{"id":"https://openalex.org/W4416953641","doi":"https://doi.org/10.1016/j.sysconle.2025.106309","title":"System realizations by mammillary models with an application to propofol pharmacokinetics","display_name":"System realizations by mammillary models with an application to propofol pharmacokinetics","publication_year":2025,"publication_date":"2025-12-03","ids":{"openalex":"https://openalex.org/W4416953641","doi":"https://doi.org/10.1016/j.sysconle.2025.106309"},"language":"en","primary_location":{"id":"doi:10.1016/j.sysconle.2025.106309","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sysconle.2025.106309","pdf_url":null,"source":{"id":"https://openalex.org/S56603566","display_name":"Systems & Control Letters","issn_l":"0167-6911","issn":["0167-6911","1872-7956"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systems & Control Letters","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.sysconle.2025.106309","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017158075","display_name":"Veronica Beltrami","orcid":"https://orcid.org/0000-0002-1965-3357"},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Veronica Beltrami","raw_affiliation_strings":["Department of Engineering and Architecture, University of Parma, Parma, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1965-3357","affiliations":[{"raw_affiliation_string":"Department of Engineering and Architecture, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048869539","display_name":"Luca Consolini","orcid":"https://orcid.org/0000-0002-3577-9398"},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Consolini","raw_affiliation_strings":["Department of Engineering and Architecture, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering and Architecture, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025409316","display_name":"Mattia Laurini","orcid":"https://orcid.org/0000-0001-9965-8803"},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mattia Laurini","raw_affiliation_strings":["Department of Engineering and Architecture, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering and Architecture, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103147175","display_name":"Marco Milanesi","orcid":"https://orcid.org/0009-0008-3969-6312"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Milanesi","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003260477","display_name":"Michele Schiavo","orcid":"https://orcid.org/0000-0002-3031-5535"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Schiavo","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077205052","display_name":"Antonio Visioli","orcid":"https://orcid.org/0000-0002-9246-5715"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Visioli","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017158075"],"corresponding_institution_ids":["https://openalex.org/I124601658"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40704057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"208","issue":null,"first_page":"106309","last_page":"106309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.2847999930381775,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.2847999930381775,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.1324000060558319,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mammillary-body","display_name":"Mammillary body","score":0.7839999794960022},{"id":"https://openalex.org/keywords/propofol","display_name":"Propofol","score":0.5519000291824341},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.5436000227928162},{"id":"https://openalex.org/keywords/transfer-function","display_name":"Transfer function","score":0.3359000086784363},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.3249000012874603},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.31209999322891235}],"concepts":[{"id":"https://openalex.org/C2777507194","wikidata":"https://www.wikidata.org/wiki/Q499802","display_name":"Mammillary body","level":3,"score":0.7839999794960022},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.5519000291824341},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5436000227928162},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4016000032424927},{"id":"https://openalex.org/C81299745","wikidata":"https://www.wikidata.org/wiki/Q334269","display_name":"Transfer function","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32440000772476196},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.31209999322891235},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C73301696","wikidata":"https://www.wikidata.org/wiki/Q5469984","display_name":"Formalism (music)","level":3,"score":0.30300000309944153},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2994999885559082},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.29260000586509705},{"id":"https://openalex.org/C2987276129","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Drug administration","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25600001215934753}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.sysconle.2025.106309","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sysconle.2025.106309","pdf_url":null,"source":{"id":"https://openalex.org/S56603566","display_name":"Systems & Control Letters","issn_l":"0167-6911","issn":["0167-6911","1872-7956"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systems & Control Letters","raw_type":"journal-article"},{"id":"pmh:oai:iris.unibs.it:11379/635876","is_oa":true,"landing_page_url":"https://hdl.handle.net/11379/635876","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.sysconle.2025.106309","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sysconle.2025.106309","pdf_url":null,"source":{"id":"https://openalex.org/S56603566","display_name":"Systems & Control Letters","issn_l":"0167-6911","issn":["0167-6911","1872-7956"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systems & Control Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3254049092","display_name":null,"funder_award_id":"CUP D53D23001180006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1970391638","https://openalex.org/W1983841857","https://openalex.org/W1985908492","https://openalex.org/W1990002766","https://openalex.org/W1991081533","https://openalex.org/W1998121032","https://openalex.org/W2000898041","https://openalex.org/W2021317570","https://openalex.org/W2043756932","https://openalex.org/W2047792948","https://openalex.org/W2056226574","https://openalex.org/W2069970818","https://openalex.org/W2101037112","https://openalex.org/W2108799133","https://openalex.org/W2116285012","https://openalex.org/W2119052316","https://openalex.org/W2122171313","https://openalex.org/W2146004164","https://openalex.org/W2170831233","https://openalex.org/W2488700677","https://openalex.org/W2883595456","https://openalex.org/W2992732831","https://openalex.org/W3035139130","https://openalex.org/W3174700184","https://openalex.org/W4206595925","https://openalex.org/W4214758613","https://openalex.org/W4232235567","https://openalex.org/W4244179002","https://openalex.org/W4281391081","https://openalex.org/W4281669218","https://openalex.org/W4404192075"],"related_works":[],"abstract_inverted_index":{"This":[0,44],"work":[1],"addresses":[2],"the":[3,37],"problem":[4],"of":[5,40],"linear":[6],"system":[7,90],"realizations":[8,85],"by":[9],"mammillary":[10,34,84],"and":[11,16,42,63],"mammillary-like":[12],"models,":[13,32],"offering":[14],"necessary":[15],"sufficient":[17],"conditions":[18],"under":[19],"which":[20],"a":[21,78],"given":[22],"transfer":[23],"function":[24],"can":[25,86],"be":[26],"represented":[27],"in":[28,48,69],"this":[29],"form.":[30],"Compartmental":[31],"particularly":[33],"ones,":[35],"reflect":[36],"physiological":[38],"dynamics":[39],"distribution":[41],"elimination.":[43],"is":[45],"especially":[46],"relevant":[47],"clinical":[49],"pharmacology,":[50],"where":[51],"model":[52,81],"parameters":[53],"correspond":[54],"to":[55,59,77],"meaningful":[56],"biological":[57],"processes":[58],"support":[60,87],"interpretability,":[61],"personalization,":[62],"safe":[64],"drug":[65],"delivery,":[66],"such":[67],"as":[68],"total":[70],"intravenous":[71],"anesthesia.":[72],"To":[73],"conclude,":[74],"an":[75],"application":[76],"propofol":[79],"infusion":[80],"illustrates":[82],"how":[83],"physiologically":[88],"interpretable":[89],"representations.":[91]},"counts_by_year":[],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-12-03T00:00:00"}