{"id":"https://openalex.org/W4367172711","doi":"https://doi.org/10.1021/acs.jcim.3c00018","title":"Investigation of Anti-Alzheimer\u2019s Mechanisms of Sarsasapogenin Derivatives by Network-Based Combining Structure-Based Methods","display_name":"Investigation of Anti-Alzheimer\u2019s Mechanisms of Sarsasapogenin Derivatives by Network-Based Combining Structure-Based Methods","publication_year":2023,"publication_date":"2023-04-27","ids":{"openalex":"https://openalex.org/W4367172711","doi":"https://doi.org/10.1021/acs.jcim.3c00018","pmid":"https://pubmed.ncbi.nlm.nih.gov/37104820"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.3c00018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00018","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091350328","display_name":"Moran Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Moran Zhou","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101618776","display_name":"Jiamin Sun","orcid":"https://orcid.org/0009-0001-0692-3047"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiamin Sun","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089542096","display_name":"Zhuohang Yu","orcid":"https://orcid.org/0009-0001-0840-681X"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuohang Yu","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047875875","display_name":"Zengrui Wu","orcid":"https://orcid.org/0000-0003-3095-6006"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zengrui Wu","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400650","display_name":"Weihua Li","orcid":"https://orcid.org/0000-0001-7055-9836"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihua Li","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101576373","display_name":"Guixia Liu","orcid":"https://orcid.org/0000-0001-9648-844X"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guixia Liu","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102988160","display_name":"Lei Ma","orcid":"https://orcid.org/0000-0003-1412-3864"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Ma","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431408","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0003-3825-3620"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rui Wang","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052049405","display_name":"Yun Tang","orcid":"https://orcid.org/0000-0003-2340-1109"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Tang","raw_affiliation_strings":["Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5052049405","https://openalex.org/A5100431408","https://openalex.org/A5102988160"],"corresponding_institution_ids":["https://openalex.org/I143593769"],"apc_list":null,"apc_paid":null,"fwci":1.1886,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.81301436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"63","issue":"9","first_page":"2881","last_page":"2894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.6051128506660461},{"id":"https://openalex.org/keywords/network-structure","display_name":"Network structure","score":0.54256272315979},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5212748050689697},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4871468245983124},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4416365623474121},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4409819543361664},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4332275390625},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2754754424095154},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23628833889961243},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17960572242736816},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1720324158668518}],"concepts":[{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.6051128506660461},{"id":"https://openalex.org/C2988224531","wikidata":"https://www.wikidata.org/wiki/Q20830730","display_name":"Network structure","level":2,"score":0.54256272315979},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5212748050689697},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4871468245983124},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4416365623474121},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4409819543361664},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4332275390625},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2754754424095154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23628833889961243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17960572242736816},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1720324158668518},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013150","descriptor_name":"Spirostans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013150","descriptor_name":"Spirostans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013150","descriptor_name":"Spirostans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013150","descriptor_name":"Spirostans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013150","descriptor_name":"Spirostans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013150","descriptor_name":"Spirostans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.3c00018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.3c00018","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:37104820","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37104820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.4000000059604645,"display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G1104558580","display_name":null,"funder_award_id":"82173746","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3218487116","display_name":null,"funder_award_id":"82104066","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3472599621","display_name":null,"funder_award_id":"03-28","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G8602362317","display_name":null,"funder_award_id":"BP0719034","funder_id":"https://openalex.org/F4320327912","funder_display_name":"Higher Education Discipline Innovation Project"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320327912","display_name":"Higher Education Discipline Innovation Project","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1804731458","https://openalex.org/W1973141016","https://openalex.org/W1984084871","https://openalex.org/W2046204255","https://openalex.org/W2055631421","https://openalex.org/W2079749054","https://openalex.org/W2115086145","https://openalex.org/W2117085967","https://openalex.org/W2119963782","https://openalex.org/W2124306294","https://openalex.org/W2125297232","https://openalex.org/W2134374955","https://openalex.org/W2135910194","https://openalex.org/W2138180968","https://openalex.org/W2138186107","https://openalex.org/W2139461145","https://openalex.org/W2141982524","https://openalex.org/W2151099239","https://openalex.org/W2159887157","https://openalex.org/W2167212630","https://openalex.org/W2169678694","https://openalex.org/W2170121787","https://openalex.org/W2204695023","https://openalex.org/W2207018250","https://openalex.org/W2222589778","https://openalex.org/W2295730657","https://openalex.org/W2435165854","https://openalex.org/W2517534055","https://openalex.org/W2522920646","https://openalex.org/W2539985226","https://openalex.org/W2550990189","https://openalex.org/W2558999090","https://openalex.org/W2559588208","https://openalex.org/W2571390534","https://openalex.org/W2587598315","https://openalex.org/W2594675254","https://openalex.org/W2610345393","https://openalex.org/W2614597148","https://openalex.org/W2763890154","https://openalex.org/W2766388141","https://openalex.org/W2767891136","https://openalex.org/W2771328536","https://openalex.org/W2775724624","https://openalex.org/W2787229753","https://openalex.org/W2789253060","https://openalex.org/W2793307510","https://openalex.org/W2793951981","https://openalex.org/W2794844698","https://openalex.org/W2800176717","https://openalex.org/W2807593250","https://openalex.org/W2896646632","https://openalex.org/W2902812092","https://openalex.org/W2909175109","https://openalex.org/W2911493122","https://openalex.org/W2923272749","https://openalex.org/W2941198005","https://openalex.org/W2946412700","https://openalex.org/W2971801381","https://openalex.org/W2972561249","https://openalex.org/W3012700547","https://openalex.org/W3043872269","https://openalex.org/W3045405700","https://openalex.org/W3104537585","https://openalex.org/W3125322711","https://openalex.org/W3157975388","https://openalex.org/W3177828909","https://openalex.org/W3198479934","https://openalex.org/W3211795435","https://openalex.org/W3216881676","https://openalex.org/W4206046172","https://openalex.org/W4206240023","https://openalex.org/W4206774749","https://openalex.org/W4224663364","https://openalex.org/W4225498544","https://openalex.org/W4230443436","https://openalex.org/W4242984713","https://openalex.org/W4293240378"],"related_works":["https://openalex.org/W4206379684","https://openalex.org/W2898732673","https://openalex.org/W2410053581","https://openalex.org/W3011171625","https://openalex.org/W2038043644","https://openalex.org/W38065404","https://openalex.org/W3002327824","https://openalex.org/W1487182515","https://openalex.org/W1999242485","https://openalex.org/W4367172711"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,5,186],"(AD),":[2],"a":[3,47,74,105,175],"neurodegenerative":[4],"with":[6],"no":[7],"cure,":[8],"affects":[9],"millions":[10],"of":[11,18,131,143,153,158,180,185],"people":[12],"worldwide":[13],"and":[14,51,78,135,173,183],"has":[15],"become":[16,174],"one":[17],"the":[19,30,33,114,132,141,150,156],"biggest":[20],"healthcare":[21],"challenges.":[22],"Some":[23],"investigated":[24],"compounds":[25,172],"play":[26],"anti-AD":[27,59,144],"roles":[28],"at":[29],"cellular":[31],"or":[32,171],"animal":[34],"level,":[35],"but":[36],"their":[37],"molecular":[38,107],"mechanisms":[39,152],"remain":[40],"unclear.":[41],"In":[42],"this":[43],"study,":[44],"we":[45,64,148],"designed":[46],"strategy":[48,163],"combining":[49],"network-based":[50,85],"structure-based":[52,106],"methods":[53],"together":[54],"to":[55,99,117,167],"identify":[56],"targets":[57,182],"for":[58,89,102,112,129,155],"sarsasapogenin":[60],"derivatives":[61],"(AAs).":[62],"First,":[63],"collected":[65],"drug-target":[66],"interactions":[67],"(DTIs)":[68],"data":[69],"from":[70],"public":[71],"databases,":[72],"constructed":[73],"global":[75],"DTI":[76,90],"network,":[77],"generated":[79],"drug-substructure":[80],"associations.":[81],"After":[82],"network":[83],"construction,":[84],"models":[86],"were":[87,127],"built":[88],"prediction.":[91],"The":[92],"best":[93],"bSDTNBI-FCFP_4":[94],"model":[95,189],"was":[96,110,190],"further":[97],"used":[98],"predict":[100],"DTIs":[101],"AAs.":[103],"Second,":[104],"docking":[108],"method":[109],"employed":[111],"rescreening":[113],"prediction":[115],"results":[116],"obtain":[118],"more":[119],"credible":[120],"target":[121,142],"proteins.":[122],"Finally,":[123],"<i>in":[124],"vitro</i>":[125],"experiments":[126],"conducted":[128],"validation":[130],"predicted":[133],"targets,":[134],"Nrf2":[136],"showed":[137],"significant":[138],"evidence":[139],"as":[140],"compound":[145],"AA13.":[146],"Moreover,":[147],"analyzed":[149],"potential":[151],"AA13":[154],"treatment":[157],"AD.":[159],"Generally,":[160],"our":[161,193],"combined":[162],"could":[164],"be":[165],"applied":[166],"other":[168],"novel":[169],"drugs":[170],"useful":[176],"tool":[177],"in":[178],"identification":[179],"new":[181],"elucidation":[184],"mechanisms.":[187],"Our":[188],"deployed":[191],"on":[192],"NetInfer":[194],"web":[195],"server":[196],"(http://lmmd.ecust.edu.cn/netinfer/).":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}