{"id":"https://openalex.org/W3121291085","doi":"https://doi.org/10.1021/acs.jcim.0c01319","title":"Direct Observation of \u03b2-Barrel Intermediates in the Self-Assembly of Toxic SOD1<sub>28\u201338</sub> and Absence in Nontoxic Glycine Mutants","display_name":"Direct Observation of \u03b2-Barrel Intermediates in the Self-Assembly of Toxic SOD1<sub>28\u201338</sub> and Absence in Nontoxic Glycine Mutants","publication_year":2021,"publication_date":"2021-01-14","ids":{"openalex":"https://openalex.org/W3121291085","doi":"https://doi.org/10.1021/acs.jcim.0c01319","mag":"3121291085","pmid":"https://pubmed.ncbi.nlm.nih.gov/33445870"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c01319","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c01319","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7902411","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015199573","display_name":"Yunxiang Sun","orcid":"https://orcid.org/0000-0001-9799-7131"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]},{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Yunxiang Sun","raw_affiliation_strings":["Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"],"raw_orcid":"https://orcid.org/0000-0001-9799-7131","affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101445261","display_name":"Junchao Huang","orcid":"https://orcid.org/0000-0003-1066-3206"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]},{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Junchao Huang","raw_affiliation_strings":["Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000121893","display_name":"Xiangmei Duan","orcid":"https://orcid.org/0000-0002-7022-753X"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangmei Duan","raw_affiliation_strings":["School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"],"raw_orcid":"https://orcid.org/0000-0002-7022-753X","affiliations":[{"raw_affiliation_string":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100626869","display_name":"Feng Ding","orcid":"https://orcid.org/0000-0003-1850-6336"},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng Ding","raw_affiliation_strings":["Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States"],"raw_orcid":"https://orcid.org/0000-0003-1850-6336","affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015199573","https://openalex.org/A5100626869"],"corresponding_institution_ids":["https://openalex.org/I109935558","https://openalex.org/I8078737"],"apc_list":null,"apc_paid":null,"fwci":2.0558,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.86809628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"61","issue":"2","first_page":"966","last_page":"975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7667145729064941},{"id":"https://openalex.org/keywords/sod1","display_name":"SOD1","score":0.7203809022903442},{"id":"https://openalex.org/keywords/fibril","display_name":"Fibril","score":0.6418014764785767},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.6212608814239502},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5986508727073669},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.589094340801239},{"id":"https://openalex.org/keywords/random-coil","display_name":"Random coil","score":0.4849967658519745},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"Protein secondary structure","score":0.47260504961013794},{"id":"https://openalex.org/keywords/glycine","display_name":"Glycine","score":0.46822497248649597},{"id":"https://openalex.org/keywords/barrel","display_name":"Barrel (horology)","score":0.45590490102767944},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3613463044166565},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.33834308385849},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.08575576543807983},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08389708399772644}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7667145729064941},{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.7203809022903442},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.6418014764785767},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6212608814239502},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5986508727073669},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.589094340801239},{"id":"https://openalex.org/C34349673","wikidata":"https://www.wikidata.org/wiki/Q899124","display_name":"Random coil","level":3,"score":0.4849967658519745},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.47260504961013794},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.46822497248649597},{"id":"https://openalex.org/C172227984","wikidata":"https://www.wikidata.org/wiki/Q1400397","display_name":"Barrel (horology)","level":2,"score":0.45590490102767944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3613463044166565},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.33834308385849},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.08575576543807983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08389708399772644},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.0c01319","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c01319","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:33445870","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33445870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7902411","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7902411","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7902411","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7902411","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6200000047683716,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G5366165637","display_name":"\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u7406\u6027\u805a\u96c6\u53ca\u03b1B-crystallin\u5185\u6e90\u6027\u86cb\u767d\u5bf9\u5176\u8c03\u63a7\u673a\u5236\u7684\u5206\u5b50\u6a21\u62df\u7814\u7a76","funder_award_id":"11904189","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5554497658","display_name":null,"funder_award_id":"R35GM119691","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6588206067","display_name":"Inhibition of Human Islet Amyloid Polypeptide Aggregation","funder_award_id":"5r35gm119691-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7344724567","display_name":"CAREER: Multiscale Study of the Structure and Dynamics of Nanoparticle-Protein Coronae","funder_award_id":"1553945","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322605","display_name":"Ningbo University","ror":"https://ror.org/03et85d35"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1123993534","https://openalex.org/W1605885548","https://openalex.org/W1961186421","https://openalex.org/W1984569087","https://openalex.org/W2008708467","https://openalex.org/W2015622675","https://openalex.org/W2019823285","https://openalex.org/W2034128254","https://openalex.org/W2040931022","https://openalex.org/W2082680257","https://openalex.org/W2082923159","https://openalex.org/W2084414517","https://openalex.org/W2084670683","https://openalex.org/W2097259690","https://openalex.org/W2097758424","https://openalex.org/W2107696550","https://openalex.org/W2117503265","https://openalex.org/W2118780761","https://openalex.org/W2128806688","https://openalex.org/W2134731229","https://openalex.org/W2138023380","https://openalex.org/W2140315476","https://openalex.org/W2144482528","https://openalex.org/W2145727014","https://openalex.org/W2156215695","https://openalex.org/W2162166182","https://openalex.org/W2229673765","https://openalex.org/W2266335314","https://openalex.org/W2330416673","https://openalex.org/W2464369392","https://openalex.org/W2511181291","https://openalex.org/W2519805918","https://openalex.org/W2561434175","https://openalex.org/W2586253893","https://openalex.org/W2727929522","https://openalex.org/W2735416135","https://openalex.org/W2740121245","https://openalex.org/W2766672565","https://openalex.org/W2791679570","https://openalex.org/W2794773520","https://openalex.org/W2803584042","https://openalex.org/W2810022805","https://openalex.org/W2885863704","https://openalex.org/W2890980244","https://openalex.org/W2896637074","https://openalex.org/W2898293688","https://openalex.org/W2903257335","https://openalex.org/W2917512848","https://openalex.org/W2922924672","https://openalex.org/W2937182873","https://openalex.org/W2942624373","https://openalex.org/W2946968312","https://openalex.org/W2947366776","https://openalex.org/W2950609855","https://openalex.org/W2958817025","https://openalex.org/W2971913174","https://openalex.org/W2975394974"],"related_works":["https://openalex.org/W2068672340","https://openalex.org/W1993310102","https://openalex.org/W4380624196","https://openalex.org/W2061052403","https://openalex.org/W2314847820","https://openalex.org/W2042651182","https://openalex.org/W1967158227","https://openalex.org/W1996911561","https://openalex.org/W2098727165","https://openalex.org/W2352240406"],"abstract_inverted_index":{"Soluble":[0],"low-molecular-weight":[1],"oligomers":[2,168,193,214],"formed":[3,178],"during":[4,194],"the":[5,13,26,36,47,56,68,75,102,110,151,159,186,195,204,212,221,231],"early":[6],"stage":[7],"of":[8,41,50,61,67,140,153,191,197],"amyloid":[9,29,103,226],"aggregation":[10,43,120,124],"are":[11,31],"considered":[12],"major":[14],"toxic":[15,51,111,198,213],"species":[16],"in":[17,28,94,215],"amyloidosis.":[18],"The":[19,188],"structure\u2013function":[20],"relationship":[21],"between":[22],"oligomeric":[23,52],"assemblies":[24],"and":[25,38,59,85,114,150,169,224],"cytotoxicity":[27],"diseases":[30],"still":[32],"elusive":[33],"due":[34],"to":[35,100],"heterogeneous":[37],"transient":[39],"nature":[40],"these":[42],"intermediates.":[44,125,156,187],"To":[45],"uncover":[46],"structural":[48],"characteristics":[49],"intermediates,":[53],"we":[54],"compared":[55],"self-assembly":[57],"dynamics":[58,89],"structures":[60],"SOD1":[62,95,112,128,199],"28\u201338,":[63],"a":[64,236],"cytotoxic":[65],"fragment":[66],"superoxide":[69],"dismutase":[70],"1":[71],"(SOD1)":[72],"associated":[73],"with":[74,79,172,220],"amyotrophic":[76],"lateral":[77],"sclerosis,":[78],"its":[80,115],"two":[81],"nontoxic":[82,116,160,205],"mutants":[83,117,162,207],"G33V":[84],"G33W":[86],"using":[87],"molecular":[88],"simulations.":[90],"Single-point":[91],"glycine":[92],"substitutions":[93],"28\u201338":[96,113,129,200],"have":[97],"been":[98],"reported":[99],"abolish":[101],"toxicity.":[104],"Our":[105],"simulation":[106],"results":[107],"showed":[108],"that":[109],"followed":[118],"different":[119],"pathways":[121],"featuring":[122],"distinct":[123],"Specifically,":[126],"wild-type":[127],"initially":[130],"self-assembled":[131],"into":[132,165,175],"random-coil-rich":[133],"oligomers,":[134],"among":[135],"which":[136],"fibrillar":[137],"aggregates":[138],"composed":[139],"well-defined":[141,229],"curved":[142],"single-layer":[143],"\u03b2-sheets":[144,181],"were":[145],"nucleated":[146],"via":[147,218],"coil-to-sheet":[148],"conversions":[149],"formation":[152],"\u03b2-barrels":[154,184,210],"as":[155,185,211,235],"In":[157],"contrast,":[158],"G33V/G33W":[161],"readily":[163],"assembled":[164],"small":[166],"\u03b2-sheet-rich":[167],"then":[170],"coagulated":[171],"each":[173],"other":[174],"cross-\u03b2":[176],"fibrils":[177],"by":[179],"two-layer":[180],"without":[182],"forming":[183,225],"direct":[189],"observation":[190],"\u03b2-barrel":[192,232],"assembly":[196],"fragments":[201],"but":[202],"not":[203],"glycine-substitution":[206],"strongly":[208],"supports":[209],"amyloidosis,":[216],"probably":[217],"interactions":[219],"cell":[222],"membrane":[223],"pores.":[227],"With":[228],"structures,":[230],"might":[233],"serve":[234],"novel":[237],"therapeutic":[238],"target":[239],"against":[240],"amyloid-related":[241],"diseases.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2021-02-01T00:00:00"}