{"id":"https://openalex.org/W4307857927","doi":"https://doi.org/10.1021/acs.jcim.2c00583","title":"An Integrated Machine Learning Model To Spot Peptide Binding Pockets in 3D Protein Screening","display_name":"An Integrated Machine Learning Model To Spot Peptide Binding Pockets in 3D Protein Screening","publication_year":2022,"publication_date":"2022-11-02","ids":{"openalex":"https://openalex.org/W4307857927","doi":"https://doi.org/10.1021/acs.jcim.2c00583","pmid":"https://pubmed.ncbi.nlm.nih.gov/36320100"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c00583","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00583","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077504384","display_name":"Daniela Trisciuzzi","orcid":"https://orcid.org/0000-0002-8799-6562"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]},{"id":"https://openalex.org/I4210165610","display_name":"Molecular Discovery (United Kingdom)","ror":"https://ror.org/0576dtf44","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210165610"]}],"countries":["GB","IT"],"is_corresponding":true,"raw_author_name":"Daniela Trisciuzzi","raw_affiliation_strings":["Department of Pharmacy\u2212Pharmaceutical Sciences, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, 70125Bari, Italy","Molecular Discovery Ltd., Kinetic Business Centre, Theobald Street, Elstree, Borehamwood, HertfordshireWD6 4PJ, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy\u2212Pharmaceutical Sciences, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, 70125Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Molecular Discovery Ltd., Kinetic Business Centre, Theobald Street, Elstree, Borehamwood, HertfordshireWD6 4PJ, United Kingdom","institution_ids":["https://openalex.org/I4210165610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088363622","display_name":"Lydia Siragusa","orcid":"https://orcid.org/0000-0003-4596-7242"},"institutions":[{"id":"https://openalex.org/I4210165610","display_name":"Molecular Discovery (United Kingdom)","ror":"https://ror.org/0576dtf44","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210165610"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lydia Siragusa","raw_affiliation_strings":["Molecular Discovery Ltd., Kinetic Business Centre, Theobald Street, Elstree, Borehamwood, HertfordshireWD6 4PJ, United Kingdom","Molecular Horizon s.r.l., Via Montelino, 30, 06084Bettona (PG), Italy"],"affiliations":[{"raw_affiliation_string":"Molecular Discovery Ltd., Kinetic Business Centre, Theobald Street, Elstree, Borehamwood, HertfordshireWD6 4PJ, United Kingdom","institution_ids":["https://openalex.org/I4210165610"]},{"raw_affiliation_string":"Molecular Horizon s.r.l., Via Montelino, 30, 06084Bettona (PG), Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083725137","display_name":"Massimo Baroni","orcid":"https://orcid.org/0000-0003-0866-148X"},"institutions":[{"id":"https://openalex.org/I4210165610","display_name":"Molecular Discovery (United Kingdom)","ror":"https://ror.org/0576dtf44","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210165610"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Massimo Baroni","raw_affiliation_strings":["Molecular Discovery Ltd., Kinetic Business Centre, Theobald Street, Elstree, Borehamwood, HertfordshireWD6 4PJ, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Molecular Discovery Ltd., Kinetic Business Centre, Theobald Street, Elstree, Borehamwood, HertfordshireWD6 4PJ, United Kingdom","institution_ids":["https://openalex.org/I4210165610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049965061","display_name":"Gabriele Cruciani","orcid":"https://orcid.org/0000-0002-4162-8692"},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Cruciani","raw_affiliation_strings":["Department of Chemistry, Biology and Biotechnology, Universit\u00e0 degli Studi di Perugia, via Elce di Sotto, 8, 06123Perugia (PG), Italy"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Biology and Biotechnology, Universit\u00e0 degli Studi di Perugia, via Elce di Sotto, 8, 06123Perugia (PG), Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024737795","display_name":"Orazio Nicolotti","orcid":"https://orcid.org/0000-0001-6533-5539"},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Orazio Nicolotti","raw_affiliation_strings":["Department of Pharmacy\u2212Pharmaceutical Sciences, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, 70125Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy\u2212Pharmaceutical Sciences, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, 70125Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5077504384"],"corresponding_institution_ids":["https://openalex.org/I4210165610","https://openalex.org/I5561750"],"apc_list":null,"apc_paid":null,"fwci":2.0587,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87744305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"62","issue":"24","first_page":"6812","last_page":"6824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.7605661153793335},{"id":"https://openalex.org/keywords/linear-discriminant-analysis","display_name":"Linear discriminant analysis","score":0.6191081404685974},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5550230741500854},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47356903553009033},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.47012484073638916},{"id":"https://openalex.org/keywords/peptide-library","display_name":"Peptide library","score":0.4391981065273285},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43113645911216736},{"id":"https://openalex.org/keywords/medoid","display_name":"Medoid","score":0.42080992460250854},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.37505221366882324},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.3604688346385956},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34955400228500366},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.34897202253341675},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3302992582321167},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3076659142971039},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2789123058319092},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22554951906204224},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.1843181848526001}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7605661153793335},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.6191081404685974},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5550230741500854},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47356903553009033},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.47012484073638916},{"id":"https://openalex.org/C2776471321","wikidata":"https://www.wikidata.org/wiki/Q7166526","display_name":"Peptide library","level":4,"score":0.4391981065273285},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43113645911216736},{"id":"https://openalex.org/C63085389","wikidata":"https://www.wikidata.org/wiki/Q4287912","display_name":"Medoid","level":3,"score":0.42080992460250854},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.37505221366882324},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.3604688346385956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34955400228500366},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.34897202253341675},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3302992582321167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3076659142971039},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2789123058319092},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22554951906204224},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.1843181848526001},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.2c00583","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00583","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:36320100","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36320100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:ricerca.uniba.it:11586/443641","is_oa":false,"landing_page_url":"https://hdl.handle.net/11586/443641","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7599999904632568}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1553877445","https://openalex.org/W1768303176","https://openalex.org/W1831040894","https://openalex.org/W1855822212","https://openalex.org/W1970431511","https://openalex.org/W1983142511","https://openalex.org/W1985112697","https://openalex.org/W1987200512","https://openalex.org/W1988534836","https://openalex.org/W1992229282","https://openalex.org/W1993617475","https://openalex.org/W2001816314","https://openalex.org/W2015461838","https://openalex.org/W2023272942","https://openalex.org/W2025458374","https://openalex.org/W2029675956","https://openalex.org/W2032676191","https://openalex.org/W2033882981","https://openalex.org/W2039350725","https://openalex.org/W2043816461","https://openalex.org/W2051906299","https://openalex.org/W2052367365","https://openalex.org/W2053717624","https://openalex.org/W2054954101","https://openalex.org/W2057846043","https://openalex.org/W2063460347","https://openalex.org/W2071791280","https://openalex.org/W2074557538","https://openalex.org/W2074978477","https://openalex.org/W2077946617","https://openalex.org/W2080653934","https://openalex.org/W2095178327","https://openalex.org/W2121776789","https://openalex.org/W2135683724","https://openalex.org/W2138885636","https://openalex.org/W2142796125","https://openalex.org/W2149579871","https://openalex.org/W2153801855","https://openalex.org/W2168385765","https://openalex.org/W2175130792","https://openalex.org/W2211683704","https://openalex.org/W2295245722","https://openalex.org/W2320891771","https://openalex.org/W2460730303","https://openalex.org/W2727758171","https://openalex.org/W2767199579","https://openalex.org/W2770354547","https://openalex.org/W2795859997","https://openalex.org/W2799327292","https://openalex.org/W2800677598","https://openalex.org/W2801891815","https://openalex.org/W2810711993","https://openalex.org/W2810742317","https://openalex.org/W2900875696","https://openalex.org/W2902800472","https://openalex.org/W2904980022","https://openalex.org/W2916487223","https://openalex.org/W2921262115","https://openalex.org/W2931205426","https://openalex.org/W2949301320","https://openalex.org/W2951683758","https://openalex.org/W2952059807","https://openalex.org/W3000230289","https://openalex.org/W3043660595","https://openalex.org/W3080742388","https://openalex.org/W3199607358","https://openalex.org/W3204734866","https://openalex.org/W4212772504","https://openalex.org/W4229332892"],"related_works":["https://openalex.org/W3133849001","https://openalex.org/W2022056881","https://openalex.org/W2081066201","https://openalex.org/W3048556888","https://openalex.org/W1520302806","https://openalex.org/W4324086039","https://openalex.org/W3121974022","https://openalex.org/W3174411893","https://openalex.org/W3180887190","https://openalex.org/W2605300748"],"abstract_inverted_index":{"The":[0],"prediction":[1],"of":[2,7,14,48,63,135,142],"peptide-protein":[3,58,156,167],"binding":[4,46],"sites":[5],"is":[6],"utmost":[8],"importance":[9],"to":[10,37,117,164],"tackle":[11],"the":[12,43,88,93,107,119,139,143],"onset":[13],"severe":[15],"neurodegenerative":[16],"diseases":[17],"and":[18,81,98,129,153],"cancer.":[19],"In":[20],"this":[21],"work,":[22],"we":[23],"detail":[24],"a":[25,71],"novel":[26],"machine":[27],"learning":[28],"model":[29,160],"based":[30,78],"on":[31,79,146],"Linear":[32],"Discriminant":[33],"Analysis":[34],"(LDA)":[35],"demonstrating":[36],"be":[38,162],"highly":[39],"predictive":[40],"in":[41,111],"detecting":[42],"putative":[44,94],"protein":[45],"regions":[47,66,123],"small":[49],"peptides.":[50],"Starting":[51],"from":[52,57,137],"439":[53],"high-quality":[54],"pockets":[55,97,141],"derived":[56],"crystallographic":[59,155],"complexes,":[60,157],"three":[61],"sets":[62],"well-established":[64],"peptide-binding":[65],"were":[67],"first":[68],"selected":[69],"through":[70],"Partitioning":[72],"Around":[73],"Medoids":[74],"(PAM)":[75],"clustering":[76],"algorithm":[77],"morphological":[80],"energetic":[82],"3D":[83],"GRID-MIF":[84,100],"molecular":[85],"descriptors.":[86],"Next,":[87],"best":[89],"combination":[90],"between":[91],"all":[92,138],"interacting":[95,121],"peptide":[96,122],"related":[99],"scores":[101],"was":[102],"automatically":[103],"explored":[104],"by":[105],"using":[106],"LDA-based":[108,159],"protocol":[109],"implemented":[110],"BioGPS.":[112],"This":[113],"approach":[114],"proved":[115],"successful":[116],"recognize":[118],"actual":[120],"(that":[124],"is,":[125],"AUC":[126],"=":[127],"0.86":[128],"partial":[130],"ROC":[131],"enrichment":[132],"at":[133],"5%":[134],"0.48)":[136],"other":[140],"protein.":[144],"Validated":[145],"two":[147],"external":[148],"collections":[149],"sets,":[150],"including":[151],"445":[152],"347":[154],"our":[158],"could":[161],"effective":[163],"further":[165],"run":[166],"virtual":[168],"screening":[169],"campaigns.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}