{"id":"https://openalex.org/W4409450024","doi":"https://doi.org/10.1016/j.compbiolchem.2025.108466","title":"PathwayMind: An innovative tool and database for pathway perturbation analysis, uncovering critical pathways for drugs and target protein sets","display_name":"PathwayMind: An innovative tool and database for pathway perturbation analysis, uncovering critical pathways for drugs and target protein sets","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409450024","doi":"https://doi.org/10.1016/j.compbiolchem.2025.108466","pmid":"https://pubmed.ncbi.nlm.nih.gov/40250332"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2025.108466","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2025.108466","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079994412","display_name":"O. P. Sharma","orcid":"https://orcid.org/0000-0003-3506-4752"},"institutions":[{"id":"https://openalex.org/I4210126694","display_name":"Cardiovascular Center Frankfurt","ror":"https://ror.org/03e2b2m72","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210126694"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Om Prakash Sharma","raw_affiliation_strings":["Partex N.V, Frankfurter Str. 27, Eschborn, 65760, Germany. Electronic address: ombioinfo@gmail.com"],"affiliations":[{"raw_affiliation_string":"Partex N.V, Frankfurter Str. 27, Eschborn, 65760, Germany. Electronic address: ombioinfo@gmail.com","institution_ids":["https://openalex.org/I4210126694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079994412"],"corresponding_institution_ids":["https://openalex.org/I4210126694"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":0.8734,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72374851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"118","issue":null,"first_page":"108466","last_page":"108466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"Pathway analysis","score":0.5918872356414795},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5010604858398438},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49225226044654846},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.4481489062309265},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3138303756713867},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21379512548446655},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15211758017539978}],"concepts":[{"id":"https://openalex.org/C2779230013","wikidata":"https://www.wikidata.org/wiki/Q25303877","display_name":"Pathway analysis","level":4,"score":0.5918872356414795},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5010604858398438},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49225226044654846},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.4481489062309265},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3138303756713867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21379512548446655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15211758017539978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2025.108466","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2025.108466","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:40250332","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40250332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W74841586","https://openalex.org/W87675469","https://openalex.org/W1970006885","https://openalex.org/W1982428412","https://openalex.org/W2020413892","https://openalex.org/W2028133290","https://openalex.org/W2031421819","https://openalex.org/W2037442572","https://openalex.org/W2038252445","https://openalex.org/W2042656127","https://openalex.org/W2049069843","https://openalex.org/W2051083170","https://openalex.org/W2051448304","https://openalex.org/W2061475404","https://openalex.org/W2063493723","https://openalex.org/W2105734437","https://openalex.org/W2106391842","https://openalex.org/W2110687686","https://openalex.org/W2110762994","https://openalex.org/W2111065008","https://openalex.org/W2113624587","https://openalex.org/W2128601422","https://openalex.org/W2157646380","https://openalex.org/W2163500926","https://openalex.org/W2165253681","https://openalex.org/W2165681080","https://openalex.org/W2288766329","https://openalex.org/W2332255734","https://openalex.org/W2332308455","https://openalex.org/W2537220355","https://openalex.org/W2557530941","https://openalex.org/W2558585189","https://openalex.org/W2595827275","https://openalex.org/W2735725443","https://openalex.org/W2749464300","https://openalex.org/W2800698537","https://openalex.org/W2886907366","https://openalex.org/W2898946138","https://openalex.org/W2910649981","https://openalex.org/W2919041616","https://openalex.org/W2966775399","https://openalex.org/W2969609247","https://openalex.org/W2979832776","https://openalex.org/W2981350712","https://openalex.org/W2983567120","https://openalex.org/W2986995081","https://openalex.org/W2996865998","https://openalex.org/W3010060875","https://openalex.org/W3093053585","https://openalex.org/W3094495363","https://openalex.org/W3137864305","https://openalex.org/W3210261039","https://openalex.org/W3217134861","https://openalex.org/W4213094331","https://openalex.org/W4225254767","https://openalex.org/W4285605236","https://openalex.org/W4290973443","https://openalex.org/W4291021611","https://openalex.org/W4294216483","https://openalex.org/W4297387438","https://openalex.org/W4313299691","https://openalex.org/W4376131110","https://openalex.org/W4377088065","https://openalex.org/W4386034846","https://openalex.org/W4386929087","https://openalex.org/W4388034160","https://openalex.org/W4388237485","https://openalex.org/W4389563588","https://openalex.org/W4390537804","https://openalex.org/W4390726926","https://openalex.org/W4391174578","https://openalex.org/W4391682234","https://openalex.org/W4403398955","https://openalex.org/W6696256432","https://openalex.org/W6702859070","https://openalex.org/W6768806997","https://openalex.org/W6804790254","https://openalex.org/W6861771932","https://openalex.org/W6873147562"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2119683611","https://openalex.org/W2151866902","https://openalex.org/W2794999358"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}