{"id":"https://openalex.org/W4321374315","doi":"https://doi.org/10.1021/acs.jcim.2c01656","title":"MecDDI: Clarified Drug\u2013Drug Interaction Mechanism Facilitating Rational Drug Use and Potential Drug\u2013Drug Interaction Prediction","display_name":"MecDDI: Clarified Drug\u2013Drug Interaction Mechanism Facilitating Rational Drug Use and Potential Drug\u2013Drug Interaction Prediction","publication_year":2023,"publication_date":"2023-02-20","ids":{"openalex":"https://openalex.org/W4321374315","doi":"https://doi.org/10.1021/acs.jcim.2c01656","pmid":"https://pubmed.ncbi.nlm.nih.gov/36802582"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c01656","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c01656","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100671989","display_name":"Wei Hu","orcid":"https://orcid.org/0000-0002-9107-8027"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Hu","raw_affiliation_strings":["Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441828","display_name":"Wei Zhang","orcid":"https://orcid.org/0009-0007-8335-8663"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063377124","display_name":"Ying Zhou","orcid":"https://orcid.org/0000-0003-2778-555X"},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhou","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China","institution_ids":["https://openalex.org/I76130692","https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085405957","display_name":"Yongchao Luo","orcid":"https://orcid.org/0000-0002-4140-5392"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongchao Luo","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"],"raw_orcid":"https://orcid.org/0000-0002-4140-5392","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053361327","display_name":"Xiuna Sun","orcid":"https://orcid.org/0000-0001-7991-5825"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuna Sun","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000871321","display_name":"Huimin Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Xu","raw_affiliation_strings":["Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013707848","display_name":"Shuiyang Shi","orcid":"https://orcid.org/0009-0007-9638-5089"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuiyang Shi","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416723","display_name":"Teng Li","orcid":"https://orcid.org/0000-0001-9042-9211"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Teng Li","raw_affiliation_strings":["Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074381516","display_name":"Yichao Xu","orcid":"https://orcid.org/0000-0002-0476-9787"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yichao Xu","raw_affiliation_strings":["Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103056524","display_name":"Qianqian Yang","orcid":"https://orcid.org/0000-0002-0421-2954"},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Hangzhou First People's Hospital","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianqian Yang","raw_affiliation_strings":["Clinical Pharmacy Research Center, Zhejiang University School of Medicine, Hangzhou 310009, China","Department of Pharmacy, Affiliated Hangzhou First Peoples Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy Research Center, Zhejiang University School of Medicine, Hangzhou 310009, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hangzhou First Peoples Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210148790","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027440092","display_name":"Yunqing Qiu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunqing Qiu","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China","institution_ids":["https://openalex.org/I76130692","https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755257","display_name":"Feng Zhu","orcid":"https://orcid.org/0000-0001-8069-0053"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Zhu","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China","Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"],"raw_orcid":"https://orcid.org/0000-0001-8069-0053","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083128057","display_name":"Haibin Dai","orcid":"https://orcid.org/0000-0002-5768-2714"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haibin Dai","raw_affiliation_strings":["Clinical Pharmacy Research Center, Zhejiang University School of Medicine, Hangzhou 310009, China","Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy Research Center, Zhejiang University School of Medicine, Hangzhou 310009, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China","institution_ids":["https://openalex.org/I4210158318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5083128057","https://openalex.org/A5100755257"],"corresponding_institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":3.4916,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.93683617,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"63","issue":"5","first_page":"1626","last_page":"1636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9713000059127808,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7314225435256958},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.6796858906745911},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.679489254951477},{"id":"https://openalex.org/keywords/drug-drug-interaction","display_name":"Drug-drug interaction","score":0.5306590795516968},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.47038260102272034},{"id":"https://openalex.org/keywords/complement","display_name":"Complement (music)","score":0.4440736174583435},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.4437527358531952},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.431179016828537},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.27298253774642944},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.26565974950790405},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.09268569946289062}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7314225435256958},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6796858906745911},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.679489254951477},{"id":"https://openalex.org/C2910466267","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug-drug interaction","level":3,"score":0.5306590795516968},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.47038260102272034},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.4440736174583435},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4437527358531952},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.431179016828537},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27298253774642944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26565974950790405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09268569946289062},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.2c01656","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c01656","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:36802582","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36802582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5899999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2446395889","display_name":null,"funder_award_id":"81872798","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5970591423","display_name":null,"funder_award_id":"2018QNA7023","funder_id":"https://openalex.org/F4320329878","funder_display_name":"Central University Basic Research Fund of China"},{"id":"https://openalex.org/G8196091623","display_name":null,"funder_award_id":"U1909208","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8951279597","display_name":null,"funder_award_id":"LR21H300001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329878","display_name":"Central University Basic Research Fund of China","ror":null},{"id":"https://openalex.org/F4320336605","display_name":"National Ten Thousand Talent Program","ror":null},{"id":"https://openalex.org/F4320338110","display_name":"Science and Technology Department of Zhejiang Province","ror":"https://ror.org/05yj3y977"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W1935434993","https://openalex.org/W2003562401","https://openalex.org/W2014304044","https://openalex.org/W2069898171","https://openalex.org/W2103562758","https://openalex.org/W2118027190","https://openalex.org/W2118534378","https://openalex.org/W2535158955","https://openalex.org/W2569667639","https://openalex.org/W2590206251","https://openalex.org/W2608081584","https://openalex.org/W2610316990","https://openalex.org/W2766443370","https://openalex.org/W2767891136","https://openalex.org/W2767969791","https://openalex.org/W2778894067","https://openalex.org/W2787862015","https://openalex.org/W2792771303","https://openalex.org/W2802200505","https://openalex.org/W2810911197","https://openalex.org/W2893429695","https://openalex.org/W2893618043","https://openalex.org/W2896111339","https://openalex.org/W2899070097","https://openalex.org/W2904281537","https://openalex.org/W2908938827","https://openalex.org/W2909626307","https://openalex.org/W2912634552","https://openalex.org/W2912693327","https://openalex.org/W2914208656","https://openalex.org/W2917152313","https://openalex.org/W2920555099","https://openalex.org/W2923257762","https://openalex.org/W2927648804","https://openalex.org/W2946536556","https://openalex.org/W2953991268","https://openalex.org/W2965220254","https://openalex.org/W2966354200","https://openalex.org/W2976234849","https://openalex.org/W2981132553","https://openalex.org/W2982197252","https://openalex.org/W2982291409","https://openalex.org/W2991546386","https://openalex.org/W2994923450","https://openalex.org/W3005539395","https://openalex.org/W3011211676","https://openalex.org/W3011304812","https://openalex.org/W3011727570","https://openalex.org/W3016862200","https://openalex.org/W3024894285","https://openalex.org/W3026210884","https://openalex.org/W3026919773","https://openalex.org/W3035765591","https://openalex.org/W3042488336","https://openalex.org/W3044445445","https://openalex.org/W3067852576","https://openalex.org/W3089843526","https://openalex.org/W3092072640","https://openalex.org/W3097430462","https://openalex.org/W3117350753","https://openalex.org/W3119678165","https://openalex.org/W3120881044","https://openalex.org/W3125369761","https://openalex.org/W3129931914","https://openalex.org/W3130309548","https://openalex.org/W3133892763","https://openalex.org/W3135719128","https://openalex.org/W3135761017","https://openalex.org/W3146401251","https://openalex.org/W3157639914","https://openalex.org/W3185514738","https://openalex.org/W3195161349","https://openalex.org/W3201817707","https://openalex.org/W3203595099","https://openalex.org/W3204559909","https://openalex.org/W3205082786","https://openalex.org/W3206046197","https://openalex.org/W3206204155","https://openalex.org/W3207373390","https://openalex.org/W3210331473","https://openalex.org/W3212244575","https://openalex.org/W3213715512","https://openalex.org/W3215524294","https://openalex.org/W3217681006","https://openalex.org/W4200111237","https://openalex.org/W4200115987","https://openalex.org/W4200159056","https://openalex.org/W4200351086","https://openalex.org/W4206010614","https://openalex.org/W4206501708","https://openalex.org/W4206789529","https://openalex.org/W4214687508","https://openalex.org/W4214811587","https://openalex.org/W4220992850","https://openalex.org/W4223455620","https://openalex.org/W4224946912","https://openalex.org/W4226140942","https://openalex.org/W4254589074","https://openalex.org/W4281555140","https://openalex.org/W4281626913","https://openalex.org/W4281850946","https://openalex.org/W4285008608","https://openalex.org/W4286252253","https://openalex.org/W4290038694","https://openalex.org/W4292583032","https://openalex.org/W4310433439","https://openalex.org/W4313405519"],"related_works":["https://openalex.org/W3082755771","https://openalex.org/W2395332729","https://openalex.org/W2407625558","https://openalex.org/W2485789143","https://openalex.org/W2040338448","https://openalex.org/W2415873281","https://openalex.org/W2463344692","https://openalex.org/W4248267070","https://openalex.org/W2341529717","https://openalex.org/W4251539487"],"abstract_inverted_index":{"Drug-drug":[0],"interactions":[1],"(DDIs)":[2],"are":[3,47,61],"a":[4,26,65,82,88,104,142,169],"major":[5],"concern":[6],"in":[7,124],"clinical":[8],"practice":[9],"and":[10,136,139,182,205],"have":[11,31,81],"been":[12,32],"recognized":[13],"as":[14,196],"one":[15],"of":[16,91,159,172],"the":[17,36,77,114,117,127,151,156,201],"key":[18],"threats":[19,158],"to":[20,34,80,111,155,161,178,188,200],"public":[21,162],"health.":[22],"To":[23],"address":[24],"such":[25,96],"critical":[27],"threat,":[28],"many":[29],"studies":[30],"conducted":[33],"clarify":[35,113],"mechanism":[37],"underlying":[38,116,129],"each":[39],"DDI,":[40],"based":[41,149],"on":[42,64,150],"which":[43],"alternative":[44,180],"therapeutic":[45],"strategies":[46],"successfully":[48],"proposed.":[49],"Moreover,":[50],"artificial":[51],"intelligence-based":[52],"models":[53],"for":[54,87,145,185],"predicting":[55],"DDIs,":[56],"especially":[57],"multilabel":[58],"classification":[59,144],"models,":[60],"highly":[62],"dependent":[63],"reliable":[66],"DDI":[67,173],"data":[68,184],"set":[69],"with":[70],"clear":[71,170],"mechanistic":[72,85],"information.":[73],"These":[74],"successes":[75],"highlight":[76],"imminent":[78],"necessity":[79],"platform":[83,97,105,121],"providing":[84,141],"clarifications":[86],"large":[89],"number":[90],"existing":[92,118],"DDIs.":[93,119,191],"However,":[94],"no":[95],"is":[98,122,193,206],"available":[99,202],"yet.":[100],"In":[101],"this":[102],"study,":[103],"entitled":[106],"\"MecDDI\"":[107],"was":[108],"therefore":[109],"introduced":[110],"systematically":[112],"mechanisms":[115,128],"This":[120],"unique":[123],"(a)":[125],"clarifying":[126],"over":[130],"1,78,000":[131],"DDIs":[132,148,160],"by":[133],"explicit":[134],"descriptions":[135],"graphic":[137],"illustrations":[138],"(b)":[140],"systematic":[143],"all":[146],"collected":[147],"clarified":[152],"mechanisms.":[153],"Due":[154],"long-lasting":[157],"health,":[163],"MecDDI":[164,192],"could":[165],"offer":[166],"medical":[167],"scientists":[168,187],"clarification":[171],"mechanisms,":[174],"support":[175],"healthcare":[176],"professionals":[177],"identify":[179],"therapeutics,":[181],"prepare":[183],"algorithm":[186],"predict":[189],"new":[190],"now":[194],"expected":[195],"an":[197],"indispensable":[198],"complement":[199],"pharmaceutical":[203],"platforms":[204],"freely":[207],"accessible":[208],"at:":[209],"https://idrblab.org/mecddi/.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}