{"id":"https://openalex.org/W4392622756","doi":"https://doi.org/10.1021/acs.jcim.3c01151","title":"DeePNAP: A Deep Learning Method to Predict Protein\u2013Nucleic Acid Binding Affinity from Their Sequences","display_name":"DeePNAP: A Deep Learning Method to Predict Protein\u2013Nucleic Acid Binding Affinity from Their Sequences","publication_year":2024,"publication_date":"2024-03-08","ids":{"openalex":"https://openalex.org/W4392622756","doi":"https://doi.org/10.1021/acs.jcim.3c01151","pmid":"https://pubmed.ncbi.nlm.nih.gov/38458968"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.3c01151","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c01151","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082269815","display_name":"Uddeshya Pandey","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140410","display_name":"Indian Institute of Science Education and Research, Tirupati","ror":"https://ror.org/032d0e990","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210140410"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Uddeshya Pandey","raw_affiliation_strings":["Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India","institution_ids":["https://openalex.org/I4210140410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093420381","display_name":"Sasi M. Behara","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140410","display_name":"Indian Institute of Science Education and Research, Tirupati","ror":"https://ror.org/032d0e990","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210140410"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sasi M. Behara","raw_affiliation_strings":["Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India","institution_ids":["https://openalex.org/I4210140410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101523609","display_name":"Siddhant Sharma","orcid":"https://orcid.org/0009-0007-5909-6659"},"institutions":[{"id":"https://openalex.org/I4210140410","display_name":"Indian Institute of Science Education and Research, Tirupati","ror":"https://ror.org/032d0e990","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210140410"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Siddhant Sharma","raw_affiliation_strings":["Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India","institution_ids":["https://openalex.org/I4210140410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048158663","display_name":"Rachit S. Patil","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140410","display_name":"Indian Institute of Science Education and Research, Tirupati","ror":"https://ror.org/032d0e990","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210140410"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rachit S. Patil","raw_affiliation_strings":["Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India","institution_ids":["https://openalex.org/I4210140410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055469781","display_name":"Souparnika Nambiar","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140410","display_name":"Indian Institute of Science Education and Research, Tirupati","ror":"https://ror.org/032d0e990","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210140410"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Souparnika Nambiar","raw_affiliation_strings":["Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India","institution_ids":["https://openalex.org/I4210140410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021349116","display_name":"Debasish Koner","orcid":"https://orcid.org/0000-0002-5116-4908"},"institutions":[{"id":"https://openalex.org/I65181880","display_name":"Indian Institute of Technology Hyderabad","ror":"https://ror.org/01j4v3x97","country_code":"IN","type":"education","lineage":["https://openalex.org/I65181880"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Debasish Koner","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi 502284, India"],"raw_orcid":"https://orcid.org/0000-0002-5116-4908","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi 502284, India","institution_ids":["https://openalex.org/I65181880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076879492","display_name":"Hussain Bhukya","orcid":"https://orcid.org/0000-0002-5225-1579"},"institutions":[{"id":"https://openalex.org/I4210140410","display_name":"Indian Institute of Science Education and Research, Tirupati","ror":"https://ror.org/032d0e990","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210140410"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Hussain Bhukya","raw_affiliation_strings":["Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India"],"raw_orcid":"https://orcid.org/0000-0002-5225-1579","affiliations":[{"raw_affiliation_string":"Department of Biology, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India","institution_ids":["https://openalex.org/I4210140410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5021349116","https://openalex.org/A5076879492"],"corresponding_institution_ids":["https://openalex.org/I4210140410","https://openalex.org/I65181880"],"apc_list":null,"apc_paid":null,"fwci":1.8188,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.84476454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"64","issue":"6","first_page":"1806","last_page":"1815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generalizability-theory","display_name":"Generalizability theory","score":0.7133485078811646},{"id":"https://openalex.org/keywords/nucleic-acid","display_name":"Nucleic acid","score":0.479825496673584},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4740792512893677},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46458345651626587},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.44324785470962524},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4328416585922241},{"id":"https://openalex.org/keywords/binding-affinities","display_name":"Binding affinities","score":0.41885870695114136},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"Protein secondary structure","score":0.41728007793426514},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3907046616077423},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34041088819503784},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.31222009658813477},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28831738233566284},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24740612506866455},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.161271333694458}],"concepts":[{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.7133485078811646},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.479825496673584},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4740792512893677},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46458345651626587},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44324785470962524},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4328416585922241},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.41885870695114136},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.41728007793426514},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3907046616077423},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34041088819503784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31222009658813477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28831738233566284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24740612506866455},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.161271333694458},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.3c01151","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c01151","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:38458968","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38458968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1409706172","display_name":null,"funder_award_id":"DST/INSPIRE/04/2019/002108","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6154852565","display_name":null,"funder_award_id":"DST/INSPIRE/04/2019/001476","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F1176867654","display_name":"Indian Institute of Science Education and Research Tirupati","ror":null},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320332009","display_name":"International Institute of Information Technology, Hyderabad","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W2638695","https://openalex.org/W1948562438","https://openalex.org/W2011441819","https://openalex.org/W2051582477","https://openalex.org/W2095719702","https://openalex.org/W2099861795","https://openalex.org/W2166670554","https://openalex.org/W2327237011","https://openalex.org/W2394692748","https://openalex.org/W2605361745","https://openalex.org/W2743262308","https://openalex.org/W2898173676","https://openalex.org/W2904602199","https://openalex.org/W2949907488","https://openalex.org/W2950473530","https://openalex.org/W2960563220","https://openalex.org/W2975359141","https://openalex.org/W3005404186","https://openalex.org/W3021106530","https://openalex.org/W3030546965","https://openalex.org/W3034675470","https://openalex.org/W3036898627","https://openalex.org/W3104537585","https://openalex.org/W3106930452","https://openalex.org/W3116625060","https://openalex.org/W3128962351","https://openalex.org/W3138178466","https://openalex.org/W3177828909","https://openalex.org/W3186179742","https://openalex.org/W3191108515","https://openalex.org/W3199848756","https://openalex.org/W3204054344","https://openalex.org/W3207938489","https://openalex.org/W3210842402","https://openalex.org/W3215048338","https://openalex.org/W3216934231","https://openalex.org/W4225852968","https://openalex.org/W4286669150","https://openalex.org/W4293149883","https://openalex.org/W4324367800","https://openalex.org/W4376635982"],"related_works":["https://openalex.org/W2118717649","https://openalex.org/W2413243053","https://openalex.org/W410723623","https://openalex.org/W2015341305","https://openalex.org/W2035068594","https://openalex.org/W4225593417","https://openalex.org/W2573498121","https://openalex.org/W3022298670","https://openalex.org/W3160494304","https://openalex.org/W3006162251"],"abstract_inverted_index":{"Predicting":[0],"the":[1,16,45,51,64,74,80,89,137,153,162,192,214],"protein\u2013nucleic":[2],"acid":[3],"(PNA)":[4],"binding":[5,33,97,147,154,238],"affinity":[6,34,98,155],"solely":[7],"from":[8,121,136,167,176],"their":[9,168,254],"sequences":[10],"is":[11],"of":[12,21,28,50,88,141,164,216,243,253],"paramount":[13],"importance":[14],"for":[15,32,54,110,203,240],"experimental":[17,195],"design":[18],"and":[19,47,57,59,76,124,134,143,156,179,194,210],"analysis":[20],"PNA":[22,52,65,145,204],"interactions":[23],"(PNAIs).":[24],"A":[25],"large":[26],"number":[27],"currently":[29],"developed":[30,222],"models":[31],"prediction":[35],"are":[36,69],"limited":[37],"to":[38,79,161,186,235],"specific":[39],"PNAIs":[40,165,244],"while":[41],"also":[42,60,221],"relying":[43],"on":[44],"sequence":[46,178],"structural":[48],"information":[49],"complexes":[53,205],"both":[55,132,177],"training":[56,82],"testing,":[58],"as":[61,96,231],"inputs.":[62],"As":[63],"complex":[66,146],"structures":[67],"available":[68],"scarce,":[70],"this":[71],"significantly":[72],"limits":[73],"diversity":[75],"generalizability":[77,215],"due":[78,160],"small":[81],"data":[83,126],"set.":[84],"Additionally,":[85,218],"a":[86,92,106,116,122,223,232,241,250],"majority":[87],"tools":[90,173],"predict":[91,237],"single":[93],"parameter,":[94],"such":[95],"or":[99],"free":[100,157],"energy":[101,158],"changes":[102,159],"upon":[103],"mutations,":[104],"rendering":[105],"model":[107,119,150],"less":[108],"versatile":[109],"usage.":[111],"Hence,":[112],"we":[113,219],"propose":[114],"DeePNAP,":[115],"machine":[117],"learning-based":[118],"built":[120],"vast":[123],"heterogeneous":[125],"set":[127],"with":[128,197,245],"14,401":[129],"entries":[130],"(from":[131],"eukaryotes":[133],"prokaryotes)":[135],"ProNAB":[138],"database,":[139],"consisting":[140],"wild-type":[142],"mutant":[144],"parameters.":[148],"Our":[149],"precisely":[151],"predicts":[152],"mutation(s)":[163],"exclusively":[166],"sequences.":[169],"While":[170],"other":[171],"similar":[172],"extract":[174],"features":[175,185],"structure":[180],"information,":[181],"DeePNAP":[182,227],"employs":[183],"sequence-based":[184],"yield":[187],"high":[188,246],"correlation":[189],"coefficients":[190],"between":[191],"predicted":[193],"values":[196],"low":[198],"root":[199],"mean":[200],"squared":[201],"errors":[202],"in":[206,256],"predicting":[207],"K":[208],"D":[209],"\u0394\u0394":[211],"G,":[212],"implying":[213],"DeePNAP.":[217],"have":[220],"web":[224],"interface":[225],"hosting":[226],"that":[228],"can":[229],"serve":[230],"powerful":[233],"tool":[234],"rapidly":[236],"affinities":[239],"myriad":[242],"precision":[247],"toward":[248],"developing":[249],"deeper":[251],"understanding":[252],"implications":[255],"various":[257],"biological":[258],"systems.":[259],"Web":[260],"interface:":[261],"http://14.139.174.41:8080/":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}