{"id":"https://openalex.org/W4321004024","doi":"https://doi.org/10.1021/acs.jcim.2c01459","title":"Systematic Description of the Content Variation of Natural Products (NPs): To Prompt the Yield of High-Value NPs and the Discovery of New Therapeutics","display_name":"Systematic Description of the Content Variation of Natural Products (NPs): To Prompt the Yield of High-Value NPs and the Discovery of New Therapeutics","publication_year":2023,"publication_date":"2023-02-16","ids":{"openalex":"https://openalex.org/W4321004024","doi":"https://doi.org/10.1021/acs.jcim.2c01459","pmid":"https://pubmed.ncbi.nlm.nih.gov/36795011"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c01459","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c01459","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014228220","display_name":"Hongquan Xu","orcid":"https://orcid.org/0009-0001-5705-4857"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongquan Xu","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441828","display_name":"Wei Zhang","orcid":"https://orcid.org/0009-0007-8335-8663"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Innovation Institute for Affiliated Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","The Second Affiliated Hospital, Zhejiang University School of Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Institute for Affiliated Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"The Second Affiliated Hospital, Zhejiang University School of Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046274878","display_name":"Ying Zhou","orcid":"https://orcid.org/0000-0002-0295-8736"},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhou","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China","institution_ids":["https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102807611","display_name":"Zixuan Yue","orcid":"https://orcid.org/0000-0002-1286-2471"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixuan Yue","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113978850","display_name":"Tianci Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianci Yan","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320702","display_name":"Yuanyuan Zhang","orcid":"https://orcid.org/0009-0000-8822-2406"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324593","display_name":"Yuhong Liu","orcid":"https://orcid.org/0000-0001-5278-7333"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhong Liu","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113200278","display_name":"Yanfeng Hong","orcid":null},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanfeng Hong","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045866883","display_name":"Shuiping Liu","orcid":"https://orcid.org/0000-0002-8831-7947"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuiping Liu","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":"https://orcid.org/0000-0002-8831-7947","affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755257","display_name":"Feng Zhu","orcid":"https://orcid.org/0000-0001-8069-0053"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Zhu","raw_affiliation_strings":["Innovation Institute for Affiliated Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","The Second Affiliated Hospital, Zhejiang University School of Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":"https://orcid.org/0000-0001-8069-0053","affiliations":[{"raw_affiliation_string":"Innovation Institute for Affiliated Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"The Second Affiliated Hospital, Zhejiang University School of Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061697130","display_name":"Lin Tao","orcid":"https://orcid.org/0000-0001-7494-4758"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Tao","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":"https://orcid.org/0000-0001-7494-4758","affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I163151501"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5045866883","https://openalex.org/A5061697130","https://openalex.org/A5100755257"],"corresponding_institution_ids":["https://openalex.org/I163151501","https://openalex.org/I4210158318","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":1.8846,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.83975778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"63","issue":"5","first_page":"1615","last_page":"1625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yield","display_name":"Yield (engineering)","score":0.5379171371459961},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.46969011425971985},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45916327834129333},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.09728309512138367}],"concepts":[{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5379171371459961},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.46969011425971985},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45916327834129333},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09728309512138367},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.2c01459","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c01459","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:36795011","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36795011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1611211863","display_name":null,"funder_award_id":"2020C03010","funder_id":"https://openalex.org/F4320327829","funder_display_name":"Primary Research and Development Plan of Zhejiang Province"},{"id":"https://openalex.org/G2446395889","display_name":null,"funder_award_id":"81872798","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5970591423","display_name":null,"funder_award_id":"2018QNA7023","funder_id":"https://openalex.org/F4320329878","funder_display_name":"Central University Basic Research Fund of China"},{"id":"https://openalex.org/G6053663346","display_name":null,"funder_award_id":"201908330151","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G6571045748","display_name":null,"funder_award_id":"LQ17H160009","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G8139108554","display_name":null,"funder_award_id":"81802371","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8601426346","display_name":null,"funder_award_id":"4125C5021720421","funder_id":"https://openalex.org/F4320324716","funder_display_name":"Hangzhou Normal University"},{"id":"https://openalex.org/G8951279597","display_name":null,"funder_award_id":"LR21H300001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320324716","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15"},{"id":"https://openalex.org/F4320327829","display_name":"Primary Research and Development Plan of Zhejiang Province","ror":null},{"id":"https://openalex.org/F4320329878","display_name":"Central University Basic Research Fund of China","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W1465972928","https://openalex.org/W1971513938","https://openalex.org/W1985669808","https://openalex.org/W1993457224","https://openalex.org/W2006964053","https://openalex.org/W2007055380","https://openalex.org/W2022955339","https://openalex.org/W2030211802","https://openalex.org/W2039574315","https://openalex.org/W2076619641","https://openalex.org/W2085935968","https://openalex.org/W2091642227","https://openalex.org/W2091944654","https://openalex.org/W2095507914","https://openalex.org/W2111581388","https://openalex.org/W2112092738","https://openalex.org/W2130527334","https://openalex.org/W2135732933","https://openalex.org/W2136159476","https://openalex.org/W2142678031","https://openalex.org/W2148671784","https://openalex.org/W2280722423","https://openalex.org/W2300993165","https://openalex.org/W2515810634","https://openalex.org/W2564219696","https://openalex.org/W2575918694","https://openalex.org/W2622296711","https://openalex.org/W2623779517","https://openalex.org/W2739661954","https://openalex.org/W2742290435","https://openalex.org/W2761152574","https://openalex.org/W2766193612","https://openalex.org/W2766490148","https://openalex.org/W2767140282","https://openalex.org/W2774548355","https://openalex.org/W2793371195","https://openalex.org/W2803325216","https://openalex.org/W2888079468","https://openalex.org/W2898264436","https://openalex.org/W2898468989","https://openalex.org/W2899291554","https://openalex.org/W2900090807","https://openalex.org/W2901903103","https://openalex.org/W2903829928","https://openalex.org/W2908659803","https://openalex.org/W2910764018","https://openalex.org/W2912356384","https://openalex.org/W2932386949","https://openalex.org/W2970519837","https://openalex.org/W2988596226","https://openalex.org/W2996322062","https://openalex.org/W2996785294","https://openalex.org/W3006225361","https://openalex.org/W3011366455","https://openalex.org/W3023181049","https://openalex.org/W3026855384","https://openalex.org/W3027771447","https://openalex.org/W3032755985","https://openalex.org/W3035506365","https://openalex.org/W3036141688","https://openalex.org/W3042698891","https://openalex.org/W3048708590","https://openalex.org/W3081949166","https://openalex.org/W3089574919","https://openalex.org/W3092386449","https://openalex.org/W3097145107","https://openalex.org/W3099939732","https://openalex.org/W3108860514","https://openalex.org/W3118695441","https://openalex.org/W3119952098","https://openalex.org/W3120353886","https://openalex.org/W3124865939","https://openalex.org/W3125567894","https://openalex.org/W3126411618","https://openalex.org/W3132651820","https://openalex.org/W3134660576","https://openalex.org/W3136954866","https://openalex.org/W3150587312","https://openalex.org/W3157162197","https://openalex.org/W3163969667","https://openalex.org/W3169941591","https://openalex.org/W3174245009","https://openalex.org/W3176573565","https://openalex.org/W3178708729","https://openalex.org/W3191073120","https://openalex.org/W3197092605","https://openalex.org/W3198777738","https://openalex.org/W3203580469","https://openalex.org/W3206478579","https://openalex.org/W3209785949","https://openalex.org/W3213852803","https://openalex.org/W4200509090","https://openalex.org/W4200553915","https://openalex.org/W4205519906","https://openalex.org/W4224223132","https://openalex.org/W4225164599","https://openalex.org/W4229369858","https://openalex.org/W4247001379","https://openalex.org/W4280589125","https://openalex.org/W4281658583"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2366107444","https://openalex.org/W4388145910","https://openalex.org/W1976205134","https://openalex.org/W2381570729","https://openalex.org/W4248336175","https://openalex.org/W3009369890","https://openalex.org/W2031260042","https://openalex.org/W2391445434","https://openalex.org/W4312490297"],"abstract_inverted_index":{"Natural":[0],"products":[1],"(NPs)":[2],"have":[3],"long":[4],"been":[5],"associated":[6],"with":[7,101],"human":[8],"production":[9],"and":[10,35,78,87,94,112,133,141,157,165,170,196,199,215],"play":[11],"a":[12,46,61,186,205],"key":[13],"role":[14],"in":[15,22,51],"the":[16,28,73,109,123,128,131,161,171,191,210,217],"survival":[17],"of":[18,32,75,122,130,163,173,212,219],"species.":[19],"Significant":[20],"variations":[21,50,74],"NP":[23,52,76,118,166,174,197],"content":[24,53,119,175],"may":[25],"severely":[26],"affect":[27],"\"return":[29],"on":[30],"investment\"":[31],"NP-based":[33],"industries":[34],"render":[36],"ecological":[37],"systems":[38],"vulnerable.":[39],"Thus,":[40],"it":[41],"is":[42,185,200],"crucial":[43],"to":[44,54,148,167,202],"construct":[45],"platform":[47,83],"that":[48,125],"relates":[49],"their":[55,79],"corresponding":[56,80],"mechanisms.":[57,81],"In":[58,182],"this":[59],"study,":[60],"publicly":[62],"accessible":[63],"online":[64],"platform,":[65],"NPcVar":[66,184],"(http://npcvar.idrblab.net/),":[67],"was":[68],"developed,":[69],"which":[70,146],"systematically":[71],"described":[72],"contents":[77,198],"The":[82],"comprises":[84],"2201":[85],"NPs":[86,214],"694":[88],"biological":[89],"resources,":[90],"including":[91],"plants,":[92],"bacteria,":[93],"fungi,":[95],"curated":[96,140],"using":[97],"126":[98],"diverse":[99],"factors":[100,113,137],"26,425":[102],"records.":[103],"Each":[104],"record":[105],"contains":[106],"information":[107],"about":[108],"species,":[110,194],"NP,":[111],"involved,":[114],"as":[115,117,204],"well":[116],"data,":[120],"parts":[121],"plant":[124],"produce":[126],"NPs,":[127],"location":[129],"experiment,":[132],"reference":[134],"information.":[135],"All":[136],"were":[138,180],"manually":[139],"categorized":[142],"into":[143],"42":[144],"classes":[145],"belong":[147],"four":[149],"mechanisms":[150],"(molecular":[151],"regulation,":[152],"species":[153,164],"factor,":[154],"environmental":[155],"condition,":[156],"combined":[158],"factor).":[159],"Additionally,":[160],"cross-links":[162],"well-established":[168],"databases":[169],"visualization":[172],"under":[176],"various":[177],"experimental":[178],"conditions":[179],"provided.":[181],"conclusion,":[183],"valuable":[187],"resource":[188],"for":[189,208],"understanding":[190],"relationship":[192],"between":[193],"factors,":[195],"anticipated":[201],"serve":[203],"promising":[206],"tool":[207],"improving":[209],"yield":[211],"high-value":[213],"facilitating":[216],"development":[218],"new":[220],"therapeutics.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
