{"id":"https://openalex.org/W4320709424","doi":"https://doi.org/10.1021/acs.jcim.2c01597","title":"Phosphorylation at Ser289 Enhances the Oligomerization of Tau Repeat R2","display_name":"Phosphorylation at Ser289 Enhances the Oligomerization of Tau Repeat R2","publication_year":2023,"publication_date":"2023-02-14","ids":{"openalex":"https://openalex.org/W4320709424","doi":"https://doi.org/10.1021/acs.jcim.2c01597","pmid":"https://pubmed.ncbi.nlm.nih.gov/36786552"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c01597","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c01597","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.2c01597","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.2c01597","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051331539","display_name":"Viet Hoang Man","orcid":"https://orcid.org/0000-0002-8907-6479"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Viet Hoang Man","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":"https://orcid.org/0000-0002-8907-6479","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014231261","display_name":"Xibing He","orcid":"https://orcid.org/0000-0001-7431-7893"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xibing He","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":"https://orcid.org/0000-0001-7431-7893","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060005941","display_name":"Fengyang Han","orcid":"https://orcid.org/0000-0002-2775-9717"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fengyang Han","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037219221","display_name":"Lianjin Cai","orcid":"https://orcid.org/0000-0001-5354-4050"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lianjin Cai","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103026903","display_name":"Luxuan Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luxuan Wang","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067943599","display_name":"Taoyu Niu","orcid":"https://orcid.org/0009-0004-2214-1397"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taoyu Niu","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064395685","display_name":"Jingchen Zhai","orcid":"https://orcid.org/0000-0003-2691-8867"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingchen Zhai","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055500102","display_name":"Beihong Ji","orcid":"https://orcid.org/0000-0003-0387-4056"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beihong Ji","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":"https://orcid.org/0000-0003-0387-4056","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103016385","display_name":"Jie Gao","orcid":"https://orcid.org/0000-0002-6580-0581"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Gao","raw_affiliation_strings":["Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100643054","display_name":"Junmei Wang","orcid":"https://orcid.org/0000-0002-9607-8229"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junmei Wang","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"],"raw_orcid":"https://orcid.org/0000-0002-9607-8229","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5051331539","https://openalex.org/A5100643054"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":4.1469,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.94695691,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"63","issue":"4","first_page":"1351","last_page":"1361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.9168850183486938},{"id":"https://openalex.org/keywords/dimer","display_name":"Dimer","score":0.76904296875},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7192162871360779},{"id":"https://openalex.org/keywords/monomer","display_name":"Monomer","score":0.6238274574279785},{"id":"https://openalex.org/keywords/tau-protein","display_name":"Tau protein","score":0.5124464631080627},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4769667387008667},{"id":"https://openalex.org/keywords/microtubule","display_name":"Microtubule","score":0.42196792364120483},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2812384366989136},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.21639162302017212},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1424294412136078},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.13757702708244324}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.9168850183486938},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.76904296875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7192162871360779},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6238274574279785},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5124464631080627},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4769667387008667},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.42196792364120483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2812384366989136},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21639162302017212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1424294412136078},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.13757702708244324},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.2c01597","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c01597","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.2c01597","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:36786552","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36786552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10032562","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10032562","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10032562/pdf/ci2c01597.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.2c01597","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c01597","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.2c01597","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3684679819","display_name":null,"funder_award_id":"K25AG070277","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4239805006","display_name":null,"funder_award_id":"1955260","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5396146307","display_name":null,"funder_award_id":"R01GM147673","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4320709424.pdf","grobid_xml":"https://content.openalex.org/works/W4320709424.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1966078827","https://openalex.org/W1969979382","https://openalex.org/W1972970370","https://openalex.org/W1976499671","https://openalex.org/W1984770038","https://openalex.org/W2018423808","https://openalex.org/W2018733438","https://openalex.org/W2035266068","https://openalex.org/W2053191438","https://openalex.org/W2057477511","https://openalex.org/W2059889568","https://openalex.org/W2067174909","https://openalex.org/W2087277033","https://openalex.org/W2102701929","https://openalex.org/W2128572087","https://openalex.org/W2133179696","https://openalex.org/W2135867962","https://openalex.org/W2136750984","https://openalex.org/W2137140827","https://openalex.org/W2141920771","https://openalex.org/W2144288821","https://openalex.org/W2161605421","https://openalex.org/W2162166182","https://openalex.org/W2165988981","https://openalex.org/W2185034389","https://openalex.org/W2190496005","https://openalex.org/W2280090275","https://openalex.org/W2326962045","https://openalex.org/W2470785930","https://openalex.org/W2555870966","https://openalex.org/W2597238462","https://openalex.org/W2605143093","https://openalex.org/W2619949586","https://openalex.org/W2743744603","https://openalex.org/W2774675034","https://openalex.org/W2788827529","https://openalex.org/W2800724568","https://openalex.org/W2809078375","https://openalex.org/W2896801782","https://openalex.org/W2899709077","https://openalex.org/W2910535194","https://openalex.org/W2948376986","https://openalex.org/W2982479034","https://openalex.org/W2982627636","https://openalex.org/W3013140349","https://openalex.org/W3016792105","https://openalex.org/W3020493787","https://openalex.org/W3107820844","https://openalex.org/W3119165379","https://openalex.org/W3164741933","https://openalex.org/W3167427671","https://openalex.org/W3172648581","https://openalex.org/W3193404200","https://openalex.org/W3197229223","https://openalex.org/W3208229530","https://openalex.org/W4200405629","https://openalex.org/W4206055706","https://openalex.org/W4221049185","https://openalex.org/W4226373958","https://openalex.org/W4238843899","https://openalex.org/W4289550098","https://openalex.org/W4309087248"],"related_works":["https://openalex.org/W1975231683","https://openalex.org/W2953251415","https://openalex.org/W2092889823","https://openalex.org/W2126853599","https://openalex.org/W894066805","https://openalex.org/W1972220625","https://openalex.org/W2127915608","https://openalex.org/W2407990031","https://openalex.org/W2949498492","https://openalex.org/W4380758692"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"In":[7,81],"tauopathies":[8],"such":[9],"as":[10],"Alzheimer\u2019s":[11],"disease":[12],"(AD),":[13],"aberrant":[14,95],"phosphorylation":[15,72,96,136,152,178,198,236],"causes":[16],"the":[17,56,61,76,86,93,135,139,143,146,149,151,165,170,175,177,188,197,218,245],"dissociation":[18],"of":[19,48,60,79,88,92,98,107,126,141,164,190,226,248],"tau":[20,26,62,66,100,108,205,230,249],"proteins":[21],"from":[22,32],"microtubules.":[23],"The":[24],"dissociated":[25],"then":[27],"aggregates":[28],"into":[29,242],"sequent":[30],"forms":[31],"soluble":[33],"oligomers":[34,51],"to":[35,54,70,128,161,169,174,203],"paired":[36],"helical":[37],"filaments":[38],"and":[39,104,145,157,182],"insoluble":[40],"neurofibrillary":[41],"tangles":[42],"(NFTs).":[43],"NFTs":[44],"is":[45,73,201],"a":[46,122,210],"hallmark":[47],"AD,":[49],"while":[50],"are":[52],"found":[53],"be":[55,240],"most":[57],"toxic":[58],"form":[59],"aggregates.":[63],"Therefore,":[64],"understanding":[65],"oligomerization":[67,189],"with":[68,121],"regard":[69],"abnormal":[71],"important":[74,224],"for":[75],"therapeutic":[77],"development":[78],"AD.":[80],"this":[82],"study,":[83],"we":[84],"investigated":[85],"impact":[87],"phosphorylated":[89,166,211,219],"Ser289,":[90],"one":[91],"40":[94],"sites":[97],"full-length":[99],"proteins,":[101],"on":[102],"monomeric":[103],"dimeric":[105],"structures":[106,140],"repeat":[109],"R2":[110,167,191,220],"peptides.":[111,192],"We":[112,207],"carried":[113],"out":[114],"intensive":[115],"replica":[116],"exchange":[117],"molecular":[118],"dynamics":[119],"simulation":[120,124],"total":[123],"time":[125],"up":[127],"0.1":[129],"ms.":[130],"Our":[131,232],"result":[132,194],"showed":[133],"that":[134,196,235],"significantly":[137],"affected":[138],"both":[142],"monomer":[144],"dimer.":[147],"For":[148],"monomer,":[150],"enhanced":[153],"ordered\u2013disordered":[154],"structural":[155],"transition":[156],"intramolecular":[158],"interaction,":[159],"leading":[160],"more":[162],"compactness":[163],"compared":[168],"wild-type":[171],"one.":[172],"As":[173],"dimer,":[176,221],"increased":[179],"intermolecular":[180],"interaction":[181],"\u03b2-sheet":[183],"formation,":[184],"which":[185],"can":[186],"accelerate":[187],"This":[193],"suggests":[195],"at":[199,237],"Ser289":[200,215,238],"likely":[202],"promote":[204],"aggregation.":[206,231],"also":[208],"observed":[209],"Ser289-Na":[212],"+":[213],"-phosphorylated":[214],"bridge":[216],"in":[217,229,244],"suggesting":[222],"an":[223],"role":[225],"cation":[227],"ions":[228],"findings":[233],"suggest":[234],"should":[239],"taken":[241],"account":[243],"inhibitor":[246],"screening":[247],"oligomerization.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":2}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}