{"id":"https://openalex.org/W3209646263","doi":"https://doi.org/10.1021/acs.jcim.1c00915","title":"Hyperactive Antifreeze Proteins Promote Ice Growth before Binding to It","display_name":"Hyperactive Antifreeze Proteins Promote Ice Growth before Binding to It","publication_year":2021,"publication_date":"2021-10-29","ids":{"openalex":"https://openalex.org/W3209646263","doi":"https://doi.org/10.1021/acs.jcim.1c00915","mag":"3209646263","pmid":"https://pubmed.ncbi.nlm.nih.gov/34711054"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c00915","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00915","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022243333","display_name":"Shaoli Cui","orcid":"https://orcid.org/0000-0002-7343-725X"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4391767646","display_name":"State Key Laboratory of Medicinal Chemical Biology","ror":"https://ror.org/032p70522","country_code":null,"type":"facility","lineage":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaoli Cui","raw_affiliation_strings":["Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China"],"raw_orcid":"https://orcid.org/0000-0002-7343-725X","affiliations":[{"raw_affiliation_string":"Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100457939","display_name":"Weijia Zhang","orcid":"https://orcid.org/0000-0001-9200-6036"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4391767646","display_name":"State Key Laboratory of Medicinal Chemical Biology","ror":"https://ror.org/032p70522","country_code":null,"type":"facility","lineage":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijia Zhang","raw_affiliation_strings":["Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China"],"raw_orcid":"https://orcid.org/0000-0001-9200-6036","affiliations":[{"raw_affiliation_string":"Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101639531","display_name":"Xueguang Shao","orcid":"https://orcid.org/0000-0001-5027-4382"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4391767646","display_name":"State Key Laboratory of Medicinal Chemical Biology","ror":"https://ror.org/032p70522","country_code":null,"type":"facility","lineage":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xueguang Shao","raw_affiliation_strings":["Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China"],"raw_orcid":"https://orcid.org/0000-0001-5027-4382","affiliations":[{"raw_affiliation_string":"Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010656224","display_name":"Wensheng Cai","orcid":"https://orcid.org/0000-0002-6457-7058"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4391767646","display_name":"State Key Laboratory of Medicinal Chemical Biology","ror":"https://ror.org/032p70522","country_code":null,"type":"facility","lineage":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wensheng Cai","raw_affiliation_strings":["Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China"],"raw_orcid":"https://orcid.org/0000-0002-6457-7058","affiliations":[{"raw_affiliation_string":"Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010656224","https://openalex.org/A5101639531"],"corresponding_institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4391767646"],"apc_list":null,"apc_paid":null,"fwci":1.963,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.8597653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"62","issue":"21","first_page":"5165","last_page":"5174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12202","display_name":"nanoparticles nucleation surface interactions","score":0.9661999940872192,"subfield":{"id":"https://openalex.org/subfields/1902","display_name":"Atmospheric Science"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.90829998254776,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifreeze-protein","display_name":"Antifreeze protein","score":0.9802628755569458},{"id":"https://openalex.org/keywords/antifreeze","display_name":"Antifreeze","score":0.7662927508354187},{"id":"https://openalex.org/keywords/ice-crystals","display_name":"Ice crystals","score":0.649160623550415},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5133542418479919},{"id":"https://openalex.org/keywords/adsorption","display_name":"Adsorption","score":0.4582485556602478},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.34693747758865356},{"id":"https://openalex.org/keywords/chemical-engineering","display_name":"Chemical engineering","score":0.3403695821762085},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20537275075912476},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20281746983528137},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.11682853102684021},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10175919532775879},{"id":"https://openalex.org/keywords/meteorology","display_name":"Meteorology","score":0.07263985276222229}],"concepts":[{"id":"https://openalex.org/C141734981","wikidata":"https://www.wikidata.org/wiki/Q421541","display_name":"Antifreeze protein","level":2,"score":0.9802628755569458},{"id":"https://openalex.org/C2776170207","wikidata":"https://www.wikidata.org/wiki/Q503288","display_name":"Antifreeze","level":2,"score":0.7662927508354187},{"id":"https://openalex.org/C125388846","wikidata":"https://www.wikidata.org/wiki/Q1325808","display_name":"Ice crystals","level":2,"score":0.649160623550415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5133542418479919},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.4582485556602478},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34693747758865356},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3403695821762085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20537275075912476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20281746983528137},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11682853102684021},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10175919532775879},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.07263985276222229},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D007053","descriptor_name":"Ice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007053","descriptor_name":"Ice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007053","descriptor_name":"Ice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021301","descriptor_name":"Antifreeze Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021301","descriptor_name":"Antifreeze Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021301","descriptor_name":"Antifreeze Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021301","descriptor_name":"Antifreeze Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021301","descriptor_name":"Antifreeze Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021301","descriptor_name":"Antifreeze Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.1c00915","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00915","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:34711054","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34711054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":0.800000011920929,"display_name":"Clean water and sanitation"}],"awards":[{"id":"https://openalex.org/G247785969","display_name":"\u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u7684\u91cd\u8981\u6027\u91c7\u6837\u65b9\u6cd5\u53ca\u5e94\u7528\u7814\u7a76","funder_award_id":"22073050","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7457422375","display_name":null,"funder_award_id":"20JCYBJC01480","funder_id":"https://openalex.org/F4320323993","funder_display_name":"Natural Science Foundation of Tianjin City"},{"id":"https://openalex.org/G8063075859","display_name":null,"funder_award_id":"22174075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8091428363","display_name":null,"funder_award_id":"63211019","funder_id":"https://openalex.org/F4320323021","funder_display_name":"Nankai University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323021","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1555425311","https://openalex.org/W1850312678","https://openalex.org/W1877147113","https://openalex.org/W1978498560","https://openalex.org/W1978537574","https://openalex.org/W1979125069","https://openalex.org/W1999283969","https://openalex.org/W1999458597","https://openalex.org/W2002119104","https://openalex.org/W2002555240","https://openalex.org/W2004765394","https://openalex.org/W2012708621","https://openalex.org/W2015520136","https://openalex.org/W2021520922","https://openalex.org/W2023657602","https://openalex.org/W2024318496","https://openalex.org/W2028729126","https://openalex.org/W2029667189","https://openalex.org/W2035687084","https://openalex.org/W2039879995","https://openalex.org/W2042545194","https://openalex.org/W2052038479","https://openalex.org/W2057477511","https://openalex.org/W2064811858","https://openalex.org/W2065329899","https://openalex.org/W2074117796","https://openalex.org/W2088793989","https://openalex.org/W2090026561","https://openalex.org/W2090392341","https://openalex.org/W2092204065","https://openalex.org/W2109532360","https://openalex.org/W2109851377","https://openalex.org/W2117957872","https://openalex.org/W2128572087","https://openalex.org/W2128775520","https://openalex.org/W2133694749","https://openalex.org/W2135448686","https://openalex.org/W2142348708","https://openalex.org/W2157014055","https://openalex.org/W2314880391","https://openalex.org/W2319469731","https://openalex.org/W2343925409","https://openalex.org/W2436008330","https://openalex.org/W2519717301","https://openalex.org/W2560537606","https://openalex.org/W2563476458","https://openalex.org/W2610277909","https://openalex.org/W2614170801","https://openalex.org/W2684267623","https://openalex.org/W2748145815","https://openalex.org/W2754194219","https://openalex.org/W2757431628","https://openalex.org/W2762772696","https://openalex.org/W2766530880","https://openalex.org/W2767786323","https://openalex.org/W2786807390","https://openalex.org/W2790756794","https://openalex.org/W2794389022","https://openalex.org/W2799559164","https://openalex.org/W2806751886","https://openalex.org/W2820141969","https://openalex.org/W2885292964","https://openalex.org/W2892199603","https://openalex.org/W2932093865","https://openalex.org/W2940995621","https://openalex.org/W2945989881","https://openalex.org/W2969107345","https://openalex.org/W2969864176","https://openalex.org/W2972541248","https://openalex.org/W3007789978","https://openalex.org/W3015019106","https://openalex.org/W3027968755","https://openalex.org/W3083627374","https://openalex.org/W3094384243","https://openalex.org/W3114668048","https://openalex.org/W3139447337"],"related_works":["https://openalex.org/W1964791917","https://openalex.org/W1999201992","https://openalex.org/W51383163","https://openalex.org/W2039510063","https://openalex.org/W2345753121","https://openalex.org/W2375475822","https://openalex.org/W2091994167","https://openalex.org/W2289576126","https://openalex.org/W3163147672","https://openalex.org/W2057763717"],"abstract_inverted_index":{"The":[0,75,205],"antifreeze":[1,4,39,213,217],"mechanism":[2,197],"of":[3,17,35,53,100,120,163,171,189,212],"proteins":[5,214],"(AFPs)":[6],"evolved":[7],"by":[8,134],"organisms":[9],"has":[10],"been":[11],"widely":[12],"studied.":[13],"However,":[14],"detailed":[15],"knowledge":[16],"the":[18,29,32,36,46,50,61,88,92,98,101,105,108,113,118,126,129,136,139,144,152,161,164,169,186,195,210],"synergy":[19,80],"between":[20,81,198],"AFPs":[21],"and":[22,42,64,71,83,107,138,181,194,200,215],"ice":[23,43,55,84,93,102,114,127,140,153,165,192,201],"crystals":[24,44,141,202],"still":[25],"remains":[26],"fragmentary.":[27],"In":[28,173],"present":[30],"contribution,":[31],"cooperative":[33],"effect":[34],"hyperactive":[37],"insect":[38],"protein":[40,110,199],"TmAFP":[41,82,89,124,150,190],"on":[45,97],"interfacial":[47,130],"water":[48,131],"during":[49],"entire":[51],"process":[52,188],"inhibiting":[54,168,191],"growth":[56,94,115,170],"is":[57,132,203],"systematically":[58],"investigated":[59],"at":[60],"atomic":[62],"level":[63],"compared":[65],"with":[66,219],"its":[67],"low":[68],"activity":[69],"mutant":[70,106],"a":[72,78,157],"nonantifreeze":[73,109],"protein.":[74],"results":[76,206],"indicate":[77],"significant":[79],"crystals,":[85,103],"which":[86,148],"enables":[87],"to":[90,117,142,151],"promote":[91,112],"before":[95],"adsorbing":[96],"surfaces":[99],"while":[104],"cannot":[111],"due":[116],"lack":[119],"this":[121,174],"synergy.":[122],"When":[123],"approaches":[125],"surface,":[128,154,166],"induced":[133],"both":[135],"AFP":[137],"form":[143],"anchored":[145],"clathrate":[146],"motif,":[147],"binds":[149],"resulting":[155],"in":[156,160,185],"local":[158],"increase":[159],"curvature":[162],"thereby":[167],"ice.":[172],"study,":[175],"three":[176],"stages,":[177],"namely,":[178],"promotion,":[179],"adsorption,":[180],"inhibition,":[182],"are":[183,207],"observed":[184],"complete":[187],"growth,":[193],"synergistic":[196],"revealed.":[204],"helpful":[208],"for":[209],"design":[211],"bioinspired":[216],"materials":[218],"superior":[220],"performance.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}