{"id":"https://openalex.org/W3035236133","doi":"https://doi.org/10.1021/acs.jcim.0c00447","title":"Comparative Dynamics and Functional Mechanisms of the CYP17A1 Tunnels Regulated by Ligand Binding","display_name":"Comparative Dynamics and Functional Mechanisms of the CYP17A1 Tunnels Regulated by Ligand Binding","publication_year":2020,"publication_date":"2020-06-12","ids":{"openalex":"https://openalex.org/W3035236133","doi":"https://doi.org/10.1021/acs.jcim.0c00447","mag":"3035236133","pmid":"https://pubmed.ncbi.nlm.nih.gov/32530640"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c00447","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00447","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077588162","display_name":"Fei Xiao","orcid":"https://orcid.org/0000-0001-5262-2475"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Xiao","raw_affiliation_strings":["Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064400107","display_name":"Xingyu Song","orcid":"https://orcid.org/0000-0003-1154-7864"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyu Song","raw_affiliation_strings":["Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112401234","display_name":"Peiyi Tian","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiyi Tian","raw_affiliation_strings":["Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060206590","display_name":"Mi Gan","orcid":"https://orcid.org/0000-0002-3292-3921"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mi Gan","raw_affiliation_strings":["Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031922505","display_name":"Gennady M. Verkhivker","orcid":"https://orcid.org/0000-0002-4507-4471"},"institutions":[{"id":"https://openalex.org/I185071736","display_name":"Chapman University","ror":"https://ror.org/0452jzg20","country_code":"US","type":"education","lineage":["https://openalex.org/I185071736"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gennady M. Verkhivker","raw_affiliation_strings":["Department of Biomedical and Pharmaceutical Sciences, Chapman University Pharmacy School, 9401 Jeronimo Rd, Irvine, California 92618, United States","Department of Computational and Data Sciences, Chapman University, One University Drive, Orange, California 92866, United States"],"raw_orcid":"https://orcid.org/0000-0002-4507-4471","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Pharmaceutical Sciences, Chapman University Pharmacy School, 9401 Jeronimo Rd, Irvine, California 92618, United States","institution_ids":["https://openalex.org/I185071736"]},{"raw_affiliation_string":"Department of Computational and Data Sciences, Chapman University, One University Drive, Orange, California 92866, United States","institution_ids":["https://openalex.org/I185071736"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101617943","display_name":"Guang Hu","orcid":"https://orcid.org/0000-0002-8754-1541"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guang Hu","raw_affiliation_strings":["Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China"],"raw_orcid":"https://orcid.org/0000-0002-8754-1541","affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5031922505","https://openalex.org/A5101617943"],"corresponding_institution_ids":["https://openalex.org/I185071736","https://openalex.org/I3923682"],"apc_list":null,"apc_paid":null,"fwci":3.0335,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.91077065,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"60","issue":"7","first_page":"3632","last_page":"3647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.8624619245529175},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.6298664212226868},{"id":"https://openalex.org/keywords/cyp17a1","display_name":"CYP17A1","score":0.46602463722229004},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.45560306310653687},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38820981979370117},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.370918333530426},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.2916242480278015},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1908608078956604},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.1406373679637909},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.1082446277141571},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10008659958839417}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8624619245529175},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6298664212226868},{"id":"https://openalex.org/C142716871","wikidata":"https://www.wikidata.org/wiki/Q408305","display_name":"CYP17A1","level":3,"score":0.46602463722229004},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.45560306310653687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38820981979370117},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.370918333530426},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2916242480278015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1908608078956604},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1406373679637909},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1082446277141571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10008659958839417}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013254","descriptor_name":"Steroid 17-alpha-Hydroxylase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013254","descriptor_name":"Steroid 17-alpha-Hydroxylase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013254","descriptor_name":"Steroid 17-alpha-Hydroxylase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.0c00447","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00447","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:32530640","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32530640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.4300000071525574,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G384094312","display_name":null,"funder_award_id":"1601168C","funder_id":"https://openalex.org/F4320321605","funder_display_name":"Government of Jiangsu Province"},{"id":"https://openalex.org/G5732843278","display_name":null,"funder_award_id":"31872723","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6332583000","display_name":null,"funder_award_id":"2016M590495","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W241512211","https://openalex.org/W423419411","https://openalex.org/W1966078827","https://openalex.org/W1968973920","https://openalex.org/W1969952491","https://openalex.org/W1976499671","https://openalex.org/W1986743126","https://openalex.org/W1987491348","https://openalex.org/W1989849610","https://openalex.org/W2011601475","https://openalex.org/W2013847640","https://openalex.org/W2014118668","https://openalex.org/W2015642465","https://openalex.org/W2015688756","https://openalex.org/W2018684250","https://openalex.org/W2020153068","https://openalex.org/W2022950330","https://openalex.org/W2025116694","https://openalex.org/W2037805556","https://openalex.org/W2056002345","https://openalex.org/W2069518737","https://openalex.org/W2082620440","https://openalex.org/W2083967315","https://openalex.org/W2085038958","https://openalex.org/W2085347260","https://openalex.org/W2101017457","https://openalex.org/W2101414808","https://openalex.org/W2103388612","https://openalex.org/W2104995186","https://openalex.org/W2113994268","https://openalex.org/W2128572087","https://openalex.org/W2130061417","https://openalex.org/W2131288855","https://openalex.org/W2132629607","https://openalex.org/W2133002676","https://openalex.org/W2137825366","https://openalex.org/W2144999739","https://openalex.org/W2147993766","https://openalex.org/W2148012276","https://openalex.org/W2161069015","https://openalex.org/W2169678694","https://openalex.org/W2309551856","https://openalex.org/W2325652290","https://openalex.org/W2330231511","https://openalex.org/W2376573086","https://openalex.org/W2399237148","https://openalex.org/W2416192302","https://openalex.org/W2461552319","https://openalex.org/W2518031329","https://openalex.org/W2561607416","https://openalex.org/W2596679549","https://openalex.org/W2604162743","https://openalex.org/W2619817401","https://openalex.org/W2728165287","https://openalex.org/W2735198445","https://openalex.org/W2769289310","https://openalex.org/W2770590458","https://openalex.org/W2791059288","https://openalex.org/W2801132645","https://openalex.org/W2806719596","https://openalex.org/W2807292831","https://openalex.org/W2897126718","https://openalex.org/W2897683199","https://openalex.org/W2901099223","https://openalex.org/W2904897856","https://openalex.org/W2907653052","https://openalex.org/W2916087834","https://openalex.org/W2924293762","https://openalex.org/W2940886822","https://openalex.org/W2944202352","https://openalex.org/W2944767593","https://openalex.org/W2971923887","https://openalex.org/W2979469940","https://openalex.org/W2981180040","https://openalex.org/W2982509229","https://openalex.org/W3004329511","https://openalex.org/W3005293298","https://openalex.org/W3006316865"],"related_works":["https://openalex.org/W2142312240","https://openalex.org/W178050054","https://openalex.org/W2461552319","https://openalex.org/W4380904910","https://openalex.org/W2769289310","https://openalex.org/W2939998722","https://openalex.org/W2169750653","https://openalex.org/W2195592873","https://openalex.org/W2011309992","https://openalex.org/W1971782741"],"abstract_inverted_index":{"As":[0],"an":[1,28,71],"important":[2],"member":[3],"of":[4,21,42,57,82,93,108,115,160,168,195,202,208,236,264,273],"cytochrome":[5],"P450":[6],"(CYP)":[7],"enzymes,":[8],"CYP17A1":[9,37,77,135],"is":[10,142],"a":[11,15,49,80,143,200,269],"dual-function":[12],"monooxygenase":[13],"with":[14,79,242],"critical":[16,116],"role":[17],"in":[18,134,279],"the":[19,39,88,91,106,139,158,186,196,221,225,243,250,257,260,265],"synthesis":[20],"many":[22],"human":[23],"steroid":[24],"hormones,":[25],"making":[26],"it":[27],"attractive":[29],"therapeutic":[30],"target.":[31],"The":[32,122,183,234],"emerging":[33],"structural":[34],"information":[35],"about":[36],"and":[38,54,95,100,111,129,152,163,173,188,199,212,219,230,252,262,268,276],"growing":[40],"number":[41],"inhibitors":[43],"for":[44,48,119],"these":[45],"enzymes":[46],"call":[47],"systematic":[50],"strategy":[51,74],"to":[52,75,84,178,249],"delineate":[53],"classify":[55],"mechanisms":[56,275],"ligand":[58,120,148,180],"transport":[59],"through":[60],"tunnels":[61,110,131],"that":[62],"control":[63],"catalytic":[64],"activity.":[65],"In":[66],"this":[67,237],"work,":[68],"we":[69],"applied":[70],"integrated":[72,153],"computational":[73,155],"different":[76],"systems":[78],"panel":[81],"ligands":[83],"systematically":[85],"study":[86],"at":[87],"atomic":[89],"level":[90],"mechanism":[92],"ligand-binding":[94],"tunneling":[96,181],"dynamics.":[97],"Atomistic":[98],"simulations":[99],"binding":[101,136],"free":[102],"energy":[103],"computations":[104],"identify":[105],"dynamics":[107,211],"dominant":[109],"characterize":[112],"energetic":[113],"properties":[114],"residues":[117,204],"responsible":[118],"binding.":[121,149],"common":[123],"transporting":[124],"pathways":[125],"including":[126,157],"S,":[127],"3,":[128],"2c":[130,140],"were":[132],"identified":[133],"systems,":[137],"while":[138],"tunnel":[141,197,209,226],"newly":[144],"formed":[145],"pathway":[146],"upon":[147],"We":[150,215],"employed":[151],"several":[154],"approaches":[156],"analysis":[159,177],"functional":[161,193],"motions":[162,190],"sequence":[164],"conservation,":[165],"atomistic":[166,271],"modeling":[167],"dynamic":[169],"residue":[170],"interaction":[171],"networks,":[172],"perturbation":[174],"response":[175],"scanning":[176],"dissect":[179],"mechanisms.":[182],"results":[184,235],"revealed":[185],"hinge-binding":[187],"sliding":[189],"as":[191,205],"main":[192],"modes":[194],"dynamic,":[198],"group":[201],"mediating":[203],"key":[206],"regulators":[207],"conformational":[210,228],"allosteric":[213,232,277],"communications.":[214],"have":[216],"also":[217],"examined":[218],"quantified":[220],"mutational":[222],"effects":[223],"on":[224],"composition,":[227],"dynamics,":[229],"long-range":[231],"behavior.":[233],"investigation":[238],"are":[239],"fully":[240],"consistent":[241],"experimental":[244],"data,":[245],"providing":[246],"novel":[247],"rationale":[248],"experiments":[251],"offering":[253],"valuable":[254],"insights":[255],"into":[256],"relationships":[258],"between":[259],"structure":[261],"function":[263],"channel":[266],"networks":[267],"robust":[270],"model":[272],"activation":[274],"interactions":[278],"CYP":[280],"enzymes.":[281]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
