{"id":"https://openalex.org/W4416408453","doi":"https://doi.org/10.1016/j.compbiolchem.2025.108788","title":"Computational modeling of anti-VEGFA drug interactions with VEGF-A: Insights into therapeutic strategies for neovascular AMD","display_name":"Computational modeling of anti-VEGFA drug interactions with VEGF-A: Insights into therapeutic strategies for neovascular AMD","publication_year":2025,"publication_date":"2025-11-20","ids":{"openalex":"https://openalex.org/W4416408453","doi":"https://doi.org/10.1016/j.compbiolchem.2025.108788","pmid":"https://pubmed.ncbi.nlm.nih.gov/41265309"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2025.108788","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2025.108788","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.compbiolchem.2025.108788","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061426020","display_name":"A Parra","orcid":"https://orcid.org/0000-0001-5908-8092"},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"\u00c1ngel Parra-S\u00e1nchez","raw_affiliation_strings":["Neuroprosthesis and Visual Rehabilitation Laboratory, Bioengineering Institute, University Miguel Hern\u00e1ndez of Elche, Elche 03202, Spain. Electronic address: a.parra@umh.es"],"raw_orcid":"https://orcid.org/0000-0001-5908-8092","affiliations":[{"raw_affiliation_string":"Neuroprosthesis and Visual Rehabilitation Laboratory, Bioengineering Institute, University Miguel Hern\u00e1ndez of Elche, Elche 03202, Spain. Electronic address: a.parra@umh.es","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120657680","display_name":"Alba Rom\u00e1n-Vallina","orcid":null},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alba Rom\u00e1n-Vallina","raw_affiliation_strings":["Neuroprosthesis and Visual Rehabilitation Laboratory, Bioengineering Institute, University Miguel Hern\u00e1ndez of Elche, Elche 03202, Spain. Electronic address: alba.roman01@goumh.umh.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprosthesis and Visual Rehabilitation Laboratory, Bioengineering Institute, University Miguel Hern\u00e1ndez of Elche, Elche 03202, Spain. Electronic address: alba.roman01@goumh.umh.es","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037134228","display_name":"Eduardo Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-7052-6011"},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Fern\u00e1ndez","raw_affiliation_strings":["Neuroprosthesis and Visual Rehabilitation Laboratory, Bioengineering Institute, University Miguel Hern\u00e1ndez of Elche, Elche 03202, Spain; Biomedical Research Network Center (CIBER-BBN), Madrid 28029, Spain. Electronic address: e.fernandez@umh.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprosthesis and Visual Rehabilitation Laboratory, Bioengineering Institute, University Miguel Hern\u00e1ndez of Elche, Elche 03202, Spain; Biomedical Research Network Center (CIBER-BBN), Madrid 28029, Spain. Electronic address: e.fernandez@umh.es","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063483625","display_name":"Gema Mart\u0131\u0301nez","orcid":"https://orcid.org/0000-0002-9795-2846"},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gema Mart\u00ednez-Navarrete","raw_affiliation_strings":["Neuroprosthesis and Visual Rehabilitation Laboratory, Bioengineering Institute, University Miguel Hern\u00e1ndez of Elche, Elche 03202, Spain; Institute for Health and Biomedical Research (ISABIAL), Alicante 03010, Spain. Electronic address: gema.martinezn@umh.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprosthesis and Visual Rehabilitation Laboratory, Bioengineering Institute, University Miguel Hern\u00e1ndez of Elche, Elche 03202, Spain; Institute for Health and Biomedical Research (ISABIAL), Alicante 03010, Spain. Electronic address: gema.martinezn@umh.es","institution_ids":["https://openalex.org/I111262870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061426020"],"corresponding_institution_ids":["https://openalex.org/I111262870"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":{"value":2960,"currency":"USD","value_usd":2960},"fwci":1.5232,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86228407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"120","issue":"Pt 1","first_page":"108788","last_page":"108788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.5638999938964844,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.5638999938964844,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.16030000150203705,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5770999789237976},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.5649999976158142},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5347999930381775},{"id":"https://openalex.org/keywords/macular-degeneration","display_name":"Macular degeneration","score":0.5317999720573425},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.46540001034736633},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.46209999918937683},{"id":"https://openalex.org/keywords/drug-design","display_name":"Drug design","score":0.45350000262260437},{"id":"https://openalex.org/keywords/rational-design","display_name":"Rational design","score":0.4505000114440918},{"id":"https://openalex.org/keywords/aflibercept","display_name":"Aflibercept","score":0.4417000114917755}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5781000256538391},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5770999789237976},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.5649999976158142},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5347999930381775},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.5317999720573425},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.46540001034736633},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46209999918937683},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45820000767707825},{"id":"https://openalex.org/C192071366","wikidata":"https://www.wikidata.org/wiki/Q2991682","display_name":"Drug design","level":2,"score":0.45350000262260437},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.4505000114440918},{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.4417000114917755},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.41780000925064087},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.3955000042915344},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.3896999955177307},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.3822000026702881},{"id":"https://openalex.org/C2780929884","wikidata":"https://www.wikidata.org/wiki/Q737460","display_name":"Blindness","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33869999647140503},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.32359999418258667},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.32269999384880066},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C2780430158","wikidata":"https://www.wikidata.org/wiki/Q7685902","display_name":"Target protein","level":3,"score":0.3059999942779541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29679998755455017},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2953000068664551},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C126061179","wikidata":"https://www.wikidata.org/wiki/Q189627","display_name":"van der Waals force","level":3,"score":0.28130000829696655},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.26739999651908875},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.25}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2025.108788","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2025.108788","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:41265309","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41265309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.compbiolchem.2025.108788","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2025.108788","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1778093014","display_name":null,"funder_award_id":"FPU231/04360","funder_id":"https://openalex.org/F4320321864","funder_display_name":"Generalitat Valenciana"},{"id":"https://openalex.org/G6544587925","display_name":null,"funder_award_id":"PID2022- 141606OB-I00","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8084826230","display_name":null,"funder_award_id":"PDC2022-133952-100","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8258730580","display_name":null,"funder_award_id":"CIPROM/2023/25","funder_id":"https://openalex.org/F4320321864","funder_display_name":"Generalitat Valenciana"},{"id":"https://openalex.org/G8310920753","display_name":null,"funder_award_id":"PDC2022\\u2013133952\\u2013100","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1887310754","https://openalex.org/W1948562438","https://openalex.org/W1985043086","https://openalex.org/W2004196006","https://openalex.org/W2009964074","https://openalex.org/W2062594120","https://openalex.org/W2093044616","https://openalex.org/W2103210604","https://openalex.org/W2129434797","https://openalex.org/W2132629607","https://openalex.org/W2146980524","https://openalex.org/W2376573086","https://openalex.org/W2512372054","https://openalex.org/W2734721636","https://openalex.org/W2751260413","https://openalex.org/W2804822363","https://openalex.org/W2903574414","https://openalex.org/W2987335406","https://openalex.org/W3185197558","https://openalex.org/W4200587227","https://openalex.org/W4285494768","https://openalex.org/W4294908254","https://openalex.org/W4307380505","https://openalex.org/W4391360858","https://openalex.org/W4399437467","https://openalex.org/W4399731408","https://openalex.org/W4406606431","https://openalex.org/W4407723275","https://openalex.org/W4410473472"],"related_works":[],"abstract_inverted_index":{"Vascular":[0],"endothelial":[1],"growth":[2],"factor":[3],"A":[4],"(VEGF-A)":[5],"is":[6],"the":[7,15,47,101,194,225,231],"main":[8],"driver":[9],"of":[10,34,53,87,174,183,196,227,234],"pathological":[11],"angiogenesis":[12],"and":[13,64,74,91,112,125,144,199,220,230,240],"represents":[14],"primary":[16],"therapeutic":[17,149],"target":[18],"in":[19,50,85],"neovascular":[20],"age-related":[21],"macular":[22],"degeneration":[23],"(nAMD).":[24],"Several":[25],"anti-VEGF":[26,57,207,236],"agents":[27,237],"are":[28],"currently":[29],"available,":[30],"but":[31,138],"systematic":[32,191],"comparisons":[33],"their":[35],"molecular":[36,71,201],"interactions":[37,84,129,166],"with":[38,187],"VEGF-A":[39,143,152],"remain":[40],"limited.":[41],"In":[42],"this":[43],"study,":[44],"we":[45],"performed":[46],"first":[48],"integrated":[49],"silico":[51],"evaluation":[52],"six":[54],"clinically":[55],"relevant":[56],"drugs:":[58],"abicipar,":[59],"aflibercept,":[60],"bevacizumab,":[61],"brolucizumab,":[62],"faricimab,":[63],"ranibizumab.":[65],"Structural":[66],"modeling,":[67],"residue":[68],"conservation":[69,198],"analysis,":[70],"docking":[72],"(HADDOCK),":[73],"binding":[75,136],"affinity":[76],"prediction":[77],"(PRODIGY)":[78],"were":[79,167],"employed":[80],"to":[81,223],"assess":[82],"drug-VEGF-A":[83],"terms":[86],"stability,":[88],"energetic":[89],"contributions,":[90],"key":[92],"conserved":[93,116],"residues.":[94,117],"Our":[95],"results":[96],"showed":[97],"that":[98,214],"bevacizumab":[99],"exhibited":[100],"most":[102],"stable":[103],"interaction":[104],"profile,":[105],"dominated":[106],"by":[107,114],"van":[108],"der":[109],"Waals":[110],"forces":[111],"supported":[113],"highly":[115],"Aflibercept":[118],"displayed":[119],"strong":[120],"electrostatic":[121],"stabilization,":[122],"while":[123],"ranibizumab":[124],"brolucizumab":[126],"achieved":[127],"robust":[128],"through":[130],"mixed":[131],"forces.":[132],"Faricimab":[133],"presented":[134],"weaker":[135],"stability":[137,157,176],"its":[139,148],"dual-target":[140],"mechanism,":[141],"involving":[142],"angiopoietin-2,":[145],"may":[146],"extend":[147],"efficacy":[150],"beyond":[151],"inhibition.":[153],"Abicipar":[154],"demonstrated":[155],"favorable":[156],"despite":[158],"structural":[159],"differences":[160],"from":[161],"conventional":[162],"antibodies.":[163],"Notably,":[164],"hydrophobic":[165],"consistently":[168],"identified":[169],"as":[170,203],"a":[171,218],"central":[172],"determinant":[173],"complex":[175],"across":[177],"all":[178],"drugs,":[179],"whereas":[180],"an":[181],"excess":[182],"charged":[184],"residues":[185],"correlated":[186],"reduced":[188],"affinity.":[189],"This":[190],"analysis":[192],"highlights":[193],"coexistence":[195],"evolutionary":[197],"rational":[200,232],"engineering":[202],"complementary":[204],"strategies":[205],"shaping":[206],"drug":[208],"performance.":[209],"Overall,":[210],"our":[211],"findings":[212],"demonstrate":[213],"computational":[215],"modeling":[216],"offers":[217],"cost-effective":[219],"predictive":[221],"tool":[222],"guide":[224],"optimization":[226],"current":[228],"therapies":[229],"design":[233],"next-generation":[235],"for":[238],"nAMD":[239],"other":[241],"retinal":[242],"vascular":[243],"disorders.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-01-20T17:24:06.736184","created_date":"2025-11-20T00:00:00"}