{"id":"https://openalex.org/W3198820576","doi":"https://doi.org/10.1021/acs.jcim.1c00818","title":"Dissecting the Role of <i>N</i>-Glycan at N413 in Toll-like Receptor 3 via Molecular Dynamics Simulations","display_name":"Dissecting the Role of <i>N</i>-Glycan at N413 in Toll-like Receptor 3 via Molecular Dynamics Simulations","publication_year":2021,"publication_date":"2021-09-08","ids":{"openalex":"https://openalex.org/W3198820576","doi":"https://doi.org/10.1021/acs.jcim.1c00818","mag":"3198820576","pmid":"https://pubmed.ncbi.nlm.nih.gov/34494836"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c00818","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00818","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100354980","display_name":"Yibo Wang","orcid":"https://orcid.org/0000-0003-1262-4497"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yibo Wang","raw_affiliation_strings":["Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China","State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China"],"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037820123","display_name":"Siru Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siru Wu","raw_affiliation_strings":["Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China","Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China"],"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438418","display_name":"Cong Zhang","orcid":"https://orcid.org/0009-0000-5403-2866"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Zhang","raw_affiliation_strings":["Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China","Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China"],"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008644113","display_name":"Yushan Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yushan Jin","raw_affiliation_strings":["Department of Immunology and Department of Cell & Systems Biology, University of Toronto, Toronto, M5S 1A1, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Immunology and Department of Cell & Systems Biology, University of Toronto, Toronto, M5S 1A1, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100618787","display_name":"Xiaohui Wang","orcid":"https://orcid.org/0000-0002-3415-5612"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohui Wang","raw_affiliation_strings":["Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China","Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China"],"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100618787"],"corresponding_institution_ids":["https://openalex.org/I126520041","https://openalex.org/I19820366","https://openalex.org/I4210092888"],"apc_list":null,"apc_paid":null,"fwci":0.1618,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.45921149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"62","issue":"21","first_page":"5258","last_page":"5266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll","display_name":"Toll","score":0.8018661737442017},{"id":"https://openalex.org/keywords/glycan","display_name":"Glycan","score":0.7507694959640503},{"id":"https://openalex.org/keywords/toll-like-receptor","display_name":"Toll-like receptor","score":0.6423978805541992},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5754291415214539},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5059303641319275},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.47085872292518616},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.44747963547706604},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3996274471282959},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.329711377620697},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22096052765846252},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18370628356933594},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.1760547161102295},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.13220995664596558},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.13100776076316833},{"id":"https://openalex.org/keywords/glycoprotein","display_name":"Glycoprotein","score":0.08245551586151123}],"concepts":[{"id":"https://openalex.org/C2778025104","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll","level":2,"score":0.8018661737442017},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.7507694959640503},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.6423978805541992},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5754291415214539},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5059303641319275},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47085872292518616},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.44747963547706604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3996274471282959},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.329711377620697},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22096052765846252},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18370628356933594},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1760547161102295},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.13220995664596558},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.13100776076316833},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.08245551586151123},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.1c00818","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00818","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:34494836","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34494836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4177265180","display_name":null,"funder_award_id":"NA170152","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G6890854325","display_name":null,"funder_award_id":"21807098","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7425789316","display_name":null,"funder_award_id":"21877106","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8884713483","display_name":null,"funder_award_id":"91956121","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1883052656","https://openalex.org/W1969017401","https://openalex.org/W1972758026","https://openalex.org/W1984093225","https://openalex.org/W1996790111","https://openalex.org/W2021520922","https://openalex.org/W2028062152","https://openalex.org/W2028161249","https://openalex.org/W2029667189","https://openalex.org/W2032595287","https://openalex.org/W2035687084","https://openalex.org/W2038758364","https://openalex.org/W2049449151","https://openalex.org/W2059414193","https://openalex.org/W2060872117","https://openalex.org/W2077486035","https://openalex.org/W2084655660","https://openalex.org/W2090877072","https://openalex.org/W2101624429","https://openalex.org/W2104630342","https://openalex.org/W2112154906","https://openalex.org/W2113971181","https://openalex.org/W2113994268","https://openalex.org/W2117398821","https://openalex.org/W2117458899","https://openalex.org/W2118439154","https://openalex.org/W2120818714","https://openalex.org/W2123681603","https://openalex.org/W2133449490","https://openalex.org/W2137604324","https://openalex.org/W2150736048","https://openalex.org/W2150981663","https://openalex.org/W2157504720","https://openalex.org/W2164866041","https://openalex.org/W2167742884","https://openalex.org/W2257036949","https://openalex.org/W2555870966","https://openalex.org/W2612812586","https://openalex.org/W2759204647","https://openalex.org/W2784697675","https://openalex.org/W2918436385","https://openalex.org/W2932408267","https://openalex.org/W2982249668","https://openalex.org/W3119569277"],"related_works":["https://openalex.org/W2757240192","https://openalex.org/W592613903","https://openalex.org/W2353712315","https://openalex.org/W588210059","https://openalex.org/W3022029543","https://openalex.org/W2359940423","https://openalex.org/W2378169260","https://openalex.org/W582981267","https://openalex.org/W2489749982","https://openalex.org/W1773535258"],"abstract_inverted_index":{"Toll-like":[0],"receptor":[1,7],"3":[2],"(TLR3)":[3],"is":[4],"an":[5],"endosomal":[6],"involved":[8],"in":[9,40,45,56,123,131,151,216],"initiating":[10],"immune":[11,219],"responses":[12],"upon":[13],"viral":[14],"infection":[15],"by":[16,177,223],"directly":[17],"recognizing":[18],"double-stranded":[19],"RNA":[20],"(dsRNA).":[21],"As":[22],"one":[23],"of":[24,34,38,54,72,97,139,149,167,190,199,210,214,221],"the":[25,32,52,79,95,112,116,124,132,135,152,158,165,168,185,195,211,217],"most":[26],"heavily":[27],"glycosylated":[28,133],"TLR":[29],"family":[30],"members,":[31],"role":[33,53,213],"glycan":[35,101,159,191],"at":[36,59,102,160,192],"N413":[37,103,129,153,161,193],"TLR3":[39,82,125,140,150,200,224,232],"ligand":[41],"recognition":[42,201,220],"has":[43],"been":[44],"debate":[46],"for":[47,90,230],"decades.":[48],"Herein,":[49],"to":[50,87,111,163],"investigate":[51],"glycans":[55,215],"TLR3,":[57],"specifically":[58],"amino":[60],"acid":[61],"residue":[62],"N413,":[63],"molecular":[64],"dynamic":[65],"simulations":[66],"were":[67],"performed.":[68],"The":[69,100],"loop":[70],"region":[71],"LRR12":[73],"(residues":[74],"323-355),":[75],"which":[76],"protrudes":[77],"from":[78,108],"dsRNA":[80,93,107,122,143,169,222],"binding":[81,117,126,136,170],"lateral":[83],"surface":[84],"was":[85,130,144,174],"found":[86],"be":[88],"vital":[89],"interacting":[91,141],"with":[92,142,202],"via":[94],"formation":[96],"hydrogen":[98],"bonds.":[99],"not":[104],"only":[105],"prevented":[106],"being":[109],"exposed":[110],"bulk":[113],"water":[114],"during":[115],"process":[118],"but":[119],"further":[120,206],"stabilized":[121],"site.":[127],"When":[128],"form,":[134],"free":[137],"energy":[138],"significantly":[145],"lower":[146],"than":[147],"that":[148,184],"unglycosylated":[154],"form.":[155],"Additionally,":[156],"as":[157],"functioned":[162],"alter":[164],"dynamics":[166,198],"process,":[171],"its":[172],"flexibility":[173],"meanwhile":[175],"influenced":[176],"dsRNA.":[178,203],"In":[179],"all,":[180],"these":[181],"results":[182],"demonstrate":[183],"size,":[186],"length,":[187],"and":[188,197,225],"branch":[189],"affect":[194],"thermodynamics":[196],"This":[204],"study":[205],"extends":[207],"our":[208],"understanding":[209],"biological":[212],"innate":[218],"provides":[226],"a":[227],"new":[228],"perspective":[229],"modulating":[231],"function.":[233]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
