{"id":"https://openalex.org/W3130801441","doi":"https://doi.org/10.1021/acs.jcim.0c01175","title":"Recent Force Field Strategies for Intrinsically Disordered Proteins","display_name":"Recent Force Field Strategies for Intrinsically Disordered Proteins","publication_year":2021,"publication_date":"2021-02-16","ids":{"openalex":"https://openalex.org/W3130801441","doi":"https://doi.org/10.1021/acs.jcim.0c01175","mag":"3130801441","pmid":"https://pubmed.ncbi.nlm.nih.gov/33591749"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c01175","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c01175","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8256680","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007783043","display_name":"Junxi Mu","orcid":"https://orcid.org/0000-0003-1192-2791"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junxi Mu","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458874","display_name":"Hao Liu","orcid":"https://orcid.org/0000-0003-0994-6284"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409987","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-6558-791X"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, School of Medicine, Shanghai Jiao Tong University, Shanghai 20025, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, School of Medicine, Shanghai Jiao Tong University, Shanghai 20025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032088629","display_name":"Ray Luo","orcid":"https://orcid.org/0000-0002-6346-8271"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ray Luo","raw_affiliation_strings":["Departments of Molecular Biology and Biochemistry, Chemical and Molecular Engineering, Materials Science and Engineering, and Biomedical Engineering, University of California, Irvine, California 92697-3900, United States"],"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology and Biochemistry, Chemical and Molecular Engineering, Materials Science and Engineering, and Biomedical Engineering, University of California, Irvine, California 92697-3900, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100456783","display_name":"Haifeng Chen","orcid":"https://orcid.org/0000-0002-7496-4182"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai-Feng Chen","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5032088629","https://openalex.org/A5100409987","https://openalex.org/A5100456783"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":7.3187,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.98266712,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"61","issue":"3","first_page":"1037","last_page":"1047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"Intrinsically disordered proteins","score":0.7086279988288879},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.5175692439079285},{"id":"https://openalex.org/keywords/force-field","display_name":"Force field (fiction)","score":0.4918231964111328},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.35677772760391235},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3460044264793396},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.24864178895950317},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.2312023937702179},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18555790185928345},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.12602448463439941},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10982605814933777}],"concepts":[{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.7086279988288879},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.5175692439079285},{"id":"https://openalex.org/C10803110","wikidata":"https://www.wikidata.org/wiki/Q1341441","display_name":"Force field (fiction)","level":2,"score":0.4918231964111328},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.35677772760391235},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3460044264793396},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.24864178895950317},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2312023937702179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18555790185928345},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12602448463439941},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10982605814933777},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jcim.0c01175","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c01175","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:33591749","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33591749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0j18j8r6","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0j18j8r6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chemical Information and Modeling, vol 61, iss 3","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8256680","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8256680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8256680","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8256680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Chem Inf Model","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1028801227","display_name":null,"funder_award_id":"2020YFA0907700","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G3416316426","display_name":null,"funder_award_id":"31770771","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4167180622","display_name":null,"funder_award_id":"2018YFC0310803","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G7299905311","display_name":null,"funder_award_id":"GM130367","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7349745844","display_name":null,"funder_award_id":"31620103901","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8654760","display_name":null,"funder_award_id":"21977068","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W170374744","https://openalex.org/W1581457496","https://openalex.org/W1629766434","https://openalex.org/W1908381757","https://openalex.org/W1911670820","https://openalex.org/W1952317074","https://openalex.org/W1963819448","https://openalex.org/W1966510662","https://openalex.org/W1967734507","https://openalex.org/W1968790827","https://openalex.org/W1969493239","https://openalex.org/W1971372975","https://openalex.org/W1972217505","https://openalex.org/W1972399880","https://openalex.org/W1972493045","https://openalex.org/W1974030600","https://openalex.org/W1976499671","https://openalex.org/W1979716756","https://openalex.org/W1980540331","https://openalex.org/W1981338975","https://openalex.org/W1990583916","https://openalex.org/W1992898397","https://openalex.org/W1993177346","https://openalex.org/W1995907662","https://openalex.org/W1998045383","https://openalex.org/W2000456051","https://openalex.org/W2007016963","https://openalex.org/W2009218781","https://openalex.org/W2016033647","https://openalex.org/W2016170088","https://openalex.org/W2021032453","https://openalex.org/W2023812284","https://openalex.org/W2023921624","https://openalex.org/W2024726841","https://openalex.org/W2027408247","https://openalex.org/W2036131411","https://openalex.org/W2037076861","https://openalex.org/W2040809566","https://openalex.org/W2041189078","https://openalex.org/W2050333027","https://openalex.org/W2054881399","https://openalex.org/W2060757799","https://openalex.org/W2064546088","https://openalex.org/W2066041565","https://openalex.org/W2066951434","https://openalex.org/W2067795298","https://openalex.org/W2069098917","https://openalex.org/W2069123478","https://openalex.org/W2070753604","https://openalex.org/W2072404760","https://openalex.org/W2073745520","https://openalex.org/W2075093176","https://openalex.org/W2079372760","https://openalex.org/W2084652423","https://openalex.org/W2085986834","https://openalex.org/W2107131134","https://openalex.org/W2109154308","https://openalex.org/W2114823344","https://openalex.org/W2120881407","https://openalex.org/W2122199548","https://openalex.org/W2123431154","https://openalex.org/W2137195231","https://openalex.org/W2137322489","https://openalex.org/W2138480068","https://openalex.org/W2138906088","https://openalex.org/W2144288821","https://openalex.org/W2149472608","https://openalex.org/W2149655632","https://openalex.org/W2161605421","https://openalex.org/W2162166182","https://openalex.org/W2165204791","https://openalex.org/W2165581033","https://openalex.org/W2171047927","https://openalex.org/W2222589778","https://openalex.org/W2234602429","https://openalex.org/W2317261396","https://openalex.org/W2326242291","https://openalex.org/W2326384661","https://openalex.org/W2327000477","https://openalex.org/W2327421019","https://openalex.org/W2328723871","https://openalex.org/W2335130470","https://openalex.org/W2399447404","https://openalex.org/W2404280981","https://openalex.org/W2408877124","https://openalex.org/W2416486977","https://openalex.org/W2419136832","https://openalex.org/W2420659973","https://openalex.org/W2473162468","https://openalex.org/W2486238113","https://openalex.org/W2555870966","https://openalex.org/W2563821493","https://openalex.org/W2565914957","https://openalex.org/W2586455802","https://openalex.org/W2594008643","https://openalex.org/W2609476392","https://openalex.org/W2765209572","https://openalex.org/W2767578351","https://openalex.org/W2788196490","https://openalex.org/W2789997233","https://openalex.org/W2790647401","https://openalex.org/W2793329686","https://openalex.org/W2800697076","https://openalex.org/W2802761313","https://openalex.org/W2807706353","https://openalex.org/W2807883426","https://openalex.org/W2885610180","https://openalex.org/W2897706713","https://openalex.org/W2901388919","https://openalex.org/W2908607056","https://openalex.org/W2909282192","https://openalex.org/W2910835939","https://openalex.org/W2922133186","https://openalex.org/W2937433810","https://openalex.org/W2955817155","https://openalex.org/W2958051773","https://openalex.org/W2962660969","https://openalex.org/W2968572727","https://openalex.org/W2972778003","https://openalex.org/W2981013945","https://openalex.org/W2981350008","https://openalex.org/W2991486247","https://openalex.org/W3013264144","https://openalex.org/W3037337145","https://openalex.org/W3045578956","https://openalex.org/W3080264551","https://openalex.org/W3085821975","https://openalex.org/W3087418727","https://openalex.org/W3103660675","https://openalex.org/W3155420723"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W4293203577","https://openalex.org/W4288038979","https://openalex.org/W2964159616","https://openalex.org/W2969721268","https://openalex.org/W2981013945","https://openalex.org/W2609476392","https://openalex.org/W4311574921","https://openalex.org/W4249964859"],"abstract_inverted_index":{"Intrinsically":[0],"disordered":[1],"proteins":[2],"(IDPs)":[3],"are":[4,25,115],"widely":[5],"distributed":[6],"across":[7],"eukaryotic":[8],"cells,":[9],"playing":[10],"important":[11,58],"roles":[12],"in":[13,117],"molecular":[14,16,76],"recognition,":[15],"assembly,":[17],"post-translational":[18],"modification,":[19],"and":[20,36,97],"other":[21],"biological":[22],"processes.":[23],"IDPs":[24,112],"also":[26,114],"associated":[27],"with":[28,132],"many":[29],"diseases":[30],"such":[31],"as":[32],"cancers,":[33],"cardiovascular":[34],"diseases,":[35],"neurodegenerative":[37],"diseases.":[38],"Due":[39],"to":[40,61,104],"their":[41,50],"structural":[42],"flexibility,":[43],"conventional":[44],"experimental":[45,121],"methods":[46],"cannot":[47],"reliably":[48],"capture":[49],"heterogeneous":[51],"structures.":[52,64],"Molecular":[53],"dynamics":[54,77],"simulation":[55],"becomes":[56],"an":[57],"complementary":[59],"tool":[60],"quantify":[62],"IDP":[63],"This":[65],"review":[66,131],"covers":[67],"recent":[68],"force":[69,100,139],"field":[70],"strategies":[71,82],"proposed":[72],"for":[73,124,135,137,141],"more":[74],"accurate":[75],"simulations":[78],"of":[79,110],"IDPs.":[80,127,142],"The":[81],"include":[83],"adjusting":[84],"dihedral":[85],"parameters,":[86,93],"adding":[87],"grid-based":[88],"energy":[89],"correction":[90],"map":[91],"(CMAP)":[92],"refining":[94],"protein-water":[95],"interactions,":[96],"others.":[98],"Different":[99],"fields":[101,140],"were":[102],"found":[103],"perform":[105],"well":[106],"on":[107],"specific":[108,111],"observables":[109,122],"but":[113],"limited":[116],"reproducing":[118],"all":[119,125],"available":[120],"consistently":[123],"tested":[126],"We":[128],"conclude":[129],"the":[130],"perspective":[133],"areas":[134],"improvements":[136],"future":[138]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":14}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
