{"id":"https://openalex.org/W4225252144","doi":"https://doi.org/10.1016/j.neuroimage.2022.119243","title":"Examining the effect of chronic intranasal oxytocin administration on the neuroanatomy and behavior of three autism-related mouse models","display_name":"Examining the effect of chronic intranasal oxytocin administration on the neuroanatomy and behavior of three autism-related mouse models","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4225252144","doi":"https://doi.org/10.1016/j.neuroimage.2022.119243","pmid":"https://pubmed.ncbi.nlm.nih.gov/35508216"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2022.119243","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119243","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2022.119243","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024454716","display_name":"Zsuzsa Lindenmaier","orcid":"https://orcid.org/0000-0002-2895-3976"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Zsuzsa Lindenmaier","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Electronic address: zsu.lindenmaier@gmail.com","Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2895-3976","affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Electronic address: zsu.lindenmaier@gmail.com","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079310882","display_name":"Jacob Ellegood","orcid":"https://orcid.org/0000-0003-1504-3321"},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jacob Ellegood","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084728803","display_name":"Monique Stuive","orcid":null},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Monique Stuive","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077189965","display_name":"Kaitlyn Easson","orcid":"https://orcid.org/0000-0002-5650-3673"},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kaitlyn Easson","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085334412","display_name":"Yohan Yee","orcid":"https://orcid.org/0000-0001-7083-1932"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yohan Yee","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074344610","display_name":"Darren Fernandes","orcid":"https://orcid.org/0000-0002-0625-7515"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Darren Fernandes","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028689323","display_name":"Jane A. Foster","orcid":"https://orcid.org/0000-0002-8579-4705"},"institutions":[{"id":"https://openalex.org/I59293822","display_name":"St. Joseph\u2019s Healthcare Hamilton","ror":"https://ror.org/009z39p97","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I59293822"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jane Foster","raw_affiliation_strings":["Department of Psychiatry and Behavioral Neurosciences, McMaster University, St.Joseph's Healthcare, Hamilton, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Neurosciences, McMaster University, St.Joseph's Healthcare, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I59293822","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011012659","display_name":"Evdokia Anagnostou","orcid":"https://orcid.org/0000-0002-3455-9887"},"institutions":[{"id":"https://openalex.org/I2801420703","display_name":"Holland Bloorview Kids Rehabilitation Hospital","ror":"https://ror.org/03qea8398","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801420703"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Evdokia Anagnostou","raw_affiliation_strings":["Autism Research Center, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autism Research Center, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada","institution_ids":["https://openalex.org/I2801420703"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058105019","display_name":"Jason P. Lerch","orcid":"https://orcid.org/0000-0002-4871-8578"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210101881","display_name":"Wellcome Centre for Integrative Neuroimaging","ror":"https://ror.org/0172mzb45","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210101881","https://openalex.org/I87048295"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"Jason P. Lerch","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Wellcome Centre for Integrative NeuroImaging, University of Oxford, Oxford, United Kingdom","Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Wellcome Centre for Integrative NeuroImaging, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Wellcome Centre for Integrative NeuroImaging, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210101881"]},{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Wellcome Centre for Integrative NeuroImaging, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210101881","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5024454716"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":2.0369,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.85881247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"257","issue":null,"first_page":"119243","last_page":"119243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10699","display_name":"Primate Behavior and Ecology","score":0.9868999719619751,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroanatomy","display_name":"Neuroanatomy","score":0.8455091714859009},{"id":"https://openalex.org/keywords/oxytocin","display_name":"Oxytocin","score":0.7986903190612793},{"id":"https://openalex.org/keywords/autism","display_name":"Autism","score":0.706490695476532},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5517624020576477},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5214502215385437},{"id":"https://openalex.org/keywords/oxytocin-receptor","display_name":"Oxytocin receptor","score":0.5075277090072632},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.45562079548835754},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4403468072414398},{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.41431209444999695},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4114094376564026},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.19230583310127258},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18576553463935852},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.08528196811676025}],"concepts":[{"id":"https://openalex.org/C103378370","wikidata":"https://www.wikidata.org/wiki/Q948647","display_name":"Neuroanatomy","level":2,"score":0.8455091714859009},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.7986903190612793},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.706490695476532},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5517624020576477},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5214502215385437},{"id":"https://openalex.org/C181612422","wikidata":"https://www.wikidata.org/wiki/Q14908140","display_name":"Oxytocin receptor","level":3,"score":0.5075277090072632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45562079548835754},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4403468072414398},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.41431209444999695},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4114094376564026},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19230583310127258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18576553463935852},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.08528196811676025},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009445","descriptor_name":"Neuroanatomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009445","descriptor_name":"Neuroanatomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009445","descriptor_name":"Neuroanatomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012919","descriptor_name":"Social Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012919","descriptor_name":"Social Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012919","descriptor_name":"Social Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051860","descriptor_name":"Fragile X Mental Retardation Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051860","descriptor_name":"Fragile X Mental Retardation Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051860","descriptor_name":"Fragile X Messenger Ribonucleoprotein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuroimage.2022.119243","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119243","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:35508216","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35508216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:doaj.org/article:95fe065d86e04c59bae0dee97876a494","is_oa":true,"landing_page_url":"https://doaj.org/article/95fe065d86e04c59bae0dee97876a494","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 257, Iss , Pp 119243- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2022.119243","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119243","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310859","display_name":"Ontario Brain Institute","ror":"https://ror.org/05ecdew94"},{"id":"https://openalex.org/F4320311238","display_name":"Fondation Brain Canada","ror":"https://ror.org/01bcmwk98"},{"id":"https://openalex.org/F4320323139","display_name":"Azrieli Foundation","ror":"https://ror.org/009svts64"},{"id":"https://openalex.org/F4320323654","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57"},{"id":"https://openalex.org/F4320329131","display_name":"Kids Brain Health Network","ror":null},{"id":"https://openalex.org/F4320334392","display_name":"Health Canada","ror":"https://ror.org/05p8nb362"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W46255818","https://openalex.org/W759650844","https://openalex.org/W812470321","https://openalex.org/W1197974428","https://openalex.org/W1527304491","https://openalex.org/W1642338065","https://openalex.org/W1750764127","https://openalex.org/W1823169087","https://openalex.org/W1827567735","https://openalex.org/W1891773028","https://openalex.org/W1951724000","https://openalex.org/W1965939967","https://openalex.org/W1966295032","https://openalex.org/W1970928383","https://openalex.org/W1971321176","https://openalex.org/W1974565082","https://openalex.org/W1980625058","https://openalex.org/W1985576902","https://openalex.org/W1990725440","https://openalex.org/W1997120050","https://openalex.org/W1997981295","https://openalex.org/W2001999652","https://openalex.org/W2007655600","https://openalex.org/W2009431403","https://openalex.org/W2010456410","https://openalex.org/W2011113754","https://openalex.org/W2016423032","https://openalex.org/W2018530860","https://openalex.org/W2020374060","https://openalex.org/W2027637514","https://openalex.org/W2030850484","https://openalex.org/W2035269878","https://openalex.org/W2035561357","https://openalex.org/W2037021857","https://openalex.org/W2040622276","https://openalex.org/W2043581439","https://openalex.org/W2044266604","https://openalex.org/W2047270577","https://openalex.org/W2049356067","https://openalex.org/W2052578932","https://openalex.org/W2054356301","https://openalex.org/W2057498829","https://openalex.org/W2060947458","https://openalex.org/W2061553452","https://openalex.org/W2065016435","https://openalex.org/W2066838264","https://openalex.org/W2070389026","https://openalex.org/W2074726570","https://openalex.org/W2088620464","https://openalex.org/W2090046164","https://openalex.org/W2095069422","https://openalex.org/W2096358139","https://openalex.org/W2097364496","https://openalex.org/W2098277878","https://openalex.org/W2100638793","https://openalex.org/W2104582585","https://openalex.org/W2106919606","https://openalex.org/W2116573486","https://openalex.org/W2123491442","https://openalex.org/W2131051578","https://openalex.org/W2134806674","https://openalex.org/W2136145485","https://openalex.org/W2136891170","https://openalex.org/W2141796362","https://openalex.org/W2145850516","https://openalex.org/W2146332995","https://openalex.org/W2146678743","https://openalex.org/W2146727059","https://openalex.org/W2163274894","https://openalex.org/W2216419462","https://openalex.org/W2253101848","https://openalex.org/W2284518303","https://openalex.org/W2292938069","https://openalex.org/W2301452501","https://openalex.org/W2316811866","https://openalex.org/W2437503399","https://openalex.org/W2438632701","https://openalex.org/W2514199772","https://openalex.org/W2554596146","https://openalex.org/W2566979214","https://openalex.org/W2584425130","https://openalex.org/W2595560054","https://openalex.org/W2613152254","https://openalex.org/W2753247456","https://openalex.org/W2754170262","https://openalex.org/W2756096060","https://openalex.org/W2758053316","https://openalex.org/W2783778692","https://openalex.org/W2789329186","https://openalex.org/W2790186425","https://openalex.org/W2803810267","https://openalex.org/W2810744002","https://openalex.org/W2893539678","https://openalex.org/W2912308393","https://openalex.org/W2945853245","https://openalex.org/W2990589677","https://openalex.org/W2998881907","https://openalex.org/W3000114612","https://openalex.org/W3000167470","https://openalex.org/W3040621325","https://openalex.org/W3087713769","https://openalex.org/W3119880798","https://openalex.org/W3120256748","https://openalex.org/W3145961904","https://openalex.org/W3206744275","https://openalex.org/W6637037342","https://openalex.org/W6661606298","https://openalex.org/W6665804894","https://openalex.org/W6732593081","https://openalex.org/W6737346572"],"related_works":["https://openalex.org/W2132648106","https://openalex.org/W4235489569","https://openalex.org/W4380149088","https://openalex.org/W2051548602","https://openalex.org/W4254694048","https://openalex.org/W2027958963","https://openalex.org/W2291241852","https://openalex.org/W2774915408","https://openalex.org/W4375859936","https://openalex.org/W1608517055"],"abstract_inverted_index":{"Although":[0],"initially":[1],"showing":[2],"great":[3],"potential,":[4],"oxytocin":[5,28,59,84,108,215,302],"treatment":[6,45,85,105,256,272,280,287,300],"has":[7],"encountered":[8],"a":[9,51,74,95,183,268,282],"translational":[10],"hurdle":[11],"in":[12,50,86,160,174,200,212,224,262,275],"its":[13],"promise":[14],"of":[15,20,27,43,53,120,138,148,219,247,255,264,271,318],"treating":[16],"the":[17,25,32,40,123,136,145,157,198,220,238,245,265,276,307],"social":[18,228,260],"deficits":[19],"autism.":[21],"Some":[22],"debate":[23],"surrounds":[24],"ability":[26],"to":[29,56,92,101,122,144,196,214,312],"successfully":[30],"enter":[31],"brain,":[33],"and":[34,63,103,130,163,182,207,230,314],"therefore":[35],"modify":[36],"neuroanatomy.":[37],"Moreover,":[38],"given":[39],"heterogeneous":[41],"nature":[42],"autism,":[44,313],"will":[46],"only":[47],"amerliorate":[48],"symptoms":[49],"subset":[52,104],"patients.":[54],"Therefore,":[55],"determine":[57],"whether":[58,64],"changes":[60,199],"brain":[61],"circuitry,":[62],"it":[65],"does":[66],"so":[67],"variably,":[68],"depending":[69],"on":[70,81,97,237,259,289,306],"genotype,":[71],"we":[72],"implemented":[73],"large":[75],"randomized,":[76],"blinded,":[77],"placebo-controlled,":[78],"preclinical":[79],"study":[80],"chronic":[82,299],"intranasal":[83],"three":[87,173,308],"different":[88],"mouse":[89,133,309],"models":[90,310],"related":[91,311],"autism":[93],"with":[94,153,168,189,279,301],"focus":[96],"using":[98,202],"neuroanatomical":[99],"phenotypes":[100],"assess":[102,197],"response.":[106],"Intranasal":[107],"(0.6IU)":[109],"was":[110,222,250,257,273,291],"administered":[111],"daily,":[112],"for":[113],"28":[114],"days,":[115],"starting":[116],"at":[117],"5":[118],"weeks":[119],"age":[121],"16p11.2":[124],"deletion,":[125],"Shank3":[126],"(exon":[127],"4-9)":[128],"knockout,":[129],"Fmr1":[131,277],"knockout":[132],"models.":[134],"Given":[135],"sensitivity":[137],"structural":[139],"magnetic":[140],"resonance":[141],"imaging":[142,167],"(MRI)":[143],"neurological":[146],"effects":[147,249,305],"interventions":[149],"like":[150],"drugs,":[151],"along":[152],"many":[154],"other":[155,286],"advantages,":[156],"mice":[158,221],"underwent":[159],"vivo":[161,166,175,194],"longitudinal":[162],"high-resolution":[164],"ex":[165,193],"MRI.":[169],"The":[170,217],"scans":[171,181],"included":[172],"T1weighted,":[176],"90":[177],"um":[178],"isotropic":[179,191],"resolution":[180,192],"T2-weighted,":[184],"3D":[185],"fast":[186],"spin":[187],"echo":[188],"40um":[190],"scan":[195],"neuroanatomy":[201,239],"established":[203],"automated":[204],"image":[205],"registration":[206],"deformation":[208],"based":[209],"morphometry":[210],"approaches":[211],"response":[213,319],"treatment.":[216],"behavior":[218,261,290],"assessed":[223],"multiple":[225,295],"domains,":[226],"including":[227],"behaviours":[229],"repetitive":[231],"behaviours,":[232],"among":[233],"others.":[234],"Treatment":[235],"effect":[236,254,270,288],"did":[240],"not":[241],"reach":[242],"significance,":[243],"although":[244,267],"pattern":[246,317],"trending":[248],"promising.":[251],"No":[252,285],"significant":[253,269],"found":[258,274],"any":[263],"strains,":[266],"mouse,":[278],"normalizing":[281],"grooming":[283],"deficit.":[284],"observed":[292],"that":[293],"survived":[294],"comparisons":[296],"correction.":[297],"Overall,":[298],"had":[303],"limited":[304],"no":[315],"promising":[316],"susceptibility":[320],"emerged.":[321]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-20T07:56:41.581041","created_date":"2022-05-04T00:00:00"}
