{"id":"https://openalex.org/W3137949575","doi":"https://doi.org/10.1021/acs.jcim.0c01394","title":"Macrolides May Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Entry into Cells: A Quantitative Structure Activity Relationship Study and Experimental Validation","display_name":"Macrolides May Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Entry into Cells: A Quantitative Structure Activity Relationship Study and Experimental Validation","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3137949575","doi":"https://doi.org/10.1021/acs.jcim.0c01394","mag":"3137949575","pmid":"https://pubmed.ncbi.nlm.nih.gov/33734704"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c01394","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c01394","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084568389","display_name":"Jorge G\u00e1lvez","orcid":"https://orcid.org/0000-0003-0928-8437"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jorge Galvez","raw_affiliation_strings":["Molecular Topology and Drug Design Unit, Department of Physical Chemistry, Universitat de Valencia, Burjassot 46100, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0928-8437","affiliations":[{"raw_affiliation_string":"Molecular Topology and Drug Design Unit, Department of Physical Chemistry, Universitat de Valencia, Burjassot 46100, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068234333","display_name":"Riccardo Zanni","orcid":"https://orcid.org/0000-0002-3388-3730"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Riccardo Zanni","raw_affiliation_strings":["Molecular Topology and Drug Design Unit, Department of Physical Chemistry, Universitat de Valencia, Burjassot 46100, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3388-3730","affiliations":[{"raw_affiliation_string":"Molecular Topology and Drug Design Unit, Department of Physical Chemistry, Universitat de Valencia, Burjassot 46100, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087754640","display_name":"Mar\u00eda G\u00e1lvez-Llompart","orcid":"https://orcid.org/0000-0002-0718-4143"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210135619","display_name":"Instituto de Tecnolog\u00eda Qu\u00edmica","ror":"https://ror.org/038792a28","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210135619","https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Galvez-Llompart","raw_affiliation_strings":["Instituto de Tecnolog\u00eda Qu\u00edmica, UPV-CSIC, Universidad Polit\u00edcnica de Valencia, Valencia 46022, Spain","Molecular Topology and Drug Design Unit, Department of Physical Chemistry, Universitat de Valencia, Burjassot 46100, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0718-4143","affiliations":[{"raw_affiliation_string":"Instituto de Tecnolog\u00eda Qu\u00edmica, UPV-CSIC, Universidad Polit\u00edcnica de Valencia, Valencia 46022, Spain","institution_ids":["https://openalex.org/I4210135619"]},{"raw_affiliation_string":"Molecular Topology and Drug Design Unit, Department of Physical Chemistry, Universitat de Valencia, Burjassot 46100, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076532552","display_name":"J. Benlloch","orcid":"https://orcid.org/0000-0001-6073-1436"},"institutions":[{"id":"https://openalex.org/I4210135990","display_name":"Instituto de Instrumentaci\u00f3n para Imagen Molecular","ror":"https://ror.org/03p80e845","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210135990","https://openalex.org/I60053951"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Maria Benlloch","raw_affiliation_strings":["Instituto de Instrumentaci\u00f3n para Imagen Molecular, Centro Mixto CSIC\u2014Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia 46022, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Instrumentaci\u00f3n para Imagen Molecular, Centro Mixto CSIC\u2014Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia 46022, Spain","institution_ids":["https://openalex.org/I4210135990","https://openalex.org/I60053951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084568389"],"corresponding_institution_ids":["https://openalex.org/I16097986"],"apc_list":null,"apc_paid":null,"fwci":1.2352,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.82303075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"61","issue":"4","first_page":"2016","last_page":"2025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronavirus","display_name":"Coronavirus","score":0.6794026494026184},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.6479809284210205},{"id":"https://openalex.org/keywords/viral-life-cycle","display_name":"Viral life cycle","score":0.5568397045135498},{"id":"https://openalex.org/keywords/azithromycin","display_name":"Azithromycin","score":0.5477345585823059},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5446999073028564},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.5443375706672668},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5188766121864319},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.4692264497280121},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.44176965951919556},{"id":"https://openalex.org/keywords/clarithromycin","display_name":"Clarithromycin","score":0.43955492973327637},{"id":"https://openalex.org/keywords/coronaviridae","display_name":"Coronaviridae","score":0.4335099458694458},{"id":"https://openalex.org/keywords/viral-entry","display_name":"Viral entry","score":0.4306430220603943},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.41615140438079834},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3953714966773987},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37574541568756104},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.35513579845428467},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.26275742053985596},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.2625841498374939},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.26207220554351807},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.25428539514541626},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.23715952038764954},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.18813714385032654},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09575784206390381}],"concepts":[{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.6794026494026184},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6479809284210205},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.5568397045135498},{"id":"https://openalex.org/C2778907293","wikidata":"https://www.wikidata.org/wiki/Q165399","display_name":"Azithromycin","level":3,"score":0.5477345585823059},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5446999073028564},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5443375706672668},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5188766121864319},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4692264497280121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44176965951919556},{"id":"https://openalex.org/C2776962512","wikidata":"https://www.wikidata.org/wiki/Q118551","display_name":"Clarithromycin","level":3,"score":0.43955492973327637},{"id":"https://openalex.org/C2776844884","wikidata":"https://www.wikidata.org/wiki/Q1134583","display_name":"Coronaviridae","level":5,"score":0.4335099458694458},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.4306430220603943},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.41615140438079834},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3953714966773987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37574541568756104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35513579845428467},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26275742053985596},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2625841498374939},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.26207220554351807},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.25428539514541626},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.23715952038764954},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.18813714385032654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09575784206390381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.0c01394","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c01394","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:33734704","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33734704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:digital.csic.es:10261/237207","is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/237207","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:roderic.uv.es:10550/104708","is_oa":false,"landing_page_url":"https://hdl.handle.net/10550/104708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"G\u00e1lvez, Jorge Zanni, Riccardo G\u00e1lvez-Llompart, Mar\u00eda Benlloch Baviera, Jos\u00e9 Mar\u00eda 2021 Macrolides May Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Entry into Cells: A Quantitative Structure Activity Relationship Study and Experimental Validation Journal of chemical information and modeling 61 4 2016 2025","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2073165032","display_name":null,"funder_award_id":"E202020E079","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G3944635923","display_name":null,"funder_award_id":"871029","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G7357036661","display_name":null,"funder_award_id":"695536 (4D-PET)","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W89026408","https://openalex.org/W136298881","https://openalex.org/W311927316","https://openalex.org/W1875854053","https://openalex.org/W1956084686","https://openalex.org/W1974478886","https://openalex.org/W2021993761","https://openalex.org/W2041404228","https://openalex.org/W2061835342","https://openalex.org/W2072817986","https://openalex.org/W2073235663","https://openalex.org/W2077367365","https://openalex.org/W2096667163","https://openalex.org/W2103552203","https://openalex.org/W2110842901","https://openalex.org/W2112825470","https://openalex.org/W2131514892","https://openalex.org/W2132350432","https://openalex.org/W2148377766","https://openalex.org/W2152733931","https://openalex.org/W2158274156","https://openalex.org/W2256756668","https://openalex.org/W2404033622","https://openalex.org/W2418487773","https://openalex.org/W2615242605","https://openalex.org/W2621263135","https://openalex.org/W2728927239","https://openalex.org/W2804586924","https://openalex.org/W2939293777","https://openalex.org/W2969059233","https://openalex.org/W2999001809","https://openalex.org/W3001195213","https://openalex.org/W3001897055","https://openalex.org/W3009912996","https://openalex.org/W3010930696","https://openalex.org/W3015620943","https://openalex.org/W3017062452","https://openalex.org/W3017258575","https://openalex.org/W3023082818","https://openalex.org/W3023605265","https://openalex.org/W3025941145","https://openalex.org/W3027630905","https://openalex.org/W3036505266","https://openalex.org/W3042376507","https://openalex.org/W3044118599","https://openalex.org/W3083605260","https://openalex.org/W3084975857","https://openalex.org/W3089113296","https://openalex.org/W3092379492","https://openalex.org/W3096612840","https://openalex.org/W3104432614","https://openalex.org/W3133917342","https://openalex.org/W4206550329","https://openalex.org/W4211013255"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4396858017","https://openalex.org/W4400165188","https://openalex.org/W4206422705","https://openalex.org/W4320009247","https://openalex.org/W3186872001"],"abstract_inverted_index":{"The":[0],"global":[1],"pandemic":[2],"caused":[3],"by":[4,144,172],"the":[5,16,23,31,43,48,54,102,106,136,139,145,156,174,181,204,215],"emerging":[6],"severe":[7],"acute":[8],"respiratory":[9],"syndrome":[10],"coronavirus":[11,216],"2":[12],"(SARS-CoV-2)":[13],"is":[14,34,59],"threatening":[15],"health":[17],"and":[18,28,45,117,124,153,162,208],"economic":[19],"systems":[20],"worldwide.":[21],"Despite":[22],"enormous":[24],"efforts":[25],"of":[26,47,56,128,159,196,221],"scientists":[27],"clinicians":[29],"around":[30],"world,":[32],"there":[33],"still":[35],"no":[36],"drug":[37],"or":[38],"vaccine":[39],"available":[40],"worldwide":[41],"for":[42,53,214],"treatment":[44],"prevention":[46],"infection.":[49,73,222],"A":[50],"rapid":[51],"strategy":[52],"identification":[55],"new":[57],"treatments":[58],"based":[60,85],"on":[61,86,203],"repurposing":[62],"existing":[63],"clinically":[64],"approved":[65],"drugs":[66],"that":[67,150],"show":[68],"antiviral":[69,188],"activity":[70,82,189],"against":[71,111,191],"SARS-CoV-2":[72,96,175],"In":[74],"this":[75],"study,":[76],"after":[77],"developing":[78],"a":[79,125,186],"quantitative":[80],"structure":[81],"relationship":[83],"analysis":[84],"molecular":[87],"topology,":[88],"several":[89],"macrolide":[90,183],"antibiotics":[91,184],"are":[92],"identified":[93],"as":[94,165,167],"promising":[95],"spike":[97,206],"protein":[98,207],"inhibitors.":[99],"To":[100],"confirm":[101],"in":[103,119,138,211],"silico":[104],"results,":[105],"best":[107],"candidates":[108],"were":[109,132],"tested":[110],"two":[112],"human":[113],"coronaviruses":[114],"(i.e.,":[115],"229E-GFP":[116],"SARS-CoV-2)":[118],"cell":[120,130,170],"culture.":[121],"Time-of-addition":[122],"experiments":[123,148],"surrogate":[126],"model":[127],"viral":[129,160,205],"entry":[131,176],"used":[133],"to":[134,198],"identify":[135],"steps":[137],"virus":[140,163],"life":[141],"cycle":[142],"inhibited":[143],"compounds.":[146],"Infection":[147],"demonstrated":[149],"azithromycin,":[151],"clarithromycin,":[152],"lexithromycin":[154],"reduce":[155],"intracellular":[157],"accumulation":[158],"RNA":[161],"spread":[164],"well":[166],"prevent":[168],"virus-induced":[169],"death,":[171],"inhibiting":[173],"into":[177],"cells.":[178],"Even":[179],"though":[180],"three":[182],"display":[185],"narrow":[187],"window":[190],"SARS-CoV-2,":[192],"it":[193],"may":[194],"be":[195],"interest":[197],"further":[199],"investigate":[200],"their":[201,209],"effect":[202],"potential":[210],"combination":[212],"therapies":[213],"disease":[217],"19":[218],"early":[219],"stage":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
