{"id":"https://openalex.org/W4304114270","doi":"https://doi.org/10.1021/acs.jcim.2c00836","title":"Screening ssDNA Aptamers Against Human Vascular Endothelial Factor 165 via Semirational Design","display_name":"Screening ssDNA Aptamers Against Human Vascular Endothelial Factor 165 via Semirational Design","publication_year":2022,"publication_date":"2022-10-10","ids":{"openalex":"https://openalex.org/W4304114270","doi":"https://doi.org/10.1021/acs.jcim.2c00836","pmid":"https://pubmed.ncbi.nlm.nih.gov/36215718"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c00836","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00836","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008793882","display_name":"Haiyi Zhang","orcid":"https://orcid.org/0000-0003-4260-1894"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyi Zhang","raw_affiliation_strings":["Biotechnology Department, College of Life Science and Technology, Jinan University, Guangzhou 510632, China"],"affiliations":[{"raw_affiliation_string":"Biotechnology Department, College of Life Science and Technology, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083782796","display_name":"Xiyao Zhang","orcid":"https://orcid.org/0000-0001-6965-860X"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiyao Zhang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China","Institute of Biomedicine Jinan University, Guangzhou 510632, China","National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China"],"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Biomedicine Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047022394","display_name":"Guanhong Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanhong Huang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China","Institute of Biomedicine Jinan University, Guangzhou 510632, China","National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China"],"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Biomedicine Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450471","display_name":"Feifei Li","orcid":"https://orcid.org/0009-0007-0254-0368"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifei Li","raw_affiliation_strings":["Biotechnology Department, College of Life Science and Technology, Jinan University, Guangzhou 510632, China"],"affiliations":[{"raw_affiliation_string":"Biotechnology Department, College of Life Science and Technology, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110334920","display_name":"Fengmei Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fengmei Wu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China","Institute of Biomedicine Jinan University, Guangzhou 510632, China","National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China"],"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Biomedicine Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100931066","display_name":"Chunfang Xie","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunfang Xie","raw_affiliation_strings":["Biotechnology Department, College of Life Science and Technology, Jinan University, Guangzhou 510632, China"],"affiliations":[{"raw_affiliation_string":"Biotechnology Department, College of Life Science and Technology, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062152682","display_name":"Daling Liu","orcid":"https://orcid.org/0000-0003-4130-4492"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daling Liu","raw_affiliation_strings":["Biotechnology Department, College of Life Science and Technology, Jinan University, Guangzhou 510632, China"],"affiliations":[{"raw_affiliation_string":"Biotechnology Department, College of Life Science and Technology, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113601229","display_name":"Dongsheng Yao","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongsheng Yao","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China","Institute of Biomedicine Jinan University, Guangzhou 510632, China","National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China"],"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Biomedicine Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5110334920","https://openalex.org/A5113601229"],"corresponding_institution_ids":["https://openalex.org/I159948400"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10068347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"20","first_page":"4983","last_page":"4991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.9953699111938477},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"Circular dichroism","score":0.6199387311935425},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"Surface plasmon resonance","score":0.5762799978256226},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5575719475746155},{"id":"https://openalex.org/keywords/isothermal-titration-calorimetry","display_name":"Isothermal titration calorimetry","score":0.43565812706947327},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.38113948702812195},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3527265787124634},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3436053991317749},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.275240421295166},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2573859691619873},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.22692614793777466},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.15431687235832214}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9953699111938477},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.6199387311935425},{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.5762799978256226},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5575719475746155},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.43565812706947327},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38113948702812195},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3527265787124634},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3436053991317749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.275240421295166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2573859691619873},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.22692614793777466},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15431687235832214}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012825","descriptor_name":"Silicon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012825","descriptor_name":"Silicon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012825","descriptor_name":"Silicon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052156","descriptor_name":"SELEX Aptamer Technique","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D052156","descriptor_name":"SELEX Aptamer Technique","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D052156","descriptor_name":"SELEX Aptamer Technique","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.2c00836","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00836","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:36215718","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36215718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1991867442","https://openalex.org/W2011375682","https://openalex.org/W2014874042","https://openalex.org/W2023373190","https://openalex.org/W2054205048","https://openalex.org/W2054618173","https://openalex.org/W2056285082","https://openalex.org/W2063406653","https://openalex.org/W2064480546","https://openalex.org/W2069365500","https://openalex.org/W2074988418","https://openalex.org/W2077130806","https://openalex.org/W2079321730","https://openalex.org/W2087325106","https://openalex.org/W2104525153","https://openalex.org/W2114050457","https://openalex.org/W2115735904","https://openalex.org/W2156113162","https://openalex.org/W2156412704","https://openalex.org/W2157732921","https://openalex.org/W2160373161","https://openalex.org/W2162072149","https://openalex.org/W2239206025","https://openalex.org/W2475310774","https://openalex.org/W2803244189","https://openalex.org/W2921434986","https://openalex.org/W2928631204","https://openalex.org/W3092532134","https://openalex.org/W3215616565"],"related_works":["https://openalex.org/W2967136651","https://openalex.org/W2033684641","https://openalex.org/W2913646003","https://openalex.org/W2081632393","https://openalex.org/W2147509954","https://openalex.org/W1970773045","https://openalex.org/W2898457449","https://openalex.org/W2390834423","https://openalex.org/W2990980575","https://openalex.org/W2416394875"],"abstract_inverted_index":{"As":[0],"a":[1,38,42,53,103,198],"valid":[2],"tumor":[3],"marker,":[4],"vascular":[5],"endothelial":[6],"growth":[7],"factor":[8],"165":[9],"(VEGF165)":[10],"is":[11],"an":[12,59,181],"effective":[13],"therapeutic":[14],"target":[15,54],"for":[16,23,55,86,106,125,200],"anticancer":[17],"treatments.":[18],"Aptamers":[19],"hold":[20],"great":[21],"promise":[22],"the":[24,56,136,148,185,201],"development":[25],"of":[26,58,142,187,203],"anti-VEGF":[27],"strategies.":[28],"In":[29],"this":[30],"study,":[31],"anti-VEGF165":[32],"ssDNA":[33,60,65],"aptamers":[34,89,126,138,173,179],"were":[35,81,108,119],"screened":[36],"using":[37,114],"semirational":[39,191],"design":[40,192],"and":[41,77,93,99,122,129,170,193],"multilevel":[43,194],"screening":[44,156,164,195,202],"strategy.":[45],"Recombinant":[46],"human":[47],"VEGF165":[48],"protein":[49],"was":[50],"used":[51,82,158],"as":[52],"construction":[57],"virtual":[61],"aptamer":[62,145,188],"library":[63],"with":[64,95,174],"that":[66,135],"had":[67,147,180],"one":[68,96,175],"sole":[69,97,176],"secondary":[70,98],"structure.":[71],"After":[72],"silicon-assisted":[73],"prescreening,":[74],"circular":[75],"dichroism":[76],"isothermal":[78],"titration":[79],"calorimetry":[80],"to":[83,167],"further":[84],"screen":[85],"candidates.":[87],"Three":[88],"(nos.":[90],"524,":[91,127],"529,":[92,128],"64)":[94],"tertiary":[100],"structure,":[101],"showing":[102],"high":[104],"affinity":[105],"VEGF165,":[107],"identified.":[109],"The":[110,155,178],"<i>K</i><sub>D</sub>":[111],"values":[112],"obtained":[113],"surface":[115],"plasmon":[116],"resonance":[117],"analysis":[118],"36.3,":[120],"288,":[121],"79.3":[123],"nM":[124],"64,":[130],"respectively.":[131],"Cytological":[132],"tests":[133],"revealed":[134],"three":[137],"inhibit":[139],"rhVEGF165-induced":[140],"proliferation":[141],"HUVECs.":[143],"Specifically,":[144],"529":[146],"strongest":[149],"inhibitory":[150],"effect":[151],"(nearly":[152],"100%":[153],"inhibition).":[154],"strategy":[157,196],"in":[159,172,183],"our":[160],"study":[161],"showed":[162],"improved":[163],"efficiency":[165],"relative":[166],"other":[168,204],"methods":[169],"resulted":[171],"conformation.":[177],"advantage":[182],"ensuring":[184],"uniqueness":[186],"targeting.":[189],"This":[190],"provide":[197],"reference":[199],"aptamers.":[205]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
