{"id":"https://openalex.org/W4328048392","doi":"https://doi.org/10.1021/acs.jcim.2c01281","title":"Structural Dynamics of Lys11-Selective Deubiquitinylase Cezanne-1 during the Catalytic Cycle","display_name":"Structural Dynamics of Lys11-Selective Deubiquitinylase Cezanne-1 during the Catalytic Cycle","publication_year":2023,"publication_date":"2023-03-21","ids":{"openalex":"https://openalex.org/W4328048392","doi":"https://doi.org/10.1021/acs.jcim.2c01281","pmid":"https://pubmed.ncbi.nlm.nih.gov/36943332"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c01281","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1021/acs.jcim.2c01281","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://dx.doi.org/10.1021/acs.jcim.2c01281","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056300815","display_name":"Metehan Ilter","orcid":"https://orcid.org/0000-0003-3579-4552"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Metehan Ilter","raw_affiliation_strings":["Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039803191","display_name":"Eric Schulze","orcid":"https://orcid.org/0000-0002-6912-1412"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eric Schulze-Niemand","raw_affiliation_strings":["Medical Faculty, Institute for Experimental Internal Medicine, Otto von Guericke University, 39120 Magdeburg, Germany","Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Medical Faculty, Institute for Experimental Internal Medicine, Otto von Guericke University, 39120 Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048683029","display_name":"Michael Naumann","orcid":"https://orcid.org/0000-0002-8060-2313"},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Naumann","raw_affiliation_strings":["Medical Faculty, Institute for Experimental Internal Medicine, Otto von Guericke University, 39120 Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Medical Faculty, Institute for Experimental Internal Medicine, Otto von Guericke University, 39120 Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083460661","display_name":"Matthias Stein","orcid":"https://orcid.org/0000-0001-7793-0052"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Stein","raw_affiliation_strings":["Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083460661"],"corresponding_institution_ids":["https://openalex.org/I4210127568"],"apc_list":null,"apc_paid":null,"fwci":0.3045,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.62171347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"63","issue":"7","first_page":"2084","last_page":"2094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubiquitin","display_name":"Ubiquitin","score":0.7093654870986938},{"id":"https://openalex.org/keywords/proteolysis","display_name":"Proteolysis","score":0.5671107769012451},{"id":"https://openalex.org/keywords/catalysis","display_name":"Catalysis","score":0.5484630465507507},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5194994211196899},{"id":"https://openalex.org/keywords/scissile-bond","display_name":"Scissile bond","score":0.5052114129066467},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5017974376678467},{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.47878849506378174},{"id":"https://openalex.org/keywords/cleavage","display_name":"Cleavage (geology)","score":0.44665947556495667},{"id":"https://openalex.org/keywords/catalytic-cycle","display_name":"Catalytic cycle","score":0.43856868147850037},{"id":"https://openalex.org/keywords/covalent-bond","display_name":"Covalent bond","score":0.434981107711792},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40125036239624023},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3778654634952545},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.289697527885437},{"id":"https://openalex.org/keywords/active-site","display_name":"Active site","score":0.24706128239631653},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22299876809120178},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16624850034713745},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.07911783456802368}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7093654870986938},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5671107769012451},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5484630465507507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5194994211196899},{"id":"https://openalex.org/C87282627","wikidata":"https://www.wikidata.org/wiki/Q3623657","display_name":"Scissile bond","level":4,"score":0.5052114129066467},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5017974376678467},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.47878849506378174},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.44665947556495667},{"id":"https://openalex.org/C63338738","wikidata":"https://www.wikidata.org/wiki/Q287862","display_name":"Catalytic cycle","level":3,"score":0.43856868147850037},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.434981107711792},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40125036239624023},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3778654634952545},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.289697527885437},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.24706128239631653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22299876809120178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16624850034713745},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.07911783456802368},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025821","descriptor_name":"Polyubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025821","descriptor_name":"Polyubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025821","descriptor_name":"Polyubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.2c01281","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1021/acs.jcim.2c01281","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:36943332","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36943332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10091412","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10091412","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10091412/pdf/ci2c01281.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.2c01281","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1021/acs.jcim.2c01281","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1599909685","display_name":null,"funder_award_id":"IMPRS","funder_id":"https://openalex.org/F4320322434","funder_display_name":"Max-Planck-Gesellschaft"},{"id":"https://openalex.org/G3517681755","display_name":null,"funder_award_id":"IMPRS ProEng","funder_id":"https://openalex.org/F4320322434","funder_display_name":"Max-Planck-Gesellschaft"},{"id":"https://openalex.org/G3663005422","display_name":null,"funder_award_id":"ZS/2016/04/78155","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G6720320153","display_name":null,"funder_award_id":"CA20113","funder_id":"https://openalex.org/F4320320366","funder_display_name":"European Cooperation in Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320317967","display_name":"International Max Planck Research School for Environmental, Cellular and Molecular Microbiology","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320366","display_name":"European Cooperation in Science and Technology","ror":"https://ror.org/01bstzn19"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320327553","display_name":"International Max Planck Research School for Advanced Methods in Process and Systems Engineering","ror":null},{"id":"https://openalex.org/F4320328159","display_name":"Ministerium f\u00fcr Wirtschaft, Wissenschaft und Digitalisierung","ror":null},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1607931568","https://openalex.org/W1948562438","https://openalex.org/W1971190621","https://openalex.org/W1972266008","https://openalex.org/W1976499671","https://openalex.org/W1978189250","https://openalex.org/W1979320080","https://openalex.org/W1992682414","https://openalex.org/W2008310735","https://openalex.org/W2011301426","https://openalex.org/W2029667189","https://openalex.org/W2031168104","https://openalex.org/W2032997281","https://openalex.org/W2035687084","https://openalex.org/W2043666236","https://openalex.org/W2045440995","https://openalex.org/W2052247259","https://openalex.org/W2059680729","https://openalex.org/W2067174909","https://openalex.org/W2070867726","https://openalex.org/W2071299561","https://openalex.org/W2075110858","https://openalex.org/W2079204784","https://openalex.org/W2119415370","https://openalex.org/W2130479394","https://openalex.org/W2132629607","https://openalex.org/W2147917253","https://openalex.org/W2152630268","https://openalex.org/W2231663276","https://openalex.org/W2277286928","https://openalex.org/W2512372054","https://openalex.org/W2530082208","https://openalex.org/W2555870966","https://openalex.org/W2556724632","https://openalex.org/W2587794567","https://openalex.org/W2613065881","https://openalex.org/W2755866416","https://openalex.org/W2757682641","https://openalex.org/W2767932875","https://openalex.org/W2772137821","https://openalex.org/W2810432477","https://openalex.org/W2892113269","https://openalex.org/W2914591999","https://openalex.org/W2944979483","https://openalex.org/W2949223833","https://openalex.org/W2981609597","https://openalex.org/W2995511870","https://openalex.org/W3006394146","https://openalex.org/W3014590847","https://openalex.org/W3019370877","https://openalex.org/W3035965352","https://openalex.org/W3099878876","https://openalex.org/W3104537585","https://openalex.org/W3120941209","https://openalex.org/W3150635270","https://openalex.org/W3161247919","https://openalex.org/W3211799364","https://openalex.org/W3217622509","https://openalex.org/W4210757594","https://openalex.org/W4211196614","https://openalex.org/W4213443989","https://openalex.org/W4221053926","https://openalex.org/W4221121488","https://openalex.org/W4224982965","https://openalex.org/W4226406325","https://openalex.org/W4255701985","https://openalex.org/W4282944824","https://openalex.org/W4283515446"],"related_works":["https://openalex.org/W2021279721","https://openalex.org/W1965104714","https://openalex.org/W2949992629","https://openalex.org/W2042205983","https://openalex.org/W2106356673","https://openalex.org/W2403947567","https://openalex.org/W1517318877","https://openalex.org/W1965473334","https://openalex.org/W2162392654","https://openalex.org/W2030539700"],"abstract_inverted_index":{"Deubiquitinylating":[0],"enzymes":[1],"(DUBs)":[2],"regulate":[3],"the":[4,24,27,48,55,81,115,163,170,174,177,182,188,194,201,205,213,218],"deubiquitinylation":[5],"process":[6,100,225],"of":[7,26,30,39,62,66,96,101,114,125,149,169,181,187,193,199,207,212,222,226,231,254],"post-translationally":[8],"modified":[9],"proteins":[10],"and":[11,51,64,103,118,139,228,278],"thus":[12],"control":[13,65],"protein":[14,249],"signaling":[15],"in":[16,41,267],"various":[17],"cellular":[18],"processes.":[19],"The":[20,152,166,209,224],"DUB":[21,82,121,232],"Cezanne-1":[22,40,120,133,156,233],"catalyzes":[23],"cleavage":[25,192],"iso-peptide":[28,189],"bond":[29],"Lys11-linked":[31],"polyubiquitin":[32],"chains":[33],"with":[34,80,238],"high":[35],"selectivity.":[36],"Crystal":[37],"structures":[38,90,250],"different":[42],"states":[43,75,141,277],"provide":[44],"important":[45],"insight":[46],"regarding":[47],"complex":[49],"formation":[50],"global":[52],"changes":[53,95],"during":[54,98],"catalytic":[56,164,229],"cycle":[57,237],"but":[58],"are":[59,70,92,106],"lacking":[60],"details":[61],"dynamics":[63,111],"activation.":[67],"Activity-based":[68,252],"probes":[69,253],"used":[71],"to":[72,89,162,258,264,269,272],"isolate":[73],"intermediate":[74],"upon":[76],"forming":[77],"covalent":[78],"bonds":[79],"active":[83],"site.":[84],"Those,":[85],"however,":[86],"may":[87],"lead":[88,257],"that":[91,131,144,243],"non-native.":[93],"Conformational":[94],"Cezanne-1,":[97],"its":[99,145],"activation":[102,146,227],"proteolytic":[104],"activity,":[105],"investigated":[107],"using":[108],"all-atom":[109],"molecular":[110],"(MD)":[112],"simulations":[113],"ubiquitin-free,":[116],"diubiquitin-bound,":[117],"monoubiquitin-bound":[119],"for":[122],"a":[123,235],"total":[124],"\u223c18":[126],"\u03bcs.":[127],"Our":[128],"results":[129],"show":[130],"ubiquitin-free":[132],"dynamically":[134],"shuttles":[135],"between":[136],"catalytically":[137,153,178],"competent":[138,154,179],"incompetent":[140],"which":[142,262],"suggests":[143],"is":[147,234],"independent":[148],"substrate":[150,160,279],"binding.":[151,280],"substrate-free":[155,220],"promotes":[157],"distal":[158,214],"ubiquitin":[159,172,203,215],"access":[161],"center.":[165],"subsequent":[167,210],"binding":[168],"proximal":[171,202],"shifts":[173],"equilibrium":[175],"toward":[176],"state":[180,221],"dyad,":[183],"thereby":[184],"promoting":[185],"proteolysis":[186],"bond.":[190],"After":[191],"scissile":[195],"bond,":[196],"sequential":[197],"dissociation":[198],"first":[200],"induces":[204],"inactivation":[206],"Cezanne-1.":[208,223],"release":[211],"fully":[216],"reconstitutes":[217],"inactive":[219],"turnover":[230],"multistage":[236],"several":[239],"critical":[240],"dynamic":[241],"transitions":[242],"cannot":[244],"be":[245,265,270],"characterized":[246],"based":[247],"on":[248],"alone.":[251],"cysteine":[255],"proteases":[256],"non-native":[259],"protein-protein":[260],"contacts,":[261],"need":[263],"resolved":[266],"order":[268],"able":[271],"issue":[273],"statements":[274],"about":[275],"physiological":[276]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}