{"id":"https://openalex.org/W3214453777","doi":"https://doi.org/10.1021/acs.jcim.1c00918","title":"Unraveling the Molecular Mechanism of Recognition of Human Interferon-Stimulated Gene Product 15 by Coronavirus Papain-Like Proteases: A Multiscale Simulation Study","display_name":"Unraveling the Molecular Mechanism of Recognition of Human Interferon-Stimulated Gene Product 15 by Coronavirus Papain-Like Proteases: A Multiscale Simulation Study","publication_year":2021,"publication_date":"2021-11-16","ids":{"openalex":"https://openalex.org/W3214453777","doi":"https://doi.org/10.1021/acs.jcim.1c00918","mag":"3214453777","pmid":"https://pubmed.ncbi.nlm.nih.gov/34784198"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c00918","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00918","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000524140","display_name":"Rajarshi Roy","orcid":"https://orcid.org/0000-0002-5788-9424"},"institutions":[{"id":"https://openalex.org/I64295750","display_name":"Indian Institute of Technology Indore","ror":"https://ror.org/01hhf7w52","country_code":"IN","type":"education","lineage":["https://openalex.org/I64295750"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajarshi Roy","raw_affiliation_strings":["Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India"],"raw_orcid":"https://orcid.org/0000-0002-5788-9424","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India","institution_ids":["https://openalex.org/I64295750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048179593","display_name":"Nisha Amarnath Jonniya","orcid":"https://orcid.org/0000-0001-8022-3113"},"institutions":[{"id":"https://openalex.org/I64295750","display_name":"Indian Institute of Technology Indore","ror":"https://ror.org/01hhf7w52","country_code":"IN","type":"education","lineage":["https://openalex.org/I64295750"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nisha Amarnath Jonniya","raw_affiliation_strings":["Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India"],"raw_orcid":"https://orcid.org/0000-0001-8022-3113","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India","institution_ids":["https://openalex.org/I64295750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031168014","display_name":"Sayan Poddar","orcid":"https://orcid.org/0000-0002-7192-293X"},"institutions":[{"id":"https://openalex.org/I64295750","display_name":"Indian Institute of Technology Indore","ror":"https://ror.org/01hhf7w52","country_code":"IN","type":"education","lineage":["https://openalex.org/I64295750"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sayan Poddar","raw_affiliation_strings":["Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India","institution_ids":["https://openalex.org/I64295750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076764398","display_name":"Md Fulbabu Sk","orcid":null},"institutions":[{"id":"https://openalex.org/I64295750","display_name":"Indian Institute of Technology Indore","ror":"https://ror.org/01hhf7w52","country_code":"IN","type":"education","lineage":["https://openalex.org/I64295750"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Md Fulbabu Sk","raw_affiliation_strings":["Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India"],"raw_orcid":"https://orcid.org/0000-0003-4341-8370","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India","institution_ids":["https://openalex.org/I64295750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090815521","display_name":"Parimal Kar","orcid":"https://orcid.org/0000-0001-8451-9739"},"institutions":[{"id":"https://openalex.org/I64295750","display_name":"Indian Institute of Technology Indore","ror":"https://ror.org/01hhf7w52","country_code":"IN","type":"education","lineage":["https://openalex.org/I64295750"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Parimal Kar","raw_affiliation_strings":["Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India"],"raw_orcid":"https://orcid.org/0000-0001-8451-9739","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India","institution_ids":["https://openalex.org/I64295750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5090815521"],"corresponding_institution_ids":["https://openalex.org/I64295750"],"apc_list":null,"apc_paid":null,"fwci":1.0638,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75885434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"61","issue":"12","first_page":"6038","last_page":"6052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteases","display_name":"Proteases","score":0.876886248588562},{"id":"https://openalex.org/keywords/papain","display_name":"Papain","score":0.7942255735397339},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.6856944561004639},{"id":"https://openalex.org/keywords/coronavirus","display_name":"Coronavirus","score":0.5944680571556091},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5616999268531799},{"id":"https://openalex.org/keywords/interferon","display_name":"Interferon","score":0.5421546101570129},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5079730153083801},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4743339419364929},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3794664144515991},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.37571901082992554},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3453790545463562},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.26398444175720215},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2561142146587372},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19934362173080444}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.876886248588562},{"id":"https://openalex.org/C2779832904","wikidata":"https://www.wikidata.org/wiki/Q410420","display_name":"Papain","level":3,"score":0.7942255735397339},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6856944561004639},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5944680571556091},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5616999268531799},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5421546101570129},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5079730153083801},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4743339419364929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3794664144515991},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.37571901082992554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3453790545463562},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26398444175720215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2561142146587372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19934362173080444},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086882","descriptor_name":"Coronavirus Papain-Like Proteases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086882","descriptor_name":"Coronavirus Papain-Like Proteases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086882","descriptor_name":"Coronavirus Papain-Like Proteases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.1c00918","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00918","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:34784198","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34784198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.4699999988079071}],"awards":[{"id":"https://openalex.org/G8822956565","display_name":null,"funder_award_id":"DST/NSM/R&D_HPC_Applications/2021/03.18","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W190626844","https://openalex.org/W1089423911","https://openalex.org/W1975580333","https://openalex.org/W1978085575","https://openalex.org/W1994279587","https://openalex.org/W1994941561","https://openalex.org/W2007572995","https://openalex.org/W2024056509","https://openalex.org/W2034133457","https://openalex.org/W2038532826","https://openalex.org/W2047813242","https://openalex.org/W2056022472","https://openalex.org/W2063628644","https://openalex.org/W2067174909","https://openalex.org/W2079100129","https://openalex.org/W2088943364","https://openalex.org/W2100561975","https://openalex.org/W2112263915","https://openalex.org/W2136747849","https://openalex.org/W2160451368","https://openalex.org/W2160620965","https://openalex.org/W2163448677","https://openalex.org/W2330799739","https://openalex.org/W2332712348","https://openalex.org/W2404280981","https://openalex.org/W2513547424","https://openalex.org/W2516470062","https://openalex.org/W2580699373","https://openalex.org/W2605968187","https://openalex.org/W2755284043","https://openalex.org/W2783351753","https://openalex.org/W2940769527","https://openalex.org/W2946614862","https://openalex.org/W2954094311","https://openalex.org/W2979780649","https://openalex.org/W2989812867","https://openalex.org/W3001118548","https://openalex.org/W3001897055","https://openalex.org/W3003380197","https://openalex.org/W3005212621","https://openalex.org/W3005775246","https://openalex.org/W3007760654","https://openalex.org/W3010992334","https://openalex.org/W3012379316","https://openalex.org/W3014347154","https://openalex.org/W3015769528","https://openalex.org/W3016010853","https://openalex.org/W3021439445","https://openalex.org/W3022970339","https://openalex.org/W3023665270","https://openalex.org/W3024783570","https://openalex.org/W3025480423","https://openalex.org/W3025838913","https://openalex.org/W3046218096","https://openalex.org/W3080335013","https://openalex.org/W3082311967","https://openalex.org/W3090085076","https://openalex.org/W3090297814","https://openalex.org/W3093756482","https://openalex.org/W3093822515","https://openalex.org/W3168788978","https://openalex.org/W3177353445"],"related_works":["https://openalex.org/W2356492519","https://openalex.org/W1513985338","https://openalex.org/W2979122009","https://openalex.org/W2092663994","https://openalex.org/W2364682546","https://openalex.org/W1972284547","https://openalex.org/W2019939922","https://openalex.org/W2075651093","https://openalex.org/W2046152936","https://openalex.org/W2327889673"],"abstract_inverted_index":{"The":[0,103,175,193],"papain-like":[1],"protease":[2],"(PLpro)":[3],"of":[4,24,36,76,78,116,121,140,168,214,223,232,236,245],"the":[5,15,33,71,81,92,114,117,138,143,150,166,172,198,212,221,229,239,243],"coronavirus":[6],"(CoV)":[7],"family":[8,241],"plays":[9],"an":[10,158],"essential":[11],"role":[12],"in":[13],"processing":[14],"viral":[16,58],"polyprotein":[17],"and":[18,28,73,100,242],"immune":[19,55],"evasion.":[20],"Additional":[21],"proteolytic":[22],"activities":[23,52,235],"PLpro":[25,61,79,135,237],"include":[26],"deubiquitination":[27],"deISGylation,":[29],"which":[30],"can":[31],"reverse":[32],"post-translational":[34],"modification":[35],"cellular":[37],"proteins":[38],"conjugated":[39],"with":[40,186,211],"ubiquitin":[41],"or":[42,44,191,206],"(Ub)":[43],"Ub-like":[45],"interferon-stimulated":[46],"gene":[47],"product":[48],"15":[49],"(ISG15).":[50],"These":[51],"regulate":[53],"innate":[54],"responses":[56],"against":[57],"infection.":[59],"Thus,":[60],"is":[62],"a":[63],"potential":[64],"antiviral":[65],"target.":[66],"Here,":[67],"we":[68],"have":[69],"described":[70],"structural":[72],"energetic":[74],"basis":[75,231],"recognition":[77],"by":[80],"human":[82],"ISG15":[83],"protein":[84,152],"(hISG15)":[85],"using":[86],"atomistic":[87],"molecular":[88,230],"dynamics":[89],"simulation":[90,105],"across":[91,132,171],"CoV":[93,173,240],"family,":[94],"i.e.,":[95],"MERS-CoV":[96],"(MCoV),":[97],"SARS-CoV":[98],"(SCoV),":[99],"SARS-CoV-2":[101],"(SCoV2).":[102],"cumulative":[104],"length":[106],"for":[107],"all":[108,133],"trajectories":[109],"was":[110,125,130],"32.0":[111],"\u03bcs.":[112],"In":[113],"absence":[115],"complete":[118],"crystal":[119],"structure":[120],"complexes,":[122],"protein-protein":[123,144],"docking":[124],"used.":[126],"A":[127],"mutation":[128,141],"(R167E)":[129],"introduced":[131],"three":[134],"to":[136,163,189],"study":[137,147,202,227],"effect":[139],"on":[142],"binding.":[145],"Our":[146,201],"reveals":[148],"that":[149,181,204],"apo-ISG15":[151],"remains":[153],"closed":[154],"while":[155,216],"it":[156],"adopts":[157],"open":[159],"conformation":[160],"when":[161],"bound":[162],"PLpro,":[164],"although":[165],"degree":[167],"openness":[169],"varies":[170],"family.":[174],"binding":[176],"free":[177],"energy":[178],"analysis":[179],"suggests":[180],"hISG15":[182],"binds":[183,208,218],"more":[184,209,219],"strongly":[185,210],"SCoV2-PLpro":[187,217,246],"compared":[188],"SCoV":[190,205],"MCoV.":[192],"intermolecular":[194],"electrostatic":[195],"interaction":[196],"drives":[197],"hISG15-PLpro":[199],"complexation.":[200],"showed":[203],"MCoV-PLpro":[207],"C-domain":[213],"hISG15,":[215],"favorably":[220],"N-domain":[222],"hISG15.":[224,248],"Overall,":[225],"our":[226],"explains":[228],"differential":[233],"deISGylating":[234],"among":[238],"specificity":[244],"toward":[247]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
