{"id":"https://openalex.org/W3164698295","doi":"https://doi.org/10.1021/acs.jcim.1c00251","title":"Alignment-Free Antimicrobial Peptide Predictors: Improving Performance by a Thorough Analysis of the Largest Available Data Set","display_name":"Alignment-Free Antimicrobial Peptide Predictors: Improving Performance by a Thorough Analysis of the Largest Available Data Set","publication_year":2021,"publication_date":"2021-06-03","ids":{"openalex":"https://openalex.org/W3164698295","doi":"https://doi.org/10.1021/acs.jcim.1c00251","mag":"3164698295","pmid":"https://pubmed.ncbi.nlm.nih.gov/34081438"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c00251","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00251","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039626731","display_name":"Sergio A. Pinacho-Castellanos","orcid":"https://orcid.org/0000-0001-5783-352X"},"institutions":[{"id":"https://openalex.org/I64663401","display_name":"Center for Scientific Research and Higher Education at Ensenada","ror":"https://ror.org/04znhwb73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I64663401"]},{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Sergio A. Pinacho-Castellanos","raw_affiliation_strings":["Centro de Investigaci\u00f3n y Desarrollo de Tecnolog\u00eda Digital (CITEDI), Instituto Polit\u00e9cnico Nacional (IPN), 22435 Tijuana, Baja California, M\u00e9xico","Departamento de Ciencias de la Computaci\u00f3n, Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada (CICESE), 22860 Ensenada, Baja California, M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n y Desarrollo de Tecnolog\u00eda Digital (CITEDI), Instituto Polit\u00e9cnico Nacional (IPN), 22435 Tijuana, Baja California, M\u00e9xico","institution_ids":["https://openalex.org/I59361560"]},{"raw_affiliation_string":"Departamento de Ciencias de la Computaci\u00f3n, Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada (CICESE), 22860 Ensenada, Baja California, M\u00e9xico","institution_ids":["https://openalex.org/I64663401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008729002","display_name":"C\u00e9sar R. Garc\u00eda\u2010Jacas","orcid":"https://orcid.org/0000-0002-3962-7658"},"institutions":[{"id":"https://openalex.org/I64663401","display_name":"Center for Scientific Research and Higher Education at Ensenada","ror":"https://ror.org/04znhwb73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I64663401"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"C\u00e9sar R. Garc\u00eda-Jacas","raw_affiliation_strings":["C\u00e1tedras CONACYT\u2014Departamento de Ciencias de la Computaci\u00f3n, Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada (CICESE), 22860 Ensenada, Baja California, M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"C\u00e1tedras CONACYT\u2014Departamento de Ciencias de la Computaci\u00f3n, Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada (CICESE), 22860 Ensenada, Baja California, M\u00e9xico","institution_ids":["https://openalex.org/I64663401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049982297","display_name":"Michael K. Gilson","orcid":"https://orcid.org/0000-0002-3375-1738"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael K. Gilson","raw_affiliation_strings":["Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States"],"affiliations":[{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075390665","display_name":"Carlos A. Brizuela","orcid":"https://orcid.org/0000-0003-4621-0380"},"institutions":[{"id":"https://openalex.org/I64663401","display_name":"Center for Scientific Research and Higher Education at Ensenada","ror":"https://ror.org/04znhwb73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I64663401"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Carlos A. Brizuela","raw_affiliation_strings":["Departamento de Ciencias de la Computaci\u00f3n, Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada (CICESE), 22860 Ensenada, Baja California, M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Computaci\u00f3n, Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada (CICESE), 22860 Ensenada, Baja California, M\u00e9xico","institution_ids":["https://openalex.org/I64663401"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008729002","https://openalex.org/A5075390665"],"corresponding_institution_ids":["https://openalex.org/I64663401"],"apc_list":null,"apc_paid":null,"fwci":7.3123,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.98257623,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"61","issue":"6","first_page":"3141","last_page":"3157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6200551390647888},{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.6033753156661987},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5395011901855469},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5394691824913025},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.5187966227531433},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4937046468257904},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.47912880778312683},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.44595882296562195}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6200551390647888},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.6033753156661987},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5395011901855469},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5394691824913025},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.5187966227531433},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4937046468257904},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.47912880778312683},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.44595882296562195},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.1c00251","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00251","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:34081438","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34081438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmid:34161087","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34161087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2949177408","display_name":null,"funder_award_id":"501/2018","funder_id":"https://openalex.org/F4320334834","funder_display_name":"Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada, Baja California"},{"id":"https://openalex.org/G7947319473","display_name":null,"funder_award_id":"A1-S-20638","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"}],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320334834","display_name":"Centro de Investigaci\u00f3n Cient\u00edfica y de Educaci\u00f3n Superior de Ensenada, Baja California","ror":"https://ror.org/059ex5q34"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W143962061","https://openalex.org/W1495061682","https://openalex.org/W1500895378","https://openalex.org/W1540105270","https://openalex.org/W1570912112","https://openalex.org/W1571439140","https://openalex.org/W1747747683","https://openalex.org/W1812571265","https://openalex.org/W1964557084","https://openalex.org/W1974797859","https://openalex.org/W1976178947","https://openalex.org/W1978444624","https://openalex.org/W1978914444","https://openalex.org/W1983394040","https://openalex.org/W1993584543","https://openalex.org/W1996851544","https://openalex.org/W1998064689","https://openalex.org/W2011897016","https://openalex.org/W2015490529","https://openalex.org/W2017337590","https://openalex.org/W2024342748","https://openalex.org/W2030391296","https://openalex.org/W2035167810","https://openalex.org/W2035755292","https://openalex.org/W2035828432","https://openalex.org/W2039324514","https://openalex.org/W2043906184","https://openalex.org/W2057069496","https://openalex.org/W2063512434","https://openalex.org/W2067402644","https://openalex.org/W2076018148","https://openalex.org/W2086190989","https://openalex.org/W2087466582","https://openalex.org/W2087882410","https://openalex.org/W2095649738","https://openalex.org/W2097606916","https://openalex.org/W2097834518","https://openalex.org/W2099071242","https://openalex.org/W2100965251","https://openalex.org/W2112862199","https://openalex.org/W2114247676","https://openalex.org/W2117767830","https://openalex.org/W2128245586","https://openalex.org/W2128495797","https://openalex.org/W2140353364","https://openalex.org/W2147454197","https://openalex.org/W2152380569","https://openalex.org/W2154290668","https://openalex.org/W2159861471","https://openalex.org/W2163316049","https://openalex.org/W2175270296","https://openalex.org/W2222575139","https://openalex.org/W2280681870","https://openalex.org/W2337957188","https://openalex.org/W2506333705","https://openalex.org/W2511835277","https://openalex.org/W2525830808","https://openalex.org/W2588463038","https://openalex.org/W2588467130","https://openalex.org/W2604037093","https://openalex.org/W2739980134","https://openalex.org/W2788314593","https://openalex.org/W2788724800","https://openalex.org/W2789918675","https://openalex.org/W2791848964","https://openalex.org/W2792378492","https://openalex.org/W2793396277","https://openalex.org/W2802643674","https://openalex.org/W2807001312","https://openalex.org/W2807152882","https://openalex.org/W2888548211","https://openalex.org/W2892506572","https://openalex.org/W2897377848","https://openalex.org/W2899841051","https://openalex.org/W2911964244","https://openalex.org/W2914712884","https://openalex.org/W2916168844","https://openalex.org/W2936599975","https://openalex.org/W2937346329","https://openalex.org/W2943554879","https://openalex.org/W2946321682","https://openalex.org/W2948009788","https://openalex.org/W2948272581","https://openalex.org/W2953705189","https://openalex.org/W2964472696","https://openalex.org/W2964774153","https://openalex.org/W2965044151","https://openalex.org/W2967960129","https://openalex.org/W2978416222","https://openalex.org/W2981285269","https://openalex.org/W2984592028","https://openalex.org/W2985233215","https://openalex.org/W2987724682","https://openalex.org/W2998197489","https://openalex.org/W2998901549","https://openalex.org/W3010686554","https://openalex.org/W3011741261","https://openalex.org/W3023042104","https://openalex.org/W3025501158","https://openalex.org/W3046470356","https://openalex.org/W3094421290","https://openalex.org/W3136918052","https://openalex.org/W4211260588","https://openalex.org/W4213151958","https://openalex.org/W4235106149","https://openalex.org/W4248018214","https://openalex.org/W4288947431","https://openalex.org/W6604128962"],"related_works":["https://openalex.org/W4238897586","https://openalex.org/W435179959","https://openalex.org/W2619091065","https://openalex.org/W2059640416","https://openalex.org/W1490753184","https://openalex.org/W2284465472","https://openalex.org/W2291782699","https://openalex.org/W1993948687","https://openalex.org/W4394984040","https://openalex.org/W2594414941"],"abstract_inverted_index":{"In":[0],"the":[1,12,28,33,41,54,78,99,148,151,156,164,175,182,212,218,224,227,248,263,266,271,279,284,288,309],"last":[2],"two":[3],"decades,":[4],"a":[5,50,72],"large":[6],"number":[7],"of":[8,14,77,150,158,217,223,265],"machine-learning-based":[9],"predictors":[10,22],"for":[11,163,167],"activities":[13],"antimicrobial":[15],"peptides":[16,267,298],"(AMPs)":[17],"have":[18,229],"been":[19],"proposed.":[20],"These":[21,69],"differ":[23],"from":[24,98,181,226],"one":[25],"another":[26],"in":[27,32,83,188,215,270,287],"learning":[29],"method":[30],"and":[31,35,59,65,94,130,135,178,204,241,296,302],"training":[34,42],"testing":[36],"data":[37,43,67,96,105,113],"sets":[38,44,97],"used.":[39],"Unfortunately,":[40],"present":[45],"several":[46,179],"drawbacks,":[47],"such":[48],"as":[49],"low":[51,73],"representativeness":[52],"regarding":[53],"experimentally":[55,101],"validated":[56,102],"AMP":[57,168],"space,":[58],"duplicated":[60],"peptide":[61,104],"sequences":[62],"between":[63,174],"negative":[64],"positive":[66],"sets.":[68],"limitations":[70],"give":[71],"confidence":[74],"to":[75,80,108,126,146,155,291],"most":[76,222],"approaches":[79],"be":[81,276],"used":[82,269],"prospective":[84],"studies.":[85],"To":[86],"address":[87],"these":[88,111],"weaknesses,":[89],"we":[90],"propose":[91],"novel":[92,112],"modeling":[93],"assessing":[95],"largest":[100],"nonredundant":[103],"set":[106],"reported":[107],"date.":[109],"From":[110],"sets,":[114],"alignment-free":[115],"quantitative":[116],"sequence-activity":[117],"models":[118,176,180,207,234,280],"(AF-QSAMs)":[119],"based":[120],"on":[121],"Random":[122],"Forest":[123],"are":[124,185,209,236,253,305],"created":[125],"identify":[127],"general":[128],"AMPs":[129],"their":[131],"antibacterial,":[132,293],"antifungal,":[133,294],"antiparasitic,":[134,295],"antiviral":[136,297],"functional":[137],"types.":[138],"An":[139],"applicability":[140],"domain":[141],"analysis":[142],"is":[143,161,172],"carried":[144],"out":[145],"determine":[147],"reliability":[149],"predictions":[152],"obtained,":[153],"which,":[154],"best":[157,213],"our":[159],"knowledge,":[160],"performed":[162],"first":[165],"time":[166],"recognition.":[169],"A":[170],"benchmarking":[171],"undertaken":[173],"proposed":[177,208,235],"literature":[183,228,289],"that":[184,247,278],"freely":[186,306],"available":[187,307],"13":[189],"programs":[190],"(ClassAMP,":[191],"iAMP-2L,":[192],"ADAM,":[193],"MLAMP,":[194],"AMPScanner":[195],"v2.0,":[196],"AntiFP,":[197],"AMPfun,":[198],"PEPred-suite,":[199],"AxPEP,":[200],"CAMPR3,":[201],"iAMPpred,":[202],"APIN,":[203],"Meta-iAVP).":[205],"The":[206,233],"those":[210],"with":[211,299],"performance":[214],"all":[216],"endpoints":[219],"modeled,":[220],"while":[221],"methods":[225],"weak-to-random":[230],"predictive":[231],"agreements.":[232],"also":[237,261],"assessed":[238],"through":[239],"<i>Y</i>-scrambling":[240],"repeated":[242],"<i>k</i>-fold":[243],"cross-validation":[244],"tests,":[245],"demonstrating":[246],"outcomes":[249],"obtained":[250],"by":[251,256,282],"them":[252],"not":[254],"given":[255],"chance.":[257],"Three":[258],"chemometric":[259],"analyses":[260],"confirmed":[262],"relevance":[264],"descriptors":[268],"modeling.":[272],"Therefore,":[273],"it":[274],"can":[275],"concluded":[277],"built":[281],"fixing":[283],"drawbacks":[285],"existing":[286],"contribute":[290],"identifying":[292],"high":[300],"effectivity":[301],"reliability.":[303],"Models":[304],"<i>via</i>":[308],"AMPDiscover":[310],"tool":[311],"at":[312],"https://biocom-ampdiscover.cicese.mx/.":[313]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":2}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2021-06-07T00:00:00"}