{"id":"https://openalex.org/W4382502747","doi":"https://doi.org/10.1021/acs.jcim.3c00041","title":"Self-Association of ACE-2 with Different RBD Amounts: A Dynamic Simulation Perspective on SARS-CoV-2 Infection","display_name":"Self-Association of ACE-2 with Different RBD Amounts: A Dynamic Simulation Perspective on SARS-CoV-2 Infection","publication_year":2023,"publication_date":"2023-06-29","ids":{"openalex":"https://openalex.org/W4382502747","doi":"https://doi.org/10.1021/acs.jcim.3c00041","pmid":"https://pubmed.ncbi.nlm.nih.gov/37382878"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.3c00041","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00041","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112947701","display_name":"Meina Ren","orcid":null},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meina Ren","raw_affiliation_strings":["Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101030027","display_name":"Ziyi Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyi Ma","raw_affiliation_strings":["Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101114789","display_name":"Lina Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Zhao","raw_affiliation_strings":["Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100646854","display_name":"Yanjiao Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjiao Wang","raw_affiliation_strings":["Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083718913","display_name":"Hailong An","orcid":"https://orcid.org/0000-0001-7947-357X"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailong An","raw_affiliation_strings":["Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":"https://orcid.org/0000-0001-7947-357X","affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921","https://openalex.org/I4210112540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034813954","display_name":"Fude Sun","orcid":"https://orcid.org/0000-0003-2914-6356"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fude Sun","raw_affiliation_strings":["Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China","institution_ids":["https://openalex.org/I184843921","https://openalex.org/I4210112540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034813954"],"corresponding_institution_ids":["https://openalex.org/I184843921","https://openalex.org/I4210112540"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.4989,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61217044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"63","issue":"14","first_page":"4423","last_page":"4432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.6614856719970703},{"id":"https://openalex.org/keywords/colocalization","display_name":"Colocalization","score":0.551285445690155},{"id":"https://openalex.org/keywords/linkage","display_name":"Linkage (software)","score":0.5354869961738586},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.506543755531311},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4410625696182251},{"id":"https://openalex.org/keywords/cluster","display_name":"Cluster (spacecraft)","score":0.42664116621017456},{"id":"https://openalex.org/keywords/intermolecular-force","display_name":"Intermolecular force","score":0.4226214587688446},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35112354159355164},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3374634087085724},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3344056010246277},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33407455682754517},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.3291882872581482},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3278465270996094},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.32175713777542114},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.26173317432403564},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.25087302923202515},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.21720126271247864},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2032994031906128},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1551009714603424},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.1492227017879486},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1056201159954071}],"concepts":[{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.6614856719970703},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.551285445690155},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.5354869961738586},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.506543755531311},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4410625696182251},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.42664116621017456},{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.4226214587688446},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35112354159355164},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3374634087085724},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3344056010246277},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33407455682754517},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3291882872581482},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3278465270996094},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.32175713777542114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26173317432403564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25087302923202515},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21720126271247864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2032994031906128},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1551009714603424},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.1492227017879486},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1056201159954071},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.3c00041","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00041","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:37382878","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37382878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1267007187","display_name":null,"funder_award_id":"ZD2020140","funder_id":"https://openalex.org/F4320321949","funder_display_name":"Department of Education of Hebei Province"},{"id":"https://openalex.org/G3433087848","display_name":null,"funder_award_id":"32201022","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8132290810","display_name":null,"funder_award_id":"C2019202244","funder_id":"https://openalex.org/F4320322163","funder_display_name":"Natural Science Foundation of Hebei Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321949","display_name":"Department of Education of Hebei Province","ror":"https://ror.org/01jkyjd96"},{"id":"https://openalex.org/F4320322163","display_name":"Natural Science Foundation of Hebei Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1806547840","https://openalex.org/W1974776643","https://openalex.org/W1990985479","https://openalex.org/W2010733432","https://openalex.org/W2014903703","https://openalex.org/W2029667189","https://openalex.org/W2035266068","https://openalex.org/W2049081132","https://openalex.org/W2051864856","https://openalex.org/W2081693079","https://openalex.org/W2119267663","https://openalex.org/W2142532813","https://openalex.org/W2171268876","https://openalex.org/W2178132894","https://openalex.org/W2327174080","https://openalex.org/W2337438199","https://openalex.org/W2564443324","https://openalex.org/W2801644977","https://openalex.org/W2910356247","https://openalex.org/W2936969503","https://openalex.org/W3009912996","https://openalex.org/W3010441732","https://openalex.org/W3014067025","https://openalex.org/W3015748784","https://openalex.org/W3022559985","https://openalex.org/W3023915741","https://openalex.org/W3034328821","https://openalex.org/W3087347658","https://openalex.org/W3094617920","https://openalex.org/W3095150813","https://openalex.org/W3095511950","https://openalex.org/W3103261964","https://openalex.org/W3108980364","https://openalex.org/W3122836723","https://openalex.org/W3130637149","https://openalex.org/W3136724264","https://openalex.org/W3148042916","https://openalex.org/W3154675071","https://openalex.org/W3155828254","https://openalex.org/W3156389344","https://openalex.org/W4200211352","https://openalex.org/W4200625712","https://openalex.org/W4205716796","https://openalex.org/W4210365826","https://openalex.org/W4212813087","https://openalex.org/W4220680013","https://openalex.org/W4283266951","https://openalex.org/W4283464776","https://openalex.org/W4295908847","https://openalex.org/W4304689848","https://openalex.org/W4304820621","https://openalex.org/W4323038710"],"related_works":["https://openalex.org/W2003702921","https://openalex.org/W2765094844","https://openalex.org/W2593354205","https://openalex.org/W1828555256","https://openalex.org/W2971595373","https://openalex.org/W3167115936","https://openalex.org/W2884852261","https://openalex.org/W2047131072","https://openalex.org/W4280573273","https://openalex.org/W2969957541"],"abstract_inverted_index":{"Transmissibility":[0],"of":[1,19,32,41,72,113,171,187,204],"SARS-CoV-2":[2,205],"initially":[3],"relies":[4],"on":[5,13,44],"its":[6],"trimeric":[7],"Spike-RBDs":[8],"to":[9,38,60,121,138],"tether":[10],"the":[11,25,47,62,65,69,82,91,100,122,125,132,139,149,152,169,184,194],"ACE-2":[12,20,73,83,102,114,153,172,188],"host":[14],"cells,":[15],"and":[16,68,106,124,164,174,193],"enhanced":[17],"self-association":[18,49,63,105,142,162,185],"engaged":[21],"with":[22,74,189],"Spike":[23],"facilitates":[24],"viral":[26,195],"infection.":[27],"Two":[28],"primary":[29],"packing":[30],"modes":[31],"Spike-ACE2":[33],"heteroproteins":[34],"exist":[35],"potentially":[36],"due":[37],"discrepant":[39],"amounts":[40,192],"RBDs":[42,86],"loading":[43],"ACE-2,":[45],"but":[46],"resultant":[48],"difference":[50],"is":[51,148],"inherently":[52],"unclear.":[53],"We":[54],"used":[55],"extensive":[56],"coarse-grained":[57],"dynamic":[58],"simulations":[59],"characterize":[61],"efficiency,":[64],"conformation":[66,119],"relevance,":[67],"molecular":[70,178],"mechanism":[71],"different":[75,190],"RBD":[76,158,191],"amounts.":[77],"It":[78],"was":[79,136],"revealed":[80],"that":[81,151],"hanging":[84],"two/full":[85],"(Mode-A)":[87],"rapidly":[88],"dimerized":[89],"into":[90],"heteroprotein":[92],"complex":[93],"in":[94,143,180],"a":[95,107,116,144,156],"compact":[96,145],"\"linear\"":[97],"conformation,":[98],"while":[99],"bare":[101],"showed":[103],"weakened":[104],"protein":[108,141,175],"complex.":[109],"The":[110,177],"RBD-tethered":[111],"ectodomains":[112,127],"presented":[115],"more":[117],"upright":[118],"relative":[120],"membrane,":[123],"intermolecular":[126],"were":[128],"predominantly":[129],"packed":[130],"by":[131,155],"neck":[133],"domains,":[134],"which":[135,167,198],"obligated":[137],"rapid":[140],"pattern.":[146],"Noted":[147],"fact":[150],"tethered":[154],"single":[157],"(Mode-B)":[159],"retained":[160],"considerable":[161],"efficiency":[163],"clustering":[165],"capability,":[166],"unravels":[168],"interrelation":[170],"colocalization":[173],"cross-linkage.":[176],"perspectives":[179],"this":[181],"study":[182],"expound":[183],"potency":[186],"activity":[196],"implications,":[197],"can":[199],"greatly":[200],"enhance":[201],"our":[202],"comprehension":[203],"infection":[206],"details.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}
