{"id":"https://openalex.org/W4385415337","doi":"https://doi.org/10.1021/acs.jcim.3c00752","title":"Computational Peptide Design Cotargeting Glucagon and Glucagon-like Peptide-1 Receptors","display_name":"Computational Peptide Design Cotargeting Glucagon and Glucagon-like Peptide-1 Receptors","publication_year":2023,"publication_date":"2023-07-31","ids":{"openalex":"https://openalex.org/W4385415337","doi":"https://doi.org/10.1021/acs.jcim.3c00752","pmid":"https://pubmed.ncbi.nlm.nih.gov/37523325"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.3c00752","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00752","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jcim.3c00752","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017350427","display_name":"Shubham Vishnoi","orcid":"https://orcid.org/0000-0002-8213-5931"},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Shubham Vishnoi","raw_affiliation_strings":["Department of Physics, Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-8213-5931","affiliations":[{"raw_affiliation_string":"Department of Physics, Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090617480","display_name":"Shayon Bhattacharya","orcid":"https://orcid.org/0000-0002-4218-0308"},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Shayon Bhattacharya","raw_affiliation_strings":["Department of Physics, Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-4218-0308","affiliations":[{"raw_affiliation_string":"Department of Physics, Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042572699","display_name":"Erica M. Walsh","orcid":null},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica M. Walsh","raw_affiliation_strings":["Merck, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108679916","display_name":"Grace Okoh","orcid":null},"institutions":[{"id":"https://openalex.org/I192545095","display_name":"United States Military Academy","ror":"https://ror.org/01jepya76","country_code":"US","type":"education","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I192545095","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Ilevbare Okoh","raw_affiliation_strings":["Merck, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I192545095"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027510844","display_name":"Damien Thompson","orcid":"https://orcid.org/0000-0003-2340-5441"},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Damien Thompson","raw_affiliation_strings":["Department of Physics, Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-2340-5441","affiliations":[{"raw_affiliation_string":"Department of Physics, Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland","institution_ids":["https://openalex.org/I230495080"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027510844","https://openalex.org/A5090617480"],"corresponding_institution_ids":["https://openalex.org/I230495080"],"apc_list":null,"apc_paid":null,"fwci":1.3004,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80371841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"63","issue":"15","first_page":"4934","last_page":"4947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-receptor","display_name":"Glucagon receptor","score":0.7403931021690369},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1-receptor","display_name":"Glucagon-like peptide 1 receptor","score":0.6736820340156555},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.647911548614502},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.6405141949653625},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"Glucagon-like peptide-1","score":0.6187280416488647},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.6043209433555603},{"id":"https://openalex.org/keywords/agonist","display_name":"Agonist","score":0.5894163846969604},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.46515947580337524},{"id":"https://openalex.org/keywords/glucagon","display_name":"Glucagon","score":0.4500022530555725},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.44612637162208557},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3868844509124756},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33500000834465027},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3103850483894348},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.23949819803237915},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.22023582458496094},{"id":"https://openalex.org/keywords/hormone","display_name":"Hormone","score":0.16001784801483154}],"concepts":[{"id":"https://openalex.org/C2778542361","wikidata":"https://www.wikidata.org/wiki/Q14904911","display_name":"Glucagon receptor","level":4,"score":0.7403931021690369},{"id":"https://openalex.org/C185280430","wikidata":"https://www.wikidata.org/wiki/Q14909910","display_name":"Glucagon-like peptide 1 receptor","level":4,"score":0.6736820340156555},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.647911548614502},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6405141949653625},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.6187280416488647},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6043209433555603},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5894163846969604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46515947580337524},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.4500022530555725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44612637162208557},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3868844509124756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33500000834465027},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3103850483894348},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.23949819803237915},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.22023582458496094},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.16001784801483154}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1021/acs.jcim.3c00752","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00752","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:37523325","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37523325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10428222","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10428222","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10428222/pdf/ci3c00752.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/24106824","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Computational_peptide_design_cotargeting_glucagon_and_glucagon-like_peptide_1_receptors/24106824","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:www.lenus.ie:10147/643805","is_oa":true,"landing_page_url":"http://hdl.handle.net/10147/643805","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"United States","raw_type":"Other"},{"id":"doi:10.34961/researchrepository-ul.24106824.v1","is_oa":true,"landing_page_url":"https://doi.org/10.34961/researchrepository-ul.24106824.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401529","display_name":"University of Limerick Institutional Repository (University of Limerick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I230495080","host_organization_name":"University of Limerick","host_organization_lineage":["https://openalex.org/I230495080"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.3c00752","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00752","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7419751492","display_name":null,"funder_award_id":"12/RC/2275_P2 (SSPC)","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320320862","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72"},{"id":"https://openalex.org/F4320337049","display_name":"Bernal Institute, University of Limerick","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W95014119","https://openalex.org/W1031578623","https://openalex.org/W1510475440","https://openalex.org/W1576285254","https://openalex.org/W1586416850","https://openalex.org/W1964058863","https://openalex.org/W1981021420","https://openalex.org/W1982046519","https://openalex.org/W1990771438","https://openalex.org/W1993392215","https://openalex.org/W2008035364","https://openalex.org/W2013962155","https://openalex.org/W2027408247","https://openalex.org/W2035266068","https://openalex.org/W2044172327","https://openalex.org/W2047567287","https://openalex.org/W2049756080","https://openalex.org/W2057477511","https://openalex.org/W2067174909","https://openalex.org/W2070753604","https://openalex.org/W2077372959","https://openalex.org/W2078171783","https://openalex.org/W2081693079","https://openalex.org/W2088871147","https://openalex.org/W2097433877","https://openalex.org/W2103945336","https://openalex.org/W2115167726","https://openalex.org/W2119446720","https://openalex.org/W2122188063","https://openalex.org/W2128572087","https://openalex.org/W2131713387","https://openalex.org/W2132629607","https://openalex.org/W2140452919","https://openalex.org/W2151022427","https://openalex.org/W2153856953","https://openalex.org/W2165414288","https://openalex.org/W2171268876","https://openalex.org/W2184351123","https://openalex.org/W2307778533","https://openalex.org/W2326843800","https://openalex.org/W2346504440","https://openalex.org/W2464238397","https://openalex.org/W2520075163","https://openalex.org/W2555870966","https://openalex.org/W2588157903","https://openalex.org/W2591832038","https://openalex.org/W2737611067","https://openalex.org/W2782378357","https://openalex.org/W2782382515","https://openalex.org/W2782947454","https://openalex.org/W2788934957","https://openalex.org/W2795481136","https://openalex.org/W2808958607","https://openalex.org/W2900829579","https://openalex.org/W2925206776","https://openalex.org/W2926290865","https://openalex.org/W2981305821","https://openalex.org/W3001942526","https://openalex.org/W3009892545","https://openalex.org/W3011366455","https://openalex.org/W3027852565","https://openalex.org/W3035446592","https://openalex.org/W3036901602","https://openalex.org/W3046840768","https://openalex.org/W3092099740","https://openalex.org/W3093042356","https://openalex.org/W3093445863","https://openalex.org/W3110573705","https://openalex.org/W3111608483","https://openalex.org/W3122866315","https://openalex.org/W3147531120","https://openalex.org/W3160773731","https://openalex.org/W3176790398","https://openalex.org/W3185159485","https://openalex.org/W3209876193","https://openalex.org/W3215996763","https://openalex.org/W4205474125","https://openalex.org/W4205612718","https://openalex.org/W4206983615","https://openalex.org/W4207056883","https://openalex.org/W4210577193","https://openalex.org/W4211244188","https://openalex.org/W4212959738","https://openalex.org/W4225098447","https://openalex.org/W4225589081","https://openalex.org/W4244821183","https://openalex.org/W4281934192","https://openalex.org/W4294069033","https://openalex.org/W4296618669","https://openalex.org/W4310712976","https://openalex.org/W4311632534","https://openalex.org/W4312095457","https://openalex.org/W4313529365","https://openalex.org/W4315490546","https://openalex.org/W4316035882","https://openalex.org/W4317214009"],"related_works":["https://openalex.org/W2065770644","https://openalex.org/W2955219150","https://openalex.org/W1993170262","https://openalex.org/W2096420012","https://openalex.org/W2061888378","https://openalex.org/W2009181770","https://openalex.org/W2154432059","https://openalex.org/W3103351591","https://openalex.org/W1994867775","https://openalex.org/W3029720909"],"abstract_inverted_index":{"Peptides":[0],"are":[1],"sustainable":[2],"alternatives":[3],"to":[4,45,76,142],"conventional":[5],"therapeutics":[6,19],"for":[7,20,106,137],"G":[8],"protein-coupled":[9],"receptor":[10,31,37],"(GPCR)":[11],"linked":[12],"disorders,":[13],"promising":[14],"biocompatible":[15],"and":[16,33,59,66,74,84,111,139,145,158],"tailorable":[17],"next-generation":[18],"metabolic":[21],"disorders":[22],"including":[23],"type-2":[24],"diabetes,":[25],"as":[26],"agonists":[27],"of":[28,109],"the":[29,34,63,148],"glucagon":[30,52],"(GCGR)":[32],"glucagon-like":[35],"peptide-1":[36],"(GLP-1R).":[38],"However,":[39],"single":[40],"agonist":[41],"peptides":[42,56],"activating":[43],"GLP-1R":[44,60,140],"stimulate":[46],"insulin":[47],"secretion":[48],"also":[49],"suppress":[50],"obesity-linked":[51],"release.":[53],"Hence,":[54],"bioactive":[55],"cotargeting":[57],"GCGR":[58,110,138],"may":[61,154],"remediate":[62],"blood":[64],"glucose":[65],"fatty":[67],"acid":[68],"metabolism":[69],"imbalance,":[70],"tackling":[71],"both":[72],"diabetes":[73],"obesity":[75],"supersede":[77],"current":[78],"monoagonist":[79],"therapy.":[80],"Here,":[81],"we":[82],"design":[83,115],"model":[85],"optimized":[86],"peptide":[87,91,130],"sequences":[88,92],"starting":[89],"from":[90,94,117],"derived":[93],"earlier":[95],"phage-displayed":[96],"library":[97],"screening,":[98],"identifying":[99],"those":[100],"with":[101],"predicted":[102,133],"molecular":[103,119],"binding":[104,135],"profiles":[105],"dual":[107],"agonism":[108],"GLP-1R.":[112],"We":[113],"derive":[114],"rules":[116],"extensive":[118],"dynamics":[120],"simulations":[121],"based":[122],"on":[123],"peptide-receptor":[124],"binding.":[125],"Our":[126],"newly":[127],"designed":[128],"coagonist":[129],"exhibits":[131],"improved":[132],"coupled":[134],"affinity":[136],"relative":[141],"endogenous":[143],"ligands":[144],"could":[146],"in":[147],"future":[149],"be":[150],"tested":[151],"experimentally,":[152],"which":[153],"provide":[155],"superior":[156],"glycemic":[157],"weight":[159],"loss":[160],"control.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3}],"updated_date":"2026-05-29T09:21:14.243279","created_date":"2025-10-10T00:00:00"}