{"id":"https://openalex.org/W4213346714","doi":"https://doi.org/10.1021/acs.jcim.1c01315","title":"Global Analysis of Heme Proteins Elucidates the Correlation between Heme Distortion and the Heme-Binding Pocket","display_name":"Global Analysis of Heme Proteins Elucidates the Correlation between Heme Distortion and the Heme-Binding Pocket","publication_year":2022,"publication_date":"2022-02-14","ids":{"openalex":"https://openalex.org/W4213346714","doi":"https://doi.org/10.1021/acs.jcim.1c01315","pmid":"https://pubmed.ncbi.nlm.nih.gov/35157473"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c01315","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c01315","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051431208","display_name":"Hiroko Kondo","orcid":"https://orcid.org/0000-0002-0782-9677"},"institutions":[{"id":"https://openalex.org/I4210116810","display_name":"RIKEN Center for Biosystems Dynamics Research","ror":"https://ror.org/023rffy11","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210116810"]},{"id":"https://openalex.org/I57930482","display_name":"Hiroshima City University","ror":"https://ror.org/001et4e78","country_code":"JP","type":"education","lineage":["https://openalex.org/I57930482"]},{"id":"https://openalex.org/I98957242","display_name":"Kitami Institute of Technology","ror":"https://ror.org/05wks2t16","country_code":"JP","type":"education","lineage":["https://openalex.org/I98957242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroko X. Kondo","raw_affiliation_strings":["Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University, 3-4-1 Ozukahigashi Asaminamiku, Hiroshima, Hiroshima 731-3194, Japan","Laboratory for Computational Molecular Design, RIKEN Center for Biosystems Dynamics Research, 6-2-3, Furuedai, Suita, Osaka 565-0874, Japan","School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0782-9677","affiliations":[{"raw_affiliation_string":"Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University, 3-4-1 Ozukahigashi Asaminamiku, Hiroshima, Hiroshima 731-3194, Japan","institution_ids":["https://openalex.org/I57930482"]},{"raw_affiliation_string":"Laboratory for Computational Molecular Design, RIKEN Center for Biosystems Dynamics Research, 6-2-3, Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":["https://openalex.org/I4210116810"]},{"raw_affiliation_string":"School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan","institution_ids":["https://openalex.org/I98957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045098159","display_name":"Masanori Fujii","orcid":"https://orcid.org/0000-0003-2050-4567"},"institutions":[{"id":"https://openalex.org/I98957242","display_name":"Kitami Institute of Technology","ror":"https://ror.org/05wks2t16","country_code":"JP","type":"education","lineage":["https://openalex.org/I98957242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Fujii","raw_affiliation_strings":["School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan","institution_ids":["https://openalex.org/I98957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050761936","display_name":"Takuma Tanioka","orcid":null},"institutions":[{"id":"https://openalex.org/I98957242","display_name":"Kitami Institute of Technology","ror":"https://ror.org/05wks2t16","country_code":"JP","type":"education","lineage":["https://openalex.org/I98957242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuma Tanioka","raw_affiliation_strings":["School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan","institution_ids":["https://openalex.org/I98957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015137270","display_name":"Yusuke Kanematsu","orcid":"https://orcid.org/0000-0003-3546-3198"},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I57930482","display_name":"Hiroshima City University","ror":"https://ror.org/001et4e78","country_code":"JP","type":"education","lineage":["https://openalex.org/I57930482"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Kanematsu","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8527, Japan","Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University, 3-4-1 Ozukahigashi Asaminamiku, Hiroshima, Hiroshima 731-3194, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3546-3198","affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8527, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University, 3-4-1 Ozukahigashi Asaminamiku, Hiroshima, Hiroshima 731-3194, Japan","institution_ids":["https://openalex.org/I57930482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101656857","display_name":"Takashi Yoshida","orcid":"https://orcid.org/0000-0002-7389-2930"},"institutions":[{"id":"https://openalex.org/I98957242","display_name":"Kitami Institute of Technology","ror":"https://ror.org/05wks2t16","country_code":"JP","type":"education","lineage":["https://openalex.org/I98957242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Yoshida","raw_affiliation_strings":["School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan","institution_ids":["https://openalex.org/I98957242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056515301","display_name":"Yu Takano","orcid":"https://orcid.org/0000-0002-4165-8672"},"institutions":[{"id":"https://openalex.org/I57930482","display_name":"Hiroshima City University","ror":"https://ror.org/001et4e78","country_code":"JP","type":"education","lineage":["https://openalex.org/I57930482"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yu Takano","raw_affiliation_strings":["Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University, 3-4-1 Ozukahigashi Asaminamiku, Hiroshima, Hiroshima 731-3194, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4165-8672","affiliations":[{"raw_affiliation_string":"Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University, 3-4-1 Ozukahigashi Asaminamiku, Hiroshima, Hiroshima 731-3194, Japan","institution_ids":["https://openalex.org/I57930482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051431208","https://openalex.org/A5056515301"],"corresponding_institution_ids":["https://openalex.org/I4210116810","https://openalex.org/I57930482","https://openalex.org/I98957242"],"apc_list":null,"apc_paid":null,"fwci":1.5049,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.79067801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"62","issue":"4","first_page":"775","last_page":"784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme","display_name":"Heme","score":0.9201135635375977},{"id":"https://openalex.org/keywords/hemeprotein","display_name":"Hemeprotein","score":0.5860109329223633},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5527276396751404},{"id":"https://openalex.org/keywords/distortion","display_name":"Distortion (music)","score":0.4988582134246826},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.40360498428344727},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.16920295357704163},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.1033986508846283}],"concepts":[{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.9201135635375977},{"id":"https://openalex.org/C20705724","wikidata":"https://www.wikidata.org/wiki/Q902628","display_name":"Hemeprotein","level":4,"score":0.5860109329223633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5527276396751404},{"id":"https://openalex.org/C126780896","wikidata":"https://www.wikidata.org/wiki/Q899871","display_name":"Distortion (music)","level":4,"score":0.4988582134246826},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40360498428344727},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16920295357704163},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1033986508846283},{"id":"https://openalex.org/C2776257435","wikidata":"https://www.wikidata.org/wiki/Q1576430","display_name":"Bandwidth (computing)","level":2,"score":0.0},{"id":"https://openalex.org/C194257627","wikidata":"https://www.wikidata.org/wiki/Q211554","display_name":"Amplifier","level":3,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006420","descriptor_name":"Hemeproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014732","descriptor_name":"Vibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014732","descriptor_name":"Vibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014732","descriptor_name":"Vibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.1c01315","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c01315","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:35157473","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35157473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3433139519","display_name":null,"funder_award_id":"20H05883","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3867326960","display_name":"Development of PyDISH, the analytic tool of the structure-function relationship for heme","funder_award_id":"21K14741","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4290301564","display_name":null,"funder_award_id":"JP19H02752","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7002037864","display_name":null,"funder_award_id":"20H05883","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7814506949","display_name":"Elucidation of dependence of secondary structure on the formation of protein structure and development of new forcefield incorporating effects of secondary structure","funder_award_id":"19K06589","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7918971302","display_name":null,"funder_award_id":"JP19K06589","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320310657","display_name":"Sumitomo Foundation","ror":"https://ror.org/01nmpj461"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1969142598","https://openalex.org/W1971552026","https://openalex.org/W1973630631","https://openalex.org/W1982855811","https://openalex.org/W1986026982","https://openalex.org/W2004436328","https://openalex.org/W2006684770","https://openalex.org/W2008103030","https://openalex.org/W2008423326","https://openalex.org/W2019137326","https://openalex.org/W2021017431","https://openalex.org/W2028323326","https://openalex.org/W2031616354","https://openalex.org/W2033990154","https://openalex.org/W2038292842","https://openalex.org/W2046412723","https://openalex.org/W2049061162","https://openalex.org/W2053372707","https://openalex.org/W2058363175","https://openalex.org/W2058968319","https://openalex.org/W2067011309","https://openalex.org/W2086172313","https://openalex.org/W2088437224","https://openalex.org/W2090927469","https://openalex.org/W2100032379","https://openalex.org/W2103613886","https://openalex.org/W2114850508","https://openalex.org/W2121673742","https://openalex.org/W2130271590","https://openalex.org/W2135973857","https://openalex.org/W2138668148","https://openalex.org/W2143254097","https://openalex.org/W2145947173","https://openalex.org/W2147988069","https://openalex.org/W2153153865","https://openalex.org/W2161088350","https://openalex.org/W2752399242","https://openalex.org/W2889060167","https://openalex.org/W2911964244","https://openalex.org/W2995720795","https://openalex.org/W3091024207"],"related_works":["https://openalex.org/W2161928213","https://openalex.org/W1980347870","https://openalex.org/W2081623409","https://openalex.org/W2216269996","https://openalex.org/W1580117864","https://openalex.org/W2169490506","https://openalex.org/W2000790287","https://openalex.org/W2139016048","https://openalex.org/W2053445543","https://openalex.org/W2952673796"],"abstract_inverted_index":{"Heme":[0],"proteins":[1],"play":[2],"diverse":[3],"and":[4,11,37,45,82,164,177],"important":[5],"biological":[6],"roles,":[7],"from":[8,169],"electron":[9],"transfer":[10],"chemical":[12],"catalysis":[13],"to":[14],"oxygen":[15,38],"transport":[16],"and/or":[17],"storage.":[18],"Although":[19],"the":[20,27,34,40,46,55,58,62,71,74,79,83,100,111,115,125,134,140,150,157,162,175,183,206],"distortion":[21,44,67,87,135,151],"of":[22,30,61,78,85,106,114,136,149,152,159,161,186,209],"heme":[23,43,47,66,86,107,137,153,190],"porphyrin":[24,138,154],"correlates":[25],"with":[26,182,192],"physical":[28],"properties":[29],"heme,":[31,187],"such":[32],"as":[33],"redox":[35,184,198],"potential":[36,185,199],"affinity,":[39],"relationship":[41,208],"between":[42,73],"protein":[48,59],"environment":[49,60,128],"is":[50,129],"unclear.":[51],"Here,":[52],"we":[53],"tested":[54],"hypothesis":[56],"that":[57,124,156,189],"heme-binding":[63,80,116,126],"pocket":[64,81,117,127],"determines":[65],"(conformation).":[68],"We":[69],"analyzed":[70],"correlations":[72],"amino":[75],"acid":[76],"composition":[77],"magnitude":[84],"along":[88,139],"12":[89],"vibrational":[90,103,143],"modes":[91],"using":[92],"machine":[93],"learning.":[94],"A":[95],"correlation":[96],"was":[97],"detected":[98],"in":[99,109],"three":[101,141],"lowest":[102,142],"modes.":[104,144],"Analysis":[105],"distortions":[108,166,179,194],"nearly":[110],"same":[112],"environments":[113],"supported":[118],"this":[119],"notion.":[120],"Our":[121],"analyses":[122],"indicate":[123],"a":[130,196],"major":[131],"factor":[132],"impacting":[133],"In":[145],"addition,":[146],"statistical":[147],"analysis":[148],"revealed":[155],"peaks":[158],"distributions":[160],"ruffling":[163,176],"breathing":[165,178],"are":[167,180],"shifted":[168],"0":[170],"(the":[171],"equilibrium":[172],"structure).":[173],"Both":[174],"correlated":[181],"so":[188],"molecules":[191],"these":[193],"have":[195],"lower":[197],"than":[200],"planar":[201],"molecules.":[202],"These":[203],"findings":[204],"explain":[205],"structure-function":[207],"heme.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}