{"id":"https://openalex.org/W3048592170","doi":"https://doi.org/10.1021/acs.jcim.0c00633","title":"Pain-CKB, A Pain-Domain-Specific Chemogenomics Knowledgebase for Target Identification and Systems Pharmacology Research","display_name":"Pain-CKB, A Pain-Domain-Specific Chemogenomics Knowledgebase for Target Identification and Systems Pharmacology Research","publication_year":2020,"publication_date":"2020-08-12","ids":{"openalex":"https://openalex.org/W3048592170","doi":"https://doi.org/10.1021/acs.jcim.0c00633","mag":"3048592170","pmid":"https://pubmed.ncbi.nlm.nih.gov/32786694"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c00633","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00633","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076924374","display_name":"Zhiwei Feng","orcid":"https://orcid.org/0000-0001-6533-8932"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Zhiwei Feng","raw_affiliation_strings":["University of Pittsburgh , , , ,","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","Drug Discovery Institute","National Center of Excellence for Computational Drug Abuse Research"],"raw_orcid":"https://orcid.org/0000-0001-6533-8932","affiliations":[{"raw_affiliation_string":"University of Pittsburgh , , , ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","institution_ids":["https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078781198","display_name":"Maozi Chen","orcid":"https://orcid.org/0000-0002-0763-6963"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Maozi Chen","raw_affiliation_strings":["University of Pittsburgh , , , ,","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","Drug Discovery Institute","National Center of Excellence for Computational Drug Abuse Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh , , , ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","institution_ids":["https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008558208","display_name":"Mingzhe Shen","orcid":"https://orcid.org/0000-0001-7461-3764"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Mingzhe Shen","raw_affiliation_strings":["University of Pittsburgh , , , ,","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","Drug Discovery Institute","National Center of Excellence for Computational Drug Abuse Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh , , , ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","institution_ids":["https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065118063","display_name":"Tianjian Liang","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Tianjian Liang","raw_affiliation_strings":["University of Pittsburgh , , , ,","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","Drug Discovery Institute","National Center of Excellence for Computational Drug Abuse Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh , , , ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","institution_ids":["https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334127","display_name":"Hui Chen","orcid":"https://orcid.org/0000-0001-5462-8029"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Hui Chen","raw_affiliation_strings":["University of Pittsburgh , , , ,","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","Drug Discovery Institute","National Center of Excellence for Computational Drug Abuse Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh , , , ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","institution_ids":["https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028011485","display_name":"Xiang\u2010Qun Xie","orcid":"https://orcid.org/0000-0002-6881-6175"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Xiang-Qun Xie","raw_affiliation_strings":["University of Pittsburgh , , , ,","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","Drug Discovery Institute","National Center of Excellence for Computational Drug Abuse Research"],"raw_orcid":"https://orcid.org/0000-0002-6881-6175","affiliations":[{"raw_affiliation_string":"University of Pittsburgh , , , ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy","institution_ids":["https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; and Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028011485","https://openalex.org/A5076924374"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032","https://openalex.org/I4210151791"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.39,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6816338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"10","first_page":"4429","last_page":"4435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/analgesic","display_name":"Analgesic","score":0.6064422130584717},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6011273860931396},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.49709299206733704},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3946661055088043},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3432452082633972},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.31850484013557434},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3084923028945923},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.25517940521240234},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19233736395835876}],"concepts":[{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6064422130584717},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6011273860931396},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.49709299206733704},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3946661055088043},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3432452082633972},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31850484013557434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3084923028945923},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25517940521240234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19233736395835876},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.0c00633","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00633","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:32786694","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32786694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1672844487","display_name":null,"funder_award_id":"P30-DA035778","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G239630723","display_name":null,"funder_award_id":"R01DA052329","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6299851986","display_name":null,"funder_award_id":"P30 DA035778A1","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1967588544","https://openalex.org/W1973940762","https://openalex.org/W1975426150","https://openalex.org/W1982734154","https://openalex.org/W1983248350","https://openalex.org/W2000214690","https://openalex.org/W2001740183","https://openalex.org/W2061745280","https://openalex.org/W2065913569","https://openalex.org/W2069676201","https://openalex.org/W2083269140","https://openalex.org/W2091159078","https://openalex.org/W2094400680","https://openalex.org/W2096541451","https://openalex.org/W2151383246","https://openalex.org/W2169678694","https://openalex.org/W2227583040","https://openalex.org/W2591997013","https://openalex.org/W2767891136","https://openalex.org/W2787229753","https://openalex.org/W2806399642","https://openalex.org/W2898364362","https://openalex.org/W2918278359","https://openalex.org/W2954728343","https://openalex.org/W2969929791","https://openalex.org/W2987928072","https://openalex.org/W3003828791","https://openalex.org/W3029946173","https://openalex.org/W3045143182","https://openalex.org/W4210702584"],"related_works":["https://openalex.org/W2330953835","https://openalex.org/W2466178061","https://openalex.org/W1989723714","https://openalex.org/W3025405409","https://openalex.org/W3030588570","https://openalex.org/W2013003323","https://openalex.org/W1981076832","https://openalex.org/W2024773645","https://openalex.org/W2001717001","https://openalex.org/W2043147644"],"abstract_inverted_index":{"A":[0],"traditional":[1],"single-target":[2],"analgesic,":[3],"though":[4],"it":[5],"may":[6,12],"be":[7,14],"highly":[8],"selective":[9],"and":[10,63,88,117,144,161,166,173],"potent,":[11],"not":[13],"sufficient":[15],"to":[16,27,99],"mitigate":[17],"pain.":[18],"An":[19],"alternative":[20],"strategy":[21],"for":[22,60,150,163],"alleviation":[23],"of":[24,37,73,94,103,168,175],"pain":[25,121],"is":[26,68,96,192],"seek":[28],"simultaneous":[29],"modulation":[30],"at":[31,194],"multiple":[32,82],"nodes":[33],"in":[34,120,130],"the":[35,71,101,113,131,164,169,176],"network":[36],"pain-signaling":[38],"pathways":[39],"through":[40],"a":[41,50],"multitarget":[42],"analgesic":[43],"or":[44,141],"drug":[45],"combinations.":[46],"Here":[47],"we":[48],"present":[49],"comprehensive":[51],"pain-domain-specific":[52],"chemogenomics":[53,76],"knowledgebase":[54],"(Pain-CKB)":[55],"with":[56,78,136],"integrated":[57],"computing":[58,110,159],"tools":[59,160],"target":[61,152],"identification":[62],"systems":[64],"pharmacology":[65],"research.":[66],"Pain-CKB":[67,125,155,190],"constructed":[69],"on":[70],"basis":[72],"our":[74],"established":[75],"technology":[77],"new":[79],"features,":[80],"including":[81,178],"compound":[83],"support,":[84,87],"multicavity":[85],"protein":[86,171],"customizable":[89],"symbol":[90],"display.":[91],"The":[92,189],"determination":[93],"bioactivity":[95],"also":[97],"revised":[98],"avoid":[100],"use":[102],"complex":[104],"machine":[105],"learning":[106],"models.":[107],"Our":[108],"one-stop":[109],"platform":[111],"describes":[112],"chemical":[114,147],"molecules,":[115],"genes,":[116],"proteins":[118],"involved":[119],"regulation.":[122],"To":[123],"date,":[124],"has":[126],"archived":[127],"272":[128],"analgesics":[129],"market,":[132],"84":[133],"pain-related":[134],"targets":[135,172],"207":[137],"available":[138],"3D":[139],"crystal":[140],"cryo-EM":[142],"structures,":[143],"234":[145],"662":[146],"agents":[148],"reported":[149],"these":[151],"proteins.":[153],"Moreover,":[154],"implements":[156],"user-friendly":[157],"web-interfaced":[158],"applications":[162],"prediction":[165],"analysis":[167],"relevant":[170],"visualization":[174],"outputs,":[177],"HTDocking,":[179],"TargetHunter,":[180],"BBB":[181],"permeation":[182],"predictor,":[183],"NGL":[184],"viewer,":[185],"Spider":[186],"Plot,":[187],"etc.":[188],"server":[191],"accessible":[193],"https://www.cbligand.org/g/pain-ckb.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}
