{"id":"https://openalex.org/W4292220010","doi":"https://doi.org/10.1021/acs.jcim.2c00569","title":"Mechanistic Investigation of Lysine-Targeted Covalent Inhibition of PI3K\u03b4 via ONIOM QM:QM Computations","display_name":"Mechanistic Investigation of Lysine-Targeted Covalent Inhibition of PI3K\u03b4 via ONIOM QM:QM Computations","publication_year":2022,"publication_date":"2022-08-18","ids":{"openalex":"https://openalex.org/W4292220010","doi":"https://doi.org/10.1021/acs.jcim.2c00569","pmid":"https://pubmed.ncbi.nlm.nih.gov/35980989"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c00569","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00569","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/hal-03795582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036587126","display_name":"Volkan F\u0131nd\u0131k","orcid":"https://orcid.org/0000-0003-1345-0943"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156043","display_name":"Laboratoire de Physique et Chimie Th\u00e9oriques","ror":"https://ror.org/02atkd403","country_code":null,"type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387156043","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR","TR"],"is_corresponding":false,"raw_author_name":"Volkan F\u0131nd\u0131k","raw_affiliation_strings":["Department of Chemistry, Faculty of Arts and Sciences, Marmara University, 34722, Istanbul, Turkey","LPCT, UMR 7019, University of Lorraine, CNRS, 54000, Nancy, France"],"raw_orcid":"https://orcid.org/0000-0003-1345-0943","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Arts and Sciences, Marmara University, 34722, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"LPCT, UMR 7019, University of Lorraine, CNRS, 54000, Nancy, France","institution_ids":["https://openalex.org/I4387156043","https://openalex.org/I90183372","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086173126","display_name":"Bet\u00fcl Tuba Var\u0131nca Ger\u00e7ik","orcid":null},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bet\u00fcl Tuba Var\u0131nca Ger\u00e7ik","raw_affiliation_strings":["Department of Chemistry, Faculty of Arts and Sciences, Marmara University, 34722, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Arts and Sciences, Marmara University, 34722, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021908171","display_name":"\u00d6yk\u00fc Sinek","orcid":null},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6yk\u00fc Sinek","raw_affiliation_strings":["Department of Chemistry, Faculty of Arts and Sciences, Marmara University, 34722, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Arts and Sciences, Marmara University, 34722, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015410968","display_name":"Safiye Sa\u011f Erdem","orcid":"https://orcid.org/0000-0001-6043-4765"},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Safiye Sa\u011f Erdem","raw_affiliation_strings":["Department of Chemistry, Faculty of Arts and Sciences, Marmara University, 34722, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-6043-4765","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Arts and Sciences, Marmara University, 34722, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019694657","display_name":"Manuel F. Ruiz\u2010L\u00f3pez","orcid":"https://orcid.org/0000-0002-2784-6319"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156043","display_name":"Laboratoire de Physique et Chimie Th\u00e9oriques","ror":"https://ror.org/02atkd403","country_code":null,"type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387156043","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Manuel F. Ruiz-L\u00f3pez","raw_affiliation_strings":["LPCT, UMR 7019, University of Lorraine, CNRS, 54000, Nancy, France"],"raw_orcid":"https://orcid.org/0000-0002-2784-6319","affiliations":[{"raw_affiliation_string":"LPCT, UMR 7019, University of Lorraine, CNRS, 54000, Nancy, France","institution_ids":["https://openalex.org/I4387156043","https://openalex.org/I90183372","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5015410968","https://openalex.org/A5019694657"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156043","https://openalex.org/I74897591","https://openalex.org/I90183372"],"apc_list":null,"apc_paid":null,"fwci":0.8773,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.69456598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"62","issue":"24","first_page":"6775","last_page":"6787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oniom","display_name":"ONIOM","score":0.7877035140991211},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7807677984237671},{"id":"https://openalex.org/keywords/qm/mm","display_name":"QM/MM","score":0.7560145258903503},{"id":"https://openalex.org/keywords/covalent-bond","display_name":"Covalent bond","score":0.7138324975967407},{"id":"https://openalex.org/keywords/active-site","display_name":"Active site","score":0.5721926689147949},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.531428337097168},{"id":"https://openalex.org/keywords/leaving-group","display_name":"Leaving group","score":0.4907437562942505},{"id":"https://openalex.org/keywords/residue","display_name":"Residue (chemistry)","score":0.4880324900150299},{"id":"https://openalex.org/keywords/lysine","display_name":"Lysine","score":0.45885732769966125},{"id":"https://openalex.org/keywords/cysteine","display_name":"Cysteine","score":0.44189125299453735},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.3343082070350647},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3091813325881958},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.3048347234725952},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.22380685806274414},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.20912781357765198},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.17933017015457153},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.10986056923866272}],"concepts":[{"id":"https://openalex.org/C2776165824","wikidata":"https://www.wikidata.org/wiki/Q7072760","display_name":"ONIOM","level":3,"score":0.7877035140991211},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7807677984237671},{"id":"https://openalex.org/C20803032","wikidata":"https://www.wikidata.org/wiki/Q207900","display_name":"QM/MM","level":3,"score":0.7560145258903503},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.7138324975967407},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5721926689147949},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.531428337097168},{"id":"https://openalex.org/C160964918","wikidata":"https://www.wikidata.org/wiki/Q320141","display_name":"Leaving group","level":3,"score":0.4907437562942505},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.4880324900150299},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.45885732769966125},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.44189125299453735},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3343082070350647},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3091813325881958},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3048347234725952},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.22380685806274414},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.20912781357765198},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17933017015457153},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10986056923866272},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009585","descriptor_name":"Nitrogen Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009585","descriptor_name":"Nitrogen Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009585","descriptor_name":"Nitrogen Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.2c00569","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00569","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:35980989","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35980989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:HAL:hal-03795582v1","is_oa":true,"landing_page_url":"https://hal.science/hal-03795582","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chemical Information and Modeling, In press, ⟨10.1021/acs.jcim.2c00569⟩","raw_type":"Journal articles"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/282059","is_oa":false,"landing_page_url":"https://hdl.handle.net/11424/282059","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-03795582v1","is_oa":true,"landing_page_url":"https://hal.science/hal-03795582","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chemical Information and Modeling, In press, ⟨10.1021/acs.jcim.2c00569⟩","raw_type":"Journal articles"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G5227622967","display_name":null,"funder_award_id":"119N133","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1832700322","https://openalex.org/W1970319122","https://openalex.org/W1977629551","https://openalex.org/W1988636074","https://openalex.org/W1990209859","https://openalex.org/W1992173555","https://openalex.org/W1997124629","https://openalex.org/W1997173539","https://openalex.org/W2006727669","https://openalex.org/W2014974825","https://openalex.org/W2017506862","https://openalex.org/W2034102180","https://openalex.org/W2035441394","https://openalex.org/W2046038611","https://openalex.org/W2047280630","https://openalex.org/W2059499978","https://openalex.org/W2063004672","https://openalex.org/W2066016719","https://openalex.org/W2066700813","https://openalex.org/W2069924395","https://openalex.org/W2073685932","https://openalex.org/W2078450884","https://openalex.org/W2091664813","https://openalex.org/W2092073972","https://openalex.org/W2092710065","https://openalex.org/W2106696077","https://openalex.org/W2107614388","https://openalex.org/W2127355894","https://openalex.org/W2133933397","https://openalex.org/W2150697053","https://openalex.org/W2157369184","https://openalex.org/W2167842934","https://openalex.org/W2172538181","https://openalex.org/W2180179715","https://openalex.org/W2265568061","https://openalex.org/W2300171696","https://openalex.org/W2322205711","https://openalex.org/W2346133479","https://openalex.org/W2484443252","https://openalex.org/W2510408460","https://openalex.org/W2569937202","https://openalex.org/W2613905013","https://openalex.org/W2742118221","https://openalex.org/W2752520345","https://openalex.org/W2771924086","https://openalex.org/W2794211762","https://openalex.org/W2806253608","https://openalex.org/W2807112095","https://openalex.org/W2808655460","https://openalex.org/W2891043151","https://openalex.org/W2898807798","https://openalex.org/W2904653639","https://openalex.org/W2908999590","https://openalex.org/W2909792245","https://openalex.org/W2933867250","https://openalex.org/W2952364608","https://openalex.org/W2952787971","https://openalex.org/W3195372273","https://openalex.org/W3208926679","https://openalex.org/W3211722196"],"related_works":["https://openalex.org/W1521034837","https://openalex.org/W2084397704","https://openalex.org/W2018645014","https://openalex.org/W2111136633","https://openalex.org/W4283773959","https://openalex.org/W2890774021","https://openalex.org/W2994232065","https://openalex.org/W2503625833","https://openalex.org/W1965994408","https://openalex.org/W2999730930"],"abstract_inverted_index":{"values.":[0],"Our":[1],"results":[2],"provide":[3],"in":[4],"depth":[5],"insight":[6],"into":[7],"the":[8,13,17],"mechanism,":[9],"which":[10],"can":[11],"pave":[12],"way":[14],"for":[15],"optimizing":[16],"inhibitor":[18],"efficiency.":[19]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}