{"id":"https://openalex.org/W3044758576","doi":"https://doi.org/10.1021/acs.jcim.0c00371","title":"Understanding the Binding Specificity of G-Protein Coupled Receptors toward G-Proteins and Arrestins: Application to the Dopamine Receptor Family","display_name":"Understanding the Binding Specificity of G-Protein Coupled Receptors toward G-Proteins and Arrestins: Application to the Dopamine Receptor Family","publication_year":2020,"publication_date":"2020-07-21","ids":{"openalex":"https://openalex.org/W3044758576","doi":"https://doi.org/10.1021/acs.jcim.0c00371","mag":"3044758576","pmid":"https://pubmed.ncbi.nlm.nih.gov/32692555"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c00371","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00371","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044744702","display_name":"Ant\u00f3nio J. Preto","orcid":"https://orcid.org/0000-0003-4203-2230"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"A. J. Preto","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alem\u00e3o - P\u00f3lo II | Rua Dom Francisco de Lemos, 3030-789 Coimbra, Portugal","University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-4203-2230","affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alem\u00e3o - P\u00f3lo II | Rua Dom Francisco de Lemos, 3030-789 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007295898","display_name":"Carlos A.V. Barreto","orcid":"https://orcid.org/0000-0003-1459-7680"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carlos A. V. Barreto","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alem\u00e3o - P\u00f3lo II | Rua Dom Francisco de Lemos, 3030-789 Coimbra, Portugal","University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-1459-7680","affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alem\u00e3o - P\u00f3lo II | Rua Dom Francisco de Lemos, 3030-789 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031622819","display_name":"Salete J. Baptista","orcid":"https://orcid.org/0000-0002-7213-5997"},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Salete J. Baptista","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, ao Km 139,7, 2695-066 Bobadela, Portugal","University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, ao Km 139,7, 2695-066 Bobadela, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084170611","display_name":"Jos\u00e9 Guilherme de Almeida","orcid":"https://orcid.org/0000-0002-1887-0157"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Guilherme de Almeida","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","European Bioinformatics Institute EMBL-EBI, Hinxton, Cambridgeshire CB10 1SD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"European Bioinformatics Institute EMBL-EBI, Hinxton, Cambridgeshire CB10 1SD, United Kingdom","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059149017","display_name":"Agostinho Lemos","orcid":"https://orcid.org/0000-0001-6956-1736"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["BE","PT"],"is_corresponding":false,"raw_author_name":"Agostinho Lemos","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","GIGA Cyclotron Research Centre In Vivo Imaging, University of Li\u00e8ge, B\u00e2timent B30, All\u00e9e du 6 Ao\u00fbt, 8, 4000 Li\u00e8ge, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-6956-1736","affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"GIGA Cyclotron Research Centre In Vivo Imaging, University of Li\u00e8ge, B\u00e2timent B30, All\u00e9e du 6 Ao\u00fbt, 8, 4000 Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010550163","display_name":"Andr\u00e9 Melo","orcid":"https://orcid.org/0000-0001-6455-7834"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Melo","raw_affiliation_strings":["REQUIMTE/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua Campo Alegre 687, s/n, 4169-007 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"REQUIMTE/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua Campo Alegre 687, s/n, 4169-007 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031900984","display_name":"M. Nat\u00e1lia D. S. Cordeiro","orcid":"https://orcid.org/0000-0003-3375-8670"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"M. N\u00e1talia D. S. Cordeiro","raw_affiliation_strings":["REQUIMTE/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua Campo Alegre 687, s/n, 4169-007 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-3375-8670","affiliations":[{"raw_affiliation_string":"REQUIMTE/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua Campo Alegre 687, s/n, 4169-007 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018926605","display_name":"Zeynep Kurkcuoglu","orcid":"https://orcid.org/0000-0001-7568-5882"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Zeynep Kurkcuoglu","raw_affiliation_strings":["Bijvoet Center for Biomolecular Research, Faculty of Science \u2212 Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bijvoet Center for Biomolecular Research, Faculty of Science \u2212 Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063368834","display_name":"Rita Melo","orcid":"https://orcid.org/0000-0003-1056-1007"},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rita Melo","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, ao Km 139,7, 2695-066 Bobadela, Portugal","University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-1056-1007","affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, ao Km 139,7, 2695-066 Bobadela, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057247289","display_name":"Irina S. Moreira","orcid":"https://orcid.org/0000-0003-2970-5250"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Irina S. Moreira","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","Department of Life Sciences, University of Coimbra, Col\u00e9gio de S. Bento, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal","University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-2970-5250","affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Department of Life Sciences, University of Coimbra, Col\u00e9gio de S. Bento, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, P\u00f3lo I, 1st floor, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5057247289"],"corresponding_institution_ids":["https://openalex.org/I76903346"],"apc_list":null,"apc_paid":null,"fwci":0.5852,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.65274364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"60","issue":"8","first_page":"3969","last_page":"3984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.8787442445755005},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.7066060304641724},{"id":"https://openalex.org/keywords/g-protein","display_name":"G protein","score":0.6525623798370361},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-kinase","display_name":"G protein-coupled receptor kinase","score":0.6207913160324097},{"id":"https://openalex.org/keywords/d1-like-receptor","display_name":"D1-like receptor","score":0.5459949970245361},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.5327017307281494},{"id":"https://openalex.org/keywords/dopamine-receptor","display_name":"Dopamine receptor","score":0.4539274573326111},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.44806140661239624},{"id":"https://openalex.org/keywords/rhodopsin","display_name":"Rhodopsin","score":0.44426265358924866},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4317507743835449},{"id":"https://openalex.org/keywords/arrestin","display_name":"Arrestin","score":0.42124372720718384},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42045944929122925},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4139016270637512},{"id":"https://openalex.org/keywords/dopamine-receptor-d3","display_name":"Dopamine receptor D3","score":0.19164228439331055},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.13619250059127808}],"concepts":[{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.8787442445755005},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7066060304641724},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.6525623798370361},{"id":"https://openalex.org/C33235085","wikidata":"https://www.wikidata.org/wiki/Q4355943","display_name":"G protein-coupled receptor kinase","level":4,"score":0.6207913160324097},{"id":"https://openalex.org/C141961939","wikidata":"https://www.wikidata.org/wiki/Q1752853","display_name":"D1-like receptor","level":5,"score":0.5459949970245361},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.5327017307281494},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.4539274573326111},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44806140661239624},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.44426265358924866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4317507743835449},{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.42124372720718384},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42045944929122925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4139016270637512},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.19164228439331055},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13619250059127808},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.0c00371","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00371","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:32692555","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32692555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G203610139","display_name":null,"funder_award_id":"PTDC/QUI-OUT/32243/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2683603038","display_name":null,"funder_award_id":"SFRH/BD/145457/2019","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3052715438","display_name":null,"funder_award_id":"IF/00578/2014","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4590339352","display_name":null,"funder_award_id":"IF/00578/2014","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G4911698294","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-031356","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G4999551246","display_name":null,"funder_award_id":"SFRH/BD/144966/2019","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G63235041","display_name":null,"funder_award_id":"UIDB/04539/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7564350104","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-031356","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7742048941","display_name":null,"funder_award_id":"CENTRO-01-0145-FEDER-000008","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G8892693454","display_name":null,"funder_award_id":"UIDB/50006/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W100092412","https://openalex.org/W253094825","https://openalex.org/W887768225","https://openalex.org/W1031578623","https://openalex.org/W1534600986","https://openalex.org/W1605984840","https://openalex.org/W1607931568","https://openalex.org/W1786514222","https://openalex.org/W1833104430","https://openalex.org/W1965517743","https://openalex.org/W1968032549","https://openalex.org/W1976682018","https://openalex.org/W1977448773","https://openalex.org/W1978265572","https://openalex.org/W1978310995","https://openalex.org/W1980470416","https://openalex.org/W1981021420","https://openalex.org/W1990771438","https://openalex.org/W1992192767","https://openalex.org/W1999597013","https://openalex.org/W1999613945","https://openalex.org/W2000658108","https://openalex.org/W2009447429","https://openalex.org/W2018718529","https://openalex.org/W2021520922","https://openalex.org/W2039913863","https://openalex.org/W2053512172","https://openalex.org/W2053549636","https://openalex.org/W2068238776","https://openalex.org/W2072803686","https://openalex.org/W2077306308","https://openalex.org/W2082178571","https://openalex.org/W2089626755","https://openalex.org/W2102648626","https://openalex.org/W2107940314","https://openalex.org/W2109154308","https://openalex.org/W2109612279","https://openalex.org/W2114715627","https://openalex.org/W2125304058","https://openalex.org/W2128693499","https://openalex.org/W2129562311","https://openalex.org/W2130606742","https://openalex.org/W2142757818","https://openalex.org/W2143463649","https://openalex.org/W2146517666","https://openalex.org/W2150757793","https://openalex.org/W2151409320","https://openalex.org/W2154019529","https://openalex.org/W2154319440","https://openalex.org/W2158405078","https://openalex.org/W2158599032","https://openalex.org/W2162368656","https://openalex.org/W2165775221","https://openalex.org/W2167857702","https://openalex.org/W2170968124","https://openalex.org/W2171268876","https://openalex.org/W2189955651","https://openalex.org/W2206954826","https://openalex.org/W2300047490","https://openalex.org/W2325132056","https://openalex.org/W2334576198","https://openalex.org/W2336982593","https://openalex.org/W2376573086","https://openalex.org/W2383568686","https://openalex.org/W2403664403","https://openalex.org/W2470044683","https://openalex.org/W2516956609","https://openalex.org/W2610574505","https://openalex.org/W2613102394","https://openalex.org/W2742394249","https://openalex.org/W2808524678","https://openalex.org/W2809171792","https://openalex.org/W2809303314","https://openalex.org/W2883968630","https://openalex.org/W2918740668","https://openalex.org/W2946834818","https://openalex.org/W2950810010","https://openalex.org/W2989686935","https://openalex.org/W2999487242","https://openalex.org/W3136918052","https://openalex.org/W4211196614","https://openalex.org/W4254687493","https://openalex.org/W6950045303"],"related_works":["https://openalex.org/W2086181965","https://openalex.org/W2010904942","https://openalex.org/W4377104832","https://openalex.org/W39049370","https://openalex.org/W4366245459","https://openalex.org/W2038392988","https://openalex.org/W1995806708","https://openalex.org/W2033688302","https://openalex.org/W4323317854","https://openalex.org/W2187936481"],"abstract_inverted_index":{"G-Protein":[0],"coupled":[1],"receptors":[2],"(GPCRs)":[3],"are":[4,38,209],"involved":[5],"in":[6,149,225],"a":[7,45,67],"myriad":[8],"of":[9,18,35,54,70,89,97,101,104,119,145,165,221,249],"pathways":[10],"key":[11],"for":[12],"human":[13,74],"physiology":[14],"through":[15],"the":[16,30,51,73,86,98,105,115,146,163,166,173,179,196,200,219],"formation":[17],"complexes":[19,37,56],"with":[20,57,151],"intracellular":[21],"partners":[22,122],"such":[23],"as":[24,161],"G-proteins":[25,153],"and":[26,32,79,112,114,125,137,178,185,205,207,212,231,236],"arrestins":[27],"(Arrs).":[28],"However,":[29],"structural":[31,52,223],"dynamical":[33],"determinants":[34],"these":[36,90],"still":[39],"largely":[40],"unknown.":[41],"Herein,":[42],"we":[43,156],"developed":[44],"computational":[46],"big-data":[47],"pipeline":[48,62],"that":[49,199],"enables":[50],"characterization":[53],"GPCR":[55],"no":[58],"available":[59,257],"structure.":[60],"This":[61],"was":[63,139,217],"used":[64],"to":[65,171,176,191],"study":[66],"well-known":[68],"group":[69],"catecholamine":[71],"receptors,":[72],"dopamine":[75],"receptor":[76,168,188],"(DXR)":[77],"family":[78,107,148],"its":[80],"complexes,":[81],"producing":[82],"novel":[83],"insights":[84],"into":[85],"physiological":[87],"properties":[88],"important":[91],"drug":[92],"targets.":[93],"A":[94],"detailed":[95],"description":[96],"protein":[99,117],"interfaces":[100,118],"all":[102,210],"members":[103],"DXR":[106,147],"(D1R,":[108],"D2R,":[109],"D3R,":[110],"D4R,":[111],"D5R)":[113],"corresponding":[116],"their":[120],"binding":[121],"(Arrs:":[123],"Arr2":[124],"Arr3;":[126],"G-proteins:":[127],"Gi1,":[128],"Gi2,":[129],"Gi3,":[130],"Go,":[131],"Gob,":[132],"Gq,":[133],"Gslo,":[134],"Gssh,":[135],"Gt2,":[136],"Gz)":[138],"generated.":[140],"To":[141],"produce":[142],"reliable":[143],"structures":[144,164],"complex":[150],"either":[152],"or":[154],"Arrs,":[155],"performed":[157],"homology":[158],"modeling":[159],"using":[160],"templates":[162],"\u03b22-adrenergic":[167],"(\u03b22AR)":[169],"bound":[170,175,190],"Gs,":[172],"rhodopsin":[174],"Gi,":[177],"recently":[180],"acquired":[181],"neurotensin":[182],"receptor-1":[183],"(NTSR1)":[184],"muscarinic":[186],"2":[187],"(M2R)":[189],"arrestin":[192],"(Arr).":[193],"Among":[194],"others,":[195],"work":[197,243],"demonstrated":[198],"three":[201],"partner":[202,251],"groups,":[203],"Arrs":[204],"Gs-":[206],"Gi-proteins,":[208],"structurally":[211],"dynamically":[213],"distinct.":[214],"Additionally,":[215],"it":[216],"revealed":[218],"involvement":[220],"different":[222],"motifs":[224],"G-protein":[226],"selective":[227],"coupling":[228],"between":[229],"D1-":[230],"D2-like":[232],"receptors.":[233],"Having":[234],"constructed":[235],"analyzed":[237],"50":[238],"models":[239],"involving":[240],"DXR,":[241],"this":[242],"represents":[244],"an":[245],"unprecedented":[246],"large-scale":[247],"analysis":[248],"GPCR-intracellular":[250],"interface":[252],"determinants.":[253],"All":[254],"data":[255],"is":[256],"at":[258],"www.moreiralab.com/resources/dxr.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
