{"id":"https://openalex.org/W7131440672","doi":"https://doi.org/10.1016/j.neuroimage.2026.121831","title":"Contrast input and manual interventions significantly affect FreeSurfer morphometry and clinical correlations","display_name":"Contrast input and manual interventions significantly affect FreeSurfer morphometry and clinical correlations","publication_year":2026,"publication_date":"2026-02-25","ids":{"openalex":"https://openalex.org/W7131440672","doi":"https://doi.org/10.1016/j.neuroimage.2026.121831","pmid":"https://pubmed.ncbi.nlm.nih.gov/41759954"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2026.121831","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.121831","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2026.121831","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063478209","display_name":"Haley Wiskoski","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Haley E. Wiskoski","raw_affiliation_strings":["Department of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA; Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":"https://orcid.org/0009-0004-2271-0406","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA; Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116558116","display_name":"Raza Mushtaq","orcid":null},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raza Mushtaq","raw_affiliation_strings":["Department of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, 85013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, 85013, USA","institution_ids":["https://openalex.org/I1324766304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126834196","display_name":"Simeon Smith","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simeon Smith","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126796895","display_name":"Caleb Boehler","orcid":null},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb Boehler","raw_affiliation_strings":["Department of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, 85013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, 85013, USA","institution_ids":["https://openalex.org/I1324766304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126790812","display_name":"Summan Zahra","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Summan Zahra","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126802942","display_name":"Juan C. Arias","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan C. Arias","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126844221","display_name":"Scott R. French","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott R. French","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118962993","display_name":"Gavin Culwell","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gavin Culwell","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126836812","display_name":"Loi Do","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loi Do","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117661768","display_name":"Cris Escareno","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cris Escareno","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117661767","display_name":"Emma Heitkamp","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Heitkamp","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057484556","display_name":"Franchell Vazquez","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franchell Vazquez","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014060810","display_name":"Edward J. Bedrick","orcid":"https://orcid.org/0000-0002-4215-795X"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2800531696","display_name":"Arizona Science Center","ror":"https://ror.org/05g3rxr48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800531696"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Bedrick","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona Health Sciences Center, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona Health Sciences Center, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I2800531696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126779566","display_name":"Kevin William Johnson","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Johnson","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073885095","display_name":"Mar\u00eda I. Altbach","orcid":"https://orcid.org/0000-0001-9368-2458"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Altbach","raw_affiliation_strings":["Department of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA; Department of Radiology and Imaging Sciences, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA; Department of Radiology and Imaging Sciences, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126812171","display_name":"Gene E. Alexander","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gene E. Alexander","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, 85721, USA; Department of Psychology, University of Arizona, Tucson, AZ, 85721, USA; Department of Psychiatry, Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, University of Arizona, Tucson, AZ, 85721, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, 85014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, 85721, USA; Department of Psychology, University of Arizona, Tucson, AZ, 85721, USA; Department of Psychiatry, Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, University of Arizona, Tucson, AZ, 85721, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, 85014, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081639252","display_name":"Theodore P. Trouard","orcid":"https://orcid.org/0000-0001-9461-2283"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore P. Trouard","raw_affiliation_strings":["Department of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA; Department of Radiology and Imaging Sciences, University of Arizona, Tucson, AZ, 85721, USA; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, 85721, USA; BIO5 Research Institute, University of Arizona, Tucson, AZ, 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA; Department of Radiology and Imaging Sciences, University of Arizona, Tucson, AZ, 85721, USA; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, 85721, USA; BIO5 Research Institute, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012686233","display_name":"Craig Weinkauf","orcid":"https://orcid.org/0000-0001-9696-5613"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig C. Weinkauf","raw_affiliation_strings":["Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA. Electronic address: cweinkauf@surgery.arizona.edu"],"raw_orcid":"https://orcid.org/0000-0001-9696-5613","affiliations":[{"raw_affiliation_string":"Division of Vascular Surgery, University of Arizona, Tucson, AZ, 85721, USA. Electronic address: cweinkauf@surgery.arizona.edu","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5063478209"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40491405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"329","issue":null,"first_page":"121831","last_page":"121831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.7348999977111816},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.6805999875068665},{"id":"https://openalex.org/keywords/brain-morphometry","display_name":"Brain morphometry","score":0.5763000249862671},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5479000210762024},{"id":"https://openalex.org/keywords/reproducibility","display_name":"Reproducibility","score":0.46959999203681946},{"id":"https://openalex.org/keywords/affect","display_name":"Affect (linguistics)","score":0.4693000018596649}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.7348999977111816},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.6805999875068665},{"id":"https://openalex.org/C145940234","wikidata":"https://www.wikidata.org/wiki/Q4955830","display_name":"Brain morphometry","level":3,"score":0.5763000249862671},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5479000210762024},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.46959999203681946},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.4693000018596649},{"id":"https://openalex.org/C33511622","wikidata":"https://www.wikidata.org/wiki/Q1851434","display_name":"Morphometrics","level":2,"score":0.43619999289512634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3790000081062317},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3402000069618225},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.3262999951839447},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31940001249313354},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3041999936103821},{"id":"https://openalex.org/C104996578","wikidata":"https://www.wikidata.org/wiki/Q827617","display_name":"Insula","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.26820001006126404},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.2590999901294708},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.25279998779296875}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuroimage.2026.121831","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.121831","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:41759954","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41759954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2026.121831","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.121831","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1976387731","display_name":null,"funder_award_id":"CTR056056","funder_id":"https://openalex.org/F4320332140","funder_display_name":"Arizona Biomedical Research Commission"},{"id":"https://openalex.org/G397643584","display_name":null,"funder_award_id":"P30 AG072980","funder_id":"https://openalex.org/F4320334288","funder_display_name":"Health Sciences, University of Arizona"},{"id":"https://openalex.org/G4280543281","display_name":null,"funder_award_id":"CTR056039","funder_id":"https://openalex.org/F4320332140","funder_display_name":"Arizona Biomedical Research Commission"},{"id":"https://openalex.org/G4558216502","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7854119329","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G8129333560","display_name":null,"funder_award_id":"R01AG070987","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8875290752","display_name":null,"funder_award_id":"R01 HL159200","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306134","display_name":"Doris Duke Charitable Foundation","ror":"https://ror.org/04n65rp89"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320311551","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517"},{"id":"https://openalex.org/F4320332140","display_name":"Arizona Biomedical Research Commission","ror":"https://ror.org/01smpj292"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334288","display_name":"Health Sciences, University of Arizona","ror":null},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320338487","display_name":"DoD Alzheimer's Disease Neuroimaging Initiative","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1983208069","https://openalex.org/W1983355263","https://openalex.org/W2004293194","https://openalex.org/W2015317023","https://openalex.org/W2025774809","https://openalex.org/W2035079822","https://openalex.org/W2042902316","https://openalex.org/W2101124066","https://openalex.org/W2101135654","https://openalex.org/W2105086806","https://openalex.org/W2110208125","https://openalex.org/W2110558605","https://openalex.org/W2113319997","https://openalex.org/W2122328291","https://openalex.org/W2124648012","https://openalex.org/W2127324977","https://openalex.org/W2133016346","https://openalex.org/W2136019660","https://openalex.org/W2139886607","https://openalex.org/W2151721316","https://openalex.org/W2155963684","https://openalex.org/W2157270343","https://openalex.org/W2157848968","https://openalex.org/W2196212278","https://openalex.org/W2205275466","https://openalex.org/W2507387536","https://openalex.org/W2803569743","https://openalex.org/W2888399000","https://openalex.org/W2893429152","https://openalex.org/W2912524930","https://openalex.org/W2965421074","https://openalex.org/W3012249566","https://openalex.org/W3020194344","https://openalex.org/W3159236653","https://openalex.org/W3198000198","https://openalex.org/W4241074797","https://openalex.org/W4286461920","https://openalex.org/W4312087275","https://openalex.org/W4361191003","https://openalex.org/W4379229306","https://openalex.org/W4381333309","https://openalex.org/W4385484220","https://openalex.org/W4387191018","https://openalex.org/W4394903788","https://openalex.org/W4401651286","https://openalex.org/W4411716119","https://openalex.org/W4411964437","https://openalex.org/W4412429765","https://openalex.org/W4412734540","https://openalex.org/W4412856946","https://openalex.org/W4413048541","https://openalex.org/W4414081990"],"related_works":[],"abstract_inverted_index":{"FreeSurfer":[0,63,166],"is":[1,189],"a":[2],"widely":[3],"used":[4],"software":[5],"for":[6,191],"quantification":[7],"of":[8,13,19,118,158,186,195],"brain":[9],"morphometrics":[10,64],"in":[11],"studies":[12,29],"neurodegeneration":[14],"and":[15,23,30,47,54,68,73,79,90,97,105,121,145,171,184,193],"aging.":[16],"However,":[17],"choice":[18,157],"input":[20,82,159],"MRI":[21],"contrast(s)":[22],"manual":[24,75,139,172],"editing":[25,140,173],"are":[26],"variable":[27],"across":[28,93,150,198],"their":[31],"influence":[32],"on":[33],"clinically":[34],"relevant":[35],"outcomes":[36,197],"remains":[37],"unclear.":[38],"Using":[39],"non-demented,":[40],"older-aged":[41],"participant":[42],"data":[43],"from":[44,65],"the":[45,116,133,175],"Carotid":[46],"Mind":[48],"study":[49],"(CAM;":[50],"N":[51,60],"=":[52,61],"123)":[53],"Alzheimer's":[55],"Disease":[56],"Neuroimaging":[57],"Initiative":[58],"(ADNI,":[59],"143),":[62],"T1-MPRAGE,":[66],"T1+T2-FLAIR,":[67],"T1+T2-SPACE":[69,96],"were":[70],"assessed":[71],"with":[72,168],"without":[74],"edits.":[76],"In":[77],"CAM":[78],"ADNI":[80],"cohorts,":[81],"contrast":[83,151,160],"significantly":[84],"affected":[85],"cortical":[86,102,125],"thickness,":[87],"surface":[88,107],"area,":[89],"volume":[91],"estimates":[92,104],"lobar":[94],"regions.":[95],"T1+T2-FLAIR":[98],"consistently":[99],"produced":[100,132],"greater":[101],"thickness":[103],"smaller":[106],"areas":[108],"than":[109],"T1-MPRAGE":[110,131,169],"alone.":[111],"These":[112,153],"systematic":[113],"differences":[114],"altered":[115],"detection":[117],"expected":[119],"age-":[120],"smoking-related":[122],"associations":[123],"to":[124],"thickness.":[126],"Expert":[127],"ratings":[128],"indicated":[129],"that":[130,156,181],"highest":[134],"baseline":[135],"segmentation":[136],"quality,":[137],"while":[138],"reliably":[141],"improved":[142],"this":[143],"quality":[144],"reduced":[146],"contrast-related":[147],"morphometric":[148,196],"biases":[149],"types.":[152],"results":[154],"suggest":[155],"may":[161],"introduce":[162],"non-biological":[163],"variation":[164],"into":[165],"morphometrics,":[167],"alone":[170],"yielding":[174],"most":[176],"reliable":[177],"outcomes.":[178],"This":[179],"indicates":[180],"careful":[182],"consideration":[183],"reporting":[185],"post-processing":[187],"protocols":[188],"critical":[190],"reproducibility":[192],"interpretation":[194],"cohorts.":[199]},"counts_by_year":[],"updated_date":"2026-04-26T08:31:28.666265","created_date":"2026-02-26T00:00:00"}