{"id":"https://openalex.org/W4283581886","doi":"https://doi.org/10.1021/acs.jcim.1c01396","title":"Novel Dimeric hHv1 Model and Structural Bioinformatic Analysis Reveal an ATP-Binding Site Resulting in a Channel Activating Effect","display_name":"Novel Dimeric hHv1 Model and Structural Bioinformatic Analysis Reveal an ATP-Binding Site Resulting in a Channel Activating Effect","publication_year":2022,"publication_date":"2022-06-27","ids":{"openalex":"https://openalex.org/W4283581886","doi":"https://doi.org/10.1021/acs.jcim.1c01396","pmid":"https://pubmed.ncbi.nlm.nih.gov/35758884"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c01396","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c01396","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087897560","display_name":"Manuel A. Llanos","orcid":"https://orcid.org/0000-0002-9120-4951"},"institutions":[{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Manuel A. Llanos","raw_affiliation_strings":["Departamento de Ciencias Biol\u00f3gicas and Laboratorio de Investigaci\u00f3n y Desarrollo de Bioactivos (LIDeB), Fac. de Ciencias Exactas, Universidad Nacional de La Plata. La Plata B1900ADU, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias Biol\u00f3gicas and Laboratorio de Investigaci\u00f3n y Desarrollo de Bioactivos (LIDeB), Fac. de Ciencias Exactas, Universidad Nacional de La Plata. La Plata B1900ADU, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008568071","display_name":"Clara Ventura","orcid":"https://orcid.org/0000-0002-3919-0062"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Clara Ventura","raw_affiliation_strings":["Facultad de Ciencias Exactas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Exactas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057633168","display_name":"Pedro Mart\u00edn","orcid":"https://orcid.org/0000-0003-3222-0350"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Pedro Mart\u00edn","raw_affiliation_strings":["Facultad de Ciencias Exactas, Departamento de Ciencias Biol\u00f3gicas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos\rAires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Exactas, Departamento de Ciencias Biol\u00f3gicas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos\rAires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020822878","display_name":"Nicol\u00e1s Enrique","orcid":"https://orcid.org/0000-0001-9130-6678"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Nicol\u00e1s Enrique","raw_affiliation_strings":["Facultad de Ciencias Exactas, Departamento de Ciencias Biol\u00f3gicas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos\rAires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Exactas, Departamento de Ciencias Biol\u00f3gicas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos\rAires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023948457","display_name":"Juan Ignacio Felice","orcid":"https://orcid.org/0000-0001-7220-4692"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Juan I. Felice","raw_affiliation_strings":["Facultad de Ciencias Exactas, Departamento de Ciencias Biol\u00f3gicas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos\rAires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Exactas, Departamento de Ciencias Biol\u00f3gicas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos\rAires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055815238","display_name":"Luciana Gavernet","orcid":"https://orcid.org/0000-0001-9285-3788"},"institutions":[{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Luciana Gavernet","raw_affiliation_strings":["Departamento de Ciencias Biol\u00f3gicas and Laboratorio de Investigaci\u00f3n y Desarrollo de Bioactivos (LIDeB), Fac. de Ciencias Exactas, Universidad Nacional de La Plata. La Plata B1900ADU, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0001-9285-3788","affiliations":[{"raw_affiliation_string":"Departamento de Ciencias Biol\u00f3gicas and Laboratorio de Investigaci\u00f3n y Desarrollo de Bioactivos (LIDeB), Fac. de Ciencias Exactas, Universidad Nacional de La Plata. La Plata B1900ADU, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I874386039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045311567","display_name":"Ver\u00f3nica Milesi","orcid":"https://orcid.org/0000-0001-8388-8727"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ver\u00f3nica Milesi","raw_affiliation_strings":["Facultad de Ciencias Exactas, Departamento de Ciencias Biol\u00f3gicas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos\rAires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Exactas, Departamento de Ciencias Biol\u00f3gicas, Instituto de Estudios Inmunol\u00f3gicos y Fisiopatol\u00f3gicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos\rAires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055815238"],"corresponding_institution_ids":["https://openalex.org/I874386039"],"apc_list":null,"apc_paid":null,"fwci":0.3135,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.50397341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"62","issue":"13","first_page":"3200","last_page":"3212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.542628288269043},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5225624442100525},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.49753859639167786},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.47600826621055603},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.47283491492271423},{"id":"https://openalex.org/keywords/adenosine-triphosphate","display_name":"Adenosine triphosphate","score":0.47021937370300293},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.4692274034023285},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4199938476085663},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3748454451560974},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3708798289299011},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36474597454071045},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1503179669380188},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.10320413112640381}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.542628288269043},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5225624442100525},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.49753859639167786},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.47600826621055603},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.47283491492271423},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.47021937370300293},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.4692274034023285},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4199938476085663},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3748454451560974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3708798289299011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36474597454071045},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1503179669380188},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10320413112640381},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.1c01396","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c01396","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:35758884","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35758884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G447787302","display_name":null,"funder_award_id":"PICT-2020-SERIEA-01731","funder_id":"https://openalex.org/F4320331467","funder_display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320322227","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929"},{"id":"https://openalex.org/F4320331467","display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1178456644","https://openalex.org/W1917503746","https://openalex.org/W1967176597","https://openalex.org/W1976064757","https://openalex.org/W1977083578","https://openalex.org/W1981546136","https://openalex.org/W1985718433","https://openalex.org/W1990667548","https://openalex.org/W1990771438","https://openalex.org/W2001754861","https://openalex.org/W2013383439","https://openalex.org/W2013648615","https://openalex.org/W2019998982","https://openalex.org/W2021520922","https://openalex.org/W2025443689","https://openalex.org/W2042914373","https://openalex.org/W2047399603","https://openalex.org/W2059376103","https://openalex.org/W2060422389","https://openalex.org/W2083903194","https://openalex.org/W2087700141","https://openalex.org/W2095036253","https://openalex.org/W2101810621","https://openalex.org/W2109279728","https://openalex.org/W2116139800","https://openalex.org/W2116280694","https://openalex.org/W2117272927","https://openalex.org/W2132455160","https://openalex.org/W2134044891","https://openalex.org/W2140831051","https://openalex.org/W2144420181","https://openalex.org/W2147993766","https://openalex.org/W2149857784","https://openalex.org/W2152856869","https://openalex.org/W2155936520","https://openalex.org/W2165042707","https://openalex.org/W2170000848","https://openalex.org/W2200595658","https://openalex.org/W2205857615","https://openalex.org/W2325334157","https://openalex.org/W2400143872","https://openalex.org/W2478508679","https://openalex.org/W2509560828","https://openalex.org/W2564618384","https://openalex.org/W2567177455","https://openalex.org/W2785269871","https://openalex.org/W2809610812","https://openalex.org/W2888699288","https://openalex.org/W2902178703","https://openalex.org/W2949713225","https://openalex.org/W2954231711","https://openalex.org/W2966361617","https://openalex.org/W2970337145","https://openalex.org/W2998956092","https://openalex.org/W3020730596","https://openalex.org/W3031810766","https://openalex.org/W3048775692","https://openalex.org/W3092337304","https://openalex.org/W3099449254","https://openalex.org/W3108191562","https://openalex.org/W3135534391","https://openalex.org/W3189348895","https://openalex.org/W3199816176","https://openalex.org/W4210697246"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2101501829","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2080105009","https://openalex.org/W2141873118","https://openalex.org/W1990923594","https://openalex.org/W2024292577","https://openalex.org/W2991688472"],"abstract_inverted_index":{"The":[0,72],"human":[1],"voltage-gated":[2],"proton":[3],"channel":[4,11,167,206],"(hHv1)":[5],"is":[6],"a":[7,19,40,56,68,104,130,224],"highly":[8],"selective":[9],"ion":[10],"codified":[12],"by":[13,93,164,174],"the":[14,61,110,114,120,137,146,159,165,175,196,205,208,211,216,220,234,239],"HVCN1":[15],"gene.":[16],"It":[17],"plays":[18],"fundamental":[20],"role":[21],"in":[22,38,47,70,147,169,178,215,244],"several":[23,48],"physiological":[24,225],"processes":[25],"such":[26,254],"as":[27,67,255],"innate":[28],"and":[29,34,65,88,99,140,172,226,260],"adaptive":[30],"immunity,":[31],"insulin":[32],"secretion,":[33],"sperm":[35],"capacitation.":[36],"Moreover,":[37],"humans,":[39],"higher":[41],"hHv1":[42,62,123,166,247],"expression/function":[43],"has":[44],"been":[45],"reported":[46],"types":[49],"of":[50,60,113,119,132,219],"cancer":[51,261],"cells.":[52,262],"Here":[53],"we":[54,102,150],"report":[55],"multitemplate":[57],"homology":[58],"model":[59,73,124],"channel,":[63],"built":[64],"refined":[66],"dimer":[69],"Rosetta.":[71],"was":[74,193,200],"then":[75],"subjected":[76],"to":[77,145,203],"extensive":[78],"Gaussian":[79],"accelerated":[80],"molecular":[81],"dynamics":[82],"(GaMD)":[83],"for":[84,251],"enhanced":[85],"conformational":[86],"sampling,":[87],"representative":[89],"snapshots":[90],"were":[91],"extracted":[92],"clustering":[94],"analysis.":[95],"Combining":[96],"different":[97],"structure-":[98],"sequence-based":[100],"methodologies,":[101],"predicted":[103],"putative":[105],"ATP-binding":[106,212],"site":[107,213],"located":[108],"on":[109,195],"intracellular":[111,155,217],"portion":[112],"channel.":[115,222],"Furthermore,":[116],"GaMD":[117],"simulations":[118],"ATP-bound":[121],"dimeric":[122],"showed":[125],"that":[126,152,210],"ATP":[127,156,192],"interacts":[128],"with":[129,238],"cluster":[131],"positively":[133],"charged":[134],"residues":[135],"from":[136],"cytoplasmic":[138],"N":[139],"C":[141],"terminal":[142],"segments.":[143],"According":[144],"silico":[148],"predictions,":[149],"found":[151],"3":[153],"mM":[154],"significantly":[157],"increases":[158],"H":[160,240],"+":[161,241],"current":[162],"mediated":[163],"expressed":[168],"HEK293":[170],"cells":[171,245],"measured":[173],"patch-clamp":[176],"technique":[177],"an":[179],"inside-out":[180],"configuration":[181],"(2.86":[182],"\u00b1":[183],"0.63":[184],"fold":[185],"over":[186],"control":[187],"at":[188],"+40":[189],"mV).":[190],"When":[191],"added":[194],"extracellular":[197],"side,":[198],"it":[199],"not":[201],"able":[202],"activate":[204],"supporting":[207],"idea":[209],"resides":[214],"face":[218],"hHV1":[221],"In":[223],"pathophysiological":[227],"context,":[228],"this":[229],"ATP-mediated":[230],"modulation":[231],"could":[232],"integrate":[233],"cell":[235],"metabolic":[236],"state":[237],"efflux,":[242],"especially":[243],"where":[246],"channels":[248],"are":[249],"relevant":[250],"pH":[252],"regulation,":[253],"pancreatic":[256],"\u03b2-cells,":[257],"immune":[258],"cells,":[259]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}
