{"id":"https://openalex.org/W4214609025","doi":"https://doi.org/10.1021/acs.jcim.1c01580","title":"Emerging Landscape of Computational Modeling in Pharmaceutical Development","display_name":"Emerging Landscape of Computational Modeling in Pharmaceutical Development","publication_year":2022,"publication_date":"2022-02-28","ids":{"openalex":"https://openalex.org/W4214609025","doi":"https://doi.org/10.1021/acs.jcim.1c01580","pmid":"https://pubmed.ncbi.nlm.nih.gov/35226809"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c01580","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c01580","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049259483","display_name":"Yuriy A. Abramov","orcid":"https://orcid.org/0000-0001-7863-3148"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuriy A. Abramov","raw_affiliation_strings":["Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States","XtalPi, Inc., 245 Main St., Cambridge, Massachusetts 02142, United States"],"raw_orcid":"https://orcid.org/0000-0001-7863-3148","affiliations":[{"raw_affiliation_string":"Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"XtalPi, Inc., 245 Main St., Cambridge, Massachusetts 02142, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109719822","display_name":"Guangxu Sun","orcid":"https://orcid.org/0000-0003-0801-5699"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangxu Sun","raw_affiliation_strings":["XtalPi, Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 3, Sf Industrial Plant, No. 2 Hongliu road, Fubao Community, Fubao Street, Futian District, Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"XtalPi, Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 3, Sf Industrial Plant, No. 2 Hongliu road, Fubao Community, Fubao Street, Futian District, Shenzhen 518100, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084151310","display_name":"Qun Zeng","orcid":"https://orcid.org/0000-0003-1385-2440"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qun Zeng","raw_affiliation_strings":["XtalPi, Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 3, Sf Industrial Plant, No. 2 Hongliu road, Fubao Community, Fubao Street, Futian District, Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"XtalPi, Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 3, Sf Industrial Plant, No. 2 Hongliu road, Fubao Community, Fubao Street, Futian District, Shenzhen 518100, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049259483"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":6.7881,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.97425735,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"62","issue":"5","first_page":"1160","last_page":"1171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.821007251739502},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6157796382904053},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5878714919090271},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4938133656978607},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4889746904373169},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.4803794026374817},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.47738927602767944},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.4414578378200531},{"id":"https://openalex.org/keywords/development","display_name":"Development (topology)","score":0.4268726110458374},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.41777801513671875},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.4058506488800049},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.40450286865234375},{"id":"https://openalex.org/keywords/software-engineering","display_name":"Software engineering","score":0.32841458916664124},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.268573522567749},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.23700428009033203},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.2061639130115509},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.12053108215332031},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08666208386421204},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.08549073338508606},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08320081233978271}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.821007251739502},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6157796382904053},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5878714919090271},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4938133656978607},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4889746904373169},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.4803794026374817},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.47738927602767944},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4414578378200531},{"id":"https://openalex.org/C2776542497","wikidata":"https://www.wikidata.org/wiki/Q5266672","display_name":"Development (topology)","level":2,"score":0.4268726110458374},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.41777801513671875},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4058506488800049},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.40450286865234375},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.32841458916664124},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.268573522567749},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23700428009033203},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2061639130115509},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12053108215332031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08666208386421204},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.08549073338508606},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08320081233978271},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.1c01580","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c01580","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:35226809","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35226809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.5,"id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":152,"referenced_works":["https://openalex.org/W178535851","https://openalex.org/W1446769090","https://openalex.org/W1484880768","https://openalex.org/W1549638721","https://openalex.org/W1551793917","https://openalex.org/W1558067684","https://openalex.org/W1563689801","https://openalex.org/W1604186570","https://openalex.org/W1910016306","https://openalex.org/W1964855514","https://openalex.org/W1968060230","https://openalex.org/W1969300284","https://openalex.org/W1970977603","https://openalex.org/W1975237618","https://openalex.org/W1979025327","https://openalex.org/W1983391718","https://openalex.org/W1996142946","https://openalex.org/W1997060636","https://openalex.org/W2001059239","https://openalex.org/W2009032263","https://openalex.org/W2029559871","https://openalex.org/W2031426306","https://openalex.org/W2040518011","https://openalex.org/W2041709994","https://openalex.org/W2043092002","https://openalex.org/W2043124791","https://openalex.org/W2044084078","https://openalex.org/W2048540332","https://openalex.org/W2053585042","https://openalex.org/W2058022821","https://openalex.org/W2058592151","https://openalex.org/W2058774104","https://openalex.org/W2065937814","https://openalex.org/W2066381187","https://openalex.org/W2066412916","https://openalex.org/W2073277935","https://openalex.org/W2076264613","https://openalex.org/W2079191942","https://openalex.org/W2087985529","https://openalex.org/W2094639770","https://openalex.org/W2096241759","https://openalex.org/W2101212670","https://openalex.org/W2106605095","https://openalex.org/W2123968367","https://openalex.org/W2128326201","https://openalex.org/W2135824076","https://openalex.org/W2139711861","https://openalex.org/W2145025659","https://openalex.org/W2149429360","https://openalex.org/W2162943526","https://openalex.org/W2166550586","https://openalex.org/W2264515365","https://openalex.org/W2274570135","https://openalex.org/W2279589763","https://openalex.org/W2302878023","https://openalex.org/W2313253053","https://openalex.org/W2318118297","https://openalex.org/W2318709054","https://openalex.org/W2319902168","https://openalex.org/W2321603802","https://openalex.org/W2324574431","https://openalex.org/W2326892341","https://openalex.org/W2327419207","https://openalex.org/W2329121727","https://openalex.org/W2342854662","https://openalex.org/W2397622277","https://openalex.org/W2399366718","https://openalex.org/W2461294028","https://openalex.org/W2468864867","https://openalex.org/W2478205589","https://openalex.org/W2478387003","https://openalex.org/W2481871662","https://openalex.org/W2496975789","https://openalex.org/W2524578291","https://openalex.org/W2541404351","https://openalex.org/W2541869068","https://openalex.org/W2542587922","https://openalex.org/W2588401523","https://openalex.org/W2589045496","https://openalex.org/W2605241063","https://openalex.org/W2605906875","https://openalex.org/W2606363443","https://openalex.org/W2621742623","https://openalex.org/W2687405497","https://openalex.org/W2733090315","https://openalex.org/W2737427399","https://openalex.org/W2744328510","https://openalex.org/W2747592475","https://openalex.org/W2749580687","https://openalex.org/W2750680263","https://openalex.org/W2755228388","https://openalex.org/W2763817162","https://openalex.org/W2768213699","https://openalex.org/W2774535559","https://openalex.org/W2775684663","https://openalex.org/W2782561453","https://openalex.org/W2784432193","https://openalex.org/W2789059526","https://openalex.org/W2789472472","https://openalex.org/W2789913372","https://openalex.org/W2791657723","https://openalex.org/W2805401872","https://openalex.org/W2889957841","https://openalex.org/W2891966865","https://openalex.org/W2892439819","https://openalex.org/W2895745265","https://openalex.org/W2896916724","https://openalex.org/W2899219348","https://openalex.org/W2914823563","https://openalex.org/W2917823094","https://openalex.org/W2919922114","https://openalex.org/W2920929444","https://openalex.org/W2935703872","https://openalex.org/W2951832941","https://openalex.org/W2952464183","https://openalex.org/W2954088480","https://openalex.org/W2956025297","https://openalex.org/W2963054903","https://openalex.org/W2965171258","https://openalex.org/W2968352198","https://openalex.org/W2971199424","https://openalex.org/W2981126929","https://openalex.org/W2996042090","https://openalex.org/W2999786154","https://openalex.org/W3003506834","https://openalex.org/W3010145447","https://openalex.org/W3012611411","https://openalex.org/W3035847987","https://openalex.org/W3039065343","https://openalex.org/W3040915268","https://openalex.org/W3041419111","https://openalex.org/W3045352698","https://openalex.org/W3087471863","https://openalex.org/W3088588908","https://openalex.org/W3097476496","https://openalex.org/W3117323264","https://openalex.org/W3118317455","https://openalex.org/W3124620085","https://openalex.org/W3134555096","https://openalex.org/W3135866733","https://openalex.org/W3162602244","https://openalex.org/W3178684664","https://openalex.org/W3184329401","https://openalex.org/W3193335134","https://openalex.org/W3196529659","https://openalex.org/W3205964505","https://openalex.org/W3211101871","https://openalex.org/W4200225804","https://openalex.org/W4200333014","https://openalex.org/W4232455096","https://openalex.org/W4239859063","https://openalex.org/W4243587049"],"related_works":["https://openalex.org/W3180887190","https://openalex.org/W2320211095","https://openalex.org/W2308164565","https://openalex.org/W2059230675","https://openalex.org/W2376003823","https://openalex.org/W2594726310","https://openalex.org/W2355193834","https://openalex.org/W2907597838","https://openalex.org/W2127264463","https://openalex.org/W3164924009"],"abstract_inverted_index":{"Computational":[0],"chemistry":[1],"applications":[2],"have":[3],"become":[4],"an":[5],"integral":[6],"part":[7,35],"of":[8,23,36,53,76,83,92,120],"the":[9,14,45,77,84],"drug":[10,24,54,69],"discovery":[11],"workflow":[12],"over":[13],"past":[15],"35":[16],"years.":[17],"However,":[18],"computational":[19,46,78],"modeling":[20,47],"in":[21,90,118],"support":[22,79,119],"development":[25],"has":[26],"remained":[27],"a":[28,33],"relatively":[29],"uncharted":[30],"territory":[31],"for":[32,49,80],"significant":[34],"both":[37],"academic":[38],"and":[39,56,64,71,114,124],"industrial":[40],"communities.":[41],"This":[42,106],"review":[43],"considers":[44],"workflows":[48,86],"three":[50],"key":[51],"components":[52],"preclinical":[55],"clinical":[57],"development,":[58,65],"namely,":[59],"process":[60],"chemistry,":[61],"analytical":[62],"research":[63],"as":[66,68],"well":[67],"product":[70],"formulation":[72],"development.":[73],"An":[74],"overview":[75],"each":[81],"step":[82],"respective":[85],"is":[87,98],"presented.":[88],"Additionally,":[89],"context":[91],"solid":[93,121],"form":[94,122],"design,":[95],"special":[96],"consideration":[97],"given":[99],"to":[100,110],"modern":[101],"physics-based":[102],"virtual":[103,116],"screening":[104,117],"methods.":[105],"covers":[107],"rational":[108],"approaches":[109],"polymorph,":[111],"coformer,":[112],"counterion,":[113],"solvent":[115],"selection":[123],"design.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}