{"id":"https://openalex.org/W4380290562","doi":"https://doi.org/10.1021/acs.jcim.3c00260","title":"A Genetic Algorithm-Based Ensemble Learning Framework for Drug Combination Prediction","display_name":"A Genetic Algorithm-Based Ensemble Learning Framework for Drug Combination Prediction","publication_year":2023,"publication_date":"2023-06-12","ids":{"openalex":"https://openalex.org/W4380290562","doi":"https://doi.org/10.1021/acs.jcim.3c00260","pmid":"https://pubmed.ncbi.nlm.nih.gov/37303117"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.3c00260","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00260","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028718810","display_name":"Lianlian Wu","orcid":"https://orcid.org/0000-0002-9611-4488"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianlian Wu","raw_affiliation_strings":["Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China","Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017060219","display_name":"Xiaona Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaona Ye","raw_affiliation_strings":["School of Film, Xiamen University, Xiamen 361005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Film, Xiamen University, Xiamen 361005, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351207","display_name":"Yixin Zhang","orcid":"https://orcid.org/0000-0002-0485-2230"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yixin Zhang","raw_affiliation_strings":["Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103016385","display_name":"Jie Gao","orcid":"https://orcid.org/0000-0002-6580-0581"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Gao","raw_affiliation_strings":["School of Public Health, Fujian Medical University, Fuzhou 350122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Fujian Medical University, Fuzhou 350122, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101081397","display_name":"Zhikai Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhikai Lin","raw_affiliation_strings":["School of Film, Xiamen University, Xiamen 361005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Film, Xiamen University, Xiamen 361005, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060765713","display_name":"Binsheng Sui","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binsheng Sui","raw_affiliation_strings":["School of Film, Xiamen University, Xiamen 361005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Film, Xiamen University, Xiamen 361005, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011387822","display_name":"Yuqi Wen","orcid":"https://orcid.org/0000-0002-2391-3297"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuqi Wen","raw_affiliation_strings":["Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103008255","display_name":"Qingqiang Wu","orcid":"https://orcid.org/0000-0001-7428-5908"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqiang Wu","raw_affiliation_strings":["School of Film, Xiamen University, Xiamen 361005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Film, Xiamen University, Xiamen 361005, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066879706","display_name":"Kunhong Liu","orcid":"https://orcid.org/0000-0002-1222-8876"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kunhong Liu","raw_affiliation_strings":["School of Film, Xiamen University, Xiamen 361005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Film, Xiamen University, Xiamen 361005, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680468","display_name":"Song He","orcid":"https://orcid.org/0000-0002-4136-6151"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Song He","raw_affiliation_strings":["Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China"],"raw_orcid":"https://orcid.org/0000-0002-4136-6151","affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045958734","display_name":"Xiaochen Bo","orcid":"https://orcid.org/0000-0003-1911-7922"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaochen Bo","raw_affiliation_strings":["Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China","Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Bioinformatics, Institute of Health Service and Transfusion Medicine, Beijing 100850, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045958734","https://openalex.org/A5066879706","https://openalex.org/A5100680468"],"corresponding_institution_ids":["https://openalex.org/I162868743","https://openalex.org/I191208505","https://openalex.org/I5740404"],"apc_list":null,"apc_paid":null,"fwci":1.2953,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.82263373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"63","issue":"12","first_page":"3941","last_page":"3954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9538999795913696,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6752942800521851},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.646449089050293},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5863246321678162},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.5493228435516357},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5493004322052002},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5420137643814087},{"id":"https://openalex.org/keywords/ensemble-learning","display_name":"Ensemble learning","score":0.526123046875},{"id":"https://openalex.org/keywords/drug-class","display_name":"Drug class","score":0.4461188316345215},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.34526264667510986},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12288492918014526},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.11543318629264832}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6752942800521851},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.646449089050293},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5863246321678162},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.5493228435516357},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5493004322052002},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5420137643814087},{"id":"https://openalex.org/C45942800","wikidata":"https://www.wikidata.org/wiki/Q245652","display_name":"Ensemble learning","level":2,"score":0.526123046875},{"id":"https://openalex.org/C2778176773","wikidata":"https://www.wikidata.org/wiki/Q2976049","display_name":"Drug class","level":3,"score":0.4461188316345215},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.34526264667510986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12288492918014526},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11543318629264832}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.3c00260","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00260","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:37303117","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37303117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"awards":[{"id":"https://openalex.org/G2632928373","display_name":"\u57fa\u4e8e\u6df1\u5ea6\u68ee\u6797\u7684\u836f\u7269\u7ec4\u5408\u9884\u6d4b\u7b97\u6cd5\u7684\u7814\u7a76","funder_award_id":"2022J01707","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G4361661467","display_name":null,"funder_award_id":"2019QY1803","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6187246181","display_name":"\u57fa\u4e8e\u8f93\u51fa\u7ea0\u9519\u7f16\u7801\u7684\u5f00\u96c6\u591a\u7c7b\u6570\u636e\u6316\u6398\u7b97\u6cd5\u7814\u7a76","funder_award_id":"61772023","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7570617536","display_name":null,"funder_award_id":"XRCZX2021025","funder_id":"https://openalex.org/F4320328113","funder_display_name":"Fujian Medical University"},{"id":"https://openalex.org/G8729286819","display_name":null,"funder_award_id":"62103436","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320328113","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1659842140","https://openalex.org/W1967539118","https://openalex.org/W1988377311","https://openalex.org/W2000950277","https://openalex.org/W2009315806","https://openalex.org/W2050399271","https://openalex.org/W2061038526","https://openalex.org/W2061136308","https://openalex.org/W2103562758","https://openalex.org/W2105217850","https://openalex.org/W2124258777","https://openalex.org/W2145128878","https://openalex.org/W2159171427","https://openalex.org/W2165863045","https://openalex.org/W2189206443","https://openalex.org/W2259538443","https://openalex.org/W2396191367","https://openalex.org/W2402506318","https://openalex.org/W2473876819","https://openalex.org/W2551072359","https://openalex.org/W2554382158","https://openalex.org/W2612467560","https://openalex.org/W2774583472","https://openalex.org/W2775061087","https://openalex.org/W2792422514","https://openalex.org/W2792455800","https://openalex.org/W2807696094","https://openalex.org/W2896829849","https://openalex.org/W2922229918","https://openalex.org/W2950860419","https://openalex.org/W2955282193","https://openalex.org/W2960677646","https://openalex.org/W2970344819","https://openalex.org/W2981742563","https://openalex.org/W2992010506","https://openalex.org/W3006176441","https://openalex.org/W3006725260","https://openalex.org/W3014199639","https://openalex.org/W3018801674","https://openalex.org/W3024423177","https://openalex.org/W3024906290","https://openalex.org/W3025935822","https://openalex.org/W3045814128","https://openalex.org/W3107514561","https://openalex.org/W3108101741","https://openalex.org/W3127930610","https://openalex.org/W3128378288","https://openalex.org/W3164087725","https://openalex.org/W3192398644","https://openalex.org/W3195784177","https://openalex.org/W3196304395","https://openalex.org/W4205719393","https://openalex.org/W4206501708","https://openalex.org/W4206796410","https://openalex.org/W4210683988","https://openalex.org/W4212966936","https://openalex.org/W4243372746","https://openalex.org/W4256664911","https://openalex.org/W4294884620","https://openalex.org/W4306787188","https://openalex.org/W4309842604"],"related_works":["https://openalex.org/W4296209631","https://openalex.org/W2561617217","https://openalex.org/W2739390136","https://openalex.org/W2033074509","https://openalex.org/W2299492079","https://openalex.org/W1966539190","https://openalex.org/W4320342502","https://openalex.org/W2565730672","https://openalex.org/W2389206451","https://openalex.org/W1989827781"],"abstract_inverted_index":{"Combination":[0],"therapy":[1],"is":[2],"a":[3,88,164],"promising":[4],"clinical":[5,66],"treatment":[6],"strategy":[7],"for":[8],"cancer":[9,80],"and":[10,20,27,102,126,143],"other":[11],"complex":[12],"diseases.":[13],"Multiple":[14],"drugs":[15],"can":[16,157],"target":[17],"multiple":[18],"proteins":[19],"pathways,":[21],"greatly":[22],"improving":[23],"the":[24,34,53,62,97,127,140,146,150,160,169,182],"therapeutic":[25],"effect":[26],"slowing":[28],"down":[29],"drug":[30,39,48,59,76,114,178],"resistance.":[31],"To":[32,73],"narrow":[33],"search":[35,128],"space":[36],"of":[37,55,99,105,129,163,185],"synergistic":[38,75],"combinations,":[40],"many":[41],"prediction":[42,147],"models":[43],"have":[44,52],"been":[45],"developed.":[46],"However,":[47],"combination":[49],"datasets":[50],"always":[51],"characteristics":[54],"class":[56,100,152],"imbalance.":[57],"Synergistic":[58],"combinations":[60,77,179],"receive":[61],"most":[63],"attention":[64],"in":[65,70,78,83,149],"application":[67],"but":[68],"are":[69,116],"small":[71],"numbers.":[72],"predict":[74],"different":[79],"cell":[81],"lines,":[82],"this":[84],"study,":[85],"we":[86],"propose":[87],"genetic":[89],"algorithm-based":[90],"ensemble":[91,155],"learning":[92],"framework,":[93],"GA-DRUG,":[94,120],"to":[95,118,134],"address":[96],"problems":[98],"imbalance":[101],"high":[103],"dimensionality":[104],"input":[106],"data.":[107],"The":[108,154],"cell-line-specific":[109],"gene":[110],"expression":[111],"profiles":[112],"under":[113],"perturbations":[115],"used":[117],"train":[119],"which":[121],"contains":[122],"imbalanced":[123],"data":[124],"processing":[125],"global":[130],"optimal":[131],"solutions.":[132],"Compared":[133],"11":[135],"state-of-the-art":[136],"algorithms,":[137],"GA-DRUG":[138],"achieves":[139],"best":[141],"performance":[142,148],"significantly":[144],"improves":[145],"minority":[151],"(Synergy).":[153],"framework":[156],"effectively":[158],"correct":[159],"classification":[161],"results":[162],"single":[165],"classifier.":[166],"In":[167],"addition,":[168],"cellular":[170],"proliferation":[171],"experiment":[172],"performed":[173],"on":[174],"several":[175],"previously":[176],"unexplored":[177],"further":[180],"confirms":[181],"predictive":[183],"ability":[184],"GA-DRUG.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
