{"id":"https://openalex.org/W4377091676","doi":"https://doi.org/10.1021/acs.jcim.3c00196","title":"Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure\u2013Activity Relationship","display_name":"Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure\u2013Activity Relationship","publication_year":2023,"publication_date":"2023-05-19","ids":{"openalex":"https://openalex.org/W4377091676","doi":"https://doi.org/10.1021/acs.jcim.3c00196","pmid":"https://pubmed.ncbi.nlm.nih.gov/37204863"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.3c00196","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00196","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10496875/pdf/nihms-1927616.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085010994","display_name":"Eric R. Hantz","orcid":"https://orcid.org/0000-0002-2588-7619"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric R. Hantz","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005403838","display_name":"Svetlana B. Tikunova","orcid":"https://orcid.org/0000-0002-2101-9996"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svetlana B. Tikunova","raw_affiliation_strings":["Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio 43210, United States"],"affiliations":[{"raw_affiliation_string":"Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015842088","display_name":"Natalya Belevych","orcid":null},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalya Belevych","raw_affiliation_strings":["Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, United States"],"affiliations":[{"raw_affiliation_string":"Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110680199","display_name":"Jonathan P. Davis","orcid":"https://orcid.org/0000-0002-5627-1550"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan P. Davis","raw_affiliation_strings":["Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio 43210, United States"],"affiliations":[{"raw_affiliation_string":"Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075518537","display_name":"Peter J. Reiser","orcid":"https://orcid.org/0000-0003-3677-4211"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Reiser","raw_affiliation_strings":["Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, United States"],"affiliations":[{"raw_affiliation_string":"Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044975181","display_name":"Steffen Lindert","orcid":"https://orcid.org/0000-0002-3976-3473"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steffen Lindert","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044975181"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.6507,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.71167736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"63","issue":"11","first_page":"3462","last_page":"3473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.9409999847412109,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.6971046924591064},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6258673667907715},{"id":"https://openalex.org/keywords/calmodulin","display_name":"Calmodulin","score":0.6239015460014343},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"Ryanodine receptor","score":0.6068611741065979},{"id":"https://openalex.org/keywords/troponin-c","display_name":"Troponin C","score":0.564032793045044},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4802544414997101},{"id":"https://openalex.org/keywords/cardiac-muscle","display_name":"Cardiac muscle","score":0.45929378271102905},{"id":"https://openalex.org/keywords/troponin-i","display_name":"Troponin I","score":0.42752954363822937},{"id":"https://openalex.org/keywords/troponin","display_name":"Troponin","score":0.42150649428367615},{"id":"https://openalex.org/keywords/inotrope","display_name":"Inotrope","score":0.4194440543651581},{"id":"https://openalex.org/keywords/trifluoperazine","display_name":"Trifluoperazine","score":0.4144071936607361},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3568858504295349},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20252883434295654},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1648213267326355},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.14784282445907593},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08458659052848816}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6971046924591064},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6258673667907715},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.6239015460014343},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.6068611741065979},{"id":"https://openalex.org/C133927893","wikidata":"https://www.wikidata.org/wiki/Q4383200","display_name":"Troponin C","level":4,"score":0.564032793045044},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4802544414997101},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.45929378271102905},{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.42752954363822937},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.42150649428367615},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.4194440543651581},{"id":"https://openalex.org/C2775891158","wikidata":"https://www.wikidata.org/wiki/Q1752915","display_name":"Trifluoperazine","level":4,"score":0.4144071936607361},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3568858504295349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20252883434295654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1648213267326355},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14784282445907593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08458659052848816},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019209","descriptor_name":"Troponin C","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019209","descriptor_name":"Troponin C","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019209","descriptor_name":"Troponin C","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019209","descriptor_name":"Troponin C","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054792","descriptor_name":"Muscle, Striated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054792","descriptor_name":"Muscle, Striated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054792","descriptor_name":"Muscle, Striated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054792","descriptor_name":"Muscle, Striated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.3c00196","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00196","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:37204863","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37204863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10496875","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10496875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10496875/pdf/nihms-1927616.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10496875","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10496875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10496875/pdf/nihms-1927616.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.5899999737739563}],"awards":[{"id":"https://openalex.org/G2387479669","display_name":null,"funder_award_id":"R01 HL137015","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3654386930","display_name":null,"funder_award_id":"2R01HL138579-05","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4212731610","display_name":null,"funder_award_id":"HL138579","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6345853531","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377091676.pdf"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W153448245","https://openalex.org/W196794146","https://openalex.org/W1062333943","https://openalex.org/W1178456644","https://openalex.org/W1556906420","https://openalex.org/W1578284467","https://openalex.org/W1924552905","https://openalex.org/W1968925070","https://openalex.org/W1970400205","https://openalex.org/W1971397263","https://openalex.org/W1980955540","https://openalex.org/W1981234963","https://openalex.org/W1985588649","https://openalex.org/W1986994957","https://openalex.org/W1994941561","https://openalex.org/W1996547062","https://openalex.org/W2004203772","https://openalex.org/W2007492501","https://openalex.org/W2008879080","https://openalex.org/W2009423060","https://openalex.org/W2013698362","https://openalex.org/W2013754612","https://openalex.org/W2027423337","https://openalex.org/W2031168104","https://openalex.org/W2033845686","https://openalex.org/W2035266068","https://openalex.org/W2040767088","https://openalex.org/W2040954790","https://openalex.org/W2045910367","https://openalex.org/W2046087379","https://openalex.org/W2049053319","https://openalex.org/W2062051632","https://openalex.org/W2065470460","https://openalex.org/W2071738728","https://openalex.org/W2080113872","https://openalex.org/W2085351556","https://openalex.org/W2089121377","https://openalex.org/W2096007970","https://openalex.org/W2096163961","https://openalex.org/W2102125543","https://openalex.org/W2102377211","https://openalex.org/W2103019222","https://openalex.org/W2106140689","https://openalex.org/W2106518341","https://openalex.org/W2116211618","https://openalex.org/W2119464371","https://openalex.org/W2134080121","https://openalex.org/W2140624551","https://openalex.org/W2141011888","https://openalex.org/W2143722956","https://openalex.org/W2145041436","https://openalex.org/W2151498741","https://openalex.org/W2160416495","https://openalex.org/W2172568378","https://openalex.org/W2281888467","https://openalex.org/W2319534362","https://openalex.org/W2345003636","https://openalex.org/W2404280981","https://openalex.org/W2548494392","https://openalex.org/W2578590075","https://openalex.org/W2610602137","https://openalex.org/W2768579739","https://openalex.org/W2885824841","https://openalex.org/W2899048634","https://openalex.org/W2899354504","https://openalex.org/W2900638318","https://openalex.org/W2908036595","https://openalex.org/W2911869066","https://openalex.org/W2912818999","https://openalex.org/W2946934695","https://openalex.org/W3038273828","https://openalex.org/W3041121713","https://openalex.org/W3081528324","https://openalex.org/W3093700579","https://openalex.org/W3122226502","https://openalex.org/W3123088436","https://openalex.org/W3175782274","https://openalex.org/W4244483017","https://openalex.org/W4281726288","https://openalex.org/W4293265795","https://openalex.org/W4307337278","https://openalex.org/W4307968398"],"related_works":["https://openalex.org/W2034066204","https://openalex.org/W2060848457","https://openalex.org/W2056880825","https://openalex.org/W49987661","https://openalex.org/W2084930795","https://openalex.org/W1968693887","https://openalex.org/W1988698924","https://openalex.org/W2396474005","https://openalex.org/W2016561299","https://openalex.org/W1994100461"],"abstract_inverted_index":{"Despite":[0],"large":[1],"investments":[2],"from":[3,11],"academia":[4],"and":[5,40,112],"industry,":[6],"heart":[7],"failure,":[8],"which":[9,31,168],"results":[10],"a":[12,19,28,143],"disruption":[13],"of":[14,22,46,59,82,95,102,124,163,192],"the":[15,35,43,57,68,74,80,93,122,161,174],"contractile":[16],"apparatus,":[17],"remains":[18],"leading":[20],"cause":[21],"death.":[23],"Cardiac":[24],"muscle":[25,98,115],"contraction":[26],"is":[27,32,52],"calcium-dependent":[29],"mechanism,":[30],"regulated":[33],"by":[34,42],"troponin":[36],"protein":[37],"complex":[38],"(cTn)":[39],"specifically":[41],"N-terminal":[44],"domain":[45],"its":[47],"calcium-binding":[48],"subunit":[49],"(cNTnC).":[50],"There":[51],"an":[53,189],"increasing":[54],"need":[55],"for":[56,147],"development":[58],"small":[60,87],"molecules":[61],"that":[62],"increase":[63],"calcium":[64,70,183],"sensitivity":[65],"without":[66],"altering":[67],"systolic":[69],"concentration,":[71],"thereby":[72],"strengthening":[73],"cardiac":[75,110],"function.":[76],"Here,":[77],"we":[78,120,141],"examined":[79],"effect":[81,101],"our":[83],"previously":[84],"identified":[85,182],"calcium-sensitizing":[86],"molecule,":[88],"ChemBridge":[89],"compound":[90,186],"7930079,":[91],"in":[92,108,129],"context":[94],"several":[96],"homologous":[97],"systems.":[99],"The":[100,179],"this":[103],"molecule":[104],"on":[105,136,151],"force":[106],"generation":[107],"isolated":[109],"trabeculae":[111],"slow":[113],"skeletal":[114],"fibers":[116],"was":[117,185],"measured.":[118],"Furthermore,":[119],"explored":[121],"use":[123],"Gaussian":[125],"accelerated":[126],"molecular":[127],"dynamics":[128],"sampling":[130],"highly":[131],"predictive":[132],"receptor":[133],"conformations":[134],"based":[135,150],"NMR-derived":[137],"starting":[138],"structures.":[139],"Additionally,":[140],"took":[142],"rational":[144],"computational":[145],"approach":[146,158],"lead":[148],"optimization":[149],"lipophilic":[152],"diphenyl":[153],"moieties.":[154],"This":[155],"integrated":[156],"structural-biochemical-physiological":[157],"led":[159],"to":[160,173],"identification":[162],"three":[164],"novel":[165],"low-affinity":[166],"binders,":[167],"had":[169],"similar":[170],"binding":[171],"affinities":[172],"known":[175],"positive":[176],"inotrope":[177],"trifluoperazine.":[178],"most":[180],"potent":[181],"sensitizer":[184],"16":[187],"with":[188],"apparent":[190],"affinity":[191],"117":[193],"\u00b1":[194],"17":[195],"\u03bcM.":[196]},"counts_by_year":[{"year":2023,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}