{"id":"https://openalex.org/W3148269790","doi":"https://doi.org/10.1021/acs.jcim.0c01450","title":"Insights into Glucose-6-phosphate Allosteric Activation of \u03b2-Glucosidase A","display_name":"Insights into Glucose-6-phosphate Allosteric Activation of \u03b2-Glucosidase A","publication_year":2021,"publication_date":"2021-04-05","ids":{"openalex":"https://openalex.org/W3148269790","doi":"https://doi.org/10.1021/acs.jcim.0c01450","mag":"3148269790","pmid":"https://pubmed.ncbi.nlm.nih.gov/33819021"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c01450","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c01450","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8085047","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063624385","display_name":"Anderson Gomes","orcid":"https://orcid.org/0000-0003-2321-2893"},"institutions":[{"id":"https://openalex.org/I164790352","display_name":"Universidade do Estado de Santa Catarina","ror":"https://ror.org/03ztsbk67","country_code":"BR","type":"education","lineage":["https://openalex.org/I164790352"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anderson A. Gomes","raw_affiliation_strings":["Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina 88520-000, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina 88520-000, Brazil","institution_ids":["https://openalex.org/I164790352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062178776","display_name":"Gustavo Felippe da Silva","orcid":null},"institutions":[{"id":"https://openalex.org/I164790352","display_name":"Universidade do Estado de Santa Catarina","ror":"https://ror.org/03ztsbk67","country_code":"BR","type":"education","lineage":["https://openalex.org/I164790352"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gustavo F. da Silva","raw_affiliation_strings":["Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina 88520-000, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina 88520-000, Brazil","institution_ids":["https://openalex.org/I164790352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033771816","display_name":"Sirish Kaushik Lakkaraju","orcid":null},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sirish K. Lakkaraju","raw_affiliation_strings":["Small Molecule Drug Discovery, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States"],"raw_orcid":"https://orcid.org/0000-0003-1553-5780","affiliations":[{"raw_affiliation_string":"Small Molecule Drug Discovery, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061308652","display_name":"B.G. Guimar\u00e3es","orcid":"https://orcid.org/0000-0002-8546-2460"},"institutions":[{"id":"https://openalex.org/I4210154871","display_name":"Funda\u00e7\u00e3o Carlos Chagas","ror":"https://ror.org/051hcjr97","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210154871"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Beatriz Gomes Guimar\u00e3es","raw_affiliation_strings":["Laboratory of Structural Biology and Protein Engineering, Instituto Carlos Chagas, FIOCRUZ Paran\u00e1, Curitiba, Parana 81350-010, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology and Protein Engineering, Instituto Carlos Chagas, FIOCRUZ Paran\u00e1, Curitiba, Parana 81350-010, Brazil","institution_ids":["https://openalex.org/I4210154871","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056944006","display_name":"Alexander D. MacKerell","orcid":"https://orcid.org/0000-0001-8287-6804"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander D. MacKerell","raw_affiliation_strings":["Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, Maryland 21201, United States"],"raw_orcid":"https://orcid.org/0000-0001-8287-6804","affiliations":[{"raw_affiliation_string":"Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002784886","display_name":"Maria de Lourdes Borba Magalh\u00e3es","orcid":"https://orcid.org/0000-0003-2699-7649"},"institutions":[{"id":"https://openalex.org/I164790352","display_name":"Universidade do Estado de Santa Catarina","ror":"https://ror.org/03ztsbk67","country_code":"BR","type":"education","lineage":["https://openalex.org/I164790352"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Maria de Lourdes B. Magalh\u00e3es","raw_affiliation_strings":["Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina 88520-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2699-7649","affiliations":[{"raw_affiliation_string":"Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina 88520-000, Brazil","institution_ids":["https://openalex.org/I164790352"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002784886"],"corresponding_institution_ids":["https://openalex.org/I164790352"],"apc_list":null,"apc_paid":null,"fwci":0.5944,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.62266575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"61","issue":"4","first_page":"1931","last_page":"1941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.8983509540557861},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6704068183898926},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.6061323881149292},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.5433162450790405},{"id":"https://openalex.org/keywords/saturated-mutagenesis","display_name":"Saturated mutagenesis","score":0.5162448883056641},{"id":"https://openalex.org/keywords/paenibacillus-polymyxa","display_name":"Paenibacillus polymyxa","score":0.4698658883571625},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"Mutagenesis","score":0.4470691680908203},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"Directed evolution","score":0.442828506231308},{"id":"https://openalex.org/keywords/cellulase","display_name":"Cellulase","score":0.4314529299736023},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"Site-directed mutagenesis","score":0.42233479022979736},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.31854790449142456},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19396045804023743}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8983509540557861},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6704068183898926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6061323881149292},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5433162450790405},{"id":"https://openalex.org/C109129352","wikidata":"https://www.wikidata.org/wiki/Q7426583","display_name":"Saturated mutagenesis","level":4,"score":0.5162448883056641},{"id":"https://openalex.org/C2779134421","wikidata":"https://www.wikidata.org/wiki/Q1949025","display_name":"Paenibacillus polymyxa","level":3,"score":0.4698658883571625},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4470691680908203},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.442828506231308},{"id":"https://openalex.org/C141603559","wikidata":"https://www.wikidata.org/wiki/Q410324","display_name":"Cellulase","level":3,"score":0.4314529299736023},{"id":"https://openalex.org/C103408237","wikidata":"https://www.wikidata.org/wiki/Q2642668","display_name":"Site-directed mutagenesis","level":4,"score":0.42233479022979736},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.31854790449142456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19396045804023743},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001617","descriptor_name":"beta-Glucosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001617","descriptor_name":"beta-Glucosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001617","descriptor_name":"beta-Glucosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.0c01450","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c01450","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:33819021","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33819021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8085047","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8085047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},{"id":"pmh:oai:repositorio.udesc.br:UDESC/3798","is_oa":true,"landing_page_url":"https://repositorio.udesc.br/handle/UDESC/3798","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UDESC","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8085047","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8085047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G157531707","display_name":null,"funder_award_id":"PAP-UDESC 2017 TR 643","funder_id":"https://openalex.org/F4320323349","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina"},{"id":"https://openalex.org/G2423302908","display_name":null,"funder_award_id":"R35 GM131710","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7276818025","display_name":null,"funder_award_id":"GM131710","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323349","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","ror":"https://ror.org/0503xdx77"},{"id":"https://openalex.org/F4320324897","display_name":"Universidade do Estado de Santa Catarina","ror":"https://ror.org/03ztsbk67"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W149585329","https://openalex.org/W575615420","https://openalex.org/W781973575","https://openalex.org/W1031578623","https://openalex.org/W1811585152","https://openalex.org/W1891123581","https://openalex.org/W1973898778","https://openalex.org/W1976327589","https://openalex.org/W1976860525","https://openalex.org/W1980292953","https://openalex.org/W1987281470","https://openalex.org/W2008062398","https://openalex.org/W2019048640","https://openalex.org/W2027487272","https://openalex.org/W2027966927","https://openalex.org/W2031940323","https://openalex.org/W2043174582","https://openalex.org/W2058975831","https://openalex.org/W2060872117","https://openalex.org/W2070753604","https://openalex.org/W2070888644","https://openalex.org/W2077662803","https://openalex.org/W2077958668","https://openalex.org/W2081908271","https://openalex.org/W2081992608","https://openalex.org/W2083722736","https://openalex.org/W2097948463","https://openalex.org/W2109587007","https://openalex.org/W2113964973","https://openalex.org/W2129887334","https://openalex.org/W2132274747","https://openalex.org/W2141855846","https://openalex.org/W2143094071","https://openalex.org/W2172892534","https://openalex.org/W2332124397","https://openalex.org/W2333804696","https://openalex.org/W2522327340","https://openalex.org/W2531567675","https://openalex.org/W2577535947","https://openalex.org/W2594096950","https://openalex.org/W2599859608","https://openalex.org/W2605771163","https://openalex.org/W2768986231","https://openalex.org/W2775625607","https://openalex.org/W2785658038","https://openalex.org/W2809218627","https://openalex.org/W2883619323","https://openalex.org/W2913730410","https://openalex.org/W2942956226","https://openalex.org/W2973523639","https://openalex.org/W2996822411","https://openalex.org/W4234253662","https://openalex.org/W4242164740"],"related_works":["https://openalex.org/W3169913254","https://openalex.org/W3136247646","https://openalex.org/W2131848808","https://openalex.org/W2089343159","https://openalex.org/W2031318672","https://openalex.org/W1548421761","https://openalex.org/W2034928589","https://openalex.org/W2151601961","https://openalex.org/W2109326579","https://openalex.org/W2084262300"],"abstract_inverted_index":{"Second-generation":[0],"ethanol":[1],"production":[2],"involves":[3],"the":[4,17,34,56,60,98,115,131,160,170,183],"use":[5],"of":[6,36,63,83,102,118,172,178,182,186],"agricultural":[7],"and":[8,27,44,93],"forestry":[9],"waste":[10],"as":[11,20,163],"feedstock,":[12],"being":[13],"an":[14,146],"alternative":[15],"to":[16,48,165],"first-generation":[18],"technology":[19,138],"it":[21],"relies":[22,39],"on":[23,40,59],"low-cost":[24],"abundant":[25],"residues":[26],"does":[28],"not":[29,107],"affect":[30],"food":[31],"agriculture.":[32],"However,":[33,97],"success":[35],"second-generation":[37],"biorefineries":[38],"energetically":[41],"efficient":[42],"processes":[43],"effective":[45],"enzyme":[46],"cocktails":[47],"convert":[49],"cellulose":[50],"into":[51,121],"fermentable":[52],"sugars.":[53],"\u03b2-glucosidases":[54],"catalyze":[55],"last":[57],"step":[58],"enzymatic":[61,89],"hydrolysis":[62,166],"cellulose;":[64],"however,":[65],"they":[66],"are":[67],"often":[68],"inhibited":[69],"by":[70,134,140],"glucose.":[71],"Previous":[72],"studies":[73],"demonstrated":[74],"that":[75],"glucose-6-phosphate":[76],"(G6P)":[77],"is":[78],"a":[79,156,175],"positive":[80],"allosteric":[81,147,180],"modulator":[82],"Bacillus":[84],"polymyxa":[85,123],"\u03b2-glucosidase":[86,124,187],"A,":[87],"improving":[88],"efficiency,":[90],"providing":[91],"thermoresistance,":[92],"imparting":[94],"glucose":[95],"tolerance.":[96],"precise":[99],"molecular":[100,116],"details":[101,117],"G6P-\u03b2-glucosidase":[103],"A":[104,125],"interactions":[105],"have":[106],"yet":[108],"been":[109],"described":[110],"so":[111],"far.":[112],"We":[113],"investigated":[114],"G6P":[119,151,179],"binding":[120,148],"B.":[122],"through":[126],"in":[127,169],"silico":[128],"docking":[129],"using":[130],"site":[132,149],"identification":[133],"ligand":[135],"competitive":[136],"saturation":[137],"followed":[139],"site-directed":[141],"mutagenesis":[142],"studies,":[143],"from":[144],"which":[145],"for":[150],"was":[152,167],"identified.":[153],"In":[154],"addition,":[155],"mechanistic":[157],"shift":[158],"toward":[159],"transglycosylation":[161],"reaction":[162],"opposed":[164],"observed":[168],"presence":[171],"G6P,":[173],"suggesting":[174],"new":[176],"role":[177],"modulation":[181],"catalytic":[184],"activity":[185],"A.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
