{"id":"https://openalex.org/W4286816991","doi":"https://doi.org/10.1021/acs.jcim.2c00500","title":"Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of Concern","display_name":"Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of Concern","publication_year":2022,"publication_date":"2022-07-24","ids":{"openalex":"https://openalex.org/W4286816991","doi":"https://doi.org/10.1021/acs.jcim.2c00500","pmid":"https://pubmed.ncbi.nlm.nih.gov/35875887"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c00500","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00500","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047852894","display_name":"Pedro A. Valiente","orcid":"https://orcid.org/0000-0002-4776-6017"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pedro A. Valiente","raw_affiliation_strings":["Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada"],"affiliations":[{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025922787","display_name":"Satra Nim","orcid":"https://orcid.org/0000-0002-7791-1238"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Satra Nim","raw_affiliation_strings":["Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada"],"affiliations":[{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080745397","display_name":"JinAh Lee","orcid":"https://orcid.org/0000-0002-7557-0265"},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"JinAh Lee","raw_affiliation_strings":["Zoonotic Virus Laboratory, Institut Pasteur Korea, 16, Daewangpangyo-ro 712 beon-gil Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Zoonotic Virus Laboratory, Institut Pasteur Korea, 16, Daewangpangyo-ro 712 beon-gil Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039249227","display_name":"Seungtaek Kim","orcid":"https://orcid.org/0000-0003-3954-5908"},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seungtaek Kim","raw_affiliation_strings":["Zoonotic Virus Laboratory, Institut Pasteur Korea, 16, Daewangpangyo-ro 712 beon-gil Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Zoonotic Virus Laboratory, Institut Pasteur Korea, 16, Daewangpangyo-ro 712 beon-gil Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043262709","display_name":"Philip M. Kim","orcid":"https://orcid.org/0000-0003-3683-152X"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Philip M. Kim","raw_affiliation_strings":["Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada","Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043262709"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":null,"apc_paid":null,"fwci":1.2133,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80039907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"62","issue":"15","first_page":"3618","last_page":"3626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.7142414450645447},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.6906534433364868},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.6075608730316162},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.5705128908157349},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.5463008880615234},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5354004502296448},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5203494429588318},{"id":"https://openalex.org/keywords/monoclonal-antibody","display_name":"Monoclonal antibody","score":0.49938201904296875},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.44284874200820923},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.42933589220046997},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.3910121023654938},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3807074725627899},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.3490942120552063},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.330924391746521},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2870730459690094},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21992674469947815},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14985328912734985},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.09058967232704163}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7142414450645447},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6906534433364868},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.6075608730316162},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5705128908157349},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5463008880615234},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5354004502296448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5203494429588318},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.49938201904296875},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.44284874200820923},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.42933589220046997},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3910121023654938},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3807074725627899},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3490942120552063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.330924391746521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2870730459690094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21992674469947815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14985328912734985},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.09058967232704163},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.2c00500","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00500","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:35875887","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35875887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1806205260","display_name":null,"funder_award_id":"PJT-153279","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G1949702599","display_name":null,"funder_award_id":"PJT-166008","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G2693556822","display_name":null,"funder_award_id":"NRF-2017M3A9G6068245","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1034882992","https://openalex.org/W1976499671","https://openalex.org/W2128796937","https://openalex.org/W2139447954","https://openalex.org/W2158084342","https://openalex.org/W2165779834","https://openalex.org/W2555870966","https://openalex.org/W2997555476","https://openalex.org/W3020695284","https://openalex.org/W3023698680","https://openalex.org/W3029682964","https://openalex.org/W3032255042","https://openalex.org/W3034202401","https://openalex.org/W3034395518","https://openalex.org/W3037426855","https://openalex.org/W3046621022","https://openalex.org/W3047003416","https://openalex.org/W3048714202","https://openalex.org/W3084236163","https://openalex.org/W3088579397","https://openalex.org/W3143907823","https://openalex.org/W3179259355","https://openalex.org/W3184893336","https://openalex.org/W3201784646","https://openalex.org/W4200192318","https://openalex.org/W4200429845","https://openalex.org/W4200619717","https://openalex.org/W4206737621","https://openalex.org/W4210943449","https://openalex.org/W4220673385","https://openalex.org/W4220807057","https://openalex.org/W4220904663","https://openalex.org/W4221072241","https://openalex.org/W4223504845"],"related_works":["https://openalex.org/W1570348606","https://openalex.org/W2073626691","https://openalex.org/W2097544532","https://openalex.org/W1973479917","https://openalex.org/W2337329154","https://openalex.org/W2951275810","https://openalex.org/W2462655579","https://openalex.org/W2328917962","https://openalex.org/W2733723768","https://openalex.org/W2287683639"],"abstract_inverted_index":{"The":[0],"COVID-19":[1],"pandemic":[2],"continues":[3],"to":[4,78,154],"spread":[5],"around":[6],"the":[7,28,51,54,79,85,110,123,129,133,147,160],"world,":[8],"with":[9,24,91,109],"several":[10],"new":[11],"variants":[12],"emerging,":[13],"particularly":[14],"those":[15],"of":[16,39,53,93,117,125,143,159],"concern":[17],"(VOCs).":[18],"Omicron":[19],"(B.1.1.529),":[20],"a":[21,36,104],"recent":[22],"VOC":[23],"many":[25],"mutations":[26,156],"in":[27],"spike":[29],"protein's":[30],"receptor-binding":[31,130],"domain":[32],"(RBD),":[33],"has":[34],"attracted":[35],"great":[37],"deal":[38],"scientific":[40],"and":[41,57,61,70,95,140],"public":[42],"interest.":[43],"We":[44,99,121],"previously":[45],"developed":[46],"two":[47],"D-peptide":[48,126],"inhibitors":[49,127],"for":[50,137],"infection":[52,90],"original":[55],"SARS-CoV-2":[56],"its":[58],"VOCs,":[59],"alpha":[60],"beta,":[62],"<i>in":[63,88],"vitro</i>.":[64],"Here,":[65],"we":[66],"demonstrated":[67],"that":[68,101,146],"Covid3":[69,102],"Covid_extended_1":[71],"maintained":[72],"their":[73],"high-affinity":[74],"binding":[75,107,112,149],"(29.4-31.3":[76],"nM)":[77],"omicron":[80,86],"RBD.":[81],"Both":[82],"D-peptides":[83],"blocked":[84],"variant":[87],"vitro</i>":[89],"IC50s":[92],"3.13":[94],"5.56":[96],"\u03bcM,":[97],"respectively.":[98],"predicted":[100],"shares":[103],"larger":[105],"overlapping":[106],"region":[108],"ACE2":[111,148],"motif":[113,131],"than":[114,157],"different":[115],"classes":[116],"neutralizing":[118],"monoclonal":[119],"antibodies.":[120],"envisioned":[122],"design":[124],"targeting":[128],"as":[132],"most":[134,158],"promising":[135],"approach":[136],"inhibiting":[138],"current":[139],"future":[141],"VOCs":[142],"SARS-CoV-2,":[144],"given":[145],"interface":[150],"is":[151],"more":[152],"limited":[153],"tolerate":[155],"RBD's":[161],"surface.":[162]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
