{"id":"https://openalex.org/W4281396788","doi":"https://doi.org/10.1016/j.compchemeng.2022.107855","title":"Dynamic simulation, optimisation and economic analysis of fed-batch vs. perfusion bioreactors for advanced mAb manufacturing","display_name":"Dynamic simulation, optimisation and economic analysis of fed-batch vs. perfusion bioreactors for advanced mAb manufacturing","publication_year":2022,"publication_date":"2022-05-24","ids":{"openalex":"https://openalex.org/W4281396788","doi":"https://doi.org/10.1016/j.compchemeng.2022.107855"},"language":"en","primary_location":{"id":"doi:10.1016/j.compchemeng.2022.107855","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compchemeng.2022.107855","pdf_url":null,"source":{"id":"https://openalex.org/S150671403","display_name":"Computers & Chemical Engineering","issn_l":"0098-1354","issn":["0098-1354","1873-4375"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers & Chemical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.research.ed.ac.uk/en/publications/3c6bb282-86b7-480a-9253-80a858f7bedb","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004333455","display_name":"Wil Jones","orcid":null},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wil Jones","raw_affiliation_strings":["Institute for Materials and Processes (IMP), School of Engineering, University of Edinburgh, The Kings Buildings, Edinburgh, EH9 3FB, Scotland, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Materials and Processes (IMP), School of Engineering, University of Edinburgh, The Kings Buildings, Edinburgh, EH9 3FB, Scotland, U.K","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042757280","display_name":"Dimitrios I. Gerogiorgis","orcid":"https://orcid.org/0000-0002-2210-6784"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dimitrios I. Gerogiorgis","raw_affiliation_strings":["Institute for Materials and Processes (IMP), School of Engineering, University of Edinburgh, The Kings Buildings, Edinburgh, EH9 3FB, Scotland, U.K"],"raw_orcid":"https://orcid.org/0000-0002-2210-6784","affiliations":[{"raw_affiliation_string":"Institute for Materials and Processes (IMP), School of Engineering, University of Edinburgh, The Kings Buildings, Edinburgh, EH9 3FB, Scotland, U.K","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042757280"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":null,"fwci":0.9233,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.71885929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"165","issue":null,"first_page":"107855","last_page":"107855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioreactor","display_name":"Bioreactor","score":0.632163941860199},{"id":"https://openalex.org/keywords/monoclonal-antibody","display_name":"Monoclonal antibody","score":0.6225048303604126},{"id":"https://openalex.org/keywords/process-engineering","display_name":"Process engineering","score":0.5435041189193726},{"id":"https://openalex.org/keywords/fed-batch-culture","display_name":"Fed-batch culture","score":0.49555981159210205},{"id":"https://openalex.org/keywords/yield","display_name":"Yield (engineering)","score":0.4787968099117279},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.43578192591667175},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4349803924560547},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.42942774295806885},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.42777183651924133},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3038397431373596},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2675008773803711},{"id":"https://openalex.org/keywords/food-science","display_name":"Food science","score":0.1859152913093567},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.18205443024635315},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1717679500579834},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.1537250280380249},{"id":"https://openalex.org/keywords/fermentation","display_name":"Fermentation","score":0.10459473729133606},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.08098635077476501}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.632163941860199},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6225048303604126},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.5435041189193726},{"id":"https://openalex.org/C167431671","wikidata":"https://www.wikidata.org/wiki/Q372004","display_name":"Fed-batch culture","level":3,"score":0.49555981159210205},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.4787968099117279},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.43578192591667175},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4349803924560547},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.42942774295806885},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.42777183651924133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3038397431373596},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2675008773803711},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.1859152913093567},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18205443024635315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1717679500579834},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1537250280380249},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.10459473729133606},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08098635077476501},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compchemeng.2022.107855","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compchemeng.2022.107855","pdf_url":null,"source":{"id":"https://openalex.org/S150671403","display_name":"Computers & Chemical Engineering","issn_l":"0098-1354","issn":["0098-1354","1873-4375"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers & Chemical Engineering","raw_type":"journal-article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/3c6bb282-86b7-480a-9253-80a858f7bedb","is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/3c6bb282-86b7-480a-9253-80a858f7bedb","pdf_url":null,"source":{"id":"https://openalex.org/S4406922455","display_name":"Edinburgh Research Explorer","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jones, W & Gerogiorgis, D I 2022, 'Dynamic simulation, optimisation AND ECONOMIC ANALYSIS of FED-BATCH vs. perfusion bioreactors for advanced mAb manufacturing', Computers and Chemical Engineering, vol. 165, 107855, pp. 107855. https://doi.org/10.1016/j.compchemeng.2022.107855","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.ed.ac.uk:openaire/3c6bb282-86b7-480a-9253-80a858f7bedb","is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/3c6bb282-86b7-480a-9253-80a858f7bedb","pdf_url":null,"source":{"id":"https://openalex.org/S4406922455","display_name":"Edinburgh Research Explorer","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jones, W & Gerogiorgis, D I 2022, 'Dynamic simulation, optimisation AND ECONOMIC ANALYSIS of FED-BATCH vs. perfusion bioreactors for advanced mAb manufacturing', Computers and Chemical Engineering, vol. 165, 107855, pp. 107855. https://doi.org/10.1016/j.compchemeng.2022.107855","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W264698278","https://openalex.org/W280875868","https://openalex.org/W562798361","https://openalex.org/W611910213","https://openalex.org/W1485541800","https://openalex.org/W1516663666","https://openalex.org/W1518541098","https://openalex.org/W1580407891","https://openalex.org/W1770883461","https://openalex.org/W1786299986","https://openalex.org/W1918896129","https://openalex.org/W1965420754","https://openalex.org/W1965476065","https://openalex.org/W1973162672","https://openalex.org/W1991629863","https://openalex.org/W1991810959","https://openalex.org/W2004033531","https://openalex.org/W2018033335","https://openalex.org/W2018908069","https://openalex.org/W2023865429","https://openalex.org/W2025592823","https://openalex.org/W2034963044","https://openalex.org/W2041505178","https://openalex.org/W2044416804","https://openalex.org/W2046290625","https://openalex.org/W2048964884","https://openalex.org/W2059109233","https://openalex.org/W2059503811","https://openalex.org/W2064261678","https://openalex.org/W2065303540","https://openalex.org/W2066564017","https://openalex.org/W2084655770","https://openalex.org/W2086795525","https://openalex.org/W2094052190","https://openalex.org/W2120323942","https://openalex.org/W2121153240","https://openalex.org/W2131774841","https://openalex.org/W2139042099","https://openalex.org/W2147401031","https://openalex.org/W2169799220","https://openalex.org/W2182560059","https://openalex.org/W2184414076","https://openalex.org/W2188846870","https://openalex.org/W2198144363","https://openalex.org/W2276836084","https://openalex.org/W2300303305","https://openalex.org/W2317051169","https://openalex.org/W2463313009","https://openalex.org/W2513769763","https://openalex.org/W2594804322","https://openalex.org/W2605426887","https://openalex.org/W2606083379","https://openalex.org/W2763110750","https://openalex.org/W2788021539","https://openalex.org/W2791949372","https://openalex.org/W2804723305","https://openalex.org/W2810851878","https://openalex.org/W2886304835","https://openalex.org/W2901902274","https://openalex.org/W2907846571","https://openalex.org/W2913679609","https://openalex.org/W2917928050","https://openalex.org/W2920890493","https://openalex.org/W2950543536","https://openalex.org/W2966080905","https://openalex.org/W2971940586","https://openalex.org/W2994701212","https://openalex.org/W2999958881","https://openalex.org/W3011553246","https://openalex.org/W3034462707","https://openalex.org/W3041123143","https://openalex.org/W3041959031","https://openalex.org/W3096518032","https://openalex.org/W3106692933","https://openalex.org/W3125235483","https://openalex.org/W3131730395","https://openalex.org/W3135506815","https://openalex.org/W3139231116","https://openalex.org/W3205987850","https://openalex.org/W4233309702","https://openalex.org/W4234236132","https://openalex.org/W4253513600","https://openalex.org/W4299940692","https://openalex.org/W6605104575","https://openalex.org/W6635534142","https://openalex.org/W6656243374","https://openalex.org/W6677747675","https://openalex.org/W6678109219","https://openalex.org/W6686877405","https://openalex.org/W6726241895","https://openalex.org/W6748136154","https://openalex.org/W6748386096"],"related_works":["https://openalex.org/W1980740090","https://openalex.org/W2818141943","https://openalex.org/W4285187183","https://openalex.org/W2552994593","https://openalex.org/W2892231651","https://openalex.org/W19926866","https://openalex.org/W2092409665","https://openalex.org/W2376673900","https://openalex.org/W2025456229","https://openalex.org/W2163269605"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}