{"id":"https://openalex.org/W4410736454","doi":"https://doi.org/10.1016/j.compbiomed.2025.110444","title":"Illicit uptake of peptide-based antibiotics through bacterial peptide transporters: an approach towards overcoming drug resistance","display_name":"Illicit uptake of peptide-based antibiotics through bacterial peptide transporters: an approach towards overcoming drug resistance","publication_year":2025,"publication_date":"2025-05-26","ids":{"openalex":"https://openalex.org/W4410736454","doi":"https://doi.org/10.1016/j.compbiomed.2025.110444","pmid":"https://pubmed.ncbi.nlm.nih.gov/40435673"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiomed.2025.110444","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.110444","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101636990","display_name":"Kalyan Ghosh","orcid":"https://orcid.org/0000-0002-7936-5103"},"institutions":[{"id":"https://openalex.org/I1317621060","display_name":"Indian Institute of Technology Guwahati","ror":"https://ror.org/0022nd079","country_code":"IN","type":"education","lineage":["https://openalex.org/I1317621060"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kalyan Ghosh","raw_affiliation_strings":["Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India","institution_ids":["https://openalex.org/I1317621060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078562557","display_name":"Shankar Prasad Kanaujia","orcid":"https://orcid.org/0000-0001-9179-5723"},"institutions":[{"id":"https://openalex.org/I1317621060","display_name":"Indian Institute of Technology Guwahati","ror":"https://ror.org/0022nd079","country_code":"IN","type":"education","lineage":["https://openalex.org/I1317621060"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shankar Prasad Kanaujia","raw_affiliation_strings":["Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India. Electronic address: spkanaujia@iitg.ac.in"],"raw_orcid":"https://orcid.org/0000-0001-9179-5723","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India. Electronic address: spkanaujia@iitg.ac.in","institution_ids":["https://openalex.org/I1317621060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078562557"],"corresponding_institution_ids":["https://openalex.org/I1317621060"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":null,"fwci":1.5551,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.82458072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"193","issue":null,"first_page":"110444","last_page":"110444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.7897603511810303},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.6905162334442139},{"id":"https://openalex.org/keywords/transporter","display_name":"Transporter","score":0.6108649969100952},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6091824769973755},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5651559829711914},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5541547536849976},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.47053155303001404},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"Antibiotic resistance","score":0.43844375014305115},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.4180172085762024},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3269367814064026},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.301780641078949},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2909016013145447},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08349624276161194}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7897603511810303},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6905162334442139},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6108649969100952},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6091824769973755},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5651559829711914},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5541547536849976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47053155303001404},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.43844375014305115},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4180172085762024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3269367814064026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.301780641078949},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2909016013145447},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08349624276161194}],"mesh":[{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiomed.2025.110444","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.110444","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:40435673","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40435673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in biology and medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2424119749","display_name":null,"funder_award_id":"BT/PR42098/BRB/10/1981/2021","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320327457","display_name":"Indian Institute of Technology Guwahati","ror":"https://ror.org/0022nd079"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1488018404","https://openalex.org/W1541731209","https://openalex.org/W1896997094","https://openalex.org/W1970581996","https://openalex.org/W1971961760","https://openalex.org/W1973166464","https://openalex.org/W1977497036","https://openalex.org/W1981737096","https://openalex.org/W1988594738","https://openalex.org/W1991727834","https://openalex.org/W1996825380","https://openalex.org/W2005480696","https://openalex.org/W2006316868","https://openalex.org/W2008872195","https://openalex.org/W2016489607","https://openalex.org/W2016666824","https://openalex.org/W2021665917","https://openalex.org/W2035687084","https://openalex.org/W2036199133","https://openalex.org/W2038532826","https://openalex.org/W2049222379","https://openalex.org/W2057477511","https://openalex.org/W2059013803","https://openalex.org/W2067521070","https://openalex.org/W2072290699","https://openalex.org/W2074473216","https://openalex.org/W2076842500","https://openalex.org/W2080678969","https://openalex.org/W2081693079","https://openalex.org/W2083771158","https://openalex.org/W2086153842","https://openalex.org/W2090353525","https://openalex.org/W2094162382","https://openalex.org/W2105668062","https://openalex.org/W2117527435","https://openalex.org/W2124026197","https://openalex.org/W2130479394","https://openalex.org/W2144288821","https://openalex.org/W2149869218","https://openalex.org/W2160451368","https://openalex.org/W2166225722","https://openalex.org/W2169678694","https://openalex.org/W2177317049","https://openalex.org/W2292301738","https://openalex.org/W2329148016","https://openalex.org/W2420145262","https://openalex.org/W2470678698","https://openalex.org/W2506998092","https://openalex.org/W2593436234","https://openalex.org/W2767891136","https://openalex.org/W2794981757","https://openalex.org/W2898283034","https://openalex.org/W2913827760","https://openalex.org/W2954094311","https://openalex.org/W2966910054","https://openalex.org/W3002782444","https://openalex.org/W3036997165","https://openalex.org/W3107020332","https://openalex.org/W3125404376","https://openalex.org/W3136987411","https://openalex.org/W3156458251","https://openalex.org/W3177828909","https://openalex.org/W3191346466","https://openalex.org/W3202287440","https://openalex.org/W3207552273","https://openalex.org/W4211238209","https://openalex.org/W4378783128","https://openalex.org/W4390885516","https://openalex.org/W4404961170","https://openalex.org/W4406015449","https://openalex.org/W4406692153","https://openalex.org/W4408568272","https://openalex.org/W4408975125","https://openalex.org/W6749487808","https://openalex.org/W7073602326"],"related_works":["https://openalex.org/W2955020749","https://openalex.org/W2029063045","https://openalex.org/W2507683919","https://openalex.org/W2076505260","https://openalex.org/W4320037900","https://openalex.org/W4226193097","https://openalex.org/W4297123388","https://openalex.org/W3032187068","https://openalex.org/W4221083638","https://openalex.org/W3152803520"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-01-20T17:24:06.736184","created_date":"2025-10-10T00:00:00"}