{"id":"https://openalex.org/W4285590326","doi":"https://doi.org/10.1021/acs.jcim.2c00367","title":"Graph Neural Network with Self-Supervised Learning for Noncoding RNA\u2013Drug Resistance Association Prediction","display_name":"Graph Neural Network with Self-Supervised Learning for Noncoding RNA\u2013Drug Resistance Association Prediction","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4285590326","doi":"https://doi.org/10.1021/acs.jcim.2c00367","pmid":"https://pubmed.ncbi.nlm.nih.gov/35838124"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.2c00367","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00367","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051810238","display_name":"Jingjing Zheng","orcid":"https://orcid.org/0000-0002-8549-4235"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Zheng","raw_affiliation_strings":["School of Software, Xinjiang University, Urumqi 830091, China"],"affiliations":[{"raw_affiliation_string":"School of Software, Xinjiang University, Urumqi 830091, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002981402","display_name":"Yurong Qian","orcid":"https://orcid.org/0000-0001-6564-4745"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yurong Qian","raw_affiliation_strings":["School of Software, Xinjiang University, Urumqi 830091, China"],"affiliations":[{"raw_affiliation_string":"School of Software, Xinjiang University, Urumqi 830091, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062028300","display_name":"Ji\u00e9 He","orcid":"https://orcid.org/0000-0003-0327-8852"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie He","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha 410083, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025060236","display_name":"Zerui Kang","orcid":"https://orcid.org/0009-0003-2107-3225"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zerui Kang","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha 410083, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085608332","display_name":"Lei Deng","orcid":"https://orcid.org/0000-0003-2869-1619"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Deng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha 410083, China","School of Software, Xinjiang University, Urumqi 830091, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha 410083, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"School of Software, Xinjiang University, Urumqi 830091, China","institution_ids":["https://openalex.org/I96908189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5085608332"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I96908189"],"apc_list":null,"apc_paid":null,"fwci":2.1838,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.89401332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"62","issue":"15","first_page":"3676","last_page":"3684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9786999821662903,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5555251836776733},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5441769361495972},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5400363802909851},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4881483018398285},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4837234318256378},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.41975364089012146},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39194220304489136},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2151922583580017},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.21139806509017944},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.16873064637184143}],"concepts":[{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5555251836776733},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5441769361495972},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5400363802909851},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4881483018398285},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4837234318256378},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.41975364089012146},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39194220304489136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2151922583580017},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21139806509017944},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.16873064637184143},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.2c00367","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.2c00367","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:35838124","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35838124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4765830214","display_name":null,"funder_award_id":"61972422","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W2023779015","https://openalex.org/W2068205741","https://openalex.org/W2157825442","https://openalex.org/W2284823004","https://openalex.org/W2542768043","https://openalex.org/W2567465856","https://openalex.org/W2747105326","https://openalex.org/W2747907311","https://openalex.org/W2768096340","https://openalex.org/W2770535734","https://openalex.org/W2778620777","https://openalex.org/W2783169572","https://openalex.org/W2802299363","https://openalex.org/W2810376110","https://openalex.org/W2892502396","https://openalex.org/W2892921986","https://openalex.org/W2901312953","https://openalex.org/W2945827670","https://openalex.org/W2963913273","https://openalex.org/W2966147228","https://openalex.org/W2972759473","https://openalex.org/W2982780080","https://openalex.org/W2990089967","https://openalex.org/W3009963727","https://openalex.org/W3012491561","https://openalex.org/W3020929333","https://openalex.org/W3026308742","https://openalex.org/W3034046925","https://openalex.org/W3044063956","https://openalex.org/W3045200674","https://openalex.org/W3080286031","https://openalex.org/W3094881119","https://openalex.org/W3100278010","https://openalex.org/W3118597568","https://openalex.org/W3157857562","https://openalex.org/W3158143432","https://openalex.org/W3172215291","https://openalex.org/W3190084302","https://openalex.org/W3194560733","https://openalex.org/W3197001103","https://openalex.org/W3198707249","https://openalex.org/W3201821663","https://openalex.org/W3202551657","https://openalex.org/W3203619936","https://openalex.org/W4211004872"],"related_works":["https://openalex.org/W2352440174","https://openalex.org/W4309440960","https://openalex.org/W2062168445","https://openalex.org/W2348940229","https://openalex.org/W2363046693","https://openalex.org/W2389491697","https://openalex.org/W4301044699","https://openalex.org/W2067476155","https://openalex.org/W2728345702","https://openalex.org/W2352562594"],"abstract_inverted_index":{"Noncoding":[0],"RNA(ncRNA)":[1],"is":[2,16,46,165],"closely":[3],"related":[4],"to":[5,37,55,92,114,149,168],"drug":[6,14,21,44,62,100,121,135,156,220],"resistance.":[7,157,221],"Identifying":[8],"the":[9,39,57,68,86,94,102,129,146,151,159,166,177,195,209,215],"association":[10,40,58,152,173,216],"between":[11,41,59,141,153,217],"ncRNA":[12,42,60,80,98,119,133,154,218],"and":[13,31,43,61,81,99,120,123,134,155,219,224],"resistance":[15,45,63,71],"of":[17,79,97,131,161,179,191,211,227],"great":[18],"significance":[19],"for":[20,118],"development.":[22],"Methods":[23],"based":[24],"on":[25],"biological":[26],"experiments":[27],"are":[28,73,229],"often":[29],"time-consuming":[30],"small-scale.":[32],"Therefore,":[33],"developing":[34],"computational":[35,51],"methods":[36,113],"distinguish":[38],"urgent.":[47],"We":[48],"develop":[49],"a":[50,76],"framework":[52],"called":[53],"GSLRDA":[54,84,108,144,164,186,212,228],"predict":[56,150],"in":[64,172,176,213],"this":[65],"work.":[66],"First,":[67],"known":[69],"ncRNA-drug":[70,103],"associations":[72],"modeled":[74],"as":[75],"bipartite":[77,104],"graph":[78,88],"drug.":[82],"Then,":[83],"uses":[85,109,145],"light":[87],"convolutional":[89],"network":[90],"(lightGCN)":[91],"learn":[93],"vector":[95,136],"representation":[96],"from":[101],"graph.":[105],"In":[106,200],"addition,":[107,201],"different":[110,116],"data":[111,225],"augmentation":[112],"generate":[115],"views":[117],"nodes":[122],"performs":[124],"self-supervised":[125,170],"learning,":[126],"further":[127,207],"improving":[128],"quality":[130],"learned":[132],"representations":[137],"through":[138],"contrastive":[139],"learning":[140,171],"nodes.":[142],"Finally,":[143],"inner":[147],"product":[148],"To":[158],"best":[160],"our":[162],"knowledge,":[163],"first":[167],"apply":[169],"prediction":[174],"tasks":[175],"field":[178],"bioinformatics.":[180],"The":[181,222],"experimental":[182],"results":[183],"show":[184],"that":[185],"takes":[187],"an":[188],"AUC":[189],"value":[190],"0.9101,":[192],"higher":[193],"than":[194],"other":[196],"eight":[197],"state-of-the-art":[198],"models.":[199],"case":[202],"studies":[203],"including":[204],"two":[205],"drugs":[206],"illustrate":[208],"effectiveness":[210],"predicting":[214],"code":[223],"sets":[226],"available":[230],"at":[231],"https://github.com/JJZ-code/GSLRDA.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10}],"updated_date":"2026-03-13T16:22:10.518609","created_date":"2025-10-10T00:00:00"}