{"id":"https://openalex.org/W3010057635","doi":"https://doi.org/10.1021/acs.jcim.0c00041","title":"Agonist-Specific Conformations of the M<sub>2</sub> Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics","display_name":"Agonist-Specific Conformations of the M<sub>2</sub> Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics","publication_year":2020,"publication_date":"2020-03-04","ids":{"openalex":"https://openalex.org/W3010057635","doi":"https://doi.org/10.1021/acs.jcim.0c00041","mag":"3010057635","pmid":"https://pubmed.ncbi.nlm.nih.gov/32130001"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.0c00041","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00041","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026174072","display_name":"Alena Rand\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0002-8403-6494"},"institutions":[{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Alena Rand\u00e1kov\u00e1","raw_affiliation_strings":["Department of Neurochemistry, Institute of Physiology CAS, Prague, CZ 142 20, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Institute of Physiology CAS, Prague, CZ 142 20, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076668710","display_name":"Dominik Nelic","orcid":"https://orcid.org/0000-0003-1926-3225"},"institutions":[{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Dominik Nelic","raw_affiliation_strings":["Department of Neurochemistry, Institute of Physiology CAS, Prague, CZ 142 20, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Institute of Physiology CAS, Prague, CZ 142 20, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003207443","display_name":"Vladim\u0131\u0301r Dole\u017eal","orcid":"https://orcid.org/0000-0003-3412-256X"},"institutions":[{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Vladim\u00edr Dole\u017eal","raw_affiliation_strings":["Department of Neurochemistry, Institute of Physiology CAS, Prague, CZ 142 20, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Institute of Physiology CAS, Prague, CZ 142 20, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108635793","display_name":"Esam E. El\u2010Fakahany","orcid":null},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esam E. El-Fakahany","raw_affiliation_strings":["Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081867399","display_name":"John Boulos","orcid":"https://orcid.org/0000-0001-8561-6418"},"institutions":[{"id":"https://openalex.org/I151583259","display_name":"Barry University","ror":"https://ror.org/04r1hh402","country_code":"US","type":"education","lineage":["https://openalex.org/I151583259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Boulos","raw_affiliation_strings":["Department of Physical Sciences, Barry University, Miami Shores, Florida 33161, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Sciences, Barry University, Miami Shores, Florida 33161, United States","institution_ids":["https://openalex.org/I151583259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048482070","display_name":"J\u00e1n Jakub\u00edk","orcid":"https://orcid.org/0000-0002-1737-1487"},"institutions":[{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Jan Jakub\u00edk","raw_affiliation_strings":["Department of Neurochemistry, Institute of Physiology CAS, Prague, CZ 142 20, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-1737-1487","affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Institute of Physiology CAS, Prague, CZ 142 20, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5048482070"],"corresponding_institution_ids":["https://openalex.org/I4210166371"],"apc_list":null,"apc_paid":null,"fwci":0.5838,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.64397739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"60","issue":"4","first_page":"2325","last_page":"2338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agonist","display_name":"Agonist","score":0.8718826770782471},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7229235768318176},{"id":"https://openalex.org/keywords/carbachol","display_name":"Carbachol","score":0.6613434553146362},{"id":"https://openalex.org/keywords/muscarinic-acetylcholine-receptor","display_name":"Muscarinic acetylcholine receptor","score":0.6390026807785034},{"id":"https://openalex.org/keywords/partial-agonist","display_name":"Partial agonist","score":0.6012991070747375},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5981982946395874},{"id":"https://openalex.org/keywords/muscarinic-acetylcholine-receptor-m5","display_name":"Muscarinic acetylcholine receptor M5","score":0.5758882761001587},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5661534667015076},{"id":"https://openalex.org/keywords/muscarinic-acetylcholine-receptor-m2","display_name":"Muscarinic acetylcholine receptor M2","score":0.47204479575157166},{"id":"https://openalex.org/keywords/muscarinic-acetylcholine-receptor-m3","display_name":"Muscarinic acetylcholine receptor M3","score":0.43715041875839233},{"id":"https://openalex.org/keywords/acetylcholine-receptor","display_name":"Acetylcholine receptor","score":0.42225825786590576},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.41263580322265625},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3686163127422333},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3064934015274048},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15800225734710693},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.048123955726623535}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.8718826770782471},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7229235768318176},{"id":"https://openalex.org/C2778988552","wikidata":"https://www.wikidata.org/wiki/Q419401","display_name":"Carbachol","level":3,"score":0.6613434553146362},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.6390026807785034},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.6012991070747375},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5981982946395874},{"id":"https://openalex.org/C64615621","wikidata":"https://www.wikidata.org/wiki/Q15333405","display_name":"Muscarinic acetylcholine receptor M5","level":5,"score":0.5758882761001587},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5661534667015076},{"id":"https://openalex.org/C47488739","wikidata":"https://www.wikidata.org/wiki/Q17861931","display_name":"Muscarinic acetylcholine receptor M2","level":4,"score":0.47204479575157166},{"id":"https://openalex.org/C116289061","wikidata":"https://www.wikidata.org/wiki/Q17861955","display_name":"Muscarinic acetylcholine receptor M3","level":4,"score":0.43715041875839233},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.42225825786590576},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.41263580322265625},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3686163127422333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3064934015274048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15800225734710693},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.048123955726623535}],"mesh":[{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018721","descriptor_name":"Muscarinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018721","descriptor_name":"Muscarinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018721","descriptor_name":"Muscarinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.0c00041","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.0c00041","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:32130001","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32130001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1943112846","display_name":null,"funder_award_id":"17-16182S","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G6874992092","display_name":null,"funder_award_id":"19-06106Y","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G7366811696","display_name":null,"funder_award_id":"RVO:67985823","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"}],"funders":[{"id":"https://openalex.org/F4320309576","display_name":"Barry University","ror":"https://ror.org/04r1hh402"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320322482","display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","ror":"https://ror.org/053avzc18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1919666397","https://openalex.org/W1948284427","https://openalex.org/W1966345506","https://openalex.org/W1967694000","https://openalex.org/W1969027187","https://openalex.org/W1983534052","https://openalex.org/W1991512318","https://openalex.org/W1993621100","https://openalex.org/W1996699176","https://openalex.org/W1997340548","https://openalex.org/W2006803138","https://openalex.org/W2027408247","https://openalex.org/W2027790571","https://openalex.org/W2029667189","https://openalex.org/W2031168104","https://openalex.org/W2051994079","https://openalex.org/W2066414494","https://openalex.org/W2066482395","https://openalex.org/W2090264443","https://openalex.org/W2109254532","https://openalex.org/W2129645905","https://openalex.org/W2135008467","https://openalex.org/W2150981663","https://openalex.org/W2161644181","https://openalex.org/W2164237331","https://openalex.org/W2295245722","https://openalex.org/W2530696470","https://openalex.org/W2652782546","https://openalex.org/W2763752752","https://openalex.org/W2784655325","https://openalex.org/W2793374998","https://openalex.org/W2890544573","https://openalex.org/W2921670360","https://openalex.org/W2944371911","https://openalex.org/W2946407865","https://openalex.org/W2946834818","https://openalex.org/W2946861851","https://openalex.org/W2947163054","https://openalex.org/W3000273592","https://openalex.org/W4234946072","https://openalex.org/W4251875480"],"related_works":["https://openalex.org/W2000618992","https://openalex.org/W2014913952","https://openalex.org/W3144716053","https://openalex.org/W4236619235","https://openalex.org/W2392689648","https://openalex.org/W2044540571","https://openalex.org/W2023374499","https://openalex.org/W4240589764","https://openalex.org/W1928783644","https://openalex.org/W2356528435"],"abstract_inverted_index":{"Binding":[0],"of":[1,14,30,54,63,103,118,160,183,196,201],"muscarinic":[2],"ligands,":[3],"both":[4],"antagonists":[5,31],"and":[6,8,23,45,138,143,187,206],"agonists,":[7],"their":[9],"effects":[10],"on":[11],"the":[12,15,33,74,78,104,112,119,123,132,153,161,194,202],"conformation":[13,39,50,83],"M2":[16,34],"acetylcholine":[17],"receptor":[18,35,79,88,124,185,188,211],"were":[19],"modeled":[20],"in":[21,36,47,80,89],"silico":[22],"compared":[24],"to":[25,32,98],"experimental":[26],"data.":[27],"After":[28],"docking":[29],"an":[37,48,81],"inactive":[38,82],"(3UON,":[40],"5ZK3,":[41],"5ZKB,":[42],"or":[43],"5ZKB)":[44],"agonists":[46,93,141],"active":[49],"(4MQS),":[51],"100":[52],"ns":[53,62],"conventional":[55],"molecular":[56,208],"dynamics":[57],"(MD)":[58],"followed":[59],"by":[60],"500":[61],"accelerated":[64,85,174,177],"MD":[65,69,178],"was":[66,129,171],"run.":[67],"Conventional":[68],"revealed":[70],"ligand-specific":[71,184],"interactions":[72,167],"with":[73,91,108,126,147,166,168],"receptor.":[75],"Antagonists":[76],"stabilized":[77],"during":[84,173],"MD.":[86,175],"The":[87,101,116],"complex":[90],"various":[92],"attained":[94],"different":[95,130],"conformations":[96,189],"specific":[97],"individual":[99],"agonists.":[100],"magnitude":[102],"TM6":[105],"movement":[106],"correlated":[107],"agonist":[109,134,150,163],"efficacy":[110],"at":[111,152,199],"non-preferential":[113],"Gs":[114],"pathway.":[115],"shape":[117],"intracellular":[120],"opening":[121],"where":[122],"interacts":[125],"a":[127,157],"G-protein":[128,154],"for":[131,181,193],"classical":[133],"carbachol,":[135],"super-agonist":[136],"iperoxo,":[137],"Gi/o-biased":[139],"partial":[140],"JR-6":[142],"JR-7,":[144],"being":[145],"compatible":[146],"experimentally":[148],"observed":[149],"bias":[151],"level.":[155],"Moreover,":[156],"wash-resistant":[158],"binding":[159,186,204],"unique":[162],"xanomeline":[164],"associated":[165],"membrane":[169],"lipids":[170],"formed":[172],"Thus,":[176],"is":[179,191],"suitable":[180],"modeling":[182],"that":[190],"essential":[192],"design":[195],"experiments":[197],"aimed":[198],"identification":[200],"secondary":[203],"sites":[205],"understanding":[207],"mechanisms":[209],"underlying":[210],"activation.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}