{"id":"https://openalex.org/W4292002633","doi":"https://doi.org/10.1021/acs.jcim.2c00799","title":"PROST: AlphaFold2-aware Sequence-Based Predictor to Estimate Protein Stability Changes upon Missense Mutations","display_name":"PROST: AlphaFold2-aware Sequence-Based Predictor to Estimate Protein Stability Changes upon Missense Mutations","publication_year":2022,"publication_date":"2022-08-16","ids":{"openalex":"https://openalex.org/W4292002633","doi":"https://doi.org/10.1021/acs.jcim.2c00799","pmid":"https://pubmed.ncbi.nlm.nih.gov/35973091"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c00799","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00799","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058792690","display_name":"Shahid Iqbal","orcid":"https://orcid.org/0000-0003-4321-8598"},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shahid Iqbal","raw_affiliation_strings":["Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia","Department of Data Science and AI, Faculty of IT, Monash University, Clayton, Victoria 3800, Australia","Monash Data Futures Institute, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Data Science and AI, Faculty of IT, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Data Futures Institute, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059460328","display_name":"Fang Ge","orcid":"https://orcid.org/0000-0001-5792-5379"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Ge","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063409460","display_name":"Fuyi Li","orcid":"https://orcid.org/0000-0001-5216-3213"},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fuyi Li","raw_affiliation_strings":["Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia","Monash Data Futures Institute, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0001-5216-3213","affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Data Futures Institute, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016330265","display_name":"Tatsuya Akutsu","orcid":null},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":null,"type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Akutsu","raw_affiliation_strings":["Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018524102","display_name":"Yuanting Zheng","orcid":"https://orcid.org/0000-0002-0897-0453"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yuanting Zheng","raw_affiliation_strings":["Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085039675","display_name":"Robin B. Gasser","orcid":"https://orcid.org/0000-0002-4423-1690"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robin B. Gasser","raw_affiliation_strings":["Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4423-1690","affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008960436","display_name":"Dong\u2010Jun Yu","orcid":"https://orcid.org/0000-0002-6786-8053"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong-Jun Yu","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China"],"raw_orcid":"https://orcid.org/0000-0002-6786-8053","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058054791","display_name":"Geoffrey I. Webb","orcid":"https://orcid.org/0000-0001-9963-5169"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Geoffrey I. Webb","raw_affiliation_strings":["Department of Data Science and AI, Faculty of IT, Monash University, Clayton, Victoria 3800, Australia","Monash Data Futures Institute, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Data Science and AI, Faculty of IT, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Data Futures Institute, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012709797","display_name":"Jiangning Song","orcid":"https://orcid.org/0000-0001-8031-9086"},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jiangning Song","raw_affiliation_strings":["Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia","Department of Data Science and AI, Faculty of IT, Monash University, Clayton, Victoria 3800, Australia","Monash Data Futures Institute, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8031-9086","affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Data Science and AI, Faculty of IT, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Data Futures Institute, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5008960436","https://openalex.org/A5012709797","https://openalex.org/A5058054791"],"corresponding_institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I36399199","https://openalex.org/I56590836"],"apc_list":null,"apc_paid":null,"fwci":3.6453,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.94428415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"62","issue":"17","first_page":"4270","last_page":"4282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9686999917030334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/missense-mutation","display_name":"Missense mutation","score":0.780353844165802},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5348528623580933},{"id":"https://openalex.org/keywords/frataxin","display_name":"Frataxin","score":0.5036353468894958},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4928617477416992},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.47450798749923706},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.469525009393692},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46895426511764526},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.46531298756599426},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40398356318473816},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3426514267921448},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28288018703460693},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.182079017162323},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13885381817817688}],"concepts":[{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.780353844165802},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5348528623580933},{"id":"https://openalex.org/C2779314966","wikidata":"https://www.wikidata.org/wiki/Q409999","display_name":"Frataxin","level":4,"score":0.5036353468894958},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4928617477416992},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47450798749923706},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.469525009393692},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46895426511764526},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.46531298756599426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40398356318473816},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3426514267921448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28288018703460693},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.182079017162323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13885381817817688},{"id":"https://openalex.org/C2779369046","wikidata":"https://www.wikidata.org/wiki/Q6072234","display_name":"Iron-binding proteins","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017388","descriptor_name":"Zygote Intrafallopian Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017388","descriptor_name":"Zygote Intrafallopian Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017388","descriptor_name":"Zygote Intrafallopian Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.2c00799","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00799","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:35973091","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35973091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.7599999904632568}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320971","display_name":"Monash University","ror":"https://ror.org/02bfwt286"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W579166296","https://openalex.org/W1975304761","https://openalex.org/W2008767710","https://openalex.org/W2023490488","https://openalex.org/W2031553026","https://openalex.org/W2064488723","https://openalex.org/W2103459989","https://openalex.org/W2104418738","https://openalex.org/W2105822562","https://openalex.org/W2107468375","https://openalex.org/W2118561568","https://openalex.org/W2120819598","https://openalex.org/W2136513422","https://openalex.org/W2149580316","https://openalex.org/W2154290668","https://openalex.org/W2157142295","https://openalex.org/W2165271176","https://openalex.org/W2262896633","https://openalex.org/W2295598076","https://openalex.org/W2335773464","https://openalex.org/W2418388116","https://openalex.org/W2428593791","https://openalex.org/W2615841538","https://openalex.org/W2793168264","https://openalex.org/W2794503008","https://openalex.org/W2884519572","https://openalex.org/W2898320067","https://openalex.org/W2900078410","https://openalex.org/W2912783011","https://openalex.org/W2916078022","https://openalex.org/W2916648886","https://openalex.org/W2945403072","https://openalex.org/W2953906682","https://openalex.org/W2955704392","https://openalex.org/W2983394854","https://openalex.org/W3000439699","https://openalex.org/W3010364596","https://openalex.org/W3012929814","https://openalex.org/W3045100294","https://openalex.org/W3087371631","https://openalex.org/W3105524694","https://openalex.org/W3105751341","https://openalex.org/W3119533938","https://openalex.org/W3136918052","https://openalex.org/W3164662464","https://openalex.org/W3171481040","https://openalex.org/W3177828909","https://openalex.org/W4206007286"],"related_works":["https://openalex.org/W2168176110","https://openalex.org/W2015566467","https://openalex.org/W2606764607","https://openalex.org/W4321168107","https://openalex.org/W3089206408","https://openalex.org/W4386070823","https://openalex.org/W2069150591","https://openalex.org/W4232163425","https://openalex.org/W2163721943","https://openalex.org/W2095784700"],"abstract_inverted_index":{")":[0],"upon":[1],"a":[2,51,118,213],"single-point":[3],"missense":[4],"mutation.":[5],"PROST":[6,48,68,92,114,168,182,211,239],"extracts":[7,24],"multiple":[8],"descriptors":[9,25,32],"from":[10,26],"the":[11,79,91,107,155,165,172,193,201],"most":[12,108],"promising":[13],"sequence-based":[14,34,129],"predictors,":[15],"such":[16,175],"as":[17,176],"BoostDDG,":[18,177],"SAAFEC-SEQ,":[19,178],"and":[20,28,43,64,74,102,126,130,145,152,160,180,231,244],"DDGun.":[21],"RPOST":[22],"also":[23],"iFeature":[27],"AlphaFold2.":[29],"The":[30,47,88,111,223],"extracted":[31],"include":[33],"features,":[35],"physicochemical":[36,41],"properties,":[37,42],"evolutionary":[38],"information,":[39],"evolutionary-based":[40],"predicted":[44],"structural":[45,219],"features.":[46,110],"predictor":[49,215],"is":[50,69,115,169,212,221],"weighted":[52],"average":[53],"ensemble":[54],"model":[55,93],"based":[56],"on":[57,71,138],"extreme":[58],"gradient":[59],"boosting":[60],"(XGBoost)":[61],"decision":[62],"trees":[63],"an":[65],"extra-trees":[66],"regressor;":[67],"trained":[70],"both":[72],"direct":[73,82],"hypothetical":[75],"reverse":[76],"mutations":[77,83],"using":[78,96],"S5294":[80],"(S2647":[81],"+":[84],"S2647":[85],"inverse":[86],"mutations).":[87],"parameters":[89],"for":[90,158,196],"are":[94,240],"optimized":[95],"grid":[97],"searching":[98],"with":[99,171,235],"5-fold":[100],"cross-validation,":[101],"feature":[103],"importance":[104],"analysis":[105],"unveils":[106],"relevant":[109],"performance":[112,166],"of":[113,167,189,192,203,226],"evaluated":[116],"in":[117,149],"blinded":[119],"manner,":[120],"employing":[121],"nine":[122,197],"distinct":[123],"data":[124,147,162,228],"sets":[125,148],"existing":[127],"state-of-the-art":[128,156],"structure-based":[131],"predictors.":[132,185],"This":[133],"method":[134],"consistently":[135],"performs":[136],"well":[137],"frataxin,":[139],"S217,":[140],"S349,":[141],"Ssym,":[142],"S669,":[143],"Myoglobin,":[144],"CAGI5":[146],"blind":[150],"tests":[151],"similarly":[153],"to":[154,237],"predictors":[157,174],"p53":[159],"S276":[161],"sets.":[163],"When":[164],"compared":[170],"latest":[173],"ACDC-NN-seq,":[179],"DDGun,":[181],"dominates":[183],"these":[184,207],"A":[186],"case":[187],"study":[188],"mutation":[190],"scanning":[191],"frataxin":[194],"protein":[195,218],"wild-type":[198],"residues":[199],"demonstrates":[200],"utility":[202],"PROST.":[204],"Taken":[205],"together,":[206],"findings":[208],"indicate":[209],"that":[210],"well-suited":[214],"when":[216],"no":[217],"information":[220],"available.":[222],"source":[224],"code":[225],"PROST,":[227],"sets,":[229],"examples,":[230],"pretrained":[232],"models":[233],"along":[234],"how":[236],"use":[238],"available":[241],"at":[242],"https://github.com/ShahidIqb/PROST":[243],"https://prost.erc.monash.edu/seq.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":2}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}
