":true,"landing_page_url":"https://hdl.handle.net/2117/396953","pdf_url":"https://upcommons.upc.edu/bitstreams/0280ef44-7f8c-4092-8bbe-765e801b2270/download","source":{"id":"https://openalex.org/S4377196262","display_name":"UPCommons institutional repository (Universitat Polit\u00e8cnica de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I9617848","host_organization_name":"Universitat Polit\u00e8cnica de Catalunya","host_organization_lineage":["https://openalex.org/I9617848"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10598794","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10598794","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10598794/pdf/ci3c01212.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.3c01212","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c01212","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c01212","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"awards":[{"id":"https://openalex.org/G1666344105","display_name":null,"funder_award_id":"CEX2021-001202-M","funder_id":"https://openalex.org/F4320321664","funder_display_name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Productiva"},{"id":"https://openalex.org/G184859499","display_name":null,"funder_award_id":"2021 SGR 00350","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G3654124718","display_name":null,"funder_award_id":"2021SGR00342","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"}],"funders":[{"id":"https://openalex.org/F4320321664","display_name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Productiva","ror":"https://ror.org/02h503d38"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387563390.pdf","grobid_xml":"https://content.openalex.org/works/W4387563390.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1574994167","https://openalex.org/W1916470139","https://openalex.org/W1960357661","https://openalex.org/W1963547997","https://openalex.org/W1969836007","https://openalex.org/W1971102429","https://openalex.org/W1974880836","https://openalex.org/W1985588649","https://openalex.org/W1992864103","https://openalex.org/W1992899488","https://openalex.org/W2001370513","https://openalex.org/W2009423060","https://openalex.org/W2009886463","https://openalex.org/W2012479646","https://openalex.org/W2018299967","https://openalex.org/W2023309667","https://openalex.org/W2027482274","https://openalex.org/W2056750804","https://openalex.org/W2057698420","https://openalex.org/W2065916228","https://openalex.org/W2067174909","https://openalex.org/W2079953901","https://openalex.org/W2081990599","https://openalex.org/W2086729168","https://openalex.org/W2088293068","https://openalex.org/W2092613403","https://openalex.org/W2092973995","https://openalex.org/W2099536948","https://openalex.org/W2106140689","https://openalex.org/W2116211618","https://openalex.org/W2121393047","https://openalex.org/W2128339707","https://openalex.org/W2130182381","https://openalex.org/W2130479394","https://openalex.org/W2144288821","https://openalex.org/W2146926552","https://openalex.org/W2158219305","https://openalex.org/W2162566713","https://openalex.org/W2214247172","https://openalex.org/W2298480233","https://openalex.org/W2300615341","https://openalex.org/W2464027273","https://openalex.org/W2468819323","https://openalex.org/W2548573003","https://openalex.org/W2558681209","https://openalex.org/W2732767128","https://openalex.org/W2735652142","https://openalex.org/W2750840532","https://openalex.org/W2767236761","https://openalex.org/W2886738135","https://openalex.org/W2911916015","https://openalex.org/W2912092319","https://openalex.org/W2942808707","https://openalex.org/W2943623664","https://openalex.org/W2950908936","https://openalex.org/W2963086398","https://openalex.org/W2982321167","https://openalex.org/W3014882016","https://openalex.org/W3049496038","https://openalex.org/W3083680488","https://openalex.org/W3133861956","https://openalex.org/W3174287371","https://openalex.org/W3176664740","https://openalex.org/W3188770510","https://openalex.org/W4207041243","https://openalex.org/W4214590973","https://openalex.org/W4221126430","https://openalex.org/W4231982692","https://openalex.org/W4250042253","https://openalex.org/W4252704769","https://openalex.org/W4306641733","https://openalex.org/W4313392413","https://openalex.org/W4317745734","https://openalex.org/W4367049415","https://openalex.org/W4378901135"],"related_works":["https://openalex.org/W3185899234","https://openalex.org/W2018226025","https://openalex.org/W2046450796","https://openalex.org/W2939998722","https://openalex.org/W2169750653","https://openalex.org/W2998398254","https://openalex.org/W2195592873","https://openalex.org/W3215749250","https://openalex.org/W4308179880","https://openalex.org/W2017996710"],"abstract_inverted_index":{"Mutants":[0],"of":[1,6,10,23,42,56,82,95,111,120,124,134,137,146,152,164],"Ras":[2],"are":[3],"oncogenic":[4],"drivers":[5],"a":[7,37,112,135,142,149,178],"large":[8],"number":[9],"human":[11],"tumors.":[12],"Despite":[13],"being":[14],"recognized":[15],"as":[16,34,58,132],"an":[17,171],"attractive":[18],"target":[19],"for":[20,28,36,74],"the":[21,25,32,46,50,102,109,118,125,138,153,165],"treatment":[22],"cancer,":[24],"high":[26],"affinity":[27],"its":[29],"substrate":[30],"tagged":[31],"protein":[33,47],"undruggable":[35],"few":[38],"years.":[39],"The":[40,77,104],"identification":[41],"cryptic":[43],"pockets":[44,90],"on":[45,117],"surface":[48],"gave":[49],"opportunity":[51],"to":[52,85],"identify":[53],"molecules":[54,62],"capable":[55],"acting":[57],"allosteric":[59,89,167],"modulators.":[60],"Several":[61],"were":[63,98],"disclosed":[64],"in":[65,92,101,177],"recent":[66],"years,":[67],"with":[68],"sotorasib":[69],"and":[70],"adagrasib":[71],"already":[72],"approved":[73],"clinical":[75],"use.":[76],"present":[78,105],"study":[79,106,115],"makes":[80],"use":[81],"computational":[83,154],"methods":[84],"characterize":[86],"eight":[87],"prospective":[88,162],"(P1-P8)":[91],"K-Ras,":[93],"four":[94],"which":[96],"(P1-P4)":[97],"previously":[99],"characterized":[100],"literature.":[103],"also":[107],"describes":[108],"results":[110],"virtual":[113],"screening":[114],"focused":[116],"discovery":[119],"hit":[121,160],"compounds,":[122,161],"binders":[123,163],"P4":[126,166],"site":[127,168],"that":[128,169],"can":[129],"be":[130],"considered":[131],"peptidomimetics":[133],"fragment":[136],"SOS":[139],"\u03b1I":[140],"helix,":[141],"guanine":[143],"exchange":[144],"factor":[145],"Ras.":[147],"After":[148],"detailed":[150],"description":[151],"procedure":[155],"followed,":[156],"we":[157],"disclose":[158],"five":[159],"exhibit":[170],"inhibitory":[172],"capability":[173],"higher":[174],"than":[175],"30%":[176],"cell":[179],"proliferation":[180],"assay":[181],"at":[182],"50":[183],"\u03bcM.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
