{"id":"https://openalex.org/W4294287432","doi":"https://doi.org/10.1021/acs.jcim.2c00931","title":"Lipid Composition Is Critical for Accurate Membrane Permeability Prediction of Cyclic Peptides by Molecular Dynamics Simulations","display_name":"Lipid Composition Is Critical for Accurate Membrane Permeability Prediction of Cyclic Peptides by Molecular Dynamics Simulations","publication_year":2022,"publication_date":"2022-09-02","ids":{"openalex":"https://openalex.org/W4294287432","doi":"https://doi.org/10.1021/acs.jcim.2c00931","pmid":"https://pubmed.ncbi.nlm.nih.gov/36053061"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c00931","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00931","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jcim.2c00931","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013321826","display_name":"Masatake Sugita","orcid":"https://orcid.org/0000-0002-6298-4055"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatake Sugita","raw_affiliation_strings":["Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6298-4055","affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042242302","display_name":"Takuya Fujie","orcid":"https://orcid.org/0000-0003-2103-6195"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Fujie","raw_affiliation_strings":["Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2103-6195","affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025154811","display_name":"Keisuke Yanagisawa","orcid":"https://orcid.org/0000-0003-0224-0035"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Yanagisawa","raw_affiliation_strings":["Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0224-0035","affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061510293","display_name":"Masahito Ohue","orcid":"https://orcid.org/0000-0002-0120-1643"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahito Ohue","raw_affiliation_strings":["Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0120-1643","affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067025136","display_name":"Yutaka Akiyama","orcid":"https://orcid.org/0000-0003-2863-8703"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yutaka Akiyama","raw_affiliation_strings":["Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2863-8703","affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Computing, Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"Middle-Molecule IT-Based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology, W8-76, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan","institution_ids":["https://openalex.org/I114531698"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067025136"],"corresponding_institution_ids":["https://openalex.org/I114531698"],"apc_list":null,"apc_paid":null,"fwci":2.0146,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87340216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"62","issue":"18","first_page":"4549","last_page":"4560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.8035436868667603},{"id":"https://openalex.org/keywords/permeation","display_name":"Permeation","score":0.6764679551124573},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.6473367810249329},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6335603594779968},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.6279527544975281},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"Membrane permeability","score":0.5663396716117859},{"id":"https://openalex.org/keywords/permeability","display_name":"Permeability (electromagnetism)","score":0.5412343144416809},{"id":"https://openalex.org/keywords/phospholipid","display_name":"Phospholipid","score":0.5317256450653076},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.48345574736595154},{"id":"https://openalex.org/keywords/bilayer","display_name":"Bilayer","score":0.4522339999675751},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25369739532470703},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.11612218618392944},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08169382810592651}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.8035436868667603},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.6764679551124573},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6473367810249329},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6335603594779968},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6279527544975281},{"id":"https://openalex.org/C2992270614","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Membrane permeability","level":3,"score":0.5663396716117859},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.5412343144416809},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5317256450653076},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48345574736595154},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.4522339999675751},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25369739532470703},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.11612218618392944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08169382810592651}],"mesh":[{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.2c00931","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00931","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:36053061","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36053061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9516681","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9516681","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.2c00931","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00931","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G198109904","display_name":"Virtual screening method for large-scale compound databases using commonality in chemical substructures","funder_award_id":"23K24939","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3111806582","display_name":"Comprehensive prediction of cryptic binding sites by multi-task deep learning","funder_award_id":"20K19917","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3349834411","display_name":null,"funder_award_id":"FOREST Program (Grant No. JPMJFR216J)","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G5081383656","display_name":"Development of computational methods for supporting druggable cyclic peptide design","funder_award_id":"17H01814","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7265995339","display_name":null,"funder_award_id":"JP22ama121026","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G8317022281","display_name":"\u30de\u30eb\u30c1\u30e2\u30c0\u30ea\u30c6\u30a3\u5275\u85ac\u3092\u62d3\u304f\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u57fa\u76e4","funder_award_id":"JPMJFR216J","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322704","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W54789453","https://openalex.org/W1963697925","https://openalex.org/W1976499671","https://openalex.org/W1977698867","https://openalex.org/W1978502680","https://openalex.org/W1984481443","https://openalex.org/W1989753444","https://openalex.org/W1996903698","https://openalex.org/W2004926660","https://openalex.org/W2007070530","https://openalex.org/W2011189520","https://openalex.org/W2021520922","https://openalex.org/W2027384625","https://openalex.org/W2034078233","https://openalex.org/W2039984482","https://openalex.org/W2047414254","https://openalex.org/W2048312836","https://openalex.org/W2051039246","https://openalex.org/W2057491831","https://openalex.org/W2067545345","https://openalex.org/W2067553925","https://openalex.org/W2074140794","https://openalex.org/W2075749349","https://openalex.org/W2092487929","https://openalex.org/W2092762355","https://openalex.org/W2096125044","https://openalex.org/W2105103540","https://openalex.org/W2106605095","https://openalex.org/W2112154906","https://openalex.org/W2121678787","https://openalex.org/W2122745784","https://openalex.org/W2125872855","https://openalex.org/W2133679578","https://openalex.org/W2135732933","https://openalex.org/W2136359146","https://openalex.org/W2141888839","https://openalex.org/W2142528678","https://openalex.org/W2157297563","https://openalex.org/W2162410267","https://openalex.org/W2279263454","https://openalex.org/W2329105392","https://openalex.org/W2333168323","https://openalex.org/W2339460745","https://openalex.org/W2345419012","https://openalex.org/W2346205968","https://openalex.org/W2473618562","https://openalex.org/W2522273126","https://openalex.org/W2529268217","https://openalex.org/W2564974142","https://openalex.org/W2569093964","https://openalex.org/W2609522315","https://openalex.org/W2785477444","https://openalex.org/W2796027835","https://openalex.org/W2803364122","https://openalex.org/W2804716008","https://openalex.org/W2808487647","https://openalex.org/W2892865232","https://openalex.org/W2900345897","https://openalex.org/W2900679761","https://openalex.org/W2904455146","https://openalex.org/W2915230923","https://openalex.org/W2942566598","https://openalex.org/W3048462249","https://openalex.org/W3080784905","https://openalex.org/W3115044263","https://openalex.org/W3177545261","https://openalex.org/W3193672628","https://openalex.org/W3196622003","https://openalex.org/W3197039015","https://openalex.org/W4241194400","https://openalex.org/W4248107770"],"related_works":["https://openalex.org/W2389992822","https://openalex.org/W2061481432","https://openalex.org/W2100090167","https://openalex.org/W2718515487","https://openalex.org/W4367601614","https://openalex.org/W2072230736","https://openalex.org/W1963901611","https://openalex.org/W2059795428","https://openalex.org/W4206087209","https://openalex.org/W2289704112"],"abstract_inverted_index":{">":[0],"0.8":[1],"between":[2],"the":[3,22,33,37,50,54,68,73,81],"experimental":[4],"and":[5,49],"calculated":[6],"permeability":[7,39],"values":[8],"were":[9],"obtained":[10,52],"with":[11,89],"both":[12],"model":[13,58],"membranes.":[14],"The":[15,42],"results":[16,74],"of":[17,40,56,67,75,83],"this":[18,47,76],"study":[19,48,77],"demonstrate":[20],"that":[21],"lipid":[23],"membrane":[24,38,57,69,91],"is":[25],"not":[26],"just":[27],"a":[28,64],"medium":[29],"but":[30],"also":[31],"among":[32],"main":[34],"factors":[35],"determining":[36],"molecules.":[41],"computational":[43],"protocol":[44],"proposed":[45],"in":[46],"findings":[51],"on":[53],"effect":[55],"composition":[59],"will":[60,78],"contribute":[61],"to":[62],"building":[63],"schematic":[65],"view":[66],"permeation":[70],"process.":[71],"Furthermore,":[72],"eventually":[79],"aid":[80],"elucidation":[82],"design":[84],"rules":[85],"for":[86],"peptide":[87],"drugs":[88],"high":[90],"permeability.":[92]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}