{"id":"https://openalex.org/W4401609970","doi":"https://doi.org/10.1016/j.compbiolchem.2024.108173","title":"Probing the effects of single point mutations in the GKWWRPS motif on the PNAIG motif within Loop 2 of sclerostin (SOST) using in-silico techniques","display_name":"Probing the effects of single point mutations in the GKWWRPS motif on the PNAIG motif within Loop 2 of sclerostin (SOST) using in-silico techniques","publication_year":2024,"publication_date":"2024-08-15","ids":{"openalex":"https://openalex.org/W4401609970","doi":"https://doi.org/10.1016/j.compbiolchem.2024.108173","pmid":"https://pubmed.ncbi.nlm.nih.gov/39182248"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2024.108173","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1016/j.compbiolchem.2024.108173","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011262199","display_name":"Mazumder Adhish","orcid":"https://orcid.org/0000-0001-5202-2904"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mazumder Adhish","raw_affiliation_strings":["School of Bio Sciences and Technology, Vellore Institute of Technology,\u00a0Vellore,\u00a0Tamil Nadu,\u00a0India"],"raw_orcid":"https://orcid.org/0000-0001-5202-2904","affiliations":[{"raw_affiliation_string":"School of Bio Sciences and Technology, Vellore Institute of Technology,\u00a0Vellore,\u00a0Tamil Nadu,\u00a0India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007657551","display_name":"I. Manjubala","orcid":"https://orcid.org/0000-0003-4873-2377"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"I. Manjubala","raw_affiliation_strings":["School of Bio Sciences and Technology, Vellore Institute of Technology,\u00a0Vellore,\u00a0Tamil Nadu,\u00a0India. Electronic address: i.manjubala@vit.ac.in"],"raw_orcid":"https://orcid.org/0000-0003-4873-2377","affiliations":[{"raw_affiliation_string":"School of Bio Sciences and Technology, Vellore Institute of Technology,\u00a0Vellore,\u00a0Tamil Nadu,\u00a0India. Electronic address: i.manjubala@vit.ac.in","institution_ids":["https://openalex.org/I876193797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007657551"],"corresponding_institution_ids":["https://openalex.org/I876193797"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":0.668,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6910493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"112","issue":null,"first_page":"108173","last_page":"108173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12991","display_name":"Phytase and its Applications","score":0.9682000279426575,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9592000246047974,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sclerostin","display_name":"Sclerostin","score":0.9261229038238525},{"id":"https://openalex.org/keywords/wnt-signaling-pathway","display_name":"Wnt signaling pathway","score":0.6953648924827576},{"id":"https://openalex.org/keywords/motif","display_name":"Motif (music)","score":0.5619577169418335},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5545368790626526},{"id":"https://openalex.org/keywords/lrp6","display_name":"LRP6","score":0.44130054116249084},{"id":"https://openalex.org/keywords/structural-motif","display_name":"Structural motif","score":0.43655213713645935},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35266345739364624},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.336540162563324},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.32703202962875366},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22249501943588257},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1967569887638092}],"concepts":[{"id":"https://openalex.org/C2779277721","wikidata":"https://www.wikidata.org/wiki/Q14887295","display_name":"Sclerostin","level":4,"score":0.9261229038238525},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6953648924827576},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.5619577169418335},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5545368790626526},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.44130054116249084},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.43655213713645935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35266345739364624},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.336540162563324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32703202962875366},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22249501943588257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1967569887638092},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2024.108173","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1016/j.compbiolchem.2024.108173","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:39182248","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39182248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322838","display_name":"VIT University","ror":"https://ror.org/00qzypv28"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1987193623","https://openalex.org/W2008314623","https://openalex.org/W2022121540","https://openalex.org/W2031101869","https://openalex.org/W2058909883","https://openalex.org/W2064488723","https://openalex.org/W2070506154","https://openalex.org/W2079790359","https://openalex.org/W2103459989","https://openalex.org/W2109513041","https://openalex.org/W2112292482","https://openalex.org/W2161062388","https://openalex.org/W2318001017","https://openalex.org/W2376573086","https://openalex.org/W2486258756","https://openalex.org/W2572080171","https://openalex.org/W2615841538","https://openalex.org/W2751476102","https://openalex.org/W2757428726","https://openalex.org/W2804822363","https://openalex.org/W2905495415","https://openalex.org/W2925676074","https://openalex.org/W2952013151","https://openalex.org/W2952023095","https://openalex.org/W2952900264","https://openalex.org/W2962786907","https://openalex.org/W2970386399","https://openalex.org/W3083008290","https://openalex.org/W3093680570","https://openalex.org/W3096176303","https://openalex.org/W3104285666","https://openalex.org/W3160513191","https://openalex.org/W4205581322","https://openalex.org/W4210570312","https://openalex.org/W4280524829","https://openalex.org/W4280576249","https://openalex.org/W4296963484","https://openalex.org/W4309210771","https://openalex.org/W4386084499","https://openalex.org/W4386827278","https://openalex.org/W4391029926","https://openalex.org/W6699619691","https://openalex.org/W6783732215","https://openalex.org/W6786108293","https://openalex.org/W6856320672"],"related_works":["https://openalex.org/W2055808176","https://openalex.org/W3128547036","https://openalex.org/W2106281886","https://openalex.org/W4206653363","https://openalex.org/W2155308439","https://openalex.org/W2107825767","https://openalex.org/W4321597908","https://openalex.org/W4248106857","https://openalex.org/W2022351074","https://openalex.org/W2515900121"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-02-03T00:53:05.648605","created_date":"2025-10-10T00:00:00"}