{"id":"https://openalex.org/W3048544252","doi":"https://doi.org/10.1021/acs.jcim.0c00479","title":"Combining Molecular Dynamics and Machine Learning to Predict Self-Solvation Free Energies and Limiting Activity Coefficients","display_name":"Combining Molecular Dynamics and Machine Learning to Predict Self-Solvation Free Energies and Limiting Activity Coefficients","publication_year":2020,"publication_date":"2020-08-10","ids":{"openalex":"https://openalex.org/W3048544252","doi":"https://doi.org/10.1021/acs.jcim.0c00479","mag":"3048544252","pmid":"https://pubmed.ncbi.nlm.nih.gov/32786697"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c00479","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00479","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jcim.0c00479","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102838222","display_name":"Julia Gebhardt","orcid":"https://orcid.org/0000-0002-5529-7337"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Gebhardt","raw_affiliation_strings":["Institute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, D-70569 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, D-70569 Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067385960","display_name":"Matthias Kiesel","orcid":"https://orcid.org/0000-0003-3368-9046"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Kiesel","raw_affiliation_strings":["Institute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, D-70569 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, D-70569 Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019754904","display_name":"Sereina Riniker","orcid":"https://orcid.org/0000-0003-1893-4031"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Sereina Riniker","raw_affiliation_strings":["Laboratory of Physical Chemistry, ETH Z\u00fcrich, Vladimir-Prelog-Weg 2, 8093 Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-1893-4031","affiliations":[{"raw_affiliation_string":"Laboratory of Physical Chemistry, ETH Z\u00fcrich, Vladimir-Prelog-Weg 2, 8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079455776","display_name":"Niels Hansen","orcid":"https://orcid.org/0000-0003-4366-6120"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Niels Hansen","raw_affiliation_strings":["Institute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, D-70569 Stuttgart, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4366-6120","affiliations":[{"raw_affiliation_string":"Institute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, D-70569 Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019754904","https://openalex.org/A5079455776"],"corresponding_institution_ids":["https://openalex.org/I100066346","https://openalex.org/I35440088"],"apc_list":null,"apc_paid":null,"fwci":4.9135,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.96011036,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"60","issue":"11","first_page":"5319","last_page":"5330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10402","display_name":"Phase Equilibria and Thermodynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solvation","display_name":"Solvation","score":0.7441991567611694},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.7192426919937134},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.7131606936454773},{"id":"https://openalex.org/keywords/force-field","display_name":"Force field (fiction)","score":0.5603741407394409},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.54572594165802},{"id":"https://openalex.org/keywords/unifac","display_name":"UNIFAC","score":0.479783833026886},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.4719884693622589},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.4635296165943146},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.41434890031814575},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3819856345653534},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.37036994099617004},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35673701763153076},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3186126947402954},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.3138098120689392},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.2457757592201233},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.24141883850097656},{"id":"https://openalex.org/keywords/activity-coefficient","display_name":"Activity coefficient","score":0.16967526078224182},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.15469065308570862},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15452557802200317},{"id":"https://openalex.org/keywords/physical-chemistry","display_name":"Physical chemistry","score":0.11746430397033691},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09257674217224121}],"concepts":[{"id":"https://openalex.org/C148093993","wikidata":"https://www.wikidata.org/wiki/Q739398","display_name":"Solvation","level":3,"score":0.7441991567611694},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.7192426919937134},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.7131606936454773},{"id":"https://openalex.org/C10803110","wikidata":"https://www.wikidata.org/wiki/Q1341441","display_name":"Force field (fiction)","level":2,"score":0.5603741407394409},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.54572594165802},{"id":"https://openalex.org/C187434265","wikidata":"https://www.wikidata.org/wiki/Q906212","display_name":"UNIFAC","level":4,"score":0.479783833026886},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.4719884693622589},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4635296165943146},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.41434890031814575},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3819856345653534},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.37036994099617004},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35673701763153076},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3186126947402954},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3138098120689392},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.2457757592201233},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.24141883850097656},{"id":"https://openalex.org/C170961132","wikidata":"https://www.wikidata.org/wiki/Q745224","display_name":"Activity coefficient","level":3,"score":0.16967526078224182},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15469065308570862},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15452557802200317},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.11746430397033691},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09257674217224121},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.0c00479","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00479","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:32786697","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32786697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":{"id":"doi:10.1021/acs.jcim.0c00479","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00479","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.7099999785423279}],"awards":[{"id":"https://openalex.org/G5643887040","display_name":null,"funder_award_id":"EXC 2075 - 390740016","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W217929088","https://openalex.org/W568649234","https://openalex.org/W864253806","https://openalex.org/W1480376833","https://openalex.org/W1968583410","https://openalex.org/W1976499671","https://openalex.org/W1977194203","https://openalex.org/W1983107047","https://openalex.org/W1983567619","https://openalex.org/W1988037271","https://openalex.org/W2003223478","https://openalex.org/W2008505552","https://openalex.org/W2008841931","https://openalex.org/W2010836354","https://openalex.org/W2011215428","https://openalex.org/W2022277441","https://openalex.org/W2026466407","https://openalex.org/W2027154929","https://openalex.org/W2031888811","https://openalex.org/W2035266068","https://openalex.org/W2047661149","https://openalex.org/W2049583921","https://openalex.org/W2050270973","https://openalex.org/W2050994366","https://openalex.org/W2059721366","https://openalex.org/W2063477305","https://openalex.org/W2070493638","https://openalex.org/W2073328513","https://openalex.org/W2075581996","https://openalex.org/W2077709135","https://openalex.org/W2080757781","https://openalex.org/W2083708888","https://openalex.org/W2084417321","https://openalex.org/W2085237940","https://openalex.org/W2085892561","https://openalex.org/W2086634221","https://openalex.org/W2101234009","https://openalex.org/W2106140689","https://openalex.org/W2122199548","https://openalex.org/W2123875295","https://openalex.org/W2125653280","https://openalex.org/W2135046866","https://openalex.org/W2146798438","https://openalex.org/W2147993766","https://openalex.org/W2151554456","https://openalex.org/W2317037952","https://openalex.org/W2331370622","https://openalex.org/W2355814361","https://openalex.org/W2378074933","https://openalex.org/W2463815613","https://openalex.org/W2547434037","https://openalex.org/W2559120476","https://openalex.org/W2588556064","https://openalex.org/W2604320291","https://openalex.org/W2688081763","https://openalex.org/W2738935215","https://openalex.org/W2760462351","https://openalex.org/W2764126709","https://openalex.org/W2784210238","https://openalex.org/W2790882754","https://openalex.org/W2791309831","https://openalex.org/W2793958807","https://openalex.org/W2801803324","https://openalex.org/W2803197268","https://openalex.org/W2887000955","https://openalex.org/W2891168382","https://openalex.org/W2895867867","https://openalex.org/W2910388551","https://openalex.org/W2911964244","https://openalex.org/W2917102081","https://openalex.org/W2919386454","https://openalex.org/W2921739509","https://openalex.org/W2929256843","https://openalex.org/W2939256725","https://openalex.org/W2942735052","https://openalex.org/W2943901179","https://openalex.org/W2948020893","https://openalex.org/W2984807135","https://openalex.org/W2988197153","https://openalex.org/W2991109877","https://openalex.org/W2991463149","https://openalex.org/W2993987612","https://openalex.org/W2995457687","https://openalex.org/W2999111804","https://openalex.org/W3005866495","https://openalex.org/W3027613487","https://openalex.org/W3104732665","https://openalex.org/W3105755622","https://openalex.org/W3210989748"],"related_works":["https://openalex.org/W3175840220","https://openalex.org/W2049601662","https://openalex.org/W1989505723","https://openalex.org/W3127534742","https://openalex.org/W2022269912","https://openalex.org/W2811043963","https://openalex.org/W2161972019","https://openalex.org/W4366465732","https://openalex.org/W4321013117","https://openalex.org/W2312858532"],"abstract_inverted_index":{"Computational":[0,34],"prediction":[1,87],"of":[2,7,28,48,60],"limiting":[3,42],"activity":[4],"coefficients":[5],"is":[6],"great":[8],"relevance":[9],"for":[10,71],"process":[11],"design.":[12],"For":[13],"highly":[14],"nonideal":[15],"mixtures":[16],"including":[17,78],"molecules":[18],"with":[19],"directed":[20],"interactions,":[21],"methods":[22],"that":[23,44],"maintain":[24],"the":[25,29,40,46],"molecular":[26,50],"character":[27],"solvent":[30],"are":[31,39],"most":[32],"promising.":[33],"expense":[35],"and":[36,63,82],"force-field":[37],"deficiencies":[38],"main":[41],"factors":[43],"prevent":[45],"use":[47],"high-throughput":[49],"dynamics":[51],"(MD)":[52],"simulations":[53,62],"in":[54,67],"a":[55],"predictive":[56],"setup.":[57],"The":[58],"combination":[59],"MD":[61],"machine":[64],"learning":[65],"used":[66],"this":[68],"work":[69],"accounts":[70],"both":[72],"issues.":[73],"Comparison":[74],"to":[75],"published":[76],"data":[77],"free-energy":[79],"simulations,":[80],"COSMO-RS":[81],"UNIFAC":[83],"models,":[84],"reveals":[85],"competitive":[86],"accuracy.":[88]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}