{"id":"https://openalex.org/W3149490662","doi":"https://doi.org/10.1021/acs.jcim.1c00086","title":"Balancing Data on Deep Learning-Based Proteochemometric Activity Classification","display_name":"Balancing Data on Deep Learning-Based Proteochemometric Activity Classification","publication_year":2021,"publication_date":"2021-03-29","ids":{"openalex":"https://openalex.org/W3149490662","doi":"https://doi.org/10.1021/acs.jcim.1c00086","mag":"3149490662","pmid":"https://pubmed.ncbi.nlm.nih.gov/33779173"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.1c00086","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00086","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00086","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00086","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053502564","display_name":"Angela Lopez-del Rio","orcid":"https://orcid.org/0000-0002-5486-7465"},"institutions":[{"id":"https://openalex.org/I1307323311","display_name":"Hospital Sant Joan de D\u00e9u Barcelona","ror":"https://ror.org/001jx2139","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I1307323311"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Angela Lopez-del Rio","raw_affiliation_strings":["B2SLab, Departament d\u2019Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, 08028 Barcelona, Spain","Department of Biomedical Engineering, Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"],"affiliations":[{"raw_affiliation_string":"B2SLab, Departament d\u2019Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, 08028 Barcelona, Spain","institution_ids":["https://openalex.org/I9617848"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain","institution_ids":["https://openalex.org/I1307323311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023202274","display_name":"Sergio Picart\u2010Armada","orcid":"https://orcid.org/0000-0002-6426-8204"},"institutions":[{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]},{"id":"https://openalex.org/I1307323311","display_name":"Hospital Sant Joan de D\u00e9u Barcelona","ror":"https://ror.org/001jx2139","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I1307323311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Picart-Armada","raw_affiliation_strings":["B2SLab, Departament d\u2019Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, 08028 Barcelona, Spain","Department of Biomedical Engineering, Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"],"affiliations":[{"raw_affiliation_string":"B2SLab, Departament d\u2019Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, 08028 Barcelona, Spain","institution_ids":["https://openalex.org/I9617848"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain","institution_ids":["https://openalex.org/I1307323311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041616492","display_name":"Alexandre Perera-Lluna","orcid":"https://orcid.org/0000-0001-6427-851X"},"institutions":[{"id":"https://openalex.org/I1307323311","display_name":"Hospital Sant Joan de D\u00e9u Barcelona","ror":"https://ror.org/001jx2139","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I1307323311"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alexandre Perera-Lluna","raw_affiliation_strings":["B2SLab, Departament d\u2019Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, 08028 Barcelona, Spain","Department of Biomedical Engineering, Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"],"affiliations":[{"raw_affiliation_string":"B2SLab, Departament d\u2019Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, 08028 Barcelona, Spain","institution_ids":["https://openalex.org/I9617848"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain","institution_ids":["https://openalex.org/I1307323311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053502564"],"corresponding_institution_ids":["https://openalex.org/I1307323311","https://openalex.org/I9617848"],"apc_list":null,"apc_paid":null,"fwci":1.507,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.84634496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"61","issue":"4","first_page":"1657","last_page":"1669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9793999791145325,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resampling","display_name":"Resampling","score":0.7855298519134521},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7199501991271973},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7189280986785889},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5874298810958862},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5805099606513977},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.569024920463562},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.542743980884552},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4823155403137207},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.43999549746513367},{"id":"https://openalex.org/keywords/test-set","display_name":"Test set","score":0.42542269825935364}],"concepts":[{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.7855298519134521},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7199501991271973},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7189280986785889},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5874298810958862},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5805099606513977},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.569024920463562},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.542743980884552},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4823155403137207},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.43999549746513367},{"id":"https://openalex.org/C169903167","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Test set","level":2,"score":0.42542269825935364},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.1c00086","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00086","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00086","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:33779173","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33779173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8594867","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8594867","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},{"id":"pmh:oai:upcommons.upc.edu:2117/353767","is_oa":true,"landing_page_url":"http://hdl.handle.net/2117/353767","pdf_url":null,"source":{"id":"https://openalex.org/S4377196262","display_name":"UPCommons institutional repository (Universitat Polit\u00e8cnica de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I9617848","host_organization_name":"Universitat Polit\u00e8cnica de Catalunya","host_organization_lineage":["https://openalex.org/I9617848"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.1c00086","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.1c00086","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00086","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1464378915","display_name":null,"funder_award_id":"2017 SGR 952","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2640468998","display_name":null,"funder_award_id":"DPI2017-89827-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G5218991717","display_name":null,"funder_award_id":"TEC2014-60337-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G5825945577","display_name":null,"funder_award_id":"780262","funder_id":"https://openalex.org/F4320323089","funder_display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320323089","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina","ror":"https://ror.org/01gm5f004"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3149490662.pdf","grobid_xml":"https://content.openalex.org/works/W3149490662.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W49891529","https://openalex.org/W639218804","https://openalex.org/W1984428215","https://openalex.org/W2052226480","https://openalex.org/W2095705004","https://openalex.org/W2102461176","https://openalex.org/W2131347449","https://openalex.org/W2148143831","https://openalex.org/W2204695023","https://openalex.org/W2268071782","https://openalex.org/W2273267066","https://openalex.org/W2521200999","https://openalex.org/W2582743722","https://openalex.org/W2734982589","https://openalex.org/W2740946158","https://openalex.org/W2767106145","https://openalex.org/W2777416523","https://openalex.org/W2784213390","https://openalex.org/W2790808809","https://openalex.org/W2806547269","https://openalex.org/W2809216727","https://openalex.org/W2809595040","https://openalex.org/W2899070097","https://openalex.org/W2912564562","https://openalex.org/W2915792373","https://openalex.org/W2959938226","https://openalex.org/W2964347220","https://openalex.org/W2971586943","https://openalex.org/W2977297276","https://openalex.org/W3037682562","https://openalex.org/W3045153201","https://openalex.org/W3087418839","https://openalex.org/W3136918052","https://openalex.org/W4252684946"],"related_works":["https://openalex.org/W2052515325","https://openalex.org/W3114272811","https://openalex.org/W3216119459","https://openalex.org/W4387327236","https://openalex.org/W2183488467","https://openalex.org/W1990237101","https://openalex.org/W4309907966","https://openalex.org/W4387896287","https://openalex.org/W2187490799","https://openalex.org/W3170838353"],"abstract_inverted_index":{"In":[0,53],"silico":[1],"analysis":[2,171],"of":[3,50,60,112,139,147,169],"biological":[4],"activity":[5,30,69],"data":[6,35,119,130,148,160],"has":[7],"become":[8],"an":[9,133],"essential":[10],"technique":[11],"in":[12,26,38,64,97,121,152,163],"pharmaceutical":[13],"development.":[14],"Specifically,":[15],"the":[16,48,51,58,75,109,117,122,136,140,153,159],"so-called":[17],"proteochemometric":[18,39,67,141],"models":[19,71],"aim":[20],"to":[21,157],"share":[22],"information":[23],"between":[24],"targets":[25],"machine":[27],"learning":[28,66],"ligand-target":[29],"prediction":[31],"models.":[32,52],"However,":[33],"bioactivity":[34],"sets":[36],"used":[37],"modeling":[40],"are":[41],"usually":[42],"imbalanced,":[43],"which":[44],"could":[45],"potentially":[46],"affect":[47],"performance":[49,137],"this":[54,170],"work,":[55],"we":[56],"explored":[57],"effect":[59,162],"different":[61],"balancing":[62],"strategies":[63,82],"deep":[65],"target-compound":[68],"classification":[70],"while":[72],"controlling":[73],"for":[74],"compound":[76],"series":[77],"bias":[78],"through":[79],"clustering.":[80],"These":[81,93],"were":[83,95],"(1)":[84],"no_resampling,":[85],"(2)":[86],"resampling_after_clustering,":[87],"(3)":[88],"resampling_before_clustering,":[89],"and":[90,102,150],"(4)":[91],"semi_resampling.":[92],"schemas":[94],"evaluated":[96],"kinases,":[98],"GPCRs,":[99],"nuclear":[100],"receptors,":[101],"proteases":[103],"from":[104],"BindingDB.":[105],"We":[106,143],"observed":[107],"that":[108,129],"predicted":[110],"proportion":[111],"positives":[113],"was":[114,127],"driven":[115],"by":[116],"actual":[118],"balance":[120,131],"test":[123],"set.":[124],"Additionally,":[125],"it":[126],"confirmed":[128],"had":[132],"impact":[134],"on":[135],"estimates":[138],"model.":[142],"recommend":[144],"a":[145,164],"combination":[146],"augmentation":[149],"clustering":[151],"training":[154],"set":[155],"(semi_resampling)":[156],"mitigate":[158],"imbalance":[161],"realistic":[165],"scenario.":[166],"The":[167],"code":[168],"is":[172],"publicly":[173],"available":[174],"at":[175],"https://github.com/b2slab/imbalance_pcm_benchmark.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-03-11T14:59:36.786465","created_date":"2025-10-10T00:00:00"}