{"id":"https://openalex.org/W3164279443","doi":"https://doi.org/10.1021/acs.jcim.1c00198","title":"Insight into the LFA-1/SARS-CoV-2 Orf7a Complex by Protein\u2013Protein Docking, Molecular Dynamics, and MM-GBSA Calculations","display_name":"Insight into the LFA-1/SARS-CoV-2 Orf7a Complex by Protein\u2013Protein Docking, Molecular Dynamics, and MM-GBSA Calculations","publication_year":2021,"publication_date":"2021-05-27","ids":{"openalex":"https://openalex.org/W3164279443","doi":"https://doi.org/10.1021/acs.jcim.1c00198","mag":"3164279443","pmid":"https://pubmed.ncbi.nlm.nih.gov/34043356"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c00198","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00198","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00198","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00198","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075412003","display_name":"Alberto Ongaro","orcid":"https://orcid.org/0000-0002-8661-2416"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Ongaro","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8661-2416","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044189374","display_name":"Erika Oselladore","orcid":"https://orcid.org/0000-0002-2546-1343"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erika Oselladore","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2546-1343","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079505297","display_name":"Maurizio Memo","orcid":"https://orcid.org/0000-0002-7543-0289"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Memo","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7543-0289","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072785722","display_name":"Giovanni Ribaudo","orcid":"https://orcid.org/0000-0003-3679-5530"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Ribaudo","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3679-5530","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078762830","display_name":"Alessandra Gianoncelli","orcid":"https://orcid.org/0000-0002-0816-5163"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandra Gianoncelli","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0816-5163","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5078762830"],"corresponding_institution_ids":["https://openalex.org/I79940851"],"apc_list":null,"apc_paid":null,"fwci":3.3244,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.9382691,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"61","issue":"6","first_page":"2780","last_page":"2787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orfs","display_name":"ORFS","score":0.7236316800117493},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.6422321796417236},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5314513444900513},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5086513161659241},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.49539339542388916},{"id":"https://openalex.org/keywords/coronavirus","display_name":"Coronavirus","score":0.4305413067340851},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.4202905297279358},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.41983819007873535},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.41840657591819763},{"id":"https://openalex.org/keywords/open-reading-frame","display_name":"Open reading frame","score":0.417196124792099},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.39470985531806946},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38143983483314514},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3620219826698303},{"id":"https://openalex.org/keywords/cell-adhesion-molecule","display_name":"Cell adhesion molecule","score":0.3069584369659424},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.2334502935409546},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.21393969655036926},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20123913884162903},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19325438141822815},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15724891424179077}],"concepts":[{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.7236316800117493},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6422321796417236},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5314513444900513},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5086513161659241},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.49539339542388916},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.4305413067340851},{"id":"https://openalex.org/C2776985958","wikidata":"https://www.wikidata.org/wiki/Q14901827","display_name":"VCAM-1","level":4,"score":0.4202905297279358},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41983819007873535},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.41840657591819763},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.417196124792099},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.39470985531806946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38143983483314514},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3620219826698303},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.3069584369659424},{"id":"https://openalex.org/C185946421","wikidata":"https://www.wikidata.org/wiki/Q3146527","display_name":"ICAM-1","level":3,"score":0.2334502935409546},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.21393969655036926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20123913884162903},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19325438141822815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15724891424179077},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/acs.jcim.1c00198","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00198","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00198","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:34043356","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34043356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:iris.unibs.it:11379/544822","is_oa":true,"landing_page_url":"http://hdl.handle.net/11379/544822","pdf_url":"http://hdl.handle.net/11379/544822","source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8189040","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8189040","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},{"id":"pmh:oai:sfera.unife.it:11392/2617210","is_oa":false,"landing_page_url":"https://hdl.handle.net/11392/2617210","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.1c00198","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00198","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00198","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.47999998927116394}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324342","display_name":"Universit\u00e0 degli Studi di Brescia","ror":"https://ror.org/02q2d2610"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3164279443.pdf"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1966126942","https://openalex.org/W1979683091","https://openalex.org/W1993279060","https://openalex.org/W2017096959","https://openalex.org/W2023443613","https://openalex.org/W2047323990","https://openalex.org/W2054394841","https://openalex.org/W2054788798","https://openalex.org/W2056097559","https://openalex.org/W2063330553","https://openalex.org/W2063559096","https://openalex.org/W2066524276","https://openalex.org/W2080518520","https://openalex.org/W2088984460","https://openalex.org/W2118495604","https://openalex.org/W2120762331","https://openalex.org/W2124001213","https://openalex.org/W2133609727","https://openalex.org/W2133641393","https://openalex.org/W2140247386","https://openalex.org/W2149078897","https://openalex.org/W2149753575","https://openalex.org/W2157281740","https://openalex.org/W2157998346","https://openalex.org/W2159721819","https://openalex.org/W2163146557","https://openalex.org/W2166625072","https://openalex.org/W2167384912","https://openalex.org/W2470899874","https://openalex.org/W2528045957","https://openalex.org/W2570970768","https://openalex.org/W2585040066","https://openalex.org/W2615136515","https://openalex.org/W2735331959","https://openalex.org/W2912818999","https://openalex.org/W3008142620","https://openalex.org/W3013834986","https://openalex.org/W3015438624","https://openalex.org/W3021126042","https://openalex.org/W3023118371","https://openalex.org/W3032534105","https://openalex.org/W3033090821","https://openalex.org/W3043868614","https://openalex.org/W3084414361","https://openalex.org/W3087404989","https://openalex.org/W3093130027","https://openalex.org/W3108729626","https://openalex.org/W3112726350"],"related_works":["https://openalex.org/W1978801575","https://openalex.org/W2029252138","https://openalex.org/W4306784270","https://openalex.org/W2101899141","https://openalex.org/W3031046715","https://openalex.org/W2017335389","https://openalex.org/W2358544099","https://openalex.org/W2072439611","https://openalex.org/W3148570048","https://openalex.org/W1976390578"],"abstract_inverted_index":{"In":[0],"the":[1,24,27,65,68,79,94],"Severe":[2],"Acute":[3],"Respiratory":[4],"Syndrome":[5],"Coronavirus":[6],"2":[7],"(SARS-CoV-2)":[8],"genome,":[9],"open":[10],"reading":[11],"frames":[12],"(ORFs)":[13],"encode":[14],"for":[15],"viral":[16],"accessory":[17],"proteins.":[18],"Among":[19],"these,":[20],"Orf7a":[21,98],"structurally":[22],"resembles":[23],"members":[25],"of":[26,67,93],"immunoglobulin":[28],"(Ig)":[29],"superfamily":[30],"and":[31,54,76,106],"intracellular":[32],"adhesion":[33],"molecules":[34],"(ICAMs),":[35],"in":[36,41],"particular.":[37],"ICAMs":[38],"are":[39],"involved":[40],"integrin":[42],"binding":[43],"through":[44],"lymphocyte":[45],"function-associated":[46],"antigen":[47],"1":[48],"(LFA-1).":[49],"Based":[50],"on":[51,55,58],"such":[52],"considerations":[53],"previous":[56],"findings":[57],"SARS-CoV,":[59],"it":[60],"has":[61],"been":[62],"postulated":[63],"that":[64],"formation":[66],"LFA-1/Orf7a":[69],"complex":[70],"could":[71],"contribute":[72],"to":[73,117],"SARS-CoV-2":[74,97],"infectivity":[75],"pathogenicity.":[77],"With":[78],"current":[80],"work,":[81],"we":[82],"aim":[83],"at":[84],"providing":[85],"insight":[86],"into":[87],"this":[88],"macromolecular":[89],"assembly,":[90],"taking":[91],"advantage":[92],"recently":[95],"reported":[96],"structure.":[99],"Protein-protein":[100],"docking,":[101],"molecular":[102],"dynamics":[103],"(MD)":[104],"simulations,":[105],"a":[107],"Molecular":[108],"Mechanical-Generalized":[109],"Born":[110],"Surface":[111],"Area":[112],"(MM-GBSA)-based":[113],"stage":[114],"were":[115],"enrolled":[116],"provide":[118],"refined":[119],"models.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":4}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}