{"id":"https://openalex.org/W2912769394","doi":"https://doi.org/10.1016/j.compbiolchem.2019.02.003","title":"Identification and structural characterization of deleterious non-synonymous single nucleotide polymorphisms in the human SKP2 gene","display_name":"Identification and structural characterization of deleterious non-synonymous single nucleotide polymorphisms in the human SKP2 gene","publication_year":2019,"publication_date":"2019-02-14","ids":{"openalex":"https://openalex.org/W2912769394","doi":"https://doi.org/10.1016/j.compbiolchem.2019.02.003","mag":"2912769394","pmid":"https://pubmed.ncbi.nlm.nih.gov/30802828"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2019.02.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2019.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014020489","display_name":"S. M. Zahid Hosen","orcid":"https://orcid.org/0000-0001-5789-3418"},"institutions":[{"id":"https://openalex.org/I17404232","display_name":"Bangladesh Council of Scientific and Industrial Research","ror":"https://ror.org/03njdre41","country_code":"BD","type":"government","lineage":["https://openalex.org/I17404232"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"S.M. Zahid Hosen","raw_affiliation_strings":["Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh. Electronic address: smzahidhosen@bcsir.gov.bd","Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh. Electronic address: smzahidhosen@bcsir.gov.bd","institution_ids":[]},{"raw_affiliation_string":"Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh","institution_ids":["https://openalex.org/I17404232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086415841","display_name":"Raju Dash","orcid":"https://orcid.org/0000-0003-4128-5308"},"institutions":[{"id":"https://openalex.org/I17404232","display_name":"Bangladesh Council of Scientific and Industrial Research","ror":"https://ror.org/03njdre41","country_code":"BD","type":"government","lineage":["https://openalex.org/I17404232"]},{"id":"https://openalex.org/I91090688","display_name":"University of Science and Technology Chittagong","ror":"https://ror.org/00w9tx359","country_code":"BD","type":"education","lineage":["https://openalex.org/I91090688"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Raju Dash","raw_affiliation_strings":["Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh; Department of Biochemistry and Biotechnology, University of Science & Technology Chittagong, Chittagong, 4202, Bangladesh. Electronic address: rajudash.bgctub@gmail.com","Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh","Department of Biochemistry and Biotechnology, University of Science & Technology Chittagong, Chittagong, 4202, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh; Department of Biochemistry and Biotechnology, University of Science & Technology Chittagong, Chittagong, 4202, Bangladesh. Electronic address: rajudash.bgctub@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh","institution_ids":["https://openalex.org/I17404232"]},{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, University of Science & Technology Chittagong, Chittagong, 4202, Bangladesh","institution_ids":["https://openalex.org/I91090688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091851715","display_name":"Md. Junaid","orcid":"https://orcid.org/0000-0003-3588-4937"},"institutions":[{"id":"https://openalex.org/I17404232","display_name":"Bangladesh Council of Scientific and Industrial Research","ror":"https://ror.org/03njdre41","country_code":"BD","type":"government","lineage":["https://openalex.org/I17404232"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Junaid","raw_affiliation_strings":["Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh. Electronic address: md.junaid@northsouth.edu","Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh. Electronic address: md.junaid@northsouth.edu","institution_ids":[]},{"raw_affiliation_string":"Molecular Modeling and Drug Design Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong, 4220, Bangladesh","institution_ids":["https://openalex.org/I17404232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057988421","display_name":"Sarmistha Mitra","orcid":"https://orcid.org/0000-0003-1554-2710"},"institutions":[{"id":"https://openalex.org/I894293524","display_name":"University of Chittagong","ror":"https://ror.org/01173vs27","country_code":"BD","type":"education","lineage":["https://openalex.org/I894293524"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Sarmistha Mitra","raw_affiliation_strings":["Department of Pharmacy, University of Chittagong, Chittagong, 4331, Bangladesh. Electronic address: sarmisthacu@gmail.com","Department of Pharmacy, University of Chittagong, Chittagong, 4331, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Chittagong, Chittagong, 4331, Bangladesh. Electronic address: sarmisthacu@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, University of Chittagong, Chittagong, 4331, Bangladesh","institution_ids":["https://openalex.org/I894293524"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073926489","display_name":"Nurul Absar","orcid":"https://orcid.org/0000-0001-9284-366X"},"institutions":[{"id":"https://openalex.org/I91090688","display_name":"University of Science and Technology Chittagong","ror":"https://ror.org/00w9tx359","country_code":"BD","type":"education","lineage":["https://openalex.org/I91090688"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Nurul Absar","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, University of Science & Technology Chittagong, Chittagong, 4202, Bangladesh. Electronic address: nurul_ustc@yahoo.com","Department of Biochemistry and Biotechnology, University of Science & Technology Chittagong, Chittagong, 4202, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, University of Science & Technology Chittagong, Chittagong, 4202, Bangladesh. Electronic address: nurul_ustc@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, University of Science & Technology Chittagong, Chittagong, 4202, Bangladesh","institution_ids":["https://openalex.org/I91090688"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086415841"],"corresponding_institution_ids":["https://openalex.org/I17404232","https://openalex.org/I91090688"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":1.4491,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.81615129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"79","issue":null,"first_page":"127","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6497327089309692},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6395061016082764},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.5154012441635132},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4958890378475189},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49103283882141113},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4417306184768677},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.42350879311561584},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4119589328765869},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.09333804249763489},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08226278424263}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6497327089309692},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6395061016082764},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5154012441635132},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4958890378475189},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49103283882141113},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4417306184768677},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.42350879311561584},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4119589328765869},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09333804249763489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08226278424263},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2019.02.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2019.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:30802828","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30802828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W241954630","https://openalex.org/W596614133","https://openalex.org/W1501553911","https://openalex.org/W1794063461","https://openalex.org/W1803102843","https://openalex.org/W1844335036","https://openalex.org/W1963514652","https://openalex.org/W1965205650","https://openalex.org/W1970430170","https://openalex.org/W1970779989","https://openalex.org/W1970858946","https://openalex.org/W1971641482","https://openalex.org/W1972780353","https://openalex.org/W1975459052","https://openalex.org/W1976757212","https://openalex.org/W1978427005","https://openalex.org/W1981895515","https://openalex.org/W1989228404","https://openalex.org/W1996779865","https://openalex.org/W2000285874","https://openalex.org/W2000559685","https://openalex.org/W2005614916","https://openalex.org/W2005962907","https://openalex.org/W2006061805","https://openalex.org/W2008708467","https://openalex.org/W2010820325","https://openalex.org/W2013257331","https://openalex.org/W2014446996","https://openalex.org/W2029667189","https://openalex.org/W2030923410","https://openalex.org/W2031150801","https://openalex.org/W2033350048","https://openalex.org/W2034048174","https://openalex.org/W2039878336","https://openalex.org/W2043429868","https://openalex.org/W2044182846","https://openalex.org/W2049706724","https://openalex.org/W2050373746","https://openalex.org/W2053126349","https://openalex.org/W2053349968","https://openalex.org/W2053579714","https://openalex.org/W2054529399","https://openalex.org/W2057659399","https://openalex.org/W2059145105","https://openalex.org/W2059607531","https://openalex.org/W2060259273","https://openalex.org/W2065825739","https://openalex.org/W2066614521","https://openalex.org/W2069197202","https://openalex.org/W2069337540","https://openalex.org/W2077680681","https://openalex.org/W2080039356","https://openalex.org/W2083799886","https://openalex.org/W2092591319","https://openalex.org/W2093847279","https://openalex.org/W2099564671","https://openalex.org/W2099589970","https://openalex.org/W2102993309","https://openalex.org/W2105323766","https://openalex.org/W2107482866","https://openalex.org/W2109372707","https://openalex.org/W2111427849","https://openalex.org/W2113002325","https://openalex.org/W2113623846","https://openalex.org/W2114886480","https://openalex.org/W2120230374","https://openalex.org/W2122732537","https://openalex.org/W2126609323","https://openalex.org/W2129069543","https://openalex.org/W2132589721","https://openalex.org/W2133641393","https://openalex.org/W2136513422","https://openalex.org/W2137924973","https://openalex.org/W2140247386","https://openalex.org/W2141481588","https://openalex.org/W2143238378","https://openalex.org/W2144015056","https://openalex.org/W2146983134","https://openalex.org/W2147544357","https://openalex.org/W2149195137","https://openalex.org/W2149592671","https://openalex.org/W2151756204","https://openalex.org/W2154319440","https://openalex.org/W2155666314","https://openalex.org/W2157122545","https://openalex.org/W2160451368","https://openalex.org/W2163721943","https://openalex.org/W2166208462","https://openalex.org/W2195303995","https://openalex.org/W2197257753","https://openalex.org/W2263648159","https://openalex.org/W2317146808","https://openalex.org/W2321673549","https://openalex.org/W2323104785","https://openalex.org/W2329078689","https://openalex.org/W2376573086","https://openalex.org/W2396129229","https://openalex.org/W2401241322","https://openalex.org/W2412985347","https://openalex.org/W2470337509","https://openalex.org/W2554136312","https://openalex.org/W2596093293","https://openalex.org/W2601530585","https://openalex.org/W2605068739","https://openalex.org/W2782733462","https://openalex.org/W4210767115","https://openalex.org/W4234821155","https://openalex.org/W4235610632"],"related_works":["https://openalex.org/W2155835698","https://openalex.org/W2076096978","https://openalex.org/W2094337488","https://openalex.org/W2350587855","https://openalex.org/W2044028228","https://openalex.org/W2047730886","https://openalex.org/W2034103052","https://openalex.org/W1593875065","https://openalex.org/W4240785775","https://openalex.org/W2027223071"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
