{"id":"https://openalex.org/W4405431538","doi":"https://doi.org/10.1016/j.compbiomed.2024.109508","title":"L-MAE: Longitudinal masked auto-encoder with time and severity-aware encoding for diabetic retinopathy progression prediction","display_name":"L-MAE: Longitudinal masked auto-encoder with time and severity-aware encoding for diabetic retinopathy progression prediction","publication_year":2024,"publication_date":"2024-12-16","ids":{"openalex":"https://openalex.org/W4405431538","doi":"https://doi.org/10.1016/j.compbiomed.2024.109508","pmid":"https://pubmed.ncbi.nlm.nih.gov/39689525"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiomed.2024.109508","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2024.109508","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.compbiomed.2024.109508","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069526099","display_name":"Rachid Zeghlache","orcid":"https://orcid.org/0000-0001-6328-3560"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I161929037","display_name":"Universit\u00e9 de Bretagne Occidentale","ror":"https://ror.org/01b8h3982","country_code":"FR","type":"education","lineage":["https://openalex.org/I161929037"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rachid Zeghlache","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France. Electronic address: rachid.zeghlache@univ-brest.fr"],"raw_orcid":"https://orcid.org/0000-0001-6328-3560","affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France. Electronic address: rachid.zeghlache@univ-brest.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I161929037","https://openalex.org/I4210161065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103324658","display_name":"Pierre-Henri Conze","orcid":"https://orcid.org/0000-0003-2214-3654"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210127572","display_name":"IMT Atlantique","ror":"https://ror.org/030hj3061","country_code":"FR","type":"education","lineage":["https://openalex.org/I205703379","https://openalex.org/I4210127572"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Henri Conze","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France; IMT Atlantique, Brest, France"],"raw_orcid":"https://orcid.org/0000-0003-2214-3654","affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France; IMT Atlantique, Brest, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210127572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027972689","display_name":"Mostafa El Habib Daho","orcid":"https://orcid.org/0000-0002-0318-0049"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mostafa El Habib Daho","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France"],"raw_orcid":"https://orcid.org/0000-0002-0318-0049","affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210161065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100630217","display_name":"Yihao Li","orcid":"https://orcid.org/0000-0003-1900-8099"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yihao Li","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210161065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004203319","display_name":"Alireza Rezaei","orcid":"https://orcid.org/0000-0001-7047-2909"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alireza Rezaei","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210161065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083156286","display_name":"Hugo Le Boit\u00e9","orcid":null},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hugo Le Boit\u00e9","raw_affiliation_strings":["Sorbonne University, Paris, France; Ophthalmology Department, Lariboisi\u00e8re Hospital, AP-HP, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-2502-4119","affiliations":[{"raw_affiliation_string":"Sorbonne University, Paris, France; Ophthalmology Department, Lariboisi\u00e8re Hospital, AP-HP, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083564913","display_name":"Ramin Tadayoni","orcid":"https://orcid.org/0000-0001-5616-3579"},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ramin Tadayoni","raw_affiliation_strings":["Ophthalmology Department, Lariboisi\u00e8re Hospital, AP-HP, Paris, France; Paris Cit\u00e9 University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Lariboisi\u00e8re Hospital, AP-HP, Paris, France; Paris Cit\u00e9 University, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076547399","display_name":"Pascal Massin","orcid":null},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Massin","raw_affiliation_strings":["Ophthalmology Department, Lariboisi\u00e8re Hospital, AP-HP, Paris, France; Paris Cit\u00e9 University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Lariboisi\u00e8re Hospital, AP-HP, Paris, France; Paris Cit\u00e9 University, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089956527","display_name":"B\u00e9atrice Cochener","orcid":"https://orcid.org/0000-0001-9718-7307"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210132604","display_name":"Centre Hospitalier R\u00e9gional Universitaire de Brest","ror":"https://ror.org/03evbwn87","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210132604","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B\u00e9atrice Cochener","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France; Ophthalmology Department, CHRU Brest, Brest, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France; Ophthalmology Department, CHRU Brest, Brest, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210132604","https://openalex.org/I4210161065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058773320","display_name":"Ikram Brahim","orcid":"https://orcid.org/0000-0001-6394-7179"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ikram Brahim","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France; INSERM U1227 Lymphocytes B et Autoimmunite (LBAI), Brest, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France; INSERM U1227 Lymphocytes B et Autoimmunite (LBAI), Brest, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210161065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028479581","display_name":"Gwenol\u00e9 Quellec","orcid":"https://orcid.org/0000-0003-1669-7140"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gwenol\u00e9 Quellec","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France"],"raw_orcid":"https://orcid.org/0000-0003-1669-7140","affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210161065"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002302573","display_name":"M. Lamard","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathieu Lamard","raw_affiliation_strings":["LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm, Brest, France; University of Western Brittany, Brest, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210161065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3080,"currency":"USD","value_usd":3080},"apc_paid":{"value":3080,"currency":"USD","value_usd":3080},"fwci":1.2779,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80639582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"185","issue":null,"first_page":"109508","last_page":"109508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11775","display_name":"COVID-19 diagnosis using AI","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/encoding","display_name":"Encoding (memory)","score":0.6039302349090576},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"Diabetic retinopathy","score":0.6019144058227539},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5650976300239563},{"id":"https://openalex.org/keywords/encoder","display_name":"Encoder","score":0.5440484881401062},{"id":"https://openalex.org/keywords/longitudinal-study","display_name":"Longitudinal study","score":0.49733999371528625},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.41076576709747314},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3639075756072998},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.23258599638938904}],"concepts":[{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.6039302349090576},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.6019144058227539},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5650976300239563},{"id":"https://openalex.org/C118505674","wikidata":"https://www.wikidata.org/wiki/Q42586063","display_name":"Encoder","level":2,"score":0.5440484881401062},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.49733999371528625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41076576709747314},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3639075756072998},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.23258599638938904},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.compbiomed.2024.109508","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2024.109508","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:39689525","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39689525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in biology and medicine","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04815207v1","is_oa":true,"landing_page_url":"https://imt-atlantique.hal.science/hal-04815207","pdf_url":"https://imt-atlantique.hal.science/hal-04815207/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computers in Biology and Medicine, 2024, 185 (February 2025), pp.109508. ⟨10.1016/j.compbiomed.2024.109508⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.compbiomed.2024.109508","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2024.109508","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3307457880","display_name":"Evaluation intelligente de la r\u00e9tinopathie diab\u00e9tique","funder_award_id":"ANR-18-RHUS-0008","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4656594441","display_name":null,"funder_award_id":"ANR18","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1966206262","https://openalex.org/W2114605070","https://openalex.org/W2742491462","https://openalex.org/W2896457183","https://openalex.org/W2907172394","https://openalex.org/W2913954081","https://openalex.org/W2963745697","https://openalex.org/W2972869264","https://openalex.org/W3003864320","https://openalex.org/W3005680577","https://openalex.org/W3035524453","https://openalex.org/W3048737435","https://openalex.org/W3092890579","https://openalex.org/W3094309160","https://openalex.org/W3094502228","https://openalex.org/W3108717672","https://openalex.org/W3160145803","https://openalex.org/W3165183789","https://openalex.org/W3167044851","https://openalex.org/W3173650575","https://openalex.org/W3175311671","https://openalex.org/W3183172876","https://openalex.org/W3195577433","https://openalex.org/W3203435379","https://openalex.org/W3205531882","https://openalex.org/W3210279979","https://openalex.org/W4214612132","https://openalex.org/W4249914127","https://openalex.org/W4280490805","https://openalex.org/W4281758439","https://openalex.org/W4283318077","https://openalex.org/W4292162382","https://openalex.org/W4295689449","https://openalex.org/W4313156423","https://openalex.org/W4313365045","https://openalex.org/W4320481312","https://openalex.org/W4362603432","https://openalex.org/W4362604465","https://openalex.org/W4376166993","https://openalex.org/W4381186824","https://openalex.org/W4381333121","https://openalex.org/W4385245566","https://openalex.org/W4385321423","https://openalex.org/W4385336375","https://openalex.org/W4386697749","https://openalex.org/W4386761084","https://openalex.org/W4386851907","https://openalex.org/W4386884172","https://openalex.org/W4390344735","https://openalex.org/W4390588537","https://openalex.org/W4390832629","https://openalex.org/W4395096959","https://openalex.org/W4395450210","https://openalex.org/W4399728346","https://openalex.org/W4401479535","https://openalex.org/W4403654787","https://openalex.org/W6654335291","https://openalex.org/W6717243457","https://openalex.org/W6765671628","https://openalex.org/W6779162283","https://openalex.org/W6840490641","https://openalex.org/W6842951055","https://openalex.org/W6857063791","https://openalex.org/W6860374873"],"related_works":["https://openalex.org/W4390516098","https://openalex.org/W2181948922","https://openalex.org/W2384362569","https://openalex.org/W2142795561","https://openalex.org/W4205302943","https://openalex.org/W2561132942","https://openalex.org/W3155418658","https://openalex.org/W4243199227","https://openalex.org/W2129146436","https://openalex.org/W2032507829"],"abstract_inverted_index":{"Pre-training":[0],"strategies":[1],"based":[2,169],"on":[3,81,170],"self-supervised":[4],"learning":[5],"(SSL)":[6],"have":[7],"demonstrated":[8],"success":[9],"as":[10],"pretext":[11,55],"tasks":[12,15,56],"for":[13,65,112,148],"downstream":[14],"in":[16,123,215],"computer":[17],"vision.":[18],"However,":[19],"while":[20],"SSL":[21,54],"methods":[22],"are":[23],"often":[24,57],"domain-agnostic,":[25],"their":[26],"direct":[27],"application":[28],"to":[29,35,49,131,193],"medical":[30,40],"imaging":[31],"is":[32,63],"challenging":[33],"due":[34],"the":[36,59,82,105,119,140,159,163,179,184,208],"distinct":[37],"nature":[38],"of":[39,115,211],"images,":[41],"including":[42],"specific":[43],"anatomical":[44],"and":[45,92,183,197],"temporal":[46,116],"patterns":[47],"relevant":[48],"disease":[50,94,126,136,185],"progression.":[51],"Additionally,":[52],"traditional":[53,99],"lack":[58],"contextual":[60],"knowledge":[61],"that":[62,79,177],"essential":[64],"clinical":[66],"decision":[67],"support.":[68],"In":[69],"this":[70,216],"paper,":[71],"we":[72,152],"developed":[73],"a":[74,88,93,143],"longitudinal":[75,145,199],"masked":[76],"auto-encoder":[77],"(MAE)":[78],"builds":[80],"Transformer-based":[83],"MAE":[84],"architecture,":[85],"specifically":[86],"introducing":[87],"time-aware":[89,180],"position":[90,181],"embedding":[91,182],"progression-aware":[95],"masking":[96,120,187],"strategy.":[97],"Unlike":[98],"sequential":[100],"approaches,":[101],"our":[102,154],"method":[103],"incorporates":[104],"actual":[106],"time":[107],"intervals":[108],"between":[109],"examinations,":[110],"allowing":[111],"better":[113],"capture":[114,132],"trends.":[117],"Furthermore,":[118],"strategy":[121],"evolves":[122],"alignment":[124],"with":[125],"progression":[127,137],"during":[128],"follow-up":[129],"exams":[130],"pathological":[133],"changes,":[134],"improving":[135],"assessments.":[138],"Using":[139],"OPHDIAT":[141],"dataset,":[142],"large-scale":[144],"screening":[146],"dataset":[147],"diabetic":[149],"retinopathy":[150],"(DR),":[151],"evaluated":[153],"pre-trained":[155],"model":[156],"by":[157],"predicting":[158],"severity":[160],"level":[161],"at":[162],"next":[164],"visit":[165],"within":[166],"three":[167],"years,":[168],"past":[171],"examination":[172],"series.":[173],"Our":[174],"findings":[175],"demonstrate":[176],"both":[178],"progression-informed":[186],"significantly":[188],"enhance":[189],"predictive":[190,209],"accuracy.":[191],"Compared":[192],"conventional":[194],"baseline":[195],"models":[196,214],"standard":[198],"Transformers,":[200],"these":[201],"simple":[202],"yet":[203],"effective":[204],"adaptations":[205],"substantially":[206],"improve":[207],"power":[210],"deep":[212],"classification":[213],"domain.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}